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Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways

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Genes & Diseases 2024年第2期11卷 1050-1065页

作者： Xiaoxuan Wang Lijuan luo Jingtao Xu Qiuping Lu Haichao Xia Yanran Huang Lulu Zhang Liping Xie Habu Jiwa Shiqiong Liang Xiaoji luo Jinyong luo Key Laboratory of Diagnostic Medicine Designated By the Chinese Ministry of Education School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China

Bladder cancer (BC) is one of the most common malignant tumors in the urinary *** to the poor prognosis and high mortality rate of the disease,it is urgent to develop new drugs with high efficacy and low toxicity to treat *** (Ecn) is a bioactive natural flavonoid oflicorice that has attracted special attention for its promising anti-tumor ***,we explored the inhibitory effects of Echinatin on BC cells and probed the possible molecular *** found that Ecnin vitro inhibited the proliferation,migration,and invasion,arrested the cell cycle at the G2/M phase,and promoted apoptosis in BC ***,Ecn had no notable cytotoxicity towards human normal *** subsequently confirmed that Ecn restrained xenograft tumor growth and metastasis of BC cells in vivo .Mechanistically,Ecn activated the p38 signaling pathway but inactivated the Wnt/β-catenin signaling pathway,while over-expression of β-catenin and the p38 inhibitor both attenuated the inhibitory effects of Ecn on BC ***,Ecn combined with cisplatin (DDP) or gemcitabine (Gem) had synergistic inhibitory effects on BC *** summary,our results validate that Ecn inhibits the tumor growth of human BC cells via p38 and Wnt/β-catenin signaling *** meaningfully,our results suggest a potential strategy to enhance DDP- or Gem-induced inhibitory effects on BC cells by combining with Ecn.

关键词： Bladder cancer Combination chemotherapy Echinatin p38 Wnt/β-catenin

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The dual role of striatal interneurons:circuit modulation and trophic support for the basal ganglia

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Neural Regeneration Research 2024年第6期19卷 1277-1283页

作者： Elliot Wegman Marlena Wosiski-Kuhn Yu luo Department of Molecular and Cellular Biosciences University of CincinnatiCincinnatiOHUSA Department of Emergency Medicine at the School of Medicine University of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program University of CincinnatiCincinnatiOHUSA

Striatal interneurons play a key role in modulating striatal-dependent behaviors,including motor activity and reward and emotional *** not only provide modulation to the basal ganglia circuitry under homeostasis but are also involved in changes to plasticity and adaptation during disease conditions such as Parkinson's or Huntington's *** review aims to summarize recent findings regarding the role of striatal cholinergic and GABAergic interneurons in providing circuit modulation to the basal ganglia in both homeostatic and disease *** addition to direct circuit modulation,striatal interneurons have also been shown to provide trophic support to maintain neuron populations in *** discuss this interesting and novel role of striatal interneurons,with a focus on the maintenance of adult dopaminergic neurons from interneuronderived sonic-hedgehog.

关键词： cholinergic dopamine GABAergic interneuron levodopa-induced dyskinesia parvalbumin sonic hedgehog striatum trophic factor

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Na_2分子X^1Σ_g^+,A^1Σ_u^+和B^1Π_u态的势能函数

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计算物理 2008年第2期25卷 225-229页

作者：谢安东周玲玲毛金文罗文浪伍冬兰阮文井冈山学院物理系江西吉安343009

使用SAC/SAC-CI方法,利用6-311++g,6-311g**及cc-PVTZ等基组,对Na2分子的基态(X1Σg+)、第一激发态(A1Σu+)和第二激发态(B1Πu)的平衡结构和谐振频率进行计算.通过对3个基组的计算结果的比较,得出6-311g**基组为3个基组中最优基组的结... 详细信息

使用SAC/SAC-CI方法,利用6-311++g,6-311g**及cc-PVTZ等基组,对Na2分子的基态(X1Σg+)、第一激发态(A1Σu+)和第二激发态(B1Πu)的平衡结构和谐振频率进行计算.通过对3个基组的计算结果的比较,得出6-311g**基组为3个基组中最优基组的结论;使用6-311g**基组,分别利用SAC的GSUM(Group Sum of Operators)方法对基态(X1Σg+),SAC-CI的GSUM方法对激发态(A1Σu+)和(B1Πu)进行单点能扫描计算,用正规方程组拟合Murrell-Sorbie函数,得到相应电子态的完整势能函数.用得到的势能函数计算与基态(X1Σg+),第一激发态(A1Σu+)和第二激发态(B1Πu)相对应的光谱常数(Be,αe,ωe和ωeχe),结果与实验数据基本吻合.

