检索结果-南通市图书馆

Chinese Journal of Natural Medicines 2021年第12期19卷 954-960页

作者： QIAN Zheng-Ming WU Zi HUANG Qi WANG Chuan-Xi TAN Guo-Yin LI Wen-Jia SUN Wan-Yang lv gen-pin GAO Hao Institute of Traditional Chinese Medicine and Natural Products College of PharmacyJinan UniversityGuangzhou 510632China Ruyuan HEC Pharm Co. Ltd.Shaoguan 512700China

An eco-friendly and fast HPLC method was developed for the determination of adenosine, inosine, guanosine and uridine in Cordyceps and related products(fermented mycelia of Hirsutella sinensis and Paecilomyces hepiali). The sample was ultrasonically extracted using 0.5% phosphoric acid solutions for 2.5 min. Sample separation was performed on a Poroshell SB-Aq column(50 mm × 4.6 mm, 2.7 μm) using eco-friendly mobile phase consisting of formic acid and ammonium formate aqueous solution at a flow rate of 1.0 m L·min;. The detection wavelength was 260 nm. The developed HPLC method showed good linearity with correlation coefficients of 1.0000 in the test range. Good precision, repeatability and stability of this method were also observed(RSD ≤ 2.81%).The recovery ranged from 91.84%-105.19%(RSD ≤ 2.59%). Compared with reported methods, the current method did not use harmful organic solvent and took only 10.5 min. It obtained a high eco-score of 91 by the "Analytical Eco-Scale" tool. The developed method is eco-friendly and fast, which is suitable for the quality evaluation of Cordyceps and related products.

关键词： Adenosine Inosine Guanosine Uridine Cordyceps

Infection with SARS-CoV-2 can cause pancreatic impairment

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第5期9卷 2143-2160页

作者： Wei Deng Linlin Bao Zhiqi Song Ling Zhang pin Yu Yanfeng Xu Jue Wang Wenjie Zhao Xiuqin Zhang Yunlin Han Yanhong Li Jiangning Liu Qi lv Xujian Liang Fengdi Li Feifei Qi Ran Deng Siyuan Wang Yibai Xiong Ruiping Xiao Hongyang Wang Chuan Qin NHC Key Laboratory of Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China Institute of Molecular Medicine College of Future TechnologyPeking UniversityBeijing 100871China Beijing Key Laboratory of Cardiometabolic Molecular Medicine Peking UniversityBeijing 100871China State Key Laboratory of Biomembrane and Membrane Biotechnology Peking-Tsinghua Center for Life SciencesBeijing 100871China Chinese Academy of Engineering Eastern Hepatobiliary Surgery Hospital225 Changhai RoadYangpu DistrictShanghai 200438China International Co-operation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery InstituteSecond Military Medical UniversityShanghai 200438PR China National Laboratory for Oncogenes and Related genes Cancer Institute of Shanghai Jiao Tong UniversityShanghai 200441PR China Changping National laboratory(CPNL) Beijing 102206China State Key Laboratory of Respiratory Health and Multimorbidity National Health Commission of the People’s Republic of ChinaBeijingPR China

Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction and an even higher risk of the occurrence of diabetes.Herein,we retrospectively analyzed pancreatic lesions in autopsy tissues from 67 SARS-CoV-2 infected non-human primates(NHPs)models and 121 vaccinated and infected NHPs from 2020 to 2023 and COVID-19 patients.Multi-label immunofluorescence revealed direct infection of both exocrine and endocrine pancreatic cells by the virus in NHPs and humans.Minor and limited phenotypic and histopathological changes were observed in adult models.Systemic proteomics and metabolomics results indicated metabolic disorders,mainly enriched in insulin resistance pathways,in infected adult NHPs,along with elevated fasting C-peptide and C-peptide/glucose ratio levels.Furthermore,in elder COVID-19 NHPs,SARS-CoV-2 infection causes loss of beta(β)cells and lower expressed-insulin in situ characterized by islet amyloidosis and necrosis,activation ofα-SMA and aggravated fibrosis consisting of lower collagen in serum,an increase of pancreatic inflammation and stress markers,ICAM-1 and G3BP1,along with more severe glycometabolic dysfunction.In contrast,vaccination maintained glucose homeostasis by activating insulin receptorαand insulin receptorβ.Overall,the cumulative risk of diabetes post-COVID-19 is closely tied to age,suggesting more attention should be paid to blood sugar management in elderly COVID-19 patients.

