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Development of a nomogram for predicting liver transplantation prognosis in hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第21期30卷 2763-2776页

作者： Li He Wan-Sheng Ji Hai-Long Jin Wen-Jing Lu Yuan-Yuan Zhang hua-Guang Wang Yu-Yu Liu Shuang Qiu Meng Xu zi-Peng Lei Qian Zheng Xiao-Li Yang Qing Zhang Department of Organ Transplantation The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China School of Clinical Medicine Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Clinical Research Center The Affiliated Hospital of Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Department of Laboratory Medicine The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Physiatry Department Naval Aviation UniversityYantai 100071Shandong ProvinceChina

BACKGROUND At present,liver transplantation(LT)is one of the best treatments for hepatocellular carcinoma(HCC).Accurately predicting the survival status after LT can significantly improve the survival rate after LT,and ensure the best way to make rational use of liver *** To develop a model for predicting prognosis after LT in patients with *** Clinical data and follow-up information of 160 patients with HCC who underwent LT were collected and *** expression levels of alphafetoprotein(AFP),des-gamma-carboxy prothrombin,Golgi protein 73,cytokeratin-18 epitopes M30 and M65 were measured using a fully automated chemiluminescence *** best cutoff value of biomarkers was determined using the Youden *** regression analysis was used to identify the independent risk factors.A forest model was constructed using the random forest *** evaluated the accuracy of the nomogram using the area under the curve,using the calibration curve to assess consistency.A decision curve analysis(DCA)was used to evaluate the clinical utility of the *** The total tumor diameter(TTD),vascular invasion(VI),AFP,and cytokeratin-18 epitopes M30(CK18-M30)were identified as important risk factors for outcome after *** nomogram had a higher predictive accuracy than the Milan,University of California,San Francisco,and Hangzhou *** calibration curve analyses indicated a good *** survival and recurrence-free survival(RFS)of high-risk groups were significantly lower than those of low-and middle-risk groups(P<0.001).The DCA shows that the model has better clinical *** The study developed a predictive nomogram based on TTD,VI,AFP,and CK18-M30 that could accurately predict overall survival and RFS after *** can screen for patients with better postoperative prognosis,and improve longterm survival for LT patients.

关键词： Hepatocellular carcinoma Liver transplantation Liver cancer Nomogram Prognosis

基于PSW-DID模型的最严格水资源管理政策评估效应

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数理统计与管理 2024年第2期43卷 223-237页

作者：韩爱华高子桓罗一方韩素华中南财经政法大学湖北武汉430073 武汉学院湖北武汉430212

水利是农业的命脉,农业节水灌溉是突破农业粮食生产的水资源瓶颈,2011年建立了最严格水资源管理制度。基于此,本文以塔里木河流域5个地州42个县市和兵团4个师为样本,使用倾向得分加权双重差分(PSW-DID)方法,从最严格水资源管理对扩大耕... 详细信息

水利是农业的命脉,农业节水灌溉是突破农业粮食生产的水资源瓶颈,2011年建立了最严格水资源管理制度。基于此,本文以塔里木河流域5个地州42个县市和兵团4个师为样本,使用倾向得分加权双重差分(PSW-DID)方法,从最严格水资源管理对扩大耕地灌溉面积以及促进农业发展两个方面,客观评价最严格水资源管理政策的实施效果。研究发现:(1)PSW-DID模型不仅解决了内生性问题,消除了样本选择性偏差,而且采用重叠权重实现了处理组与控制组之间的平衡,避免了PSM-DID模型中控制组样本损失,提升了估计的效率与稳健性;(2)最严格水资源管理红线的划定对耕地灌溉面积扩大有正向促进作用,政策实施效果因灌区类型、耕地类型不同而产生差异;(3)耕地灌溉面积扩大可以为最严格水资源管理政策在推动农业发展方面提供重要保障,在中型灌区实施该政策对农业生产总值的促进效果更加显著。

关键词：最严格水资源政策节水灌溉农业发展双重差分倾向得分加权

Association of cardiometabolic multimorbidity with all-cause and cardiovascular disease mortality among Chinese hypertensive patients

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Journal of Geriatric Cardiology 2024年第2期21卷 211-218页

