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Dynamic single-cell mapping unveils Epstein-Barr virusimprinted T-cell exhaustion and on-treatment response

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4985-4997页

作者： Miao-Zhen Qiu Chaye Wang Zhiying Wu Qi Zhao Zhibin Zhao Chun-Yu Huang Wenwei Wu Li-qiong Yang Zhi-Wei Zhou Yu Zheng Hong-Ming Pan Zexian Liu Zhao-Lei Zeng Hui-Yan luo Feng Wang Feng-Hua Wang Si-Yu Yang Meng-Xing Huang Zhexiaon Lian Haiyan Zhang Rui-Hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center510060 GuangzhouChina Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences510060 GuangzhouChina Department of Experimental Research Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University510060 GuangzhouChina Medical Research institute Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Endoscopy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University510060 GuangzhouChina Department of Gastric Surgery Sun Yat-sen University Cancer Center510060 GuangzhouChina Department of Internal Medical Oncology Zhejiang University School of MedicineSir Run Run Shaw HospitalHangzhouChina Cancer Centre Faculty of Health SciencesUniversity of MacaoMacao SARChina MOE Frontier science Centre for Precision Oncology University of MacaoMacao SARChina

Epstein-Barr virus(EBV)-associated gastric cancer(GC)manifests an intriguing immunotherapy ***,the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains *** study aimed to finely characterize the dynamic tumour immune contexture of human EBV(+)GC treated with immunochemotherapy by longitudinal scRNA-seg and paired scTCR/***(+)GC exhibits an inflamed-immune phenotype with increased T-cell and B-cell infiltration.

关键词： chemotherapy treatment EBV

Discovery of a wild,genetically pure Chinese giant salamander creates new conservation opportunities

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Zoological Research 2022年第3期43卷 469-480页

作者： Jing Chai Chen-Qi Lu Mu-Rong Yi Nian-Hua Dai Xiao-Dong Weng Ming-Xiao Di Yong Peng Yong Tang Qing-Hua Shan Kai Wang Huan-Zhang Liu Hai-Peng Zhao Jie-qiong Jin Ru-Jun Cao Ping Lu Lai-Chun luo Robert W.Murphy Ya-Ping Zhang Jing Che state key laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China institute of Biological Resources Jiangxi Academy of SciencesNanchangJiangxi 330096China Jiangxi Jiulingshan National Nature Reserve Jing’anJiangxi 330600China Sam Noble Oklahoma Museum of Natural History&Department of Biology University of OklahomaNorman 73072USA The key laboratory of Biodiversity and Conservation of Aquatic Organisms Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China School of Life science Henan UniversityKaifengHenan 475001China Jing’an County Bureau of Agriculture and Rural Affairs Jing’anJiangxi 330600China Centre for Biodiversity and Conservation Biology Royal Ontario MuseumTorontoOntario M5S 2C6Canada Yunnan key laboratory of Biodiversity and Ecological Security of Gaoligong Mountain Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life science University of the Chinese Academy of SciencesKunmingYunnan 650204China

Effective conservation of threatened biota relies on accurate assessments and scientific *** an unfortunate example,Chinese giant salamanders(Andrias,CGS)remain critically endangered in *** conservation efforts,e.g.,commercial propagation and releasing of millions of likely non-indigenous or interspecific hybrids,have further compromised conservation *** information on wild populations of CGS poses a significant conservation *** 18-month long field monitoring,we now report the discovery of a wild population of CGS in a closed nature reserve in Jiangxi Province,*** assessments reveal its genetic distinctiveness and do not detect genetic admixture with other *** on morphological and molecular evidences,we describe this CGS as a new species Andrias jiangxiensis *** is the only known species of CGS today with a genetically pure,reproducing,in situ *** discovery emphasizes the important role that closed nature reserves play in protecting species,and the necessity of integrating long-term field monitoring and genetic *** sets a new pathway for discovering and conserving endangered species,especially for those biotas that are similarly being extirpated by anthropogenic translocations and overexploitation.

