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Small cell lung cancer with peripheral neuropathy as the first symptom:Two case reports

World Journal of Clinical Cases 2025年第9期13卷 30-40页

作者： Man luo Xiao-Xi Lu Dan-Yang Meng Jin Hu Department of Neurology Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Information Technology Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Small cell lung cancer(SCLC)is the most malignant type of lung *** in the latent period and early stage of the tumor,SCLC is prone to produce distant metastases with complex and diverse clinical *** is most closely related to paraneoplastic syndrome,and some cases present as paraneoplastic peripheral neuropathy(PPN).PPN in SCLC appears early,lacks specificity,and often occurs before diagnosis of the primary *** is easy to be misdiagnosed as a primary disease of the nervous system,leading to missed diagnosis and delayed diagnosis and *** SUMMARY This paper reports two cases of SCLC with limb weakness as the first *** first symptoms of one patient were rash,limb weakness,and abnormal *** patient was repeatedly referred to the hospital for limb weakness and rash for>1 year,during which time,treatment with hormones and immunosuppressants did not lead to significant improvement,and the condition gradually *** patient was later diagnosed with SCLC,and the dyskinesia did not worsen as the dermatomyositis improved after antineoplastic and hormone *** second case presented with limb numbness and weakness as the first symptom,but the patient did not pay attention to ***,the patient was diagnosed with SCLC after facial edema caused by tumor thrombus invading the ***,he was diagnosed with extensive SCLC and died 1 year after *** The two cases had PPN and abnormal electromyography,highlighting its correlation with early clinical indicators of SCLC.

关键词： Paraneoplastic peripheral neuropathy Small cell lung cancer Peripheral neuropathy Electromyography Dermatomyositis Case report

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Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi Min Li Jiazhi Chen Zhuyong Wang Huantao Wen Ming Zhou Minjie luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

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Designing Electronic Structures of Multiscale Helical Converters for Tailored Ultrabroad Electromagnetic Absorption

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Nano-Micro Letters 2025年第1期17卷 439-455页

作者： Zhaobo Feng Chongbo Liu Xin Li Guangsheng luo Naixin Zhai Ruizhe Hu Jing Lin Jinbin Peng Yuhui Peng Renchao Che Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle School of Environmental and Chemical EngineeringNanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Physics and Materials Nanchang UniversityNanchang 330031People’s Republic of China Key Laboratory of Nondestructive Testing Ministry of EducationNanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering and TechnologyFudan UniversityShanghai 200438People’s Republic of China

Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)***,the relationship between configuration and electromagnetic(EM)loss mechanism has remained ***,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA *** calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM *** a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 *** precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm ***,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB *** innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.

关键词： Metal-nonmetal co-doping 3d-2p orbital coupling Spin polarization Helical structure Broadband EM wave absorption

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Social function scores and influencing factors in patients with residual depressive symptoms

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World Journal of Psychiatry 2025年第1期15卷 117-127页

作者： Zong-Ling Liao Xiao-Li Pu Zhi-Yi Zheng Jie luo Department 1 of Psychiatry Gele Mountain Hospital of Chongqing Mental Health CenterChongqing 400030China Department of Psychology Chongqing Jiangjin District Psychiatric HospitalChongqing 402260China Department of Psychiatry Chongqing Third Social Welfare InstituteChongqing 400036China Women and Children’s Mental Health Center Affiliated Hospital of Chongqing Population and Family Planning Research InstituteChongqing 400020China

BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still *** depressive symptoms are highly harmful,leading to low mood in patients,affecting work and interpersonal communication,increasing the risk of recurrence,and adding to the burden on *** the influencing factors of their social function is of great *** To explore the social function score and its influencing factors in patients with residual depressive *** This observational study surveyed patients with residual depressive symptoms(case group)and healthy patients undergoing physical examinations(control group).Participants were admitted between January 2022 and December *** functioning was assessed using the Sheehan Disability Scale(SDS),and scores were compared between *** influencing SDS scores in patients with residual depressive symptoms were analyzed by applying multiple linear regression while using the receiver operating characteristic curve,and these RESULTS The SDS scores of the 158 patients with depressive symptoms were 11.48±*** with the control group,the SDS scores and all items in the case group were *** scores were higher in patients with relapse,discon-tinuous medication,drug therapy alone,severe somatic symptoms,obvious residual symptoms,and anxiety scores≥*** history,medication compliance,therapy method,and residual symptoms correlated positively with SDS scores(r=0.354,0.414,0.602,and 0.456,respectively).Independent influencing factors included disease history,medication compliance,therapy method,somatic symptoms,residual symptoms,and anxiety scores(P<0.05).The areas under the curve for predicting social functional impairment using these factors were 0.713,0.559,0.684,0.729,0.668,and 0.628,respectively,with sensitivities of 79.2%,61.8%,76.8%,81.7%,63.6%,and 65.5%and specificities of 83.3%,87.5%,82.6%,83.3%,86.7%,and 92.1%,respectively.C