作者： luo-Xi XIAO zi-Yu WANG Jiang-Tao LI Hai-Mei WANG Yi-Ming HAO Pan ZHOU Yu-Lin huaNG Qiu-Ju DENG Yong-Chen HAO Na YANG Li-Zhen HAN Zhao YANG Ping-Ping JIA Yue QI Jing LIU Center for Clinical and Epidemiologic Research Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina

BACKGROUND Hypertension usually clusters with multiple ***,the association between cardiometabolic multimorbidity(CMM)and mortality in hypertensive patients is *** study aimed to investigate the association between CMM and all-cause and cardiovascular disease(CVD)mortality in Chinese patients with *** The data used in this study were from the China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Risk Factors(CONSIDER),which comprised 5006 participants aged 19–91 *** was defined as the presence of one or more of the following morbidities:diabetes mellitus,dyslipidemia,chronic kidney disease,coronary heart disease,and *** proportional hazard models were used to calculate the hazard ratios(HR)with 95%CI to determine the association between the number of CMMs and both all-cause and CVD *** Among 5006 participants[mean age:58.6±10.4 years,50%women(2509 participants)],76.4%of participants had at least one *** mortality rate was 4.57,4.76,8.48,and 16.04 deaths per 1000 person-years in hypertensive patients without any comorbidity and with one,two,and three or more morbidities,*** the fully adjusted model,hypertensive participants with two cardiometabolic diseases(HR=1.52,95%CI:1.09–2.13)and those with three or more cardiometabolic diseases(HR=2.44,95%CI:1.71–3.48)had a significantly elevated risk of all-cause *** findings were similar for CVD mortality but with a greater increase in risk *** In this study,three-fourths of hypertensive patients had *** with two or more comorbidities was associated with a significant increase in the risk of all-cause and cardiovascular mortality among hypertensive patients,suggesting more intensive treatment and control in this high-risk patient group.

关键词： hypertensive patients morbidity

Active Magnetic Compensation Based on Parametric Resonance Magnetometer

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Journal of Shanghai Jiaotong university(Science) 2024年第2期29卷 280-289页

作者：郭阳李绍良黄艺明骆曼箬刘华 School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Institute of Spacefight Control Technology Shanghai Key Laboratory of Space Intelligent Control TechnologyShanghai Engineer Research Center of InertiaShanghai 201109China

Based on the parametric resonance magnetometer(PRM)theory,this paper establishes an experimen-tal system of *** experimental results are consistent with the theoretical predictions.A PRM has been developed with sensitivity of 0.5 pT/Hz^(1/2),which can detect the magnitude of residual magnetic field;furthermore,a proportion-integration-differentiation(PID)closed-loop magnetic compensation system of the residual magnetic field also has been *** with open-loop compensation,the PID closed-loop compensation reduces the average value of the residual magnetic field in the z-axis direction from 0.0244nT to-0.0023nT,and the mean-square error from 0.2083 nT to 0.0691 *** the same way,the average value of the residual magnetic field in the y-axis direction is reduced from 0.0816nT to-0.0042nT,and the mean-square error from 0.1316nT to 0.0461 *** magnitude of residual magnetic fields in both directions is decreased to the order of picotesla(pT).In addition,based on the signal waveforms of the magnetometer,a method of verifying the effect of magnetic compensation is proposed.

关键词： magnetometer parametric resonance nuclear magnetic resonance gyroscope magnetic compensa-tion proportion-integration-differentiation(PID)

四联疗法和常规三联疗法在胃溃疡中的效果及对患者临床症状和血清学的影响

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中国实用医药 2020年第27期15卷 8-11页

作者：罗子华朱倩吴京华熊鹰深圳市龙华区中心医院消化内科 518110

目的分析四联疗法和常规三联疗法在胃溃疡中的效果,以及对患者临床症状和血清学的影响。方法 78例胃溃疡患者,根据治疗方式的不同分为观察组和对照组,各39例。对照组采用常规三联疗法,观察组采用四联疗法。对比两组患者治疗效果、幽门... 详细信息