关键词： infected elevated homeostasis

基于核壳型亲水作用色谱技术同时测定冬虫夏草中核苷和糖醇类成分的含量

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

环境昆虫学报 2022年第2期44卷 491-498页

作者：钱正明周妙霞方琼谜温宝庆李文佳吕根品李文庆暨南大学药学院广州510632 乳源东阳光药业有限公司广东韶关512721 东莞市东阳光冬虫夏草研发有限公司广东东莞523850

核苷和糖醇类成分是冬虫夏草Ophiocordyceps sinensis中两类重要的活性成分,常被作为冬虫夏草质量的评价指标。本研究采用核壳型亲水作用色谱柱技术,建立同时测定冬虫夏草中核苷和糖醇类成分含量的快速液相色谱分析方法。结果表明,在8 ... 详细信息

核苷和糖醇类成分是冬虫夏草Ophiocordyceps sinensis中两类重要的活性成分,常被作为冬虫夏草质量的评价指标。本研究采用核壳型亲水作用色谱柱技术,建立同时测定冬虫夏草中核苷和糖醇类成分含量的快速液相色谱分析方法。结果表明,在8 min内尿苷、腺苷、肌苷、鸟苷和甘露醇均实现基线分离,且各成分线性关系良好,日内精密度、日间精密度和重复性均小于3%,平均回收率在99.0%~106.1%,供试品溶液在24 h内稳定。20批冬虫夏草的尿苷、腺苷、肌苷、鸟苷和甘露醇含量与文献报道结果基本一致。本研究建立的方法快速、准确、可靠,可用于冬虫夏草核苷和糖醇类成分的同时测定。

关键词：冬虫夏草核苷糖醇核壳型亲水作用色谱同时测定

Magnetism, heat capacity, magnetocaloric effect, and magneto-transport properties of heavy fermion antiferromagnet CeGaSi

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第6期33卷 495-502页

作者：张黎博董庆新白建利刘乔宇程靖雯李存东刘品宇孙英睿黄宇任治安陈根富 Institute of Physics and Beijing National Laboratory for Condensed Matter Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China

We synthesize high-quality single crystal of CeGaSi by a Ga self-flux method and investigate its physical properties through magnetic susceptibility,specific heat and electrical resistivity measurements as well as high pressure effect.Magnetic measurements reveal that an antiferromagnetic order develops below T_(m)~10.4 K with magnetic moments orientated in the ab plane.The enhanced electronic specific heat coefficient and the negative logarithmic slope in the resistivity of CeGaSi indicate that the title compound belongs to the family of Kondo system with heavy fermion ground states.The max magnetic entropy change-ΔS_(M)^(max)(μ_(0)H⊥c,μ_(0)H=7 T) around T_(m) is found to reach up to 11.85 J·kg^(-1)·K^(-1).Remarkably,both the antiferromagnetic transition temperature and-ln T behavior increase monotonically with pressure applied to 20 kbar(1 bar=10~5 Pa),indicating that much higher pressure will be needed to reach its quantum critical point.

关键词： heavy fermion antiferromagnetic order magnetocaloric effect

Effective transmittance of Fabry–Perot cavity under non-parallel beam incidence

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第1期33卷 449-457页

作者：吕寅生谢品华徐晋李友涛张华荣 School of Environmental Science and Optoelectronic Technology University of Science and Technology of ChinaHefei 230026China Key Laboratory of Environment Optics and Technology Anhui Institute of Optics and Fine MechanicsHFIPSChinese Academy of SciencesHefei 230031China University of Chinese Academy of Sciences Beijing 100049China

The Fabry–Perot(FP) resonant cavity is widely used in laser and spectroscopic measurements due to its unique interference transfer function(ITF). In the ideal case of parallel incident light, the ITF of the FP resonant cavity can be expressed by the Airy function. However, in reality, it is difficult to achieve perfect parallelism with collimated beams. In this article, a theoretical model is established for non-parallel light incidence, which assumes that the non-parallel incident light is a cone-shaped beam, and the cone angle is used to quantify the non-parallelism of the beam. The transmittance function of the FP resonant cavity under non-parallel light incidence is derived. The accuracy of the model is experimentally verified. Based on this model, the effects of divergence angle, tilt angle and FP cavity parameters(reflectivity, cavity length)on the ITF are studied. The reasons for the decrease in peak value, broadening and asymmetry of the interference peak under non-parallel light incidence are explained. It is suggested that a fine balance between the interference peak and the collimation effect of the incident light should be considered in the design and application of FP resonant cavities, especially for tilted applications such as angle-scanned spectroscopy. The research results of this article have certain significance for the design and application of FP resonant cavities.

