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Application of Functional Markers to Identify Genes for Bacterial Blight Resistance in Oryza rufipogon

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Rice science 2010年第1期17卷 73-76页

作者： XIA Zhi-hui HAN Fei GAO Li-fen YUAN Qian-hua ZHAI Wen-xue LIU Di luo yue-hua College of Agriculture Hainan University Haikou 570228 China Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Institute of Food Crops Hainan Academy of Agricultural Sciences Haikou 571100 China

Field resistances of nine accessions of common wild rice （Oryza rufipogon Griff.） and one rice variety （IR24） were evaluated by using nine strains of bacterial blight pathogen （Xanthomonas oryzae pv. oryzae） from the Philippines. IR24 was highly susceptible to all the strains, and six common wild rice accessions resisted all the nine strains, with a resistance frequency of 67%. The accessions Yulin and Wanning were only susceptible to PXO280 and PXO71, respectively. The accession Gaozhou was susceptible to the three strains PXO79, PXO99 and PXO339, whereas resistant to the other six strains. It could be concluded that there is at least one resistance gene in each common wild rice accession. The functional markers of the genes xa5, xa13, Xa21 and Xa27 were used to detect the presence of these resistance genes in the nine tested wild rice accessions, and it was found that four wild rice accessions contained heterozygous xa13. Among the nine common wild rice accessions, five were homozygous for Xa27 and three homozygous for xa27, and the accession Laibin contained neither xa27 nor Xa27. In addition, there were no xa5 and Xa21 in all of these accessions.

关键词： Oryza rufipogon bacterial blight resistance gene functional marker

Identification of QTLs for grain size and characterization of the beneficial alleles of grain size genes in large grain rice variety BL129

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Journal of Integrative Agriculture 2016年第1期15卷 1-9页

作者： GAO Xua ZHU Xu-dong FANG Na DUAN Peng-gen WU Ying-bao luo yue-hua LI Yun-hai Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources/Agricultural College Hainan UniversityHaikou 570228P.R.China State Key Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhou 310006P.R.China State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101P.R.China

Grain size is one of the most important agronomic components of grain yield. Grain length, width and thickness are controlled by multiple quantitative trait loci （QTLs）. To understand genetic basis of large grain shape and explore the beneficial alleles for grain size improvement, we perform QTL analysis using an F2 population derived from a cross between the japonica variety Beilu 129 （BL129, wide and thick grain） and the elite indica variety huazhan （HZ, narrow and long grain）. A total number of eight major QTLs are detected on three different chromosomes. QTLs for grain width （qGW）, grain thickness （qGT）, brown grain width （qBGW）, and brown grain thickness （qBGT） explained 77.67, 36.24, 89.63, and 39.41% of total phenotypic variation, respectively. The large grain rice variety BL129 possesses the beneficial alleles of GW2 and qSW5/ GW5, which have been known to control grain width and weight, indicating that the accumulation of the beneficial alleles causes large grain shape in BL129. Further results reveal that the rare gw2 allele from BL129 increases grain width, thickness and weight of the elite indica variety huazhan, which is used as a parental line in hybrid rice breeding. Thus, our findings will help breeders to carry out molecular design breeding on rice grain size and shape.

关键词： rice quantitative trait grain size GW2 GW5

Hydrophobic tag tethering degrader as a promising paradigm of protein degradation:Past,present and future perspectives

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Chinese Chemical Letters 2024年第8期35卷 187-200页

作者： Si Ha Jiacheng Zhu hua Xiang Guoshun luo State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry China Pharmaceutical UniversityNanjing 211198China

Small molecule inhibitors have dominated the pharmaceutical landscape for a long time as the primary therapeutic paradigm targeting pathogenic ***,their efficacy heavily relies on the amino acid composition and spatial constitution of proteins,rendering them susceptible to drug resistance and failing to target undruggable *** recent years,the advent of targeted protein degradation(TPD)technology has captured substantial attention from both industry and *** an event-driven mode,TPD offers a novel approach to eliminate pathogenic proteins by promoting their degrada-tion,thus circumventing the limitations associated with traditional small molecule ***-bic tag tethering degrader(HyTTD)technology represents one such TPD approach that is currently in the burgeoning *** employ endogenous protein degradation systems to induce the degrada-tion of target proteins through the proteasome pathway,which displays significant potential for medical *** this review,we provide a comprehensive overview of the development history and the reported mechanism of action of ***,we delve into the physiological roles,structure-activity re-lationships,and medical implications of HyTTDs targeting various disease-associated ***,we propose insights into the challenges that necessitate resolution for the successful development of HyTTDs,with the ultimate goal of initiating a new age of clinical treatment leveraging the immense po-tential of HyTTDs.

