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Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2673-2682页

作者： huang Chen Rui-Ying Jiang Zhan hua Xiao-Wei Wang Xiao-Li Shi Ye Wang Qian-Qian Feng Jie luo Wu Ning Yan-Fen Shi Da-Kui Zhang Bei Wang Jian-Zheng Jie Ding-Rong Zhong Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Gastrointestinal Surgery China-Japan Friendship HospitalBeijing 100029China Department of Scientific Research GeneisBeijing 100012China

BACKGROUND RAS,BRAF,and mismatch repair(MMR)/microsatellite instability(MSI)are crucial biomarkers recommended by clinical practice guidelines for colorectal cancer(CRC).However,their characteristics and influencing factors in Chinese patients have not been thoroughly *** To analyze the clinicopathological features of KRAS,NRAS,BRAF,and PIK3CA mutations and the DNA MMR status in *** We enrolled 2271 Chinese CRC patients at the China-Japan Friendship *** proteins were tested using immunohistochemical analysis,and the KRAS/NRAS/BRAF/PIK3CA mutations were determined using quantitative polymerase chain *** status was determined using an MSI detection *** analyses were conducted using SPSS software and logistic *** The KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 44.6%,3.4%,3.7%,and 3.9% of CRC patients,*** mutations were more likely to occur in patients with moderate-to-high *** mutations were more likely to occur in patients with right-sided CRC,poorly differentiated,or no perineural *** MMR(dMMR)was detected in 7.9% of all patients and 16.8% of those with mucinous ***,NRAS,BRAF,and PIK3CA mutations were detected in 29.6%,1.1%,8.1%,and 22.3% of patients with dMMR,*** dMMR was more likely to occur in patients with a family history of CRC,aged<50 years,right-sided CRC,poorly differentiated histology,no perineural invasion,and with carcinoma in situ,stage I,or stage II *** This study analyzed the molecular profiles of KRAS,NRAS,BRAF,PIK3CA,and MMR/MSI in CRC,identifying key influencing factors,with implications for clinical management of CRC.

关键词： Colorectal cancer Deficient mismatch repair Microsatellite instability Gene mutation Comprehensive analysis

An O(rL)Infeasible Interior-point Algorithm for Symmetric Cone LCP via CHKS Function

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Acta Mathematicae Applicatae Sinica 2009年第4期25卷 593-606页

作者： zi-yan luo Nai-hua Xiu Department of Mathematics School of Science Beijing Jiaotong University Beijing 100044 China Department of Mathematics School of Science Beijing Jiaotong University Key Laboratory of Communication and Information System (Beijing Jiaotong University) Beijing Municipal Commission of Education Beijing 100044 China

In this paper, we propose a theoretical framework of an infeasible interior-point algorithm for solving monotone linear cornplementarity problems over symmetric cones （SCLCP）. The new algorithm gets Newton-like directions from the Chen-Harker-Kanzow-Smale （CHKS） smoothing equation of the SCLCP. It possesses the following features： The starting point is easily chosen; one approximate Newton step is computed and accepted at each iteration; the iterative point with unit stepsize automatically remains in the neighborhood of central path; the iterative sequence is bounded and possesses （9（rL） polynomial-time complexity under the monotonicity and solvability of the SCLCP.

关键词： Infeasible interior-point algorithm symmetric cone linear complementarity problem monotonicity polynomial complexity

Polymer Fiber Rigid Network with High Glass Transition Temperature Reinforces Stability of Organic Photovoltaics

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Nano-Micro Letters 2024年第11期16卷 56-69页

作者： Qiao Zhou Cenqi Yan Hongxiang Li Zhendong Zhu Yujie Gao Jie Xiong hua Tang Can Zhu Hailin Yu Sandra P.Gonzalez Lopez Jiayu Wang Meng Qin Jianshu Li Longbo luo Xiangyang Liu Jiaqiang Qin Shirong Lu Lei Meng Frédéric Laquai Yongfang Li Pei Cheng College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China KAUST Solar Center Physical Science and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)ThuwalKingdom of Saudi Arabia Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Department of Material Science and Technology Taizhou UniversityTaizhou 318000People’s Republic of China

Organic photovoltaics(OPVs)need to overcome limitations such as insufficient thermal stability to be *** reported approaches to improve stability either rely on the development of new materials or on tailoring the donor/acceptor morphology,however,exhibiting limited ***,it is timely to develop an easy method to enhance thermal stability without having to develop new donor/acceptor materials or donor–acceptor compatibilizers,or by introducing another third ***,a unique approach is presented,based on constructing a polymer fiber rigid network with a high glass transition temperature(T_(g))to impede the movement of acceptor and donor molecules,to immobilize the active layer morphology,and thereby to improve thermal stability.A high-T_(g) one-dimensional aramid nanofiber(ANF)is utilized for network *** OPVs with ANF network yield superior thermal stability compared to the ANF-free *** ANF network-incorporated active layer demonstrates significantly more stable morphology than the ANF-free counterpart,thereby leaving fundamental processes such as charge separation,transport,and collection,determining the device efficiency,largely *** strategy is also successfully applied to other photovoltaic *** strategy of incorporating a polymer fiber rigid network with high T_(g) offers a distinct perspective addressing the challenge of thermal instability with simplicity and universality.

