检索结果-南通市图书馆

SO_4^(2-)/TiO_2、PO_4^(3-)/TiO_2、BO_3^(3-)/TiO_2系列固体酸的酸性、结构和晶相的研究

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Chinese Journal of Structural Chemistry 1999年第3期18卷 175-181页

作者：王燕茗陈长章罗军华高冬寿李定吴茂祥马锦波中国科学院福建物质结构研究所

制备了ＳＯ４２－／ＴｉＯ２（Ⅰ）、ＰＯ４３－／ＴｉＯ２（Ⅱ）、ＢＯ３３－／ＴｉＯ２（Ⅲ）系列固体酸。用ＩＲ、Ｒａｍａｎ光谱对该系列固体酸进行结构表征，结果表明ＳＯ４２－与ＴｉＯ２表面的结合为螯合式双配位结构和共价硫酸... 详细信息

制备了ＳＯ４２－／ＴｉＯ２（Ⅰ）、ＰＯ４３－／ＴｉＯ２（Ⅱ）、ＢＯ３３－／ＴｉＯ２（Ⅲ）系列固体酸。用ＩＲ、Ｒａｍａｎ光谱对该系列固体酸进行结构表征，结果表明ＳＯ４２－与ＴｉＯ２表面的结合为螯合式双配位结构和共价硫酸盐共存，ＰＯ４３－与ＴｉＯ２表面的结合为桥式三配位结构，ＢＯ３３－与ＴｉＯ２表面的结合为单齿单配位结构和螯桥混合式三配位结构共存。用由溶液中正丁胺的吸附等温线测定固体表面酸度的方法测定了样品的酸量，结果表明酸量大小为Ⅰ＞Ⅱ＞Ⅲ。用ＸＲＤ技术对该系列固体酸进行考察，衍射图分析提示该系列固体酸主要都为锐钛矿型晶型，但Ⅰ、Ⅱ。

关键词：固体酸固体超强酸硫酸磷酸二氧化钛硼酸

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活性炭固载杂多酸催化合成柠檬酸三丁酯

精细化工 1999年第4期16卷 24-27页

作者：吴茂祥高冬寿李定罗军华王燕茗马锦波陈长章中国科学院福建物质结构研究所应用化学研究室

用自制的固载杂多酸催化柠檬酸与正丁醇反应合成柠檬酸三丁酯。探讨了催化剂用量、反应时间、反应温度、酸醇比等因素对反应结果的影响。在酸醇的摩尔比为１∶６．５、催化剂的用量为柠檬酸质量的１％、反应温度１４５℃、反应时间３ｈ... 详细信息

用自制的固载杂多酸催化柠檬酸与正丁醇反应合成柠檬酸三丁酯。探讨了催化剂用量、反应时间、反应温度、酸醇比等因素对反应结果的影响。在酸醇的摩尔比为１∶６．５、催化剂的用量为柠檬酸质量的１％、反应温度１４５℃、反应时间３ｈ的条件下，柠檬酸的酯化率可达９７．４％。