目的分析四联疗法和常规三联疗法在胃溃疡中的效果,以及对患者临床症状和血清学的影响。方法 78例胃溃疡患者,根据治疗方式的不同分为观察组和对照组,各39例。对照组采用常规三联疗法,观察组采用四联疗法。对比两组患者治疗效果、幽门螺杆菌根除率、临床症状改善情况、血清炎症因子水平以及不良反应发生情况。结果观察组治疗总有效率94.87%、幽门螺杆菌根除率92.31%均高于对照组的79.49%、74.36%,差异均具有统计学意义(P0.05)。结论常规三联疗法和四联疗法均能有效治疗胃溃疡,但四联疗法能更有效地改善临床症状,减轻炎症反应和提高幽门螺杆菌根除率,值得应用。

关键词：胃溃疡临床症状三联疗法四联疗法血清学

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粗粒土渗透及渗透变形试验缩尺方法研究

岩土力学 2024年第1期45卷 164-172页

作者：张丹邱子源金伟张梓航罗玉龙中国电建集团成都勘测设计研究院有限公司四川成都610072 河海大学水利水电学院江苏南京210024

目前还未建立适用于粗粒土渗透及渗透变形试验的缩尺方法,遵循缩尺前后粒径小于d30(颗粒级配中质量百分含量30%所对应的颗粒粒径)以及粒径小于5 mm的颗粒含量及组成不变的原则,基于等量替代法,提出了一种粗粒土渗透及渗透变形试验缩尺方... 详细信息

目前还未建立适用于粗粒土渗透及渗透变形试验的缩尺方法,遵循缩尺前后粒径小于d30(颗粒级配中质量百分含量30%所对应的颗粒粒径)以及粒径小于5 mm的颗粒含量及组成不变的原则,基于等量替代法,提出了一种粗粒土渗透及渗透变形试验缩尺方法:如果原级配中5 mm以下的颗粒含量大于等于30%,则根据试样允许最大粒径以下的大于5 mm的各粒组含量,按比例等质量替换超粒径颗粒;如果原级配中5 mm以下的颗粒含量小于30%,则根据试样允许最大粒径以下的大于d30的各粒组含量,按比例等质量替换超粒径颗粒。利用多组粗粒土渗透及渗透变形试验,论证了缩尺方法的可靠性。研究表明:提出的缩尺方法合理可行。缩尺后,土体渗透破坏型式未发生变化,渗透系数与原级配比较接近,渗透变形临界坡降和破坏坡降与原级配基本一致,缩尺级配的渗透及渗透稳定特性能够较好地反映原级配的渗透及渗透稳定特性。

关键词：粗粒土渗透及渗透变形试验缩尺方法等量替代法

亚热带森林植物的叶片和根系功能性状部分耦合但具有不同的群落性状分布格局

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Journal of Plant Ecology 2024年第1期17卷 94-110页

作者： Wenqi luo Oscar J Valverde-Barrantes Monique Weemstra James F Cahill Jr zi Wang Dong He Yongfa Chen Chengjin Chu Youshi Wang State Key Laboratory of Biocontrol School of Life Sciences/School of EcologySun Yat-sen UniversityGuangzhou 510275China International Center for Tropical Botany Department of Biological SciencesFlorida International UniversityMiamiFL 33199USA Department of Biological Sciences University of AlbertaEdmontonABT6G 2E9Canada School of Ecology and the Environment Xinjiang UniversityUrumqi 830046China

植物的生态过程依赖于叶片和根系的功能运行,但少有研究同时关注这两类性状在群落中的分布格局(CTD)。本文测定了广东亚热带森林44种共生木本植物的16个叶片和根系性状,旨在检验类比的叶片和根系性状是否耦合,是否沿类似的功能性状谱变... 详细信息

植物的生态过程依赖于叶片和根系的功能运行,但少有研究同时关注这两类性状在群落中的分布格局(CTD)。本文测定了广东亚热带森林44种共生木本植物的16个叶片和根系性状,旨在检验类比的叶片和根系性状是否耦合,是否沿类似的功能性状谱变异,是否表现出类似的CTD,其CTD和群落加权平均性状值(CWM)是否沿环境梯度表现出类似的响应。研究结果表明,叶片和根系性状变异的第一轴均呈显出由资源获取向资源保守变异的经济学谱,但叶片变异的第二轴主要由叶片碳含量表征,而根系变异的第二轴主要由反映菌根协作程度的根系粗细表征。类比的叶片和根系化学性状整体正相关,但形态性状的耦合程度较低。在群落水平上,叶片和根系性状第一轴的CWM均随海拔升高而变得更保守,而第二轴的变化则不一致。随土壤磷含量的降低或钾含量的升高,根系变得更细和在养分性状上更保守,而叶片性状无显著变化。当整合多维性状轴时,叶片性状呈发散格局,且随海拔、土壤磷和钾含量的增加呈收敛趋势;而根系性状呈收敛格局,但沿上述环境梯度呈发散趋势。该研究强调,叶片和根系性状与环境互作的差异可能导致不同的性状分布格局;植物可通过多样的地上和地下功能设计应对环境异质性。