关键词： Targeted protein degradation(TPD) Hydrophobic tag Degrader Hydrophobic tag tethering degrader(HyTTD) Targeted therapy

Preparation of PVA/GO/h-BN Janus Film with High Thermal Conductivity and Excellent Flexibility via a Density Deposition Self-assembly Method

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Chinese Journal of Polymer Science 2024年第8期42卷 1217-1226页

作者： Fang-hua luo Zhi-Tao Dong Guo-hua Chen Chen Ma huai-Yuan Wang College of Chemistry and Chemical Engineering Northeast Petroleum UniversityDaqing 163318China College of Materials Science and Engineering Huaqiao UniversityXiamen 361000China School of Chemical Engineering and Technology and State Key Laboratory for Chemical Engineering Tianjin UniversityTianjin 300350China

Janus films with asymmetric physical/chemical properties have attracted con siderable attention due to their promising applications in personal thermal management,electronic skin s,sensors,actuators,***,traditional methods for fabricating Janus films conventionally need the assistance of an interface or auxiliary equipment,which are usually complex and ***,flexible poly(vinyl alcohol)(PVA)/graphene oxide(GO)/h-BN(recorded as PVA/GO/h-BN)Janus films with thermally,optically,and electrically anisotropic properties are fabricated by a simple density deposition self-assem bly method,which just utilizes the density difference between GO and h-BN during water *** results show that the two sides of the acquired Janus films have obvious asymmetric *** the original state of the PVA/GO/h-BN Janus films,the thermal conductivity of the GO side(10.06 W·m^(-1)·K^(-1))is generally lower than that of the h-BN side(10.48W·m^(-1)·K^(-1)).But after GO is reduced,the thermal conductivity of the rGO side reaches 12.17 W·m^(-1)·K^(-1),surpassing that of the h-BN *** addition,the relative reflectance of the h-BN side of Janus film is also significantly higher than that of the rGO side,and the su rface resistance difference between the two sides is about 4 orders of *** prepared PVA/GO/h-BN Janus films show great application potential in human thermal management,light conversion switches,and electronic *** study provides a simple and versatile strategy for fabricating Janus films with multifunctional(such as thermal,optical,and electrical)anisotropies.

关键词： Janus films PVA/GO/h-BN Density deposition self-assembly method

Brassinosteroids and Auxin Down-Regulate DELLA Genes in Fiber Initiation and Elongation of Cotton

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Agricultural Sciences in China 2011年第8期10卷 1168-1176页

作者： HU Ming-yu luo Ming XIAO yue-hua LI Xian-bi TAN Kun-ling HOU Lei DONG Jing LI De-mou SONG Shui-qing ZHAO Juan ZANG Zhen-le LI Bao-li PEI Yan Key Laboratory of Biotechnology and Crop Quality Improvement Ministry of Agriculture/Biotechnology Research CenterSouthwest UniversityChongqing 400716P.R.China

Plant hormones play important roles in cotton fiber growth and ***,the interaction of phytohormones is largely unknown in fiber cells up to *** proteins are critical component in GA （gibberellic acid） signal transduction,which are also regulated by other phytohormones,such as auxin and *** understand the regulation of DELLA genes in cotton fiber growth and development,we cloned four DELLA genes from upland cotton fibers （Gossypium hirsutum L.）,named GhGAI1,GhGAI2,GhGAI3,and *** of the four predicted proteins with other reported DELLA proteins in various species displayed that they shared conserved domains and high *** profiles of the four GhGAIs in various tissues and organs as well as cotton fibers in different stages displayed that GhGAI1 has higher transcriptional levels than other GhGAIs in all detected ***,the expression level of GhGAI1 was significantly reduced in 0 dpa （day post anthesis） ovules by addition of IAA and epi-BL,and exogenous epi-BL decreased GhGAI1 level in 7 dpa ***,the levels of the other three GhGAIs in 0 dpa ovules and 7 dpa fibers were also regulated by applied *** addition,the levels of GhGAI1 were higher in Xuzhou142 fl mutant （fuzzless-lintless） than in FL （Gossypium hirsutum *** 142） from-1 to 3 dpa ovules,suggesting that GhGAI1 engaged in cotton fiber cell *** results indicated that DELLA genes are involved in the process of fiber cell initiation and elongation regulated by different phytohormones.

关键词： DELLA protein upland cotton cotton fiber development phytohormone

Impact of metabolic syndrome components on clinical outcomes in hypertriglyceridemia-induced acute pancreatitis

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World Journal of Gastroenterology 2024年第35期30卷 3996-4010页

作者： Zhen-hua Fu Zi-yue Zhao Yao-Bing Liang Dong-Yu Cheng Jian-Ming luo Hai-Xing Jiang Shan-Yu Qin Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND The incidence of hypertriglyceridemia(HTG)-induced acute pancreatitis(AP)is steadily increasing in China,becoming the second leading cause of *** complications and outcomes associated with HTG-AP are generally more severe than those seen in AP caused by other ***-AP is closely linked to metabolic dysfunction and frequently coexists with metabolic syndrome or its ***,the impact of metabolic syndrome components on HTGAP clinical outcomes remains *** To investigate the impact of metabolic syndrome component burden on clinical outcomes in *** In this retrospective study of 255 patients diagnosed with HTG-AP at the First Affiliated Hospital of Guangxi Medical University,we collected data on patient demographics,clinical scores,complications,and clinical ***,we analyzed the influence of the presence and number of individual metabolic syndrome components,including obesity,hyperglycemia,hypertension,and low high-density lipoprotein cholesterol(HDL-C),on the aforementioned parameters in HTG-AP *** This study found that metabolic syndrome components were associated with an increased risk of various complications in HTG-AP,with low HDL-C being the most significant risk factor for clinical *** risk of complications increased with the number of metabolic syndrome *** for age and sex,patients with highcomponent metabolic syndrome had significantly higher risks of renal failure[odds ratio(OR)=3.02,95%CI:1.12-8.11)],SAP(OR=5.05,95%CI:2.04-12.49),and intensive care unit admission(OR=6.41,95%CI:2.42-16.97)compared to those without metabolic *** The coexistence of multiple metabolic syndrome components can synergistically worsen the clinical course of HTGAP,making it crucial to monitor these components for effective disease management.

关键词： Hypertriglyceridemia-induced acute pancreatitis Metabolic syndrome High density lipoprotein cholesterol Obesity Hyperglycemia Hypertension Clinical outcomes

Impact of Local Climate Zones on the Urban Heat and Dry Islands in Beijing:Spatial Heterogeneity and Relative Contributions

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Journal of Meteorological Research 2024年第1期38卷 126-137页

作者： Zuofang ZHENG Fu luo Nana LI hua GAO Yuanjian YANG Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089 School of Atmospheric Physics Nanjing University of Information Science&TechnologyNanjing 210044 Key Laboratory of Urban Meteorology China Meteorological AdministrationBeijing 100089

Based on the building height and density data on a 100-m resolution,hourly 2-m temperature and humidity data at83 automatic weather stations,and gridded local climate zone(LCZ)data on a 120-m resolution in urban Beijing in2020,this study first employs the semivariogram combined with building parameters to calculate spatial correlations and has identified an LCZ grid resolution of 500 m suitable for best usage of the available observation ***,how the spatially heterogeneous LCZs affect and contribute to the canopy urban heat island intensity(UHII)and urban dry island intensity(UDII)are quantitatively *** is found that UHII is high in winter and low in summer with a unimodal diurnal variation while UDI is low in winter but high in summer with a bimodal diurnal *** LCZ with compact mid-rise(open high-rise)buildings exhibits the highest UHII(UDII),followed by the compact high-rise(compact low-rise),while the LCZ of scattered trees presents both the lowest UHII and the lowest *** most significant difference in the UHII(UDII)among the nine LCZ types in the urban area of Beijing is2.62℃(1.1 g kg^(-1)).Area-weighted averaging analysis reveals that the open mid-rise LCZ is the most significant contributor to the UHII(UDII),immediately followed by compact mid-rise(open low-rise),with the least contribution from bare rock or paved(scattered trees).The results also indicate that beyond the intrinsic physical properties of the LCZs of a city,their area proportions cannot be overlooked in evaluating their impact on the UHI and *** quantitatively findings could help urban planners to create a livable urban climate and environment by adjusting the relevant land use.

