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Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants:a randomized phase 2 trial

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Signal Transduction and Targeted Therapy 2023年第2期8卷 672-682页

作者： Nawal Al Kaabi Yun Kai Yang Yu liang Ke Xu Xue feng zhang Yun Kang Yu Qin Jin Jun wei Hou Jing zhang Tian Yang Salah Hussein Mohamed Saif ElDein Ze Hua Lei Hao zhang Shuai Shao Zhao ming liu Ning liu Xiang Zheng Ji Guo Su Sen Sen Yang Xiangfeng Cong Yao Tan Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue zhang Chang Qu Dan Ying liu Jing zhang Mengjie Yang Islam Eltantawy Peng Xiao Fu Jie Shen Jin Juan Wu Zi Bo Han li fang du fang Tang Shi chen Zhi Jing Ma fan Zheng Ya Nan Hou Xin Yu li Xin li Zhao Nian Wang Jin liang Yin Xiao Yan Mao Jin zhang liang Qu Yun Tao zhang Xiao ming Yang Guizhen Wu Qi ming li Sheikh Khalifa Medical City SEHAAbu DhabiUAE College of Medicine and Health Sciences Khalifa UniversityAbu DhabiUAE China National Biotec Group Company limited BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Clinical Medicine Office National Vaccine and Serum Institute(NVSI)BeijingChina Lanzhou Institute of Biological Products Company limited LanzhouChina Beijing Key Tech Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Company limited BeijingChina Union 71 Abu DhabiUAE G42 Healthcare Abu DhabiUAE

An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to *** participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or *** primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating *** May 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV *** results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or *** immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by *** findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages.

关键词： phase neutral spectrum

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Efficacy and safety of LY01005 versus goserelin implant in Chinese patients with prostate cancer: A multicenter, randomized, open-label, phase III, non-inferiority trial

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Chinese Medical Journal 2023年第10期136卷 1207-1215页

作者： chengyuan Gu Zengjun Wang Tianxin lin Zhiyu liu weiqing Han Xuhui zhang Chao liang Hao liu Yang Yu Zhenzhou Xu Shuang liu Jingen Wang linghua Jia Xin Yao Wenfeng liao cheng Fu Zhaohui Tan Guohua He Guoxi Zhu Rui fan Wenzeng Yang Xin chen Zhizhong liu liqiang Zhong Benkang Shi Degang Ding Shubo chen Junli wei Xudong Yao ming chen Zhanpeng Lu Qun Xie Zhiquan Hu Yinhuai Wang Hongqian Guo Tiwu fan Zhaozhao liang Peng chen wei Wang Tao Xu Chunsheng li Jinchun xing Hong liao Dalin He Zhibin Wu Jiandi Yu Zhongwen feng Mengxiang Yang Qifeng Dou Quan Zeng Yuanwei li Xin Gou Guangchen Zhou Xiaofeng Wang Rujian Zhu Zhonghua zhang Bo zhang Wanlong Tan Xueling Qu Hongliang Sun Tianyi Gan Dingwei Ye Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120China Department of Urology The Second Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116023China Department of Urology The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityHunan Cancer CenterChangshaHunan 410013China Department of Urology First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030000China Department of Urology Jiangxi Provincial People’s HospitalSchool of MedicineNanchang UniversityNanchangJiangxi 330006China Department of Urology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Urology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyangLiaoning 110043China Department of Urology Inner Mongolia People’s HospitalHohhotInner Mongolia 010010China Department of Urinary Surgery Taizhou Hospital of Traditional Chinese MedicineTaizhouJiangsu 225300China Department of Urology Linfen People’s HospitalLinfenShanxi 041000China Department of Urology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhouHenan 450006China Department of Urology The Affiliated Hospital of Hebei UniversityBaodingHebei 071000China Department of Urology Chifeng Municipal HospitalChifeng Clinical Medical College of Inner Mongolia Medical UniversityChifengInner Mongolia 024000China Department of Urology Baogang HospitalBaotouInner Mongolia 014010China Department of Oncology The Second People’s Hospital of YibinYibinSichuan 644000China Department of Urology Qilu Hospital of Shandong UniversityJinanShandong 250014China Department of Urology Henan Provincial People’s Hos