关键词： Fabry–Pérot(FP)resonant cavity interference transfer function Airy function non-parallel beam incidence

基于专利的元宇宙技术发展现状及竞争态势分析

在线全文

学校读者我要写书评

暂无评论

大学图书情报学刊 2024年第2期42卷 59-65页

作者：吕品张璐瑶温州大学体育与健康学院 325035

文章以德温特专利数据作为分析数据源,从技术生命周期、热点技术、核心技术三个方面对元宇宙技术发展现状进行阐述,对比分析主要竞争国家专利申请数量和专利布局、研发主体专利申请数量及综合竞争地位,并根据研究结论就我国如何发展元... 详细信息

文章以德温特专利数据作为分析数据源,从技术生命周期、热点技术、核心技术三个方面对元宇宙技术发展现状进行阐述,对比分析主要竞争国家专利申请数量和专利布局、研发主体专利申请数量及综合竞争地位,并根据研究结论就我国如何发展元宇宙技术提出对策建议。研究结果显示:目前元宇宙技术发展处于快速成长期;热点技术包括数据处理及数据识别类、信息通信类和系统及装置类等;核心技术包括虚拟现实、增强现实、游戏、三维及信息系统等;我国属于技术活跃者,专利活动最高,专利质量不及美国和日本,核心专利申请数量较少,同时专利国际范围较小。分析元宇宙技术发展现状及竞争态势对于国家制定相关产业政策及相关企业进行专利布局具有重要意义。

关键词：元宇宙专利分析技术发展现状竞争态势

香砂六君汤法和辛开苦降法在临床脾胃病论治中的价值分析

在线全文

学校读者我要写书评

暂无评论

中国现代药物应用 2024年第2期18卷 138-140页

作者：许亚嫔洪炳根漳州市芗城区西桥街道社区卫生服务中心 363000

目的分析香砂六君汤法和辛开苦降法在临床脾胃病论治中的价值。方法62例脾胃病患者,以随机数字表法分成香砂组和辛开组,各31例。香砂组以香砂六君汤法治疗,辛开组以辛开苦降法治疗。比较两组患者治疗前后的症状评分及治疗效果。结果治... 详细信息

目的分析香砂六君汤法和辛开苦降法在临床脾胃病论治中的价值。方法62例脾胃病患者,以随机数字表法分成香砂组和辛开组,各31例。香砂组以香砂六君汤法治疗,辛开组以辛开苦降法治疗。比较两组患者治疗前后的症状评分及治疗效果。结果治疗前后的胃胀嗳气、口干口苦、代谢障碍、腹部胀痛评分及总分,两组患者组间比较无显著差异性(P>0.05)。治疗后,香砂组胃胀嗳气、口干口苦、代谢障碍、腹部胀痛评分及总分分别为(21.96±1.55)、(20.36±2.77)、(20.05±3.96)、(21.34±1.95)、(83.76±2.95)分,较本组治疗前(8.52±2.43)、(9.96±1.51)、(11.13±2.68)、(8.05±1.55)、(37.17±2.96)分升高;治疗后,辛开组胃胀嗳气、口干口苦、代谢障碍、腹部胀痛评分及总分分别为(21.50±1.96)、(20.20±2.62)、(19.95±3.36)、(21.22±2.11)、(82.87±2.76)分,较本组治疗前(8.67±2.55)、(10.04±1.34)、(10.96±2.71)、(7.10±5.43)、(37.38±3.15)分升高,两组患者组内相比具有显著差异性(P0.05)。结论香砂六君汤法和辛开苦降法治疗脾胃病患者疗效相当,均可以显著缓解患者症状均为脾胃病治疗中可选择的治疗手段。

