检索结果-南通市图书馆

压应力激活SOST/Wnt/β-catenin 通路诱导软骨终板细胞退变

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第5期29卷 951-957页

作者：项攀车艳军罗宗平苏州大学附属第一医院骨科研究所江苏省苏州市215006 南京医科大学附属苏州医院骨科与运动医学中心江苏省苏州市215000

背景:在许多可以导致椎间盘退变的因素中(衰老、营养匮乏、机械因素等),力学负荷被认为是极其重要的因素,但其机制尚不清楚。目的:探讨硬骨素和Wnt/β-catenin信号通路在压应力诱导终板软骨退变中的作用。方法:提取4周龄雄性SD大鼠软骨... 详细信息

背景:在许多可以导致椎间盘退变的因素中(衰老、营养匮乏、机械因素等),力学负荷被认为是极其重要的因素,但其机制尚不清楚。目的:探讨硬骨素和Wnt/β-catenin信号通路在压应力诱导终板软骨退变中的作用。方法:提取4周龄雄性SD大鼠软骨终板细胞,体外利用力学加载仪器对终板软骨细胞施加压应力,于压缩细胞1,3,5,7 d,采用CCK-8法测定细胞活力;Western blot、RT-qPCR及细胞免疫荧光等检查终板软骨细胞内软骨标记物(聚集蛋白聚糖、Ⅱ型胶原)、钙化相关因子(Runx2、骨钙素)、细胞外基质降解酶及信号通路基因(硬骨素、β-catenin)等表达。结果与结论:①压应力作用下,终板软骨细胞活力会随着压应力时间、强度增加而降低;②终板软骨细胞的软骨标记物(聚集蛋白聚糖、Ⅱ型胶原)表达下降,而钙化相关因子(Runx2、骨钙素)表达上升;③压应力能促进终板软骨细胞的细胞外基质降解,基质金属蛋白酶3、基质金属蛋白酶13表达量增加;④细胞内Wnt/β-catenin信号通路表达出现异常,其特异性抑制因子硬骨素伴随着β-catenin的异常积累而表达下降。结果说明:在压应力作用下,终板软骨细胞内硬骨素的表达下降,导致Wnt/β-catenin信号通路激活,促进软骨终板的钙化、退变与细胞外基质的降解,进而促进椎间盘退变。

关键词：软骨终板软骨细胞 SOST Wnt/β-catenin 压应力椎间盘退变

Effect of magnetic field on dislocation morphology and precipitation behaviour in ultrafine-grained 7075 aluminium alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第34期93卷 128-146页

作者： Jun luo Hongyun luo Tianshu Zhao Runze Wang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing 100191China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijing 100191China

The influence of magnetic field(1 T)on dislocation morphology and precipitation behaviour of ultrafinegrained(UFG)Al 7075 alloy was investigated after ageing from 90 to 200℃ via wide angle X-ray scattering(WAXS),small angle X-ray scattering(SAXS),and transmission electron microscopy(TEM).Experimental results reveal that the improved precipitation kinetics of alloys in the thickness plane(denoted as sample II)as compared to those in the rolling plane(denoted as sample I),which arises due to a higher dislocation density(morphology of dislocation cells)of the thickness plane than that of the rolling plane(morphology of dislocations and dislocation tangles).Specifically,because of different dislocation morphologies,the magnetic field positively and negatively affects the dislocation activity in samples I and II,leading to enhanced and suppressed precipitation behaviors,***,nucleation of theηphase is facilitated in the UFG alloy at the critical temperature(140℃)because it affords a faster rate of atom diffusion and a higher dislocation density as compared to those exhibited by its coarse-grained *** systematic and comprehensive study provides new insights into dislocation morphology and precipitation behaviour of the UFG 7075 Al alloy,while enabling the optimization of precipitation kinetics.