Background:LY01005(Goserelin acetate sustained-release microsphere injection)is a modified gonadotropin-releasing hormone(GnRH)agonist injected *** phase III trial study aimed to evaluated the efficacy and safety of LY01005 in Chinese patients with prostate ***:We conducted a randomized controlled,open-label,non-inferiority trial across 49 sites in *** study included 290 patients with prostate cancer who received either LY01005 or goserelin implants every 28 days for three *** primary efficacy endpoints were the percentage of patients with testosterone suppression≤50 ng/dL at day 29 and the cumulative probability of testosterone≤50 ng/dL from day 29 to ***-inferiority was prespecified at a margin of-10%.Secondary endpoints included significant castration(≤20 ng/dL),testosterone surge within 72 h following repeated dosing,and changes in luteinizing hormone,follicle-stimulating hormone,and prostate specific antigen ***:On day 29,in the LY01005 and goserelin implant groups,testosterone concentrations fell below medical-castration levels in 99.3%(142/143)and 100%(140/140)of patients,respectively,with a difference of-0.7%(95%confidence interval[CI],-3.9%to 2.0%)between the two *** cumulative probabilities of maintaining castration from days 29 to 85 were 99.3%and 97.8%,respectively,with a between-group difference of 1.5%(95%CI,-1.3%to 4.4%).Both results met the criterion for *** endpoints were similar between *** treatments were ***01005 was associated with fewer injection-site reactions than the goserelin implant(0%vs.1.4%[2/145]).Conclusion:LY01005 is as effective as goserelin implants in reducing testosterone to castration levels,with a similar safety *** registration:***,NCT04563936.

关键词： Prostatic neoplasms LY01005 Gonadotropin-releasing hormone agonist Efficacy Safety

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Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study

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Biomedical and Environmental Sciences 2021年第1期34卷 9-18页

作者： ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia chen li SHI li Xin SU Qing XU Min XU Yu chen Yu Hong YU Xue feng YAN li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin chen Gang GAO Zheng Nan SHEN Fei Xia luo Zuo Jie QIN Ying Fen HUO Ya Nan li Qiang YE Zhen zhang Yin Fei liu Chao WANG You Min WU Sheng li YANG Tao DENG Hua Cong ZHAO Jia Jun chen Lu Lu MU Yi ming TANG Xu Lei HU Ru Ying WANG wei Qing NING Guang li Mian LU Jie li BI Yu fang Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin Hospital.Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China The First Hospital of Jilin University Changchun 130021JinlinChina Qilu Hospital of Shandong University Jinan 250012ShandongChina Affiliated Hospital of Guiyang Medical College Guiyang 550004GuizhouChina Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai 200092China Tongji Hospital.Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030HubeiChina Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120GuangdongChina The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052HenanChina The Affiliated Hospital of Southwest Medical University Luzhou 646099SichuanChina Fujian Provincial Hospital Fujian Medical UniversityFuzhou 350001FujianChina Dalian Municipal Central Hospital Dalian 116003LiaoningChina The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000ZhejiangChina The First Affiliated Hospital of Guangxi Medical University Nanning 530021GuangxiChina Jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang 330006JiangxiChina The Second Affiliated Hospital of Harbin Medical University Harbin 150086HeilongjiangChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051ZhejiangChina Central Hospital of Shanghai Jiading District Shanghai 201800China Jiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing 210028JiangsuChina The First Affiliated Hospital of Anhui Medical University Hefei 230022AnhuiChina Karamay Municipal

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains *** aimed to explore the associations between glycemic indices and SUA levels in the general Chinese *** The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid *** nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive *** A total of 30,941 men and 62,361 women were eligible for the current *** additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and *** thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.

关键词： Cross-sectional study Serum uric acid Glycemic index Glycemic status

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Expert Consensus on Nutritional Support for Children with Congenital Heart Disease(2023 Edition)

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Congenital Heart Disease 2023年第6期18卷 571-593页