关键词： Inverted organic photovoltaics Thermal stability Aramid nanofibers Morphology control Charge carrier dynamics

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超声诊断新生儿非侵入性脐静脉血栓1例

中国临床医学影像杂志 2024年第7期35卷 527-528页

作者：王紫薇罗红四川大学华西第二医院超声科出生缺陷与相关妇儿疾病教育部重点实验室四川成都610041

病例女,2天,因“出生后皮肤黄染”就诊。患儿在胎儿时期产前超声检查脐带无异常,系足月儿胎膜早破经阴道娩出,出生体质量3660 g,Apgar评分为9分(肤色扣1分)-10分-10分,否认出生后抢救史、出生后脐静脉置管史、血栓家族史。母亲仅合并妊... 详细信息

病例女,2天,因“出生后皮肤黄染”就诊。患儿在胎儿时期产前超声检查脐带无异常,系足月儿胎膜早破经阴道娩出,出生体质量3660 g,Apgar评分为9分(肤色扣1分)-10分-10分,否认出生后抢救史、出生后脐静脉置管史、血栓家族史。母亲仅合并妊娠期糖尿病,血型为O型Rh(D)阳性。院外辅助检查:患儿血型为A型Rh(D)阳性,ABO血型系统直接抗人球蛋白试验阳性,游离抗体测定及放散试验均阳性。

关键词：静脉血栓形成超声检查

地理邻近性对专利技术转移速度的影响研究——基于新能源汽车行业转化专利的计量分析

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现代情报 2024年第1期44卷 168-176页

作者：温芳芳靳华罗爽河南科技大学商学院河南洛阳471023

[目的/意义]地理邻近性作为创新活动的关键变量受到重视,考察其对专利技术转移速度的影响,有助于提升专利转化效率,为完善技术转移政策和优化产业集聚布局提供参考。[方法/过程]以新能源汽车行业的转让和许可专利为样本,采用组间差异检... 详细信息

[目的/意义]地理邻近性作为创新活动的关键变量受到重视,考察其对专利技术转移速度的影响,有助于提升专利转化效率,为完善技术转移政策和优化产业集聚布局提供参考。[方法/过程]以新能源汽车行业的转让和许可专利为样本,采用组间差异检验、相关和回归分析方法,分别借助空间距离和交通时长两类指标检验地理邻近性对专利技术转移速度的影响。[结果/结论]交易双方的空间距离和陆地交通时长越大,专利技术转移速度反而越快;最短交通时长没有影响。但疫情期间情况有所变化,地理邻近的积极作用得以显现,此时空间距离越小,专利技术转移速度越快。

关键词：地理邻近性技术转移速度专利计量地理距离专利转化时滞

Emergence of highly pathogenic avian influenza A(H5N8)clade 2.3.4.4b viruses in grebes in Inner Mongolia and Ningxia,China,in 2021

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Journal of Integrative Agriculture 2024年第1期23卷 348-353页

作者： Qiuzi Xu Xinru Lü Yi Li hua luo Zhen Zhang Xiang Li Rongxiu Qin Qing An Fengyi Qu Zhenliang Zhao Chengbo Zhang Weidong Wang Yuecheng Li Yajun Wang Xiangwei Zeng Zhijun Hou Jingqiang Ren Yulong Wang Yanbing Li Hongliang Chai College of Wildlife and Protected Area Northeast Forestry UniversityHarbin 150040China Harbin Veterinary Research Institute Chinese Academy of Agricultural SciencesHarbin 150040China Wenzhou Key Laboratory for Virology and Immunology Institute of VirologyWenzhou UniversityWenzhou 325000China Ordos Forestry and Grassland Administration Ordos 017000China Monitoring Center for Terrestrial Wildlife Epidemic Diseases Yinchuan 750000China

Highly pathogenic avian influenza(HPAI)subtype H5Nx viruses have spread globally and are a major concern for poultry,wild birds,mammals,and even humans(de Vries et al.2015;Zeng et al.2022).The hemagglutinin(HA)genes of H5 subtype viruses have evolved into multiple clades and some of these clades have been further divided into subclades(Cui et al.2022).Clade 2.***.4.4H5N8 HPAI viruses(HPAIVs)have caused several waves of disease outbreaks in wild birds and domestic poultry(Wang et al.2022).

