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Multiple inducible thermogenic mechanisms in the development of cold acclimatization

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Frigid Zone Medicine 2023年第2期3卷 83-91页

作者： Huanyu Lu wenjing luo Department of Occupational and Environmental Health the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational EnvironmentShaanxi Key LaboratorySchool of Public HealthFourth Military Medical UniversityXi'an 710000China

Extreme cold environment can threaten human health and life through increasing the risk of myocardial infarction,stroke,frostbite,and *** heat production to maintain core body temperature is a major cause of cold *** cope with cold stress,human and other mammals have developed the capacity of cold acclimatization to adapt to such a harsh *** non-shivering thermogenesis is a ubiquitous form of cold *** review article systematically summarizes the role of three inducible thermogenic forms,including food intake,circadian rhythms,and cold exposure in mediating non-shivering thermogenesis under cold exposure and presents the potential interventions for minimizing the adverse health consequences of cold temperature.

关键词： cold exposure proteomic profile hypothalamus pituitary

Clinical differences between young and older patients with optic neuritis

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Annals of Eye Science 2017年第1期2卷 339-343页

作者： wenjing luo Qiu-Shui Huang Jian-Feng He Min Han Bo Liu Yi Du The Cadre Ward in Department of Neurology the People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021China Department of Ophthalmology the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China

Background:To compare clinical features in young(18-44 years)and older patients(>44 years)with optic neuritis(ON).Methods:This is a retrospective case series *** hundred thirty-three young cases and 51 older cases diagnosed with ON were ***:The older patients had lower proportion of disc swelling(37.3%vs.57.1%,P=0.016),but higher proportion of brain plaques(21.6%vs.7.5%,P=0.007)compared with the young *** proportion of patients suffered from hypertension or hyperglycemia was nearly 6 times higher in the older patients than in the young patients(29.4%vs.5.3%,P44 years).Physicians should pay attention to the side effects of corticosteroids in elderly patients in clinical practice,although they are generally safe.

关键词： Multiple sclerosis optic disc edema periventricular plaques demyelination

Evolution of the historical polder landscape in the ancient Danyang wetland,lower Yangtze River,China,during the last 3000 years

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Journal of Geographical Sciences 2024年第10期34卷 2053-2073页

作者： HU Xiaosi WU Li ZHUANG Yijie WANG Xinyuan MA Chunmei LI Linying GUAN Houchun LU Shuguang luo wenjing XU Ziyi Provincial Key Laboratory of Earth Surface Processes and Regional Response in the Yangtze-Huaihe River Basin School of Geography and TourismAnhui Normal UniversityWuhu 241002AnhuiChina Institute of Archaeology University College LondonLondon WC1H OPYUK Aerospace Information Research Institute CASBeijing 100094China School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210023China Anhui Institute of Geological Sciences Hefei 230001China

Polder is a type of irrigation field unique to the lower Yangtze River of *** is a product of long-term and ingenuous human modifications of wetland *** the pre-Qin Period,3000 years ago,the poldered area of eastern Wuhu city was once a large lake called the ancient Danyang *** introduction of agricultural civilization and polder technology to the area during the Wu and Yue Kingdoms period gradually transformed it into an agricultural *** an accelerating rate of land reclamation under a changing late-Holocene regional climate,the ancient Danyang wetland became an aquatic system strongly influenced by intensifying anthropogenic *** this study,based on field survey data,historical documents,and remote-sensing and archaeological data,we reconstructed the spatial distribution of the polder landscape over the last 3000 years and identified their structural *** found that polder landscapes began to emerge in the Spring and Autumn Period,land reclamation intensified in the Three Kingdoms and developed rapidly in the Song Dynasty before eventually reaching the peak from the Ming and Qing *** relocation of historical sites to low-altitude areas also marked the expansion of poldered fields from the center of the wetland to the southeast and *** development and evolution of the polder landscape are related to regional climate conditions,changing social and economic statuses,and the development of agricultural technology in the Song Dynasty and succeeding periods.