关键词： Conservation Human translocation Genetic homogenization Field monitoring Taxonomy

First-principles Study on the Structural and Electrochemical Properties of Cathode Materials Na2MSiO4(M = Mn, Fe, and Co)

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First-principles Study on the Structural and Electrochemical...

Comparison of CMAS corrosion and sintering induced microstructural characteristics of APS thermal barrier coatings

第十三届全国量子化学会议

作者： Xiaoling Yang Wenshan Ning QingyunTu WeinaXie Bin Peng Nan Li Ruirui Zhao Qianshu Li qiong luo Center for Computational Quantum Chemistry School of Chemistry and Environment South China Normal University state key laboratory of explosion science and technology School of Mechatronical Engineering Beijing Institute of Technology

Na-ion batteries(NIBs) are highly-regarded alternative of Li-ion batteries(LIBs) for large-scale grid storage, due to the unlimited sodium sources. The key parameter to evaluate the performance of NIBs for large-scale energy storages is reversible capacity. Zhang et al.(J. Mater. Chem.A, 2014, 2, 11574) reported that the discharge capacity of P2NaFeSiO could reach as high as 330 mA hg. In this article,a systematic investigation on the structure s and properties of P2NaMSiO, NaMSiO, and MSiO(M =Mn, Fe, and Co) has been carried out with the aid of the GGA+U framework. The calculations reveal that P2NaMnSiO could not be used as a cathode material. In P2NaFeSiO, one Na+ per molecule rather than two could intercalate into the orthosilicate during electrochemical cycles. The study on P2NaCoSiO demonstrates that two Na per molecule could be exchanged with the two characteristic voltage plateaus at 3.01 eV and 4.47 eV, respectively. The different performances of the three P2 silicate materials are explained from the view of the electronic structures of transition metal ions.

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来源： cnki会议评论

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Journal of Materials science & technology 2019年第3期35卷 440-447页

作者： Yiyou Wu Hua luo Canying Cai Yanguo Wang Yichun Zhou Li Yang Guangwen Zhou School of Materials science and Engineering Xiangtan University key laboratory of Low Dimensional Materials & Application technology of Ministry of Education Xiangtan University Department of Mechanical Engineering & Materials science and Engineering Program State University of New York at Binghamton

The microstructural features of high-temperature sintered and CaO-MgO-Al_2O_3-SiO_2(CMAS) corroded air plasma sprayed Y_2O_3 stabilized ZrO_2(YSZ) thermal barrier coatings(TBCs) under the thermal gradient condition were comparatively studied. As-sprayed YSZ has a lamellar structure and the lamellae are composed of closely aligned columnar crystals. The sintered and the CMAS corroded YSZ coatings maintain the t'-ZrO_2 phase as the as-sprayed YSZ coating. The sintered YSZ remains the lamellar structure with reduced interlamellar gaps and grains coarsening. After the CMAS corrosion, the top layer of the YSZ coating keeps its lamellar structure consisting of some columnar grains with the CMAS infiltration into the intergrain gaps and the formation of striped Zr_2Y_2 O_7. The typical lamellar structure transforms into more equiaxed grains in the middle and bottom layers of the ceramic coating along with significant infiltration of amorphous CMAS and anorthite formation in the bottom layer owing to the high contents of Ca and Al.

关键词： YSZ thermal barrier coating APS CMAS corrosion Anorthite

Fabrication technique of micro/nano-scale speckle patterns with focused ion beam

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science china(Physics,Mechanics & Astronomy) 2012年第6期55卷 1037-1044页

作者： LI YanJie XIE HuiMin luo Qiang GU ChangZhi HU ZhenXing CHEN PengWan ZHANG QingMing AML Department of Engineering MechanicsTsinghua UniversityBeijing 100084China institute of Physics Chinese Academy of SciencesBeijing 100190China state key laboratory of explosion science and technology Beijing Institute of TechnologyBeijing 100081China