关键词：分子结构与势能函数激发态 Murrell-Sorbie函数

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Acetylacetone effectively controlled the secondary metabolites of Microcystis aeruginosa under simulated sunlight irradiation

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Journal of Environmental Sciences 2024年第1期135卷 285-295页

作者： Xiaomeng Wang Yixin luo Shujuan Zhang Lixiang Zhou Department of Environmental Engineering College of Resources and Environmental SciencesNanjing Agricultural UniversityNanjing 210095China The State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China

Inactivation of cyanobacterial cells and simultaneous control of secondary metabolites is of significant necessity for the treatment of cyanobacteria-laden ***(AcAc)has been reported a specific algicide to inactivate Microcystis aeruginosa(***)and an effective light activator to degrade *** study systematically investigated the photodegradation ability of AcAc under xenon(Xe)irradiation on the secondary metabolites of ***,mainly algal organic matter(AOM),especially toxic microcystin-LR(MC-LR).Results showed that AcAc outperformed H_(2)O_(2)in destructing the protein-like substances,humic acid-like matters,aromatic proteins and fulvic-like substances of *** MC-LR(250μg/L),0.05 mmol/L AcAc attained the same degradation efficiency(87.0%)as 0.1mmol/L H_(2)O_(2).The degradation mechanism of Xe/AcAc might involve photo-induced energy/electron transfer and formation of carbon center *** conditions(pH>9.0)were detrimental to the photoactivity of AcAc,corresponding to the observed degradation rate constant(k_(1)value)of MC-LR drastically decreasing to 0.0013 min^(-1)as solution pH exceeded *** PO_(4)^(3-)and HCO_(3)^(-)ions had obvious inhibition effects,whereas NO_(3)^(-)slightly improved k_(1)value from 0.0277 min^(-1)to 0.0321 min^(-1).The presence of AOM did not significantly inhibit MC-LR degradation in Xe/AcAc *** addition,the biological toxicity of MC-LR was greatly reduced after *** results demonstrated that AcAc was an alternative algicidal agent to effectively inactivate algal cells and simultaneously control the secondary metabolites after cell ***,the concentration and irradiation conditions should be further optimized in practical application.

关键词： Microcystis aeruginosa Photodegradation Acetylacetone Secondary metabolites Microcystin

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Ultra-low loss Rayleigh scattering enhancement via light recycling in fiber cladding

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Photonics Research 2024年第8期12卷 1813-1819页

作者： PENGTAO luo FENGYI CHEN RUOHUI WANG XUEGUANG QIAO School of Physics Northwest UniversityXi’an 710127China Engineering Research Center of Optical Fiber Well Logging Technology for Oil and Gas Resources Universities of Shaanxi ProvinceXi’an 710127China

Rayleigh backscattering enhancement(RSE)of optical fibers is an effective means to improve the performance of distributed optical fiber *** laser direct-writing techniques have been used to modulate the fiber core for ***,in-core modulation loses more transmission light,thus limiting the sensing *** this work,a cladding-type RSE(cl-RSE)structure is proposed,where the femtosecond laser is focused in the fiber cladding and an array of scatterers is written parallel to the *** refractive-index modulation structure redistributes the light in the cladding,and the backward scattered light is recovered,which enhances the Rayleigh backscattered signal with almost no effect on the core light.

关键词： fiber scattering cladding

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Laser Powder Bed Fusion of Beta-Type Titanium Alloys for Biomedical Application:A Review

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 17-28页

作者： Xuan luo Chao Yang Dongdong Li Lai-Chang Zhang State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China National Engineering Research Center of Near-Net-Shape Forming for Metallic Materials Guangdong Provincial Key Laboratory for Processing and Forming of Advanced Metallic MaterialsSouth China University of TechnologyGuangzhou510640China Centre for Advanced Materials and Manufacturing School of EngineeringEdith Cowan University270 Joondalup DriveJoondalupPerthWA6027Australia

Additive manufacturing ofβ-type titanium alloy is expected to replace Ti-6Al-4V alloy in the field of orthopedic implantation because of their low elastic modulus,excellent corrosion resistance,and *** briefly introducing the laser powder bed fusion(LPBF)process and physical phenomena,this paper reviews the recent progresses in LPBF-edβ-type Ti *** strategies to strengthening and tougheningβ-type Ti alloys are critically *** is followed by the processing routes employed to achieve to low modulus for orthopedic applications,especially a new methodology for tailoring crystallographic orientation called multi-track coupled directional *** effect of processing and compositions on performance metrics ofβ-type Ti alloys included corrosion behavior,and biocompatibility is *** the end,challenges in additive manufacturing ofβ-type Ti alloys in future are highlighted,with the aim to ensue clinical application of LPBF-edβ-type Ti alloys.

关键词： β-type Ti alloys Laser powder bed fusion Mechanical properties Elastic modulus Biocompatibility

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Multicomponent remote C（sp2）–H bond addition by Ru catalysis:An efficient access to the alkylarylation of 2H-imidazoles

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Chinese Chemical Letters 2024年第10期35卷 283-287页

作者： Yi luo Lin Dong Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University

Sequential C–H bond addition with two different coupling partners is a powerful method for the rapid and modular construction of complex molecules based on simple starting materials. Herein, an efficient ruthenium-catalysed multicomponent long-range C–H functionalization of 2H-imidazoles was *** protocol showed good substrate suitability and yielded alkyl arylation products with potential biological activity.