关键词： ancient Danyang wetland polder landscape climate change anthropogenic activities lower Yangtze River

南宁半成岩地层明暗挖地铁车站关键技术及数值分析

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隧道建设（中英文） 2020年第5期40卷 727-734页

作者：罗文静邹成路广州地铁设计研究院股份有限公司广东广州510010

为解决半成岩地层明暗挖地铁车站施工中存在的问题,结合南宁地铁3号线青秀山站,采用数值模拟分析与现场监测相结合的方法,对半成岩地层明暗挖结合地铁车站修建过程中遇到的关键问题进行分析,并提出解决问题的具体方法。研究结果表明:1)... 详细信息

为解决半成岩地层明暗挖地铁车站施工中存在的问题,结合南宁地铁3号线青秀山站,采用数值模拟分析与现场监测相结合的方法,对半成岩地层明暗挖结合地铁车站修建过程中遇到的关键问题进行分析,并提出解决问题的具体方法。研究结果表明:1)在富水半成岩地层中修建隧道可采用群井降水的方法对地层进行加固,降水后围岩黏聚力大幅度增大,有利于隧道开挖;2)站台层隧道群开挖时应合理安排施工工序,横通道在距离正线隧道开挖面大于1倍隧道洞径后方可开挖,斜扶梯通道宜在横通道二次衬砌完成后开挖;3)群洞隧道三岔口部位应根据工程条件予以加强设计,尤其是在隧道纵向上;4)在一定条件下,明挖站厅层在站台层暗挖隧道群之前施工是可行的。

关键词：半成岩地层明暗挖地铁车站群洞群井降水数值模拟

国土空间规划“双碳”计算仿真模块构建及应用

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城市规划学刊 2023年第2期 47-56页

作者：罗文静汪勰熊伟武汉市规划编审中心武汉市自然资源与规划局空间规划处武汉市自然资源和规划信息中心

“双碳”理念与国土空间规划在目标、手段及过程等方面具有内在一致的逻辑关联，然而由于两者缺乏数字联系，尚无法实现“双碳”目标的空间统筹。为将“双碳”理念纳入国土空间规划体系，有必要面向自然资源全要素，构建“双碳”空间计... 详细信息

“双碳”理念与国土空间规划在目标、手段及过程等方面具有内在一致的逻辑关联，然而由于两者缺乏数字联系，尚无法实现“双碳”目标的空间统筹。为将“双碳”理念纳入国土空间规划体系，有必要面向自然资源全要素，构建“双碳”空间计算仿真的工具模块，以评估规划方案的碳模拟值，传导自然资源要素的碳管控值，并实时监督碳实施值，从而贯穿规划的全生命周期，构建集“碳模拟”“碳管控”“碳监测”的数字化跟踪闭环。围绕“碳模拟”空间计算模块，为实现能量代谢活动碳核算向空间使用活动碳计算的逻辑转换，按照识别“双碳”要素、摸清“双碳”底数、搭建“双碳”算术的“三步走”技术路线，构建市级国土空间总体规划碳评估计算框架，并以武汉为例进行计算验证。研究发现减排增汇的关键因子包括工业用地面积、工业用地地均产值、单位GDP生产能耗降幅、能源结构调整、新建建筑规模、出行次数、出行结构等，并以碳达峰增速、增量及总量拐点为关键时点，提出关键因子的分阶段导控要求，在此基础上围绕城市规模、用地管控、空间结构—交通模式、底线约束、基础设施、实施监督等方面提出空间治理建议。

关键词：碳达峰碳中和国土空间规划计算仿真碳评估

转录因子DEC1在肿瘤发生发展过程中的作用

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中国药科大学学报 2015年第5期46卷 541-547页

作者：杨欢熊晶洛文靖奚涛中国药科大学生命科学与技术学院南京210009 南京医科大学基础医学院药理学系南京210029

转录因子DEC1属于bHLH家族,与肿瘤细胞增殖分化、淋巴细胞成熟、生物节律调节、免疫应答以及应激反应密切相关。近期研究表明,多种肿瘤组织和肿瘤细胞中DEC1异常高表达,且肿瘤组织中DEC1的表达与肿瘤分级相关。本文重点介绍DEC1与肿瘤... 详细信息

转录因子DEC1属于bHLH家族,与肿瘤细胞增殖分化、淋巴细胞成熟、生物节律调节、免疫应答以及应激反应密切相关。近期研究表明,多种肿瘤组织和肿瘤细胞中DEC1异常高表达,且肿瘤组织中DEC1的表达与肿瘤分级相关。本文重点介绍DEC1与肿瘤细胞增殖、凋亡、衰老以及侵袭转移等表型之间的关系,从而进一步阐释DEC1在肿瘤发生发展中的作用。

关键词：转录因子 DEC1 增殖凋亡侵袭转移细胞衰老

Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies

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Cancer Communications 2024年第3期44卷 408-432页