The fabrication technique of micro/nano-scale speckle patterns with focused ion beam (FIB) system is studied for digital image correlation (DIC) measurement under a scanning electron microscope (SEM).The speckle patterns are fabricated by directly etching the counterpart of the specimen to the black part of a *** intensity gradient is used to evaluate the quality of these SEM images of speckle patterns fabricated based on different templates to select an optimum *** pattern size depending on the displacement measurement sensitivity is adjusted by altering the magnification of FIB according to the relation curve of the etching size versus *** influencing factors including etching time and ion beam current are *** body translation tests and rotation tests are carried out under SEM to verify the reliability of the fabricated speckle *** calculated values are in good agreement with the imposed ones.

关键词： speckle pattern digital image correlation (DIC) micro/nano-scale focused ion beam (FIB) scanning electron microscope (SEM)

页岩储层甲烷原位燃爆压裂理论与技术研究进展

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中国矿业大学学报 2024年第3期53卷 435-455页

作者：翟成曲占庆邓守春孙伟福罗宁王宇刘厅郭天魁吴飞鹏刘静宋正昶陈尚斌杨威蔡承政中国矿业大学安全工程学院江苏徐州221116 中国矿业大学煤矿瓦斯治理国家工程研究中心江苏徐州221116 中国石油大学(华东)石油工程学院山东青岛2266580 中国科学院武汉岩土力学研究所岩土力学与工程国家重点实验室湖北武汉430071 北京理工大学爆炸科学与技术国家重点实验室北京京100081 中国矿业大学力学与土木工程学院江苏徐州221116 中国矿业大学低碳能源与动力工程学院江苏徐州221116 中国矿业大学资源与地球科学学院江苏徐州221116 中国矿业大学深部岩土力学与地下工程国家重点实验室江苏徐州221116

页岩气通常以吸附和游离状态赋存于暗色泥页岩、高碳泥页岩等产气岩中,是一种清洁、高效的能源资源.相比于常规天然气藏,页岩气储层普遍具有低孔隙度、低渗透率的特点,压裂改造提高页岩气采收率是“十四五”期间我国能源开发的重点攻关... 详细信息

页岩气通常以吸附和游离状态赋存于暗色泥页岩、高碳泥页岩等产气岩中,是一种清洁、高效的能源资源.相比于常规天然气藏,页岩气储层普遍具有低孔隙度、低渗透率的特点,压裂改造提高页岩气采收率是“十四五”期间我国能源开发的重点攻关方向.本文创新性提出了一种页岩储层甲烷原位燃爆压裂的技术构想,该技术利用页岩气储层原位解吸产生的甲烷气体与注入的助燃剂协同燃爆,产生高温高压气体冲击压裂页岩储层,创造立体裂缝网络,为页岩气提供高效运移通道.论文全面分析了甲烷原位燃爆压裂的技术构想、可行性以及关键科学问题,包括甲烷-助燃剂协同起爆机制及燃爆压力波传播特性、甲烷燃爆对井筒介质的瞬态冲击动力学响应特征与控制机制、多级燃爆压裂立体缝网逐级构建及效果评价技术等3个关键研究内容,基本涵盖了当前甲烷原位燃爆压裂理论与技术研究的最新进展.研究认为,燃爆冲击载荷作用对页岩复杂缝网的形成和扩展具有显著促进作用,甲烷燃爆压裂不需要消耗大量的压裂液,也不涉及火工品的地上运输和混合等过程,安全、经济和环保优势非常明显,是一项前瞻性、变革性技术,有助于实现我国页岩气开采技术的创新突破.