关键词： Depressive Residual symptoms Social function Influence factors

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Protein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one

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World Journal of Diabetes 2025年第1期16卷 222-225页

作者： Zi-Yu Zhao Pei-Li luo Xia Guo Zheng-Wei Huang State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative DrugsCollege of PharmacyJinan UniversityGuangzhou 511436Guangdong ProvinceChina

Ma et al recently reported in the World Journal of Diabetes that ferroptosis occurs in osteoblasts under high glucose conditions,reflecting diabetes *** condition could be protected by the upregulation of the gene encoding polycytosine RNA-binding protein 1(PCBP1).Additionally,Ma et al used a lentivirus infection system to express *** the authors’method of administration can be improved in terms of stability and cost,we propose delivering PCBP1 to treat type 2 diabetic osteoporosis by encapsulating it in protein ***,PCBP1 is small and ***,intravenous injection can help deliver PCBP1 across the mucosa while avoiding acid and enzyme-catalyzed ***,incorporating PCBP1 into nanoparticles prevents its interaction with water or oxygen and protects PCBP1’s structure and ***,the safety of the protein materials and the industrialization techniques for large-scale production of protein nanoparticles must be comprehensively investigated before clinical application.

关键词： Polycytosine RNA-binding protein 1 Protein nanoparticle Osteoblast Ferroptosis Diabetes

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BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-Rong Li Lei Xu Zi-Chun Yuan Xiao Liu Mao-Ju Tang Man luo Xiao-Wu Zhong Qiang Ma Xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

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SC-CO2与工业乳化炸药破岩效应的等效试验

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工程科学学报 2025年第2期47卷 249-258页

作者：蒋楠姚颖康朱斌罗学东江汉大学省部共建精细爆破国家重点实验室江汉大学爆破工程湖北省重点实验室中国地质大学(武汉)工程学院

如何定量化核算SC-CO2（超临界二氧化碳）破岩效率是非炸药类破岩技术在实际工程应用时重点关注的内容.本研究基于爆破当量理论计算和现场爆破试验的研究方法，通过工程类比法进行工业乳化炸药等效当量计算，选择典型代表性花岗岩及泥... 详细信息

如何定量化核算SC-CO2（超临界二氧化碳）破岩效率是非炸药类破岩技术在实际工程应用时重点关注的内容.本研究基于爆破当量理论计算和现场爆破试验的研究方法，通过工程类比法进行工业乳化炸药等效当量计算，选择典型代表性花岗岩及泥岩场地，设计进行了SC-CO2与工业炸药破岩效应等效对比现场试验；基于现场破岩等效现场试验测试数据，对比分析试验过程中SC-CO2与工业炸药破岩体积、破岩区域形态、大块率和单耗等破岩区域特征及参量数据.研究结果表明：当SC-CO2破岩体积较大时，其致裂破岩范围的长短轴较长，并且随着剪切片厚度的增加，泥岩场地二氧化碳单耗的下降速率增大，二氧化碳单耗是炸药单耗的6～11倍.SC-CO2破岩技术大块率较高，而炸药爆炸应力波分布均匀，大块率较小.SC-CO2破岩地表振速远小于工业炸药破岩，工业炸药爆破测点合振速值为SC-CO2破岩测点合振速值的9～11倍，SC-CO2破岩对周边环境震动影响较小.SC-CO2破岩测点合应力峰值高于工业炸药破岩，SC-CO2破岩试验中各测点合应力值为炸药破岩试验中对应测点值的1.2～1.6倍.