关键词： Ultrafine-grained Al alloy Precipitation behaviors Magnetic field Dislocation morphology Critical temperature

Stability of the Rarefaction Wave for a Non-isentropic Navier-Stokes/Allen-Cahn System

在线全文

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2022年第2期43卷 233-252页

作者： Ting luo School of Information Management Jiangxi University of Finance and EconomicsNanchang 330032China

This paper is concerned with the large time behavior of solutions to the Cauchy problem for a one-dimensional compressible non-isentropic Navier-Stokes/Allen-Cahn system which is a combination of the classical Navier-Stokes system with an Allen-Cahn phase field *** by the relationship between Navier-Stokes/Allen-Cahn and Navier-Stokes,the author can prove that the solutions to the one dimensional compressible non-isentropic Navier-Stokes/Allen-Cahn system tend time-asymptotically to the rarefaction wave,where the strength of the rarefaction wave is not required to be *** proof is mainly based on a basic energy method.

关键词： Navier-Stokes/Allen-Cahn system Rarefaction wave Stability

Non-spherical polymersomes driven by directional aromatic interactions

在线全文

学校读者我要写书评

暂无评论

Science China Materials 2018年第3期61卷 437-438页

作者： Mingyan luo Yunjun luo Xiaoyu Li School of Materials Science and Engineering Beijing Institute of Technology

Polymersomes,nanoscopic polymer vesicles self-assembled from synthetic block copolymers,are ideal candidates for drug delivery and synthetic biology,due to their characteristic of high stability,chemical

关键词： PEG NIPAM Nature Non-spherical polymersomes driven by directional aromatic interactions THF

Oxidation and Electrical Properties of Cu-Mn_(3)O_(4)Composite Coating Obtained by Electrodeposition on SOFC Interconnects

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2023年第1期38卷 72-78页

作者：吕烨 luo Shengyun School of Materials Science and Engineering Guizhou Minzu UniversityGuiyang 550025China

Cu-Mn_(3)O_(4)composite coating was prepared on the SUS 430 ferritic stainless steel by electrodeposition and then exposed in air at 800℃corresponding to the cathode atmosphere of solid oxide fuel cell(SOFC).A dual-layer oxide structure mainly comprising an external layer of CuO followed by(Cu,Mn,Fe)_(3)O_(4)spinel and an internal layer of Cr-rich oxide was thermally developed on the coated *** scale area-specific resistances(ASRs)of the coated steels were lower than the scale ASR of the uncoated steel after identical thermal *** external layer of CuO/(Cu,Mn,Fe)_(3)O_(4)spinel not only served as a barrier to reduce the growth rate of Cr-rich oxide internal layer and to suppress the outward diffusion of Cr,but also lowered the surface scale ASRs considerably.

关键词： solid oxide fuel cell steel interconnect Cu-Mn_(3)O_(4)composite coating area specific resistance

Plasmonic metalens for nanofabrication

在线全文

学校读者我要写书评

暂无评论

National Science Review 2018年第2期5卷 137-138页

作者： Xiangang luo State Key Laboratory of Optical Technologies on Nano-Fabrication and Micro-Engineering Institute of Optics and Electronics Chinese Academy of Sciences

INTRODUCTION Optical lithography is the primary tool for the fabrication of micro/nanostructures in micro-electronic and opto-electronic applications,which has fueled the explosive growth of the semiconductor *** the ... 详细信息

关键词： NANOFABRICATION PLASMONICS (Electronics)

Numerical analysis on shock-cylinder interaction using immersed boundary method

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2017年第9期60卷 1423-1432页

作者： luo Kun luo YuJuan JIN Tai FAN JianRen State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 China