作者： Lu Tang Huan Zhang Fen Zhou Qiuzhe Wei Mengyi Du Jianghua Wu Chenggong Li wenjing luo Jie Zhou Xindi Wang Zhaozhao Chen Yinqiang Zhang Zhongpei Huang Zhuolin Wu Yuxi Wen Huiwen Jiang Danying Liao Haiming Kou Wei Xiong Heng Mei Yu Hu Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Hubei Clinical Medical Center of Cell Therapy For Neoplastic Disease WuhanHubeiP.R.China Key Laboratory of Biological Targeted Therapy the Ministry of EducationWuhanHubeiP.R.China Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Hubei Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China

Background:Chimeric antigen receptor T(CAR-T)therapy has substantially revolutionized the clinical outcomes of patients with hematologic malignan-cies,but the cancer-intrinsic mechanisms underlying resistance to CAR-T cells remain yet to be fully *** study aims to explore the molecular deter-minants of cancer cell sensitivity to CAR-T cell-mediated killing and to provide a better understanding of the underlying mechanisms and potential modulation to improve clinical ***:The human whole-genome CRISPR/Cas9-based knockout screening was conducted to identify key genes that enable cancer cells to evade CD19 CAR-T-cell-mediated *** in vitro cytotoxicity assays and evaluation of tumor tissue and bone marrow specimens were further conducted to confirm the role of the key genes in cancer cell susceptibility to CAR-T *** addition,the specific mechanisms influencing CAR-T cell-mediated cancer clearance were elucidated in mouse and cellular ***:The CRISPR/Cas9-based knockout screening showed that the enrich-ment of autophagy-related genes(ATG3,BECN1,and RB1CC1)provided protec-tion of cancer cells from CD19 CAR-T cell-mediated *** findings were further validated by in vitro cytotoxicity assays in cells with genetic and pharmacological inhibition of ***,higher expression of the three autophagy-related proteins in tumor samples was correlated with poorer respon-siveness and worse survival in patients with relapsed/refractory B-cell lymphoma after CD19 CAR-T *** RNA sequencing analysis of bone marrow samples from B-cell leukemia patients also suggested the clinical relevance of autophagy to the therapeutic response and relapse after CD19 CAR-T cell *** inhibition of autophagy and knockout of RB1CC1 could dramatically sensitize tumor cells to CD19 CAR-T cell-mediated killing in mouse models of both B-cell leukemia and ***,our study revealed that cancer-intrinsic

关键词： CAR-T resistance Autophagy Immune evasion Apoptosis Chemotaxis

基于“社会支持”理论的综合福利设施老幼复合空间设计方法探究

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建筑学报 2021年第S2期 47-52页

作者：裘知罗文婧王竹浙江大学建筑工程学院杭州310058

基于文献调查与设施内老幼复合活动观察记录,剔除不具备活动自主性的孤儿,围绕活跃老人的活动参与意愿展开讨论。引入"社会支持"理论,围绕已发的复合活动,从工具型支持与情感型支持构建活动的社会支持四象限体系,分析各象限活动的类型... 详细信息

基于文献调查与设施内老幼复合活动观察记录,剔除不具备活动自主性的孤儿,围绕活跃老人的活动参与意愿展开讨论。引入"社会支持"理论,围绕已发的复合活动,从工具型支持与情感型支持构建活动的社会支持四象限体系,分析各象限活动的类型、功能空间属性、老年人特征与互动等级的相互关系,从支持类型与互动等级两大维度,整合"基础-拓展"功能体系,建构综合福利设施老幼复合空间功能模型,并给出典型空间单位及设计要点,为我国综合福利设施老幼复合空间设计导控体系研究提供理论基础。

关键词：综合福利设施老幼复合社会支持理论互动等级基础-拓展

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人工智能在多发性硬化研究中的应用

中华神经科杂志 2021年第3期54卷 281-284页

作者：刘春新罗文静邱伟中山大学附属第三医院神经科广州510630

多发性硬化(MS)是一种中枢神经系统脱髓鞘性自身免疫性疾病,中青年好发,致残率高。其发病机制未完全阐明,遗传异质性大,临床表型多样,缺乏特异性的生物标志物,研究数据繁杂,给MS的诊疗带来了巨大挑战。人工智能作为当今科技发展的前沿热... 详细信息

多发性硬化(MS)是一种中枢神经系统脱髓鞘性自身免疫性疾病,中青年好发,致残率高。其发病机制未完全阐明,遗传异质性大,临床表型多样,缺乏特异性的生物标志物,研究数据繁杂,给MS的诊疗带来了巨大挑战。人工智能作为当今科技发展的前沿热点,被广泛应用于医学领域,辅助各类疾病的诊断、治疗及预后判断,其无限的学习能力极大地推动了MS诊疗技术的发展。文中将对人工智能在MS诊疗中的应用作一综述。

关键词：多发性硬化机器学习人工智能深度学习