关键词：增塑剂柠檬酸三丁酯杂多酸活性炭催化

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-lin Xiong xiang-yang Wen Xin-Qiao li Ce Cai Shuo Xiao Qi luo Wen-Xi Peng dong-Ya Guo Zheng-hua An Ke Gong Jin-Yuan liao yan-Qiu zhang Yue huang Lu li Xing Wen Fei zhang Jing Duan Chen-Wei wang dong-li Shi Peng zhang Qi-Bin Yi Chao-yang li yan-Bing Xu Xiao-hua liang Ya-Qing liu Da-li zhang Xi-Lei Sun Fan zhang Gang Chen huan-Yu wang Sheng yang Xiao-Jing liu Min gao mao-Shun li Jin-Zhou wang Xing Zhou Yi Zhao wang-Chen Xue Chao Zheng Jia-Cong liu Xing-Bo Han Jin-ling Qi Jia huang Ke-Ke zhang Can Chen Xiong-Tao yang dong-Jie Hou Yu-Sa wang Rui Qiao xiang Ma Xiao-Bo li Ping wang Xin-Ying Song li-ming Song Shi-Jie Zheng Bing li Hong-Mei zhang Yue Zhu Wei Chen Jian-Jian He Zhen zhang Jin Hou Hong-jun wang yan-Chao Hao xiang-Yu wang Zong-Yuan yang Zhi-Long Wen Zhi chang Yuan-Yuan Du Rui gao Xiao-Fei Lan yan-Guo li Gang li Xu-Fang li Fang-jun Lu Hong Lu Bin Meng Feng Shi Hui wang Hui-Zhen wang Yu-Peng Xu Jia-Wei yang Xue-Juan yang Shuang-Nan zhang Chao-Yue zhang cheng-Mo zhang Zhi-cheng Tang cheng cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li luo Yong-Heng Zhao Gang Zhao li-Cai Deng Xiao-Wei liu Yi-Peng Jing Gang wang Hao-Tong zhang Jian-Rong Shi xiang-Qun Cui Yao-Quan Chu Guo-Ping li Zhong-Rui Bai Yue wu yan Cai Shu-Yun Cao Zi-huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-jun Chen Kun-Xin Chen li Chen Xue-Lei Chen Xiao-yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao dong Bing Du dong-Wei Fan Lei Feng Jian-Ning Fu Peng gao Xue-Fei Gong Bo-Zhong Gu yan-Xin Guo Zhan-Wen Han Bo-liang He Jin-liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-hua Jiang xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-hua li chang-hua li Guang-Wei li Hai-Ning li Jian li Qi li Shuang li Sha-Sha li Xin-Nan li yan li Yin-Bi li Ye-Ping li Yuan liang Chien-cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu luo Yin-Dun mao Heidi Newberg Ji-jun Ni Zhao-xiang Qi Yong-jun Qi Shi-Yin Shen Huo-ming Shi Jing Song Yi-Han Song ding-Qiang Su Hong-jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang Hong-Chi wang Jian wang Jia-Ning wang Jian-ling wang Jian-Ping wang jun-Xian wang Lei wang Meng-Xin wang shou-Guan wang Shu-Qing wang Xia wang Ya-Nan wang You wang Yue-Fei wang You-Fen wang Peng Wei ming-Zhi Wei Hong wu Ke-Fei wu Xue-Bing wu Yu-Zhong wu Xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu yan Xu Tai-Sheng yan De-hua yang Hai-Feng yang Hui-Qin yang ming yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng zhang hua-Wei zhang Jian-Nan zhang li-Pin zhang Wei zhang Yong zhang yan-Xia zhang Zheng-Chao zhang ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in june 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in june 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-li luo Hao-Tong zhang Yong-Heng Zhao Gang Zhao xiang-Qun