作者： Xuming Mo wei Cai Jirong Qi Zhuoming Xu Ying Wang weihui Yan Shoujun li Nianguo Dong Xinxin chen Jinfen liu Qiang Shu Jimei chen Haibo zhang Hao zhang Quansheng xing Qi An Xiaofeng li Xu Wang Yan He Junwu Su Taibing fan Teng ming weibing Tang li Hong Jinghao Zheng ming Ye Guocheng Sun Yiqun Ding liang Tao Yifeng Yang Zhongshi Wu Hua Cao Qiang Wang Keming Yang libing zhang Ping Wen Yanqin Cui Bo Zhai Yong Zou Qingya Tang Rui chen Chun Wu Zhiyu feng Caixia liu Yaping Mi Rufang zhang Ke lin Xin li mingan Pi Xiangming fan Shanshan Shi Peng Huang Zhengxia Pan Jiafeng Qi Renwei chen Shuguang Tao Yaqin Shu Huifeng zhang Lan Jiang Min Da Nishant Patel liang Hu Cardiac Surgery Group of Pediatric Surgery Society of Chinese Medical Association and Parenteral Enteral Nutrition Society of Chinese Medical Association Department of Cardiothoracic Surgery Children’s Hospital of Nanjing Medical UniversityNanjing210008China Department of Pediatric Surgery and Nutrition Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200092China Department of Cardiothoracic Surgery Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China Division of Pediatric Gastroenterology and Nutrition Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200092China Pediatric Cardiac Surgery Center Fuwai HospitalNational Centre for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing100037China Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Cardiovascular Center Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou510623China Department of Cardiac Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou310052China Department of Cardiovascular Surgery Guangdong Cardiovascular InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou519041China Heart Center and Shanghai Institue of Pediatric Congenital Heart Disease Shanghai Children’s Medical CenterNational Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China Heart Center Qingdao Women and Children’s HospitalQingdao266034China Department of Cardiovascular Surgery West China HospitalSichuan UniversityChengdu610041China Department of Cardiac Surgery Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing100045China Department of Pediatric Intensive Care Unit Fuwai HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing100037China Depar

The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pedia-tric nutrition guidelines or consensus worldwide,the management of congenital heart disease,and the results of multi-center clinical nutrition research for congenital heart disease following theﬁrst Chinese consensus edition of *** consensus was also shaped by the results of three discussion sessions and two questionnaires con-ducted by the 13-member collaboration *** process was informed by both clinical guidelines and expert *** quality of literature,both in English and Chinese,and the level of recommendations were evaluated using the Grading of Recommendations Assessment,Development,and Evaluations(GRADE)system.

关键词： Congenital heart disease nutrition enteral parenteral expert consensus

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Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： MA Yan ZHU Dong Shan chen Ren Bo SHI Nan Nan liu Si Hong fan Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang feng chen Hong chen li Ying feng Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI liang JIN Hai Hao LEI Xiao li Chun Yan li Min Qing li Qun Tang li Xian Yong liu Hong De liu Jin Ping liu zhang MA Yu Ting MAO Ya MO liu Fen NA Hui WANG Jing wei SONG fang li SUN Sheng WANG Dong Ting WANG ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong ming XU Shou fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng li zhang Gong Qi zhang Jin Bo zhang lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing zhang Hua Min WANG Yan Ping WANG Yong Yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

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A joint call for actions to advance taxonomy in China

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Zoological Systematics 2022年第3期47卷 188-197页

作者： Chaodong Zhu Arong luo ming Bai Michael COrr Zhonge Hou Siqin Ge Jun chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong limin Lu Xiaohua Jin Lei Cai Xinli wei Ruilin Zhao wei Miao Qingfeng Wang Zhongli Sha Qiang lin Meng Qu Jianping Jiang Jiatang li Jing Che Xuelong Jiang Xiaoyong chen lianming Gao Zongxin Ren Chunlei Xiang Shixiao luo Donghui Wu Dong liu Yanqiong Peng Tao Su chenyang Cai Tianqi Zhu Wanzhi Cai xingyue liu Hu li Huaijun Xue Zhen Ye Xuexin chen Pu Tang Shujun wei Hong Pang Qiang Xie feng zhang feng zhang Xianjin Peng Aibing zhang Taiping Gao Changfa Zhou chen Shao libin Ma Zhaoming wei Yunxia Luan Ziwei Yin Wu Dai Cong wei Xiaolei Huang Jingxian liu Xiangsheng chen Tianci Yi Zhisheng zhang Zhulidezi Aishan Qin li Hongying Hu CAS Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Mycology(SKLM) Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Aquatic Biodiversity and Conservation Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074China Department of Marine Organism Taxonomy&Phylogeny Institute of OceanologyChinese Academy of SciencesQingdao 266071China CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China State Key Laboratory of Genetic Resources and Evolution&Yunnan Key Laboratory of Biodiversity and Ecological Security of Gaoligong Mountain Kunming Institute of ZoologyChinese Academy of SciencesKunming 650221China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China CAS Key Laboratory of Plant Resource Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China CAS Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMenglaYunnan 66630

Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China.

关键词： Endangered taxonomists morphology-based taxonomy integrative taxonomy capacity building systematics

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A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism

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Journal of Molecular Cell Biology 2022年第2期14卷 56-71页

作者： lianju Qin Jing zhang Yujie Xiao Kang liu Yugui Cui fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye ming Zeng Hanyang Qian Anning Bian fan li Guang Yang Shaowen Tang Zhihong zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi wei liu li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin chen Jie Wang Meng Cao Qian Cui li chen feng chen Youjia Yu Qiang Ji Zhiwei zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping liu Ningxia liang Changying xing Jiayin liu Ningning Wang State Key Laboratory of Reproductive Medicine Center of Clinical Reproductive MedicineThe First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nephrology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166China Department of Pathology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Cardiology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Rheumatology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Obstetrics The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Dermatology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Burn and Plastic Surgery The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nuclear Medicine The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Infection The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Anesthesiology and Pain Management The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nephrology The First People’s Hospital of LianyungangLianyungang 222061China Department of Nephrology Northern Jiangsu People’s HospitalYangzhou 225001China Department of General Medicine Geriatric Hospital of Nanjing Medical UniversityNanjing 210024China Department of Nephrology BenQ Medical CenterThe Affiliated BenQ Hospital of Nanjing Medical Uni

Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven ***,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified *** of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was *** release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were *** further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude *** the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the *** followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear *** biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged *** infusion or local treatment-related adverse events ***,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity.

关键词： calciphylaxis chronic kidney disease vascular calcification multidisciplinary rescue human amnion-derived mesenchymal stem cells preclinical research regenerative medicine

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Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)

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Military Medical Research 2022年第4期9卷 389-403页

作者： Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong chen xing chen Xiao-ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu feng Qing-Jun Gao Run-fang Gao Bao-San Han Jin-Xuan Hou wei Hou Hai-Ying liao Hong luo Zheng-Ren liu Jing-Hua Lu Bin luo Xiao-Peng Ma Jun Qian Jian-Yong Qin wei wei Gang wei li-Ying Xu Hui-Chao Xue Hua-wei Yang wei-Ge Yang Chao-Jie zhang fan zhang Guan-Xin zhang Shao-Kun zhang Shu-Qun zhang Ye-Qiang zhang Yue-Peng zhang Sheng-Chu zhang Dai-wei Zhao Xiang-Min Zheng Le-wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu Department of Thyroid and Breast Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Department of Pathology University of Chicago Pritzker School of MedicineChicagoIL60637USA Department of Surgical Oncology and Breast Surgery Oncology CenterFaculty of MedicineMansoura UniversityMansoura35516Egypt Department of Breast Surgery Beijing University of Chinese MedicineBeijing100700China Department of Infectious Diseases and Tropical Medicine Faculty of MedicineMashhad University of Medical SciencesMashhad***Iran Breast Department KK Women’s and Children’s Hospital100 Bukit Timah RoadSingapore229899Singapore Department of Surgery Department of Public HealthDepartment of BiostatisticsBioinformatics and Medical InformaticsInonu University Faculty of Medicine44280MalatyaTurkey Department of General Surgery Faculty of MedicineÇanakkale Onsekiz Mart University17020ÇanakkaleTurkey Department of Radiology Cancer InstituteImam Khomeini HospitalTehran University of Medical SciencesTehran***Iran Department of Surgery College of Medicine and Medical SciencesArabian Gulf University-BahrainManama26671Bahrain Department of Radiology International Faculty of MedicineIstanbul Medipol University34810IstanbulTurkey Department of General Surgery Faculty of MedicineSakarya University54050SakaryaTurkey Department of Surgery HiU Clinic170Gwongwang-roPaldal-guSuwon16488Korea Department of Radiology Faculty of MedicineAtaturk University25240ErzurumTurkey Academic Support and Education Center Hırkai Serif DistrictKececi Cesmesi StrDoktorlar BuildingB/734091IstanbulTurkey Department of General and Digestive Surgery Hospital General CastellonAvda Benicassim S/N12812004CastellónSpain Radiology Department Ankara Training and Research Hospital305018AnkaraTurkey Department of Surgery The University of Hong KongChina The University of Hong Kong-Shenzhen Hospital Shenzhen518053China University of Miami Health System and Miller School of Medicine 1475 NW 12th AvenueM

Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the *** of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and *** approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM.

关键词： Granulomatous mastitis Granulomatous lobular mastitis Idiopathic granulomatous mastitis Diagnosis Treatment

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Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases

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Chinese Medical Journal 2017年第20期130卷 2473-2488页

作者： Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-lin Hao, Chuan-ming chen, Nan liu, Bi-cheng chen, Jiang-Hua Yang, li Nie, Jing Yu, chen Peng, Ai Yu, Sheng-Qiang li, lin Ge, Jun-Bo Huo, Yong zhang, Shu-Yang chen, Yun-Dai Dong, Yu-Gang liang, Chun Dai, Yu-Xiang Gao, Xin li, Chang-Gui Zhao, Jia-Jun chen, Hai-Bing cheng, Zhi-feng lin, Huan-Dong Guan, Yang-Tai Wang, Kai luo, Ben-Yan Dai, Ruo-lian Jiang, Quan Xue, Luan liang, Chao-Chao chen, ming fan, Song Multidisciplinary Expert Task Force on Hyperuricemia and Related Diseases

INTROduCTIONThe prevalence of hyperuricenlia （HUA） has increased in China in the recent years in relation to socioeconomic developments and changing lifestyles and diets, with a trend toward onset at younger age. HUA has become the second most common metabolic disease after diabetes mellitus. like gout, HUA is also associated with the occurrence and progression of disorders of the urinary, endocrine, metabolic, cardio-cerebrovascular, and other systems.

关键词： Consensus Gout Hyperuricemia Recommendation Uric Acid

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Electron-ion collider in China

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Frontiers of physics 2021年第6期16卷 1-78页

作者： Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu chen Xurong chen Zhuojun chen Zhufang Cui lingyun Dai weitian Deng minghui Ding Xu feng Chang Gong Longcheng Gui feng-Kun Guo chengdong Han Jun He tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin li Hengne li Minxiang li Xueqian li Yutie liang Zuotang liang chen liu Chuan liu Guoming liu Jie liu liuming liu Xiang liu Tianbo liu Xiaofeng luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui zhang Jinlong zhang Pengming zhang Yifei zhang Chao-Hsi Chang Zhenyu zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou liping Zou Guangdong Provincial Key Laboratory of Nuclear Science Institute of Quantum MatterSouth China Normal UniversityGuangzhou 510006China IRFU CEAUniversitéParis-SaclayF-91191 Gif-sur-YvetteFrance Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Nankai University Tianjin 300071China Xinyang Normal University Xinyang 464000China School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China Hunan University Changsha 410082China Nanjing University Nanjing 210093China Huazhong University of Science and Technology Wuhan 430074China European Centre for Theoretical Studies in Nuclear Physics and Related Areas(ECT*)and Fondazione Bruno Kessler Villa TambosiStrada delle Tabarelle 286I-38123 Villazzano(TN)Italy School of Physics Peking UniversityBeijing 100871China Hunan Normal University Changsha 410081China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Nanjing Normal University Nanjing 210023China Department of Physics College of SciencesNortheastern UniversityShenyang 110819China Southwest Jiaotong University Chengdu 610000China Department of Physics Faculty of ScienceUniversity of ZagrebBijenička c.3210000 ZagrebCroatia Bogoliubov Laboratory of Theoretical Physics Joint Institute for Nuclear ResearchDubna 141980Russia School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Lanzhou University Lanzhou 730000China Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityQingdao 266237China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China School of Physics Southeast UniversityNanjing 211189China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Depa

Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as *** a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been *** will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron *** proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the *** main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark *** addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the *** order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge *** document is the result of collective contributions and valuable inputs from experts across the *** EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United *** success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China.

关键词： electron ion collider nucleon structure nucleon mass exotic hadronic states quantum chromodynamics 3D-tomography helicity transverse momentum dependent parton distribution generalized parton distribution energy recovery linac polarization spin rotator

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