关键词： poultry Ningxia influenza

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双轴倾角传感器温度补偿方法

吉林大学学报（工学版） 2024年第2期54卷 558-563页

作者：林新华周子栋邵淑芳林威张瑞安徽大学物质科学与信息技术研究院合肥230601 中国科学院合肥物质科学研究院合肥230031

针对倾角传感器中三轴微机电系统(MEMS)加速度计的敏感轴与倾角传感器体坐标系不一致而产生的难以直接获取其温度特性进行温度补偿的问题,提出了一种基于转换矩阵对角元素归一化的温度补偿方法。采用传统的“六位置法”获取用于补偿灵... 详细信息

针对倾角传感器中三轴微机电系统(MEMS)加速度计的敏感轴与倾角传感器体坐标系不一致而产生的难以直接获取其温度特性进行温度补偿的问题,提出了一种基于转换矩阵对角元素归一化的温度补偿方法。采用传统的“六位置法”获取用于补偿灵敏度系数不一致和非正交导致误差的转换矩阵以及包含偏置误差的矩阵。相对于常温获取的转换矩阵,对不同温度下的转换矩阵相应对角元素归一化,以获取灵敏度系数温度特性,克服灵敏度系数不一致相关的矩阵与非正交相关的矩阵无法分离的问题,从而实现三轴加速度计灵敏度系数和偏置的温度补偿。在温度为-20℃~50℃条件下的试验结果表明,该方法可有效减小倾角传感器的温度漂移。

关键词：倾角传感器三轴加速度计温度补偿模型转换矩阵对角元素归一化

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铌微合金化和淬火速率对热成形钢组织与力学性能的影响

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材料工程 2024年第2期52卷 146-154页

作者：陈华丁灿灿胡斌罗海文北京科技大学冶金与生态工程学院北京100083

基于传统22MnB5钢设计了一种新型含Nb热成形钢,研究在不同淬火速率下Nb对热成形钢显微组织与力学性能的影响。新型Nb微合金化热成形钢与广泛应用的22MnB5商业钢种均经900℃保温3 min的固溶处理后分别水淬和油淬至室温,检测两种钢在两个... 详细信息

基于传统22MnB5钢设计了一种新型含Nb热成形钢,研究在不同淬火速率下Nb对热成形钢显微组织与力学性能的影响。新型Nb微合金化热成形钢与广泛应用的22MnB5商业钢种均经900℃保温3 min的固溶处理后分别水淬和油淬至室温,检测两种钢在两个淬火条件下的力学性能,并通过扫描电镜、背散射电子衍射仪、X射线衍射仪和透射电镜等分析合金组织。结果表明:油淬时Nb微合金化热成形钢与22MnB5钢能发生较明显的自回火,但前者的屈服强度高于后者约130 MPa,且伸长率也略有改善,对强化机制的定量计算表明这是由于含Nb钢晶粒细化形成的细晶强化以及位错强化和沉淀强化的共同作用;而在水淬条件下,两种钢的屈服强度与伸长率均相似,推测是由于冷却速率高抑制了自回火,使得马氏体相变产生的残余应力成为影响屈服强度的主导因素,而当水淬样品在170℃回火减轻内应力后,此时含Nb钢屈服强度再次高于22MnB5钢。

关键词： Nb微合金化热成形钢力学性能残余应力

三唇线虫(Trilabiatus spp.)对食用菌菌丝的危害性研究

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浙江农业学报 2011年第2期23卷 335-339页

作者：刘奇志罗子华边勇梁林琳杨道伟汤勇中国农业大学农学与生物技术学院农业部生物防治重点开放实验室北京100193

研究了三唇属线虫(Trilabiatus spp.)对蘑菇菌丝生长的影响,以确定其对蘑菇生产的危害性。分别在甘肃省天水市秦州区(2006年8月中下旬)和浙江省温州市苍南县(2009年8月初和2010年2月)调查有退菌现象的蘑菇菇床及基质(草粪培养料)、鉴定... 详细信息

研究了三唇属线虫(Trilabiatus spp.)对蘑菇菌丝生长的影响,以确定其对蘑菇生产的危害性。分别在甘肃省天水市秦州区(2006年8月中下旬)和浙江省温州市苍南县(2009年8月初和2010年2月)调查有退菌现象的蘑菇菇床及基质(草粪培养料)、鉴定线虫类群、统计线虫数量、纯化三唇线虫并接种于黑木耳及双孢蘑菇斜面培养基。退菌现象严重的木耳和双孢蘑菇基质中三唇属线虫数量多;三唇线虫可在供试的两种食用菌菌丝上大量繁殖,接种2或3周后,线虫数量可分别扩增365倍和208倍;线虫的体表细菌可协助线虫加速对菌丝生长的危害,但不单独危害菌丝。三唇属线虫可造成黑木耳和双孢蘑菇菌丝过早萎缩、变黄、变褐,影响其正常发育。

关键词：线虫三唇线虫黑木耳双孢蘑菇菌丝