Cui Guo-Ping li Yao-Quan Chu Jian-Rong Shi Gang wang Jian-Nan zhang Zhong-Rui Bai Xiao-yan Chen Feng-Fei wang yan-Xin Guo Jian-jun Chen Bing Du Xiao Kong Ya-Juan Lei Yin-Bi li Yi-Han Song Yue wu yan-Xia zhang Xin-lin Zhou Fang Zuo Peng Du lin He Wen Hou Yi-Qiao dong Jian li Guang-Wei li Shuang li Jing Song Yuan Tian Meng-Xin wang Yong-Hui Hou Zhi-Ying Huo Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-hua Jiang xiang Jiang Zi-Bo Jiang Ge Jin Ai-hua li Qi li Yin-Dun mao Zheng-Hong Tang Qing-Sheng Tao liang-Ping Tu Da-Qing wang Dan wang Jian-Ping wang Lei wang shou-Guan wang Shu-Qing wang Ya-Nan wang You wang Yue-Fei wang ming-Zhi Wei xiang-xiang Xue Xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu yan Xu De-hua yang Shi-Hai yang Zheng-Qiu Yao Yong Yu Hui Yuan Chao Zhai En-Peng zhang Jing zhang li-Ping zhang Weizhang Yong zhang Zhen-Chao zhang ming Zhao Fang Zhou Yong-Tian Zhu Jie Zhu Si-cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao zhang Xue-Qian wang Feng-Qi zhang Xiao-Ya Cui Bing-Bing Fan Jia-ming Guo Zhi-Min Guo Rui huang Wen huang Xu-Bo li Meng-Ru li yan Ma Zhi-hua Shen Yong-Gang Sun De-Zhuang wang Fei-yang wang li-Qiang wang Nan wang Tian-li wang Wei wang Xiao-yang wang Yi-Han wang Fu-Jie Yu Yu-Zhen Yin ling-Kun zhang Yi zhang Jian-yang zhang Qi Zhao Yu-Ping Zhao Xin-dong Zhu Yasir Sohail Ya-Nan Chen Tao Feng Qi-Long gao Hai-yan He Yong-Jiang huang Zeng-Bao Jiao hua Ji Yao Jiang Qiang li Xiao-ming li Wei-Bing liao huai-jun lin Hui liu Qi liu Qing-Feng liu Wei-Di liu Xiong-jun liu yang Lu Yi-Ping Lu Wen Ma Xue-Fei Miao Jie Pan Qing wang Hong-Hui wu Yuan wu Tao yang Wei-ming yang Qian Yu Jin-Yu zhang Zhi-Gang Chen liang mao yang Ren Bao-Long Shen Xun-li wang Zhe Jia He Zhu Zhen-Duo wu Si Lan School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China Department of Physics City University of Hong KongHongKong 999077China School of Materials Science and Engineering Tianjin UniversityTianjin 300072China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Department of Mechanical Engineering Research Institute for Advanced ManufacturingThe Hong Kong Polytechnic UniversityHong Kong 100872China Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Solidification Control and Digital Preparation Technology(liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Institute of Advanced Wear&Corrosion Resistance and Functional Materials Jinan UniversityGuangzhou 510632China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China School of Physical Sciences Great Bay UniversityDongguan 523000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon NeutralityUniversity of Science and Technology BeijingBeijing 100083China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China School of Computing Macquarie UniversitySydney 2113Australia Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China State Key Laborato