关键词： Remote C-H functionalization Multi-component reaction Ruthenium catalysis 2H-Imidazoles FUNCTIONALIZATION CONSTRUCTION IMIDAZOLE

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A physics-informed neural network for simulation of finite deformation in hyperelastic-magnetic coupling problems

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Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1717-1732页

作者： Lei WANG Zikun luo Mengkai LU Minghai TANG Department of Engineering Mechanics College of Mechanics and Engineering SciencesHohai University School of Mechanical Engineering and Mechanics Ningbo University

Recently, numerous studies have demonstrated that the physics-informed neural network(PINN) can effectively and accurately resolve hyperelastic finite deformation problems. In this paper, a PINN framework for tackling hyperelastic-magnetic coupling problems is proposed. Since the solution space consists of two-phase domains,two separate networks are constructed to independently predict the solution for each phase region. In addition, a conscious point allocation strategy is incorporated to enhance the prediction precision of the PINN in regions characterized by sharp *** the developed framework, the magnetic fields and deformation fields of magnetorheological elastomers(MREs) are solved under the control of hyperelastic-magnetic coupling equations. Illustrative examples are provided and contrasted with the reference results to validate the predictive accuracy of the proposed framework. Moreover, the advantages of the proposed framework in solving hyperelastic-magnetic coupling problems are validated, particularly in handling small data sets, as well as its ability in swiftly and precisely forecasting magnetostrictive motion.

关键词： 74B20 74F15 deep learning finite deformation hyperelasticmagnetic coupling O343.5 physics-informed neural network (PINN) small data set

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外偶极电场作用下H_2O,D_2O和T_2O的可逆分解电压

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化学学报 2010年第10期68卷 975-981页

作者：史顺平罗文浪朱正和刘秀华傅依备蒋刚王蓉滑亚文四川大学原子与分子物理研究所成都610065 井冈山大学信息科学学院吉安343009 中国工程物理研究院绵阳621900

采用密度泛函B3P86方法和6-311++G(3df,3pf)基组,计算了在-0.05～0.05a.u.外偶极电场作用下,H2O,D2O,T2O,H2,D2,T2,O2的电子能量、核运动能量和熵值,在此基础上通过计算H2O(g)→H2(g)+O2(g)、D2O(g)→D2(g)+O2(g)、T2O(g)→T2(g)+O2(g)的焓变ΔH、熵变ΔS、Gibbs函数变化ΔG,最后得到了H2O,D2O,T2O的可逆分解电压Er.计算结果表明,外偶极电场存在时,H2O,D2O,T2O的Gibbs自由能变ΔG和可逆分解电压Er都有明显的变化,当外偶极电场正方向增加时,其Gibbs自由能变ΔG和可逆分解电压Er均趋于线性增加;当外偶极电场负方向增加时,其Gibbs自由能变ΔG和可逆分解电压Er均趋于线性减小;在相同外偶极电场作用下,Gibbs自由能变ΔG和可逆分解电压Er随H2O,D2O,T2O依次增加.

关键词： H2O,D2O,T2O 可逆分解电压Er 外偶极电场 Gibbs自由能变ΔG

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Study of the pressure transient behavior of directional wells considering the effect of non-uniform flux distribution

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Petroleum Science 2024年第3期21卷 1765-1779页

作者： Yan-Zhong Liang Bai-Lu Teng Wan-Jing luo School of Energy Resources China University of Geosciences(Beijing)Beijing100083China

During the production,the fluid in the vicinity of the directional well enters the wellbore with different rates,leading to non-uniform flux distribution along the directional ***,in all existing studies,it is oversimplified to a uniform flux distribution,which can result in inaccurate results for field ***,this paper proposes a semi-analytical model of a directional well based on the assumption of non-uniform flux ***,the direction well is discretized into a carefully chosen series of linear sources,such that the complex well trajectory can be captured and the nonuniform flux distribution along the wellbore can be considered to model the three-dimensional flow *** using the finite difference method,we can obtain the numerical solutions of the transient flow within the *** the aid of Green's function method,we can obtain the analytical solutions of the transient flow from the matrix to the *** complete flow behavior of a directional well is perfectly represented by coupling the above two types of transient ***,on the basis of the proposed model,we conduct a comprehensive analysis of the pressure transient behavior of a directional *** computation results show that the flux variation along the direction well has a significant effect on pressure *** addition,the directional well in an infinite reservoir may exhibit the following flow regimes:wellbore afterflow,transition flow,inclined radial flow,elliptical flow,horizontal linear flow,and horizontal radial *** horizontal linear flow can be observed only if the formation thickness is much smaller than the well ***,a dip region that appears on the pressure derivative curve indicates the three-dimensional flow behavior near the wellbore.

关键词： Directional well Pressure transient behavior Semi-analytical model Non-uniform flux

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