关键词：深部页岩储层甲烷原位燃爆燃爆压裂理论燃爆压裂技术

Synthesis of Mg_5(CO_3)_4(OH)_2·4H_2O with Flower-like Micro-structure and Its Catalytic Activity for Transesterification of Dimethyl Carbonate with Phenol

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Chemical Research in Chinese Universities 2007年第6期23卷 641-645页

作者： WANG Qiang WANG Ke-li WU Xing-long luo Sheng-jun HU Chang-wen The institute for Chemical Physics Department of Chemistry State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology Beijing 100081 P. R. China Biological Engineering Department Jilin Vocational Technology College in Agriculture Engineering C ongzhuling 136100 P. R. China

A novel flower-like hydrated magnesium carbonate hydroxide, Mg5 （CO3 ）4 （OH）2·4H2O, with micro-structure composed of individual thin nano-sheets was synthesized using a facile solution route without the use of template or organic surfactant. Reaction time has an important effect on the final morphology of the product. The micro-structure and morphology of Mg5 （CO3）4 （OH）2·4H2O were characterized by means of X-ray diffractometry （XRD）, fieldemission scanning electron microscopy（FE-SEM）. Brunauer-Emmett-Teller（BET） surface areas of the samples were also measured. The probable formation mechanism of flower-like micro-structure was discussed. It was found that Mg5 （CO3）4（ OH）2·4H2O with flower-like micro-structure was a novel and efficient catalyst for the synthesis of diphenyl carbonate （DPC） by transesterification of dimethyl carbonate （DMC） with phenol.

关键词： Mg5(CO3)4(OH)2 ·4H2O Flower-like micro-structure Catalytic property Transesterification Diphenyl carbonate

地震作用下软硬互层顺层岩质边坡动力响应研究

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地球科学 2023年第8期48卷 3127-3136页

作者：李师毓吴琼王亮清罗红明秦越刘智琪中国地质大学工程学院湖北武汉430074 中国科学院武汉岩土力学研究所岩土力学与工程国家重点实验室湖北武汉430071

软硬互层顺层岩质边坡在我国强震区广泛存在,地震极易诱发该类边坡产生地质灾害.针对地震作用下软硬互层顺层岩质边坡动力响应关键科学问题开展研究,基于离散元数值模拟法,揭示了软硬互层顺层岩质边坡动力响应规律,分析了不同边坡特征... 详细信息

软硬互层顺层岩质边坡在我国强震区广泛存在,地震极易诱发该类边坡产生地质灾害.针对地震作用下软硬互层顺层岩质边坡动力响应关键科学问题开展研究,基于离散元数值模拟法,揭示了软硬互层顺层岩质边坡动力响应规律,分析了不同边坡特征因素对其动力响应的影响.结果表明:地震作用下软硬互层边坡变形破坏主要受软硬岩间层面控制,坡表剪切口和软岩位移增量明显;地震波在传播过程中,软硬岩层对地震加速度具有放大作用,其中软岩的放大作用更明显;地震波频谱特征显示:当地震波从硬岩传播至软岩时,多个固定频段被显著放大,当从软岩传播至硬岩时,频谱有所降低;坡表位移和加速度放大系数随软岩和层面强度的增加而减小,随层厚比的增加而增大;软岩强度和层厚比会改变地震波中显著放大频段的位置,二者增大时,放大频段的数量不变,频率减小;岩层层面强度降低时,放大频段的数量和频率不变,放大程度增大.

关键词：软硬互层岩质边坡地震动力响应数值模拟离散元

Recent advances of capillary electrophoresis-mass spectrometry instrumentation and methodology

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Chinese Chemical Letters 2017年第8期28卷 1640-1652页

作者： You Jiang Mu-Yi He Wen-Jing Zhang Pan luo Dan Guo Xiang Fang Wei Xu National institute of Metrology Beijing 100013China School of Life science Beijing Institute of TechnologyBeijing 100081China

Capillary electrophoresis-mass spectrometry（CE-MS） is a powerful separation and analytical technique in the field of analytical chemistry. This review provides an update of instrumentation developments in the methodology of CE-MS systems. A selection of relevant articles covers the literatures published from Jan. 2013 to Feb. 2017. Special attentions were paid to the sample injection and ionization *** of these CE-MS systems were also introduced through representative examples. General conclusions and perspectives were given at the last.

关键词： Capillary electrophoresis Mass spectrometry Instrumentation and methodology developments Interfaces Bio-analytical chemistry