Owing to their exceptional properties,high-entropy alloys(HEAs)and high-entropy materials have emerged as promising research areas and shown diverse ***,the recent advances in the field are comprehensively reviewed,organized into five *** first section introduces the background of HEAs,covering their definition,significance,application prospects,basic properties,design principles,and *** subsequent section focuses on cutting-edge high-entropy structural materials,highlighting developments such as nanostructured alloys,grain boundary engineering,eutectic systems,cryogenic alloys,thin films,micro-nano-lattice structures,additive manufacturing,high entropy metallic glasses,nano-precipitate strengthened alloys,composition modulation,alloy fibers,and refractory *** the following section,the emphasis shifts to functional materials,exploring HEAs as catalysts,magneto-caloric materials,corrosion-resistant alloys,radiation-resistant alloys,hydrogen storage systems,and materials for ***,the review encompasses functional high-entropy materials outside the realm of alloys,including thermoelectric,quantum dots,nanooxide catalysts,energy storage materials,negative thermal expansion ceramics,and high-entropy wave absorption *** paper concludes with an outlook,discussing future directions and potential growth areas in the *** this comprehensive review,researchers,engineers,and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： High entropy alloys Cutting-edge structural materials Cutting-edgefunctional materials

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin liu Yue huang Guang-cheng Xiao Qing-Cui Bu Jin-Lu Qu Shu zhang Shuang-Nan zhang Shu-Mei Jia Fang-jun Lu xiang Ma lian Tao Wei zhang li Chen li-ming Song Ti-Pei li Yu-Peng Xu Xue-Lei Cao Yong Chen Cong-Zhan liu Ce Cai Zhi chang Gang Chen Tian-xiang Chen Yi-Bao Chen Yu-Peng Chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei dong Yuan-Yuan Du Min-Xue Fu Guan-hua gao He gao Min gao ming-Yu Ge Yu-dong Gu Ju Guan cheng-cheng Guo Da-Wei Han Jia Huo Lu-hua Jiang Wei-Chun Jiang Jing Jin Yong-Jie Jin ling-Da Kong Bing li cheng-Kui li Gang li mao-Shun li Wei li Xian li Xiao-Bo li Xu-Fang li yang-Guo li Zheng-Wei li Xiao-hua liang Jing-Yuan liao Bai-Sheng liu Guo-Qing liu Hong-Wei liu Xiao-Jing liu Yi-Nong liu Bo Lu Xue-Feng Lu Qi luo Tao luo Bin Meng Yi Nang Jian-Yin Nie Ge Ou Na Sai Ren-cheng Shang Xin-Ying Song liang Sun Ying Tan You-li Tuo Chen wang Guo-Feng wang Juan wang ling-jun wang Weng-Shuai wang Yu-Sa wang xiang-yang Wen Bai-yang wu Bo-Bing wu Mei wu Shuo Xiao Shao-lin Xiong He Xu Jia-Wei yang Sheng yang yan-Ji yang Yi-jung yang Qi-Bin Yi Qian-Qing Yin Yuan You Ai-Mei zhang cheng-Mo zhang Fan zhang Hong-Mei zhang Juan zhang Tong zhang Wan-chang zhang Wen-Zhao zhang Yi zhang Yi-Fei zhang Yong-Jie zhang Yuan-Hang zhang Yue zhang Zhao zhang Zhi zhang Zi-liang zhang Hai-Sheng Zhao Xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou Jian-Feng Zhou Yu-Xuan Zhu Ren-lin Zhuang Yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases

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Chinese Medical Journal 2017年第20期130卷 2473-2488页

作者： Zou, He-Jian wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-jun Dai, lie wu, hua-xiang Zhu, Xiao-Xia Mei, chang-lin Hao, Chuan-ming Chen, Nan liu, Bi-cheng Chen, Jiang-hua yang, li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang li, lin Ge, jun-Bo Huo, Yong zhang, Shu-yang Chen, Yun-Dai dong, Yu-Gang liang, Chun Dai, Yu-xiang gao, Xin li, chang-Gui Zhao, Jia-jun Chen, Hai-Bing cheng, Zhi-Feng lin, huan-dong Guan, yang-Tai wang, Kai luo, Ben-yan Dai, Ruo-lian Jiang, Quan Xue, Luan liang, Chao-Chao Chen, ming Fan, Song Multidisciplinary Expert Task Force on Hyperuricemia and Related Diseases

INTRODUCTIONThe prevalence of hyperuricenlia （hua） has increased in China in the recent years in relation to socioeconomic developments and changing lifestyles and diets, with a trend toward onset at younger age. hua has become the second most common metabolic disease after diabetes mellitus. like gout, hua is also associated with the occurrence and progression of disorders of the urinary, endocrine, metabolic, cardio-cerebrovascular, and other systems.

关键词： Consensus Gout Hyperuricemia Recommendation Uric Acid

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： jun liu Dan-Dan li Wei dong Yu-Qi liu yang wu Da-Xuan Tang Fu-Chun zhang Meng Qiu Qi hua Jing-Yu He jun li Bai Du Ting-Hai Du lin-lin Niu Xue-jun Jiang Bo Cui Jiang-Bin Chen yang-Gan wang Hai-Rong wang Qin Yu Jing He Yi-lin mao Xiao-Fang Bin Yue Deng Yu-Dan Tian Qing-hua Han Da-Jin liu li-Qin Duan ming-jun Zhao Cui-Ying zhang Hai-Ying Dai Ze-hua li Ying Xiao You-Zhi Hu Xiao-Yu huang Kun Xing Xin Jiang Chao-Feng liu Jing An Feng-Chun li Tao Tao Jin-Fa Jiang Ying yang Yao-Rong dong Lei zhang Guang Fu Ying li Shu-Wei huang li-Ping Dou Lan-jun Sun Ying-Qiang Zhao Jie li Yun Xia jun liu Fan liu Wen-Jin He Ying li Jian-Cong Tan yang lin Ya-Bin Zhou Jian-Fei yang Guo-Qing Ma Hui-jun Chen He-Ping liu Zong-wu liu Jian-Xiong liu Xiao-Jia luo Xiao-Hong Bin Ya-Nan Yu Hai-Xia Dang Bing li Fei Teng wang-Min Qiao Xiao-Long Zhu Bing-Wei Chen Qi-Guang Chen Chun-Ti Shen Yong-yan wang Yun-Dai Chen Zhong wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch