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Journal of Hydrodynamics 2024年第2期36卷 219-231页

作者： Chen Geng Zhao-hui Qian Ke-xin Zheng Wei-xiang Ye Xian-wu luo State Key Laboratory of Hydroscience cand Engineering Deparment of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China

In the present paper,the unsteady cavitating turbulent flow over the twisted NACA66 hydrofoil is investigated based on an modified shear stress transfer k-ωpartially averaged Navier-Stokes(MSST PANS)model,i.e.,new MSST PANS(NMSST PANS)model,where the production term of kinetic energy in the turbulence model is modified with *** with the experimental data,cavitation evolution and its characteristic frequency are satisfactorily predicted by the proposed NMSST PANS *** is revealed that the interaction among the main flow,the reentrant jets,and sheet cavitation causes the formation of the primary shedding cavity near the mid-span and the secondary shedding cavity at each side of the twisted hydrofoil,and further induces the remarkable pressure gradient around shedding *** with the development of the primary and the secondary shedding cavities,the great pressure gradient associated with large cavity volume variation promotes the vortical flow generation and the spatial deformation of vortex structure during cavitation evolution,and results in the primary and the secondary U-type ***,dynamic mode decomposition(DMD)analysis is utilized to confirm the interaction among the main flow,the main reentrant jet and two side reentrant jets,and *** results indicate that the proposed NMSST PANS model is suitable to simulate the complicated cavitating turbulent flow for various engineering applications.

关键词： Cavitating turbulent flow partially averaged Navier-Stokes(PANS)model hydrofoil numerical simulation

Hypoglycemic effect and the mechanism of action of a polysaccharide from sweet corncob in a high-fat diet and streptozotocin-induced diabetic mice

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Food Science and Human Wellness 2024年第3期13卷 1543-1555页

作者： xin Wang Weiye Xiu Ye Han Zhili Wang Yu luo Yongqiang Ma Heilongjiang Provincial Key Laboratory of Cereals and Comprehensive Processing of Cereal Resources College of Food EngineeringHarbin University of CommerceHarbin 150028China

Type 2 diabetes mellitus(T2DM)is a metabolic disease caused by a glycolipid metabolism disorder and isletβ-cell ***-80-I is a biologically active water-soluble polysaccharide isolated from sweet corncob,an agricultural *** hypoglycemic effects of SCP-80-I on T2DM mice and its mechanisms were investigated in this ***-80-I was found to significantly reduce blood glucose and lipid deposition levels in T2DM mice,as well as decrease serum leptin and increase adiponectin ***,real time-polymerase chain reaction(RT-PCR)and Western blotting results revealed that SCP-80-I could regulate the expression of several glycolipid metabolisms and insulin secretion genes and proteins,including 5'-AMP-activated protein kinase(AMPK),carnitine palmitoyltransferase I(CPTI),and acetyl coenzyme A carboxylase(ACC)in the liver and AMPK,sirtuin1(Sirtl),peroxisome proliferator-activated receptorycoactivator-1(PGC-1α),and uncoupling protein 2(UCP2)in the *** have a hypoglycemic effect,SCP-80-1 regulated glycolipid metabolism and islet cell function in the liver by regulating the AMPK/AC C/CPT1 signaling pathway and the AMPK/Sirt1/PGC-1αand AMPK/Sirtl/UCP2 signaling *** findings improve our understanding of polysaccharides derived from sweet corncob and the use of SCP-80-I in the production of hypoglycemic foods.

关键词： Sweet corn cob polysaccharide Type 2 diabetes Signal pathway 5’-AMP-activated protein kinase(AMPK)

Diagnostic performance of a multiplexed gastrointestinal PCR panel for identifying diarrheal pathogens in children undergoing hematopoietic stem cell transplant

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World Journal of Pediatrics 2024年第9期20卷 966-975页