关键词： SC-CO2 工业炸药等效破岩动力效应破岩体积

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小分子药物TD-198946促进大鼠骨髓间充质干细胞的成骨分化

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中国组织工程研究 2025年第13期29卷 2648-2654页

作者：杨超罗宗平苏州大学附属第一医院骨科苏州大学骨科研究所江苏省苏州市215006

背景:小分子药物TD-198946是一种能诱导干细胞形成软骨的高效软骨生成剂,但目前尚不清楚其对成骨分化的作用。目的:探讨小分子药物TD-198946促进大鼠骨髓间充质干细胞成骨分化的效果及其作用机制。方法:提取SD大鼠骨髓间充质干细胞,利用... 详细信息

背景:小分子药物TD-198946是一种能诱导干细胞形成软骨的高效软骨生成剂,但目前尚不清楚其对成骨分化的作用。目的:探讨小分子药物TD-198946促进大鼠骨髓间充质干细胞成骨分化的效果及其作用机制。方法:提取SD大鼠骨髓间充质干细胞,利用CCK-8法评估不同浓度TD-198946对骨髓间充质干细胞增殖的影响,确定TD-198946的最佳使用浓度;然后加入最适浓度TD-198946和成骨分化培养基对骨髓间充质干细胞进行成骨诱导;成骨诱导第3天用qRT-PCR检测碱性磷酸酶、Runt相关转录因子2、骨桥蛋白、骨钙蛋白、Ⅰ型胶原基因表达;成骨诱导第7天进行碱性磷酸酶染色,Western blot检测Runt相关转录因子2、Ⅰ型胶原、AKT、p-AKT、PI3K、p-PI3K蛋白表达;成骨诱导第21天进行茜素红染色。结果与结论:①CCK-8实验结果显示,100 nmol/L TD-198946能促进骨髓间充质干细胞增殖;②碱性磷酸酶染色及茜素红染色结果显示,TD-198946能促进大鼠骨髓间充质干细胞的成骨分化;③qRT-PCR结果显示,TD-198946可促进成骨相关基因碱性磷酸酶、Runt相关转录因子2、骨桥蛋白、骨钙蛋白、Ⅰ型胶原的表达;④Western blot结果显示,TD-198946可促进Runt相关转录因子2、Ⅰ型胶原以及p-PI3K、p-AKT蛋白表达。结果表明,小分子药物TD-198946可能通过激活PI3K/AKT信号通路,诱导大鼠骨髓间充质干细胞成骨分化。

关键词：骨髓间充质干细胞 TD-198946 成骨分化 PI3K/AKT信号通路 AKT p-AKT

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Intestinal glucagon-like peptide-1:A new regulator of impaired counterregulatory responses to hypoglycemia in type 1 diabetes mellitus

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World Journal of Diabetes 2025年第1期16卷 217-221页

作者： Le-Rong Liu Yuan-Yuan luo Pei-Zhu Su Cong Zhang Zhao-Tao Li Department of Endocrinology and Metabolism Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Endocrinology Chongqing University Three Gorges HospitalChongqing 404100China Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic Diseases Chongqing University Three Gorges HospitalChongqing 404100China Department of Endocrinology The Second Affiliated HospitalChongqing Medical UniversityChongqing 400013China Department of Gastroenterology The First People's Hospital of FoshanFoshan 528000Guangdong ProvinceChina

In this article,we review the study by Jin et al,which examined the role of intestinal glucagon-like peptide-1(GLP-1)in counterregulatory responses to hypoglycemia in patients with type 1 diabetes mellitus(T1DM).With the global rise of T1DM,there is an increased burden on society and healthcare *** to insulin therapy and islet dysfunction,T1DM patients are highly vulnerable to severe hypoglycemia,a leading cause of *** healthy individuals,counterregulatory mechanisms restore blood glucose during hypoglycemia,but repeated episodes impair these *** et al demonstrated that overexpression of GLP-1 attenuates the sympathetic-adrenal reflex and disrupts the secretion of counterregulatory hormones such as glucagon during hypoglycemia,leading to counterregulatory *** findings highlight the critical role of GLP-1 in the impaired counterregulatory response to hypoglycemia in T1DM patients and provide new insights into the potential application of GLP-1-related therapies in T1DM patients.

关键词： Glucagon-like peptide-1 Impaired counterregulation Type 1 diabetes mellitus Sympathetic-adrenal reflex Glucagon

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Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen luo Xueran Kang Renwen Wan Fangqi Li Weiwei Lin Zhihua Han Beijie Qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

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