关键词：香砂六君汤法辛开苦降法脾胃病临床论治

在线全文

学校读者我要写书评

暂无评论

国外体育治理研究现状与趋势展望

湖北体育科技 2024年第3期43卷 1-8,73页

作者：吕品张璐瑶张朋温州大学体育与健康学院浙江温州325035

目的基于影响力分析和LDA主题模型,总结近年国外体育治理研究现状和主题趋势,为我国体育治理研究领域和方向进展提供参考。方法基于Web of Science数据库检索截止2023年8月的国外体育治理核心文献,使用文献计量法对国外体育治理研究的... 详细信息

目的基于影响力分析和LDA主题模型,总结近年国外体育治理研究现状和主题趋势,为我国体育治理研究领域和方向进展提供参考。方法基于Web of Science数据库检索截止2023年8月的国外体育治理核心文献,使用文献计量法对国外体育治理研究的影响力进行分析,并运用LDA主题模型对文献摘要内容进行主题聚类分析。结果筛选得到374篇文献。近年来国外体育治理研究发文量显著增长,正逐步成为体育领域研究热点并趋于稳定,且研究内容呈现多元化趋势。目前影响力排名前3的国家分别是美国、英国和澳大利亚。国外体育治理研究包括内容为:体育政策与社会发展研究、体育治理权力与主体研究、体育教练员教育相关研究、足球协会经营与治理研究、体育治理与性别研究、体育治理与运动员身体健康研究。

关键词：体育治理体育政策治理权利

Distribution of antibiotic resistance genes and their association with bacteria and viruses in decentralized sewage treatment facilities

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2022年第3期16卷 91-104页

作者： Jiaheng Zhao Bing Li pin lv Jiahui Hou Yong Qiu Xia Huang School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China

The distribution of antibiotic resistance genes(ARGs)has been intensively studied in large-scale wastewater treatment plants and livestock sources.However,small-scale decentralized sewage treatment facilities must also be explored due to their possible direct exposure to residents.In this study,six wastewater treatment facilities in developed rural areas in eastern China were investigated to understand their risks of spreading ARGs.Using metagenomics and network analysis tools,ARGs and bacterial and viral communities were identified in the influent(INF)and effluent(EFF)samples.The dominant ARGs belonged to the bacitracin class,which are different from most of municipal wastewater treatment plants(WWTPs).The dominant hosts of ARGs are Acidovorax in bacterial communities and Prymnesiovirus in viral communities.Furthermore,a positive relationship was found between ARGs and phages.The ARGs significantly correlated with phages were all hosted by specific genera of bacteria,indicating that phages had contributed to the ARG’s proliferation in sewage treatment facilities.Paying significant concern on the possible enhanced risks caused by bacteria,viruses and their related ARGs in decentralized sewage treatment facilities is necessary.

关键词： Decentralized sewage treatment facilities Antibiotic resistance genes Virus Metagenomics Network analysis

Optimization of preparation process of high-strength pellets from Panzhihua ilmenite concentrate

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research(International) 2023年第12期30卷 2391-2402页

作者： Gang-wei Zhou Wei lv Fu-rong Chen Zheng-gen Liu Man-sheng Chu Xue-wei lv School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina College of Materials Science and Engineering Chongqing UniversityChongqing400044China

The preparation of high-strength pellets from Panzhihua ilmenite concentrate is important for the hydrogen-rich smelting of titania slag and was investigated.The effects of the magnetite concentrate and heating procedure including the pre-heating temperature and period as well as roasting temperature and period on the compressive strength of the roasted pellets were investigated.High-strength ilmenite concentrate pellets(>2000 N)were prepared by optimizing the roasting process.The addition of magnetite concentrate is beneficial for increasing the compressive strength of the Panzhihua ilmenite concentrate pellet by oxidizing hematite which filled the pseudobrookite particles,functioned as a bridge bond,and improved the interconnection between the grains.The compressive strength can reach up to 2900 N when the ilmenite concentrate pellet with 15%magnetite concentrate is pre-heated above 800℃ for 20 min and then roasted at 1250℃ for 20 min.In addition,there is an overall upward trend in the compressive strength with an increase in the pre-heating temperature and period as well as the roasting temperature and period.The micromorphology and strengthening consolidation mechanism of Panzhihua ilmenite concentrate pellets were also discussed.

关键词： Ilmenite concentrate Pelletizing Roasting Compressive strength-Pellet