作者： Yue Tao Cheng-Juan luo Bing-Hua Zhang xin-yan Shen Rui-Ke Zhao Bei-Ying Ma Nan Shen Chang-Ying luo Jian-Min Wang Yi-Jun Xia Li Xie Jing Chen Xi Mo Pediatric Translational Medicine Institute Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang Rd.Shanghai200127China Department of Hematology and Oncology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang Rd.Shanghai200127China Department of Infectious Diseases Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Medical Affairs BioMérieux(Shanghai)CompanyLimitedShanghaiChina Clinical Research Institute School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Diarrhea is a common complication of hematopoietic stem cell transplantation(HSCT)and is associated with substantial morbidity,but its etiology is often *** of diarrhea in this population include infectious causes,chemotherapy-or medication-induced mucosal injury and graft-versus-host disease(GVHD).Distinguishing these potential causes of diarrhea is challenging since diarrheal symptoms are often multifactorial,and the etiologies often overlap in transplant *** objectives of this study were to evaluate whether the FilmArray gastrointestinal(GI)panel would increase diagnostic yield and the degree to which pre-transplantation colonization predicts post-transplantation *** From November 2019 to February 2021,a total of 158 patients undergoing HSCT were prospectively included in the *** specimens were obtained from all HSCT recipients prior to conditioning therapy,28±7 days after transplantation and at any new episode of *** stool samples were tested by the FilmArray GI panel and other clinical microbiological *** The primary cause of post-transplantation diarrhea was infection(57/84,67.86%),followed by medication(38/84,45.24%)and GVHD(21/84,25.00%).Ninety-five of 158 patients were colonized with at least one gastrointestinal pathogen before conditioning therapy,and the incidence of infectious diarrhea was significantly higher in colonized patients(47/95,49.47%)than in non-colonized patients(10/63,15.87%)(P<0.001).Fourteen of 19(73.68%)patients who were initially colonized with norovirus pre-transplantation developed a post-transplantation norovirus ***-four of 62(38.71%)patients colonized with Clostridium difficile developed a diarrheal *** addition,FilmArray GI panel testing improved the diagnostic yield by almost twofold in our study(55/92,59.78%vs.30/92,32.61%).Conclusions Our data show that more than half of pediatric patients who were admitted for HSCT were colonized

关键词： Children Diarrhea Hematopoietic stem cell transplantation Multiplexed polymerase chain reaction

Effectively improved piezoelectricityyinhigh-temperature Arrhenius CBT ceramics by modifying potential energy profile and spontaneous polarization

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Journal of Advanced Ceramics 2024年第8期13卷 1143-1152页

作者： Jingwen Xi Linlin Liu Hongwei Qiao Jiacheng luo xin Su xin Zhao Yugen Xu Hao Chen Zhi Tan Jianguo Zhu Nuclear Power Institution of China Chengdu 610213China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China

Enhancing the piezoelectricity of CaBi_(4)Ti_(4)O_(15)(CBT)ceramics is crucial for improving their application potential in high-temperature piezoelectric ***,we propose a strategy involving the introduction of larger Na/Bi ions at the A-site,effectively inhibiting the tilt of oxygen octahedra and flattening the potential energy *** flattening enhances the variation in polarization under external ***,substituting Nb/Mn at the B-site increases the deviation between positive and negative ionic centers,leading to stronger spontaneous polarization,while the induced defect dipoles restrict oxygen vacancy migration and increase the direct current resistivity(ρ_(dc)).The flattened potential energy profile and increased spontaneous polarization significantly enhance the overall performance of cBT ceramics,with the piezoelectric constant(d_(33))reaching 25 pC/N when the Curie temperature(Tc)=752℃.Piezoresponse force microscopy(PFM)and transmission electron microscopy(TEM)revealed submicron-long rectangular domains and nanoscale domains in the modified composition,indicating a high density of domain *** study presents an effective approach for enhancing the piezoelectric properties of bismuth layered-structured ferroelectrics(BLSFs),thereby improving the application potential of BLSFsathightemperatures.

关键词： piezoelectricity bismuth layered-structured ferroelectrics(BLSFs) potential energy profile spontaneous polarization high temperatures

Solving the subset sum problem by the quantum Ising model with variational quantum optimization based on conditional values at risk

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 43-55页

作者： Qilin Zheng Miaomiao Yu Pingyu Zhu yan Wang Weihong luo Ping Xu Institute for Quantum Information and State Key Laboratory of High Performance Computing College of Computer Science and TechnologyNational University of Defense TechnologyChangsha 410073China Hefei National Laboratory Hefei 230088China

The subset sum problem is a combinatorial optimization problem,and its complexity belongs to the nondeterministic polynomial time complete(NP-Complete)*** problem is widely used in encryption,planning or scheduling,and integer *** accurate search algorithm with polynomial time complexity has not been found,which makes it challenging to be solved on classical *** effectively solve this problem,we translate it into the quantum Ising model and solve it with a variational quantum optimization method based on conditional values at *** proposed model needs only n qubits to encode 2ndimensional search space,which can effectively save the encoding quantum *** model inherits the advantages of variational quantum algorithms and can obtain good performance at shallow circuit depths while being robust to noise,and it is convenient to be deployed in the Noisy Intermediate Scale Quantum *** investigate the effects of the scalability,the variational ansatz type,the variational depth,and noise on the ***,we also discuss the performance of the model under different conditional values at *** computer simulation,the scale can reach more than nine *** selecting the noise type,we construct simulators with different QVs and study the performance of the model with *** addition,we deploy the model on a superconducting quantum computer of the Origin Quantum Technology Company and successfully solve the subset sum *** model provides a new perspective for solving the subset sum problem.

关键词： subset sum problem quantum Ising model conditional values at risk variational quantum optimization

An Innovative Coupled Common-Node Discrete Element Method-Smoothed Particle Hydrodynamics Model Developed with LS-DYNA and Its Applications

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China Ocean Engineering 2024年第3期38卷 467-482页

作者： SHEN Zhong-xiang WANG Wen-qing XU Cheng-yue luo Jia-xin LIU Ren-wei School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China College of Harbor Coastal and Offshore EngineeringHohai UniversityNanjing 210098China

In this study,a common-node DEM-SPH coupling model based on the shared node method is proposed,and a fluid–structure coupling method using the common-node discrete element method-smoothed particle hydrodynamics(DS-SPH)method is developed using LS-DYNA *** DEM and SPH are established on the same node to create common-node DEM-SPH particles,allowing for fluid–structure *** simulations of various scenarios,including water entry of a rigid sphere,dam-break propagation over wet beds,impact on an ice plate floating on water and ice accumulation on offshore structures,are *** interaction between DS particles and SPH fluid and the crack generation mechanism and expansion characteristics of the ice plate under the interaction of structure and fluid are also *** results are compared with available data to verify the proposed coupling ***,the simulation results demonstrated that controlling the cutoff pressure of internal SPH particles could effectively control particle splashing during ice crushing failure.

关键词： common-node DEM-SPH fluid-structure interaction discrete element method smoothed particle hydrodynamics

3D-printed self-healing,biodegradable materials and their applications

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Frontiers of Mechanical Engineering 2024年第3期19卷 1-22页

作者： Yu LI Guangmeng MA Fawei GUO Chunyi luo Han WU xin luo MingtaoZHANG Chenyun WANG Qingxin JIN Yu LONG School of Mechanical Engineering Guangxi UniversityNanning 530004China State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Guangxi UniversityNanning 530004China Institute of Laser Intelligent Manufacturing and Precision Processing School of Mechanical EngineeringGuangxi UniversityNanning 530004China College of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China

3D printing is a versatile technology capable of rapidly fabricating intricate geometric structures and enhancing the performance of flexible devices in comparison to conventional fabrication ***,3D-printed devices are susceptible to failure as a result of minuscule structural impairments,thereby impacting their overall *** utilization of self-healing,biodegradable materials in 3D printing holds immense potential for increasing the longevity and safety of devices,thereby expanding the application prospects for such ***,enhancing the self-repairing capability of devices and refining the 3D printing performance of self-healing materials are still considerable challenges that need to be addressed to achieve optimal *** paper reviews recent developments in the field of advancements in 3D printing using self-healing and biodegradable ***,it investigates self-healing and biodegradable materials that are compatible with 3D printing techniques,discussing their printability,material properties,and factors that influence print ***,it explores practical applications of selfhealing and biodegradable 3D printing technology in ***,it critically offers practical perspectives on this topic.

关键词： 3D printing self-healing biodegradable soft materials covalent bonds non-covalent bonds

A cost-efficient quantum access network with qubit-based synchronization

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 12-22页

作者： Chunfeng Huang Ye Chen Tingting luo Wenjie He xin Liu Zhenrong Zhang Kejin Wei Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Multimedia Communications and Network Technology School of Computer Electronics and InformationGuangxi UniversityNanning 530004China

Quantum key distribution(QKD)is a physical layer encryption technique that enables two distant parties to exchange secure keys with information-theoretic *** the last two decades,QKD has transitioned from laboratory research to real-world applications,including multi-user quantum access networks(QANs).This network structure allows users to share a single-photon detector at a network node through time-division multiplexing,thereby significantly reducing the network ***,current QAN implementations require additional hardware for auxiliary tasks such as time *** address this issue,we propose a cost-efficient QAN that uses qubit-based *** this approach,the transmitted qubits facilitate time synchronization,eliminating the need for additional synchronization *** tested our scheme by implementing a network for two users and successfully achieved average secure key rates of 53.84 kbps and 71.90 kbps for each user over a 50-km commercial fiber *** addition,we investigated the capacity of the access network under cross-talk and loss *** simulation results demonstrate that this scheme can support a QAN with 64 users with key rates up to 1070 *** work provides a feasible and cost-effective way to implement a multi-user QKD network,further promoting the widespread application of QKD.

关键词： quantum key distribution quantum access network qubit-based synchronization

The enhanced mechanical properties of SiC nanowires/Ba_(0.75)Sr_(0.25)Al_(2)Si_(2)O_(8) ceramics with embedded SiO_(2) interface

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Journal of Advanced Ceramics 2024年第7期13卷 933-941页

作者： xin Li Xiaomeng Fan Haojie luo Xiaoke Lu Jimei Xue Fang Ye Yongsheng Liu Science and Technology on Thermostructural Composite Materials Laboratory Northwestern Polytechnical UniversityXi’an 710072China Frontier Institute of Science and Technology Xi’an Jiaotong UniversityXi’an 710049China

In this work,low-softening-temperature and low-modulus SiO_(2) was introduced as an embedded interface between SiC nanowires(SiCnws)and a Ba_(x)Sr_(1−x)Al_(2)Si_(2)O_(8) ceramic matrix to enhance strength and toughness of the *** the sintering process,molten SiO_(2) enhances the flowability of the ceramic powders and modifies the dispersion of *** strengthening effect of SiCnws was fully realized,and the flexural strength of the optimized ceramics reached 193±16 MPa,which represents an increase of 52.6%.After the formation of the embedded SiO_(2) interface with a low modulus,cracks can deflect along the SiCnws surface,which is consistent with the criterion of He and *** can effectively extend the crack propagation path,and the fracture toughness(K_(IC))is thus improved by 94.0%,reaching 3.1±0.5 MPa·m^(1/2).

关键词： multiphase ceramics SiO_(2) interface densification mechanical properties

Structural basis of negative regulation of CRISPR-Cas7-11 by TPR-CHAT

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2716-2725页

作者： Tian Hong Qinghua luo Haiyun Ma xin Wang xinqiong Li Chongrong Shen Jie Pang yan Wang Yuejia Chen Changbin Zhang Zhaoming Su Haohao Dong Xiaodi Tang Department of Laboratory Medicine State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduChina Frontiers Medical Center Tianfu Jincheng LaboratoryWest China HospitalSichuan UniversityChengduChina

CRISPR‒Cas7-11 is a Type Ⅲ-E CRISPR-associated nuclease that functions as a potent RNA editing ***-peptide repeat fused with Cas/HEF1-associated signal transducer(TPR-CHAT)acts as a regulatory protein that interacts with CRISPR RNA(crRNA)-bound Cas7-11 to form a CRISPR-guided caspase complex(Craspase).However,the precise modulation of Cas7-11’s nuclease activity by TPR-CHAT to enhance its utility requires further ***,we report cryo-electron microscopy(cryo-EM)structures of Desulfonema ishimotonii(Di)Cas7-11-crRNA,complexed with or without the full length or the N-terminus of *** structures unveil the molecular features of the Craspase *** analysis,combined with in vitro nuclease assay and electrophoretic mobility shift assay,reveals that DiTPR-CHAT negatively regulates the activity of DiCas7-11 by preventing target RNA from binding through the N-terminal 65 amino acids of DiTPR-CHAT(DiTPR-CHAT_(NTD)).Our work demonstrates that DiTPRCHAT_(NTD) can function as a small unit of DiCas7-11 regulator,potentially enabling safe applications to prevent overcutting and offtarget effects of the CRISPR‒Cas7-11 system.

关键词： CRISPR crRNA TPR