关键词：性状维度群落构建叶片性状根系性状植物经济谱群落性状结构亚热带森林

Assessing recent recurrence after hepatectomy for hepatitis Brelated hepatocellular carcinoma by a predictive model based on sarcopenia

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World Journal of Gastroenterology 2024年第12期30卷 1727-1738页

作者： Hong Peng Si-Yi Lei Wei Fan Yu Dai Yi Zhang Gen Chen Ting-Ting Xiong Tian-Zhao Liu Yue huang Xiao-Feng Wang Jin-Hui Xu Xin-hua luo Department of Infectious Diseases Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina Department of Hepatobiliary Surgery Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

BACKGROUND Sarcopenia may be associated with hepatocellular carcinoma(HCC)following *** traditional single clinical variables are still insufficient to predict *** still lack effective prediction models for recent recurrence(time to recurrence5 cm(HR=2.222,95%CI:1.285-3.842,P<0.05),and hepatitis B virus DNA level≥2000 IU/mL(HR=2.1,95%CI:1.407-3.135,P<0.05)were independent risk factors associated with postoperative recurrence of *** on the sarcopenia to assess the RFS model of hepatectomy with hepatitis B-related liver cancer disease(SAMD)was established combined with other the above risk *** area under the curve of the SAMD model was 0.782(95%CI:0.705-0.858)in the training cohort(sensitivity 81%,specificity 63%)and 0.773(95%CI:0.707-0.838)in the validation ***,a SAMD score≥110 was better to distinguish the high-risk group of postoperative recurrence of *** Sarcopenia is associated with recent recurrence after hepatectomy for hepatitis B-rel

关键词： Alpha-fetoprotein Hepatitis B virus Hepatectomy Hepatocellular carcinoma Nomogram Predictive models Recurrence Recurrence-free survival Risk factors Sarcopenia

Current Mycoplasma pneumoniae epidemic among children in Shanghai:unusual pneumonia caused by usual pathogen

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World Journal of Pediatrics 2024年第1期20卷 5-10页

作者： Xiao-Bo Zhang Wen He Yong-Hao Gui Quan Lu Yong Yin Jian-hua Zhang Xiao-Yan Dong Ying-Wen Wang Ying-zi Ye Hong Xu Jia-Yu Wang Bing Shen Dan-Ping Gu Li-Bo Wang Yi Wang Department of Respiratory Medicine Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China State Key Laboratory of Genetic Engineering at School of Life Sciences Institute of Reproduction&DevelopmentChildren's Hospital of Fudan UniversityShanghaiChina Department of Respiratory Medicine Children's Hospital of Shanghai Jiao Tong UniversityShanghaiChina Department of Respiratory Medicine Shanghai Children's Medical CenterAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Pediatric Respiratory Xinhua HospitalAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Nursing Children's Hospital of Fudan UniversityShanghaiChina Department of Infectious Diseases Children's Hospital of Fudan UniversityShanghaiChina Department of Nephrology Children's Hospital of Fudan UniversityShanghaiChina NHC Key Laboratory of Neonatal Diseases Children's Hospital of Fudan UniversityShanghaiChina Shanghai Shenkang Hospital Development Center ShanghaiChina Center for Medical Quality Control Management of Shanghai ShanghaiChina Department of Neurology Children's Hospital of Fudan University399Wanyuan RoadShanghai 201102China

Mycoplasma pneumoniae(***),primarily transmitted through respiratory droplets when infected individuals cough or sneeze,is a common cause of communityacquired pneumonia,especially among school-age children and *** infection occurs endemically with an epidemic peak every few *** worldwide incidence confirmed by direct test methods was reported to be 8.61%between 2017 and 2020 across all age groups[1].

关键词： pneumonia epidemic respiratory