The problem of shock interaction with a rigid circular cylinder has been investigated using a compressible immersed boundary method coupled with high-order weighted-essentially non-oscillatory(WENO) ***,the accuracy of the developed code is ***,influences of the incident shock Mach number on the flow-field structure and dynamic drag coefficient,as well as time evolution of the flow field are *** different shock Mach number,the flow structure shows very different *** a given dimensionless time,both the normalized shock detachment distance and the normalized vertical distance from the highest point of the primary reflected shock to the centerline of the cylinder decreases with increasing shock Mach ***,location of the upper triple point varies non-monotonically with shock Mach *** a case with given shock Mach number,the trajectory of the upper triple point and the time evolution of the normalized vertical distance from the highest point of the primary reflected shock to the centerline of the cylinder can both be predicted by linear ***,the time evolution of the normalized shock detachment distance is biased to be ***,time evolution of force exerted on the cylinder is quite unsteady for a case with given shock Mach number and given cylinder *** small shock Mach number,there exists a negative valley,and it disappears when the incident shock Mach number increases to a large value,e.g.,***,correlations to predict the occurrence of the peak drag and its value under different shock Mach numbers have been proposed.

关键词： shock-cylinder interaction immersed boundary method shock Mach number flow structure unsteady force

System deployment optimization in architecture design

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2014年第2期25卷 237-248页

作者： Xiaoxue Zhang Shu Tang Aimin luo Xueshan luo School of Information System and Management National University of Defense Technology

Optimization of architecture design has recently drawn research interest. System deployment optimization （SDO） refers to the process of optimizing systems that are being deployed to activi- ties. This paper first formulates a mathematical model to theorize and operationalize the SDO problem and then identifies optimal so- lutions to solve the SDO problem. In the solutions, the success rate of the combat task is maximized, whereas the execution time of the task and the cost of changes in the system structure are mini- mized. The presented optimized algorithm generates an optimal solution without the need to check the entire search space. A novel method is finally proposed based on the combination of heuristic method and genetic algorithm （HGA）, as well as the combination of heuristic method and particle swarm optimization （HPSO）. Experi- ment results show that the HPSO method generates solutions faster than particle swarm optimization （PSO） and genetic algo- rithm （GA） in terms of execution time and performs more efficiently than the heuristic method in terms of determining the best solution.

关键词： architecture design system deployment optimization,heuristic.

A Perspective on the Evolution of Atmospheric Blocking Theories:From Eddy-Mean flow Interaction to Nonlinear Multiscale Interaction

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2023年第4期40卷 553-569页

作者： Dehai luo Binhe luo Wenqi ZHANG Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of ScienceBeijing 100029China University of Chinese Academy of Sciences Beijing 101499China State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100091China Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of ScienceBeijing 100029China

In this paper,we first review the research advancements in blocking dynamics and highlight the merits and drawbacks of the previous theories of atmospheric ***,the dynamical mechanisms of atmospheric blocking are presented based on a nonlinear multi-scale interaction(NMI)*** studies suggested that the eddy deformation(e.g.,eddy straining,wave breaking,and eddy merging)might lead to the formation and maintenance of atmospheric ***,the results were speculative and problematic because the previous studies,based on the time-mean eddy-mean flow interaction model,cannot identify the causal relationship between the evolution of atmospheric blocking and the eddy *** on the NMI model,we indicate that the onset,growth,maintenance,and decay of atmospheric blocking is mainly produced by the spatiotemporal evolution of pre-existing upstream synoptic-scale eddies,whereas the eddy deformation is a concomitant phenomenon of the blocking *** lifetime of blocking is mainly determined by the meridional background potential vorticity gradient(PVy)because a small PVyfavors weak energy dispersion and strong nonlinearity to sustain the *** the zonal movement of atmospheric blocking is associated with the background westerly wind,PVy,and the blocking *** this NMI model,a bridge from the climate change to sub-seasonal atmospheric blocking and weather extremes might be established via examining the effect of climate change on ***,it is expected that using the NMI model to explore the dynamics of atmospheric blocking and its change is a new direction in the future.

关键词： atmospheric blocking teleconnection patterns eddy deformation potential vorticity gradient climate change nonlinear multiscale interaction