关键词： local climate zone(LCZ) urban heat island(UHI) urban dry island(UDI) distribution pattern contribution rate Beijing

Gastrointestinal contrast-enhanced ultrasonography for diagnosis and treatment of peptic ulcer in children

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World Journal of Gastroenterology 2024年第7期30卷 705-713页

作者： Yu-hua Zhang Zhi-hua Xu Shuang-Shuang Ni Hong-Xia luo Department of Ultrasound The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The detection rate of peptic ulcer in children is improving,with development of diagnostic *** is the gold standard for the diagnosis of peptic ulcer,but it is an invasive *** contrast-enhanced ultrasonography(CEUS)has the advantages of being painless,noninvasive,nonradioactive,easy to use,and *** To investigate the clinical value of CEUS for diagnosis and treatment of peptic ulcer in *** We investigated 43 children with digestive tract symptoms in our hospital from January 2021 to June *** children were examined by routine ultrasound,gastrointestinal CEUS,and *** pathological results of gastroscopy were taken as the gold *** ultrasonography was performed before gastrointestinal *** ultrasound showed the thickness of the gastroduodenal wall,gastric peristalsis,and the adjacent organs and tissues around the abdominal *** CEUS recorded the thickness of the gastroduodenal wall;the size,location and shape of the ulcer;gastric peristalsis;and adjacent organs and tissues around the abdominal *** results of routine ultrasound and gastrointestinal ultrasound were compared with those of gastroscopy to evaluate the diagnostic results and coincidence rate of routine ultrasound and gastrointestinal *** children received informed consent from their guardians for *** study was reviewed and approved by the hospital medical ethics *** Among the 43 children,17(15 male,2 female)were diagnosed with peptic ulcer by *** were 26 children with nonpeptic *** were eight cases of peptic ulcer and 35 of nonpeptic ulcer diagnosed by conventional *** diagnostic coincidence rate of peptic ulcer in children diagnosed by conventional ultrasound was 79.1%(34/43),which was significantly different from that of gastroscopy(P=0.033).It indicates that the coincidence rate of gastrointestinal contrast-enhanc

关键词： Contrast-enhanced ultrasound Peptic ulcer Children Gastrointestinal tract Abdominal pain Acoustic contrast agent

Performance improvements in complementary metal oxide semiconductor devices and circuits based on fin field-effect transistors using 3-nm ferroelectric Hf_(0.5)Zr_(0.5)O_(2)

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Rare Metals 2024年第7期43卷 3242-3249页

作者： Zhao-Hao Zhang Yan-Na luo Gao-Bo Xu Jia-Xin Yao Zhen-hua Wu Hong-Bin Zhao Qing-Zhu Zhang hua-Xiang Yin Jun luo Wen-Wu Wang Hai-Ling Tu Integrated Circuit Advanced R&D Center Institute of Microelectronics of Chinese Academy of SciencesBeijing 100029China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Advanced Materials for Smart Sensing General Research Institute for Nonferrous MetalsBeijing 100088China

In this work,a conventional HfO_(2) gate dielectric layer is replaced with a 3-nm ferroelectric(Fe) HZO layer in the gate stacks of advanced fin field-effect transistors(FinFETs).Fe-induced characteristics,e.g.,negative drain induced barrier lowering(N-DIBL) and negative differential resistance(NDR),are clearly observed for both p-and n-type HZO-based *** characteristics are attributed to the enhanced ferroelectricity of the 3-nm hafnium zirconium oxide(HZO) film,caused by Al doping from the TiAlC capping *** mechanism is verified for capacitors with structures similar to the *** to the enhanced ferroelectricity and N-DIBL phenomenon,the drain current(I_(DS))of the HZO-FinFETs is greater than that of HfO_(2)-FinFETs and obtained at a lower operating ***,circuits based on HZO-FinFET achieve higher performance than those based on HfO_(2)-FinFET at a low voltage drain(V_(DD)),which indicates the application feasibility of the HZO-FinFETs in the ultralow power integrated circuits.

关键词： FinFET Ferroelectric Hafnium zirconium oxide Subthreshold swing Low power