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Coherent control of fragmentation of methyl iodide by shaped femtosecond pulse train

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Chinese Physics B 2019年第9期28卷 157-163页

作者： Qiu-Nan Tong De-Hou Fei Zhen-Zhong Lian Hong-Xia Qi Sheng-Peng zhou Si-Zuo luo zhou Chen Zhan Hu Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China Advanced Light Field and Modern Medical Treatment Science and Technology Innovation Center of Jilin Province Jilin UniversityChangchun 130012China

Coherent control of fragmentation of CH_3I using shaped femtosecond pulse train is *** dissociation processes can be modulated by changing the separation of the shaped pulse train, and the yield of I^+under the irradiation of the optimal pulse is significantly increased compared with that using the transform-limited *** discuss the control mechanism of dissociation processes with coherent interference in time domain.A three-pulse control model is proposed to explain the counterintuitive experimental results.

关键词： coherent control fragmentation shaped pulse

新工科背景下智慧能源专业教学探索——有限元仿真在动力设备全生命周期管理课程中的应用与实践

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大学教育 2024年第20期 13-16页

作者：赵文胜郭江侯佑民罗翔宇周岭武汉大学动力与机械学院湖北武汉430072 江苏大学国家水泵及系统工程技术研究中心江苏镇江212013

为提升智慧能源专业本科生培养质量、提高学生在工程实践中的知识应用能力,文章针对当下“双碳”政策的发展和新工科背景下的能源人才需求,探讨通过线上线下相结合、辅以理论应用案例的教学方法,基于数值模拟方法和有限元仿真专业软件,... 详细信息

为提升智慧能源专业本科生培养质量、提高学生在工程实践中的知识应用能力,文章针对当下“双碳”政策的发展和新工科背景下的能源人才需求,探讨通过线上线下相结合、辅以理论应用案例的教学方法,基于数值模拟方法和有限元仿真专业软件,在课程中开展动力设备全生命周期管理工程实例研究,引导学生主动学习、提高实践能力,通过重新整合教学内容和专业知识,提升学生的专业知识应用能力,促进学生对行业发展的理解。

关键词：动力设备全生命周期教学改革新工科智慧能源数值模拟

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党建引领大部制改革助力医院高质量发展实践探索

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现代医院 2024年第1期24卷 3-6页

作者：黄子俊吕雅杰罗雪琼周凯李淳梓郭志建中山大学附属口腔医院广东广州510055

建立与现代医院管理制度相适应的治理结构和运行模式,深化医院管理机构改革,探索施行职能有机统一的大部门体制是推动公立医院高质量发展的必然要求。中山大学附属口腔医院以习近平新时代中国特色社会主义思想为指导,认真贯彻落实《国... 详细信息

建立与现代医院管理制度相适应的治理结构和运行模式,深化医院管理机构改革,探索施行职能有机统一的大部门体制是推动公立医院高质量发展的必然要求。中山大学附属口腔医院以习近平新时代中国特色社会主义思想为指导,认真贯彻落实《国务院办公厅关于推动公立医院高质量发展的意见》,将党建工作与业务工作有机融合,开展了大部制改革的实践探索,引领医院高质量发展取得阶段性成效。

关键词：公立医院党建大部制高质量发展

Expression of feeding-related peptide receptors mRNA in GT1-7 cell line and roles of leptin and orexins in control of GnRH secretion

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Acta Pharmacologica Sinica 2005年第8期26卷 976-981页

作者： ying YANG, Li-bin zhou, Shang-quan LIU, Jing-feng TANG, Feng-yin LI, Rong-ying LI, Huai-dong SONG, Ming-dao CHEN~2 Rui-jin Hospital Affiliated to Shanghai Second Medical University, Shanghai Institute of Endocrine and Metabolic Diseases, Shangha 200025. China Rui-jin Hospital Affiliated to Shanghai Second Medical University Shanghai Institute of Endocrine and Metabolic Diseases Shanghai China

Aim: To investigate the expression of feeding-related peptide receptors mRNA in GT1-7 cell line and roles of leptin and orexins in the control of GnRH secretion. Methods: Receptors of bombesin3, cholecystoldnin (CCK)-A, CCK-B, glucagonlike peptide (GLP)1, melanin-concentrating hormone (MCH)I, orexin1, orexin2, neuromedin-B, neuropeptide Y (NPY)1 and NPYS, neurotensin (NT)1, NT2, NT3, and leptin receptor long form mRNA in GT1-7 cells were detected by reversed transcriptase-polymerase chain reaction. GT1-7 cells were treated with leptin, orexin A and orexin B at a cohort of concentrations for different lengths of time, and GnRH in medium was determined by radioimmunoassay (RIA). Results: Receptors of bombesin 3, CCK-B, GLP1, MCH1, orexin1, neuromedin-B, NPY1, NPYS, NT1, NT3, and leptin receptor long form mRNA were expressed in GT1-7 cells, of which, receptors of GLP1, neuromedin-B, NPY1, and NT3 were highly expressed. No amplified fragments of orexin2, NT2, and CCK-A receptor cDNA were generated with GT1-7 RNA, indicating that the GT1-7 cells did not express mRNA of them. Leptin induced a significant stimulation of GnRH release, the results being most significant at 0.1 nmol/L for 15 min. In contrast to other studies in hypothalamic explants, neither orexin A nor orexin B affected basal GnRH secretion over a wide range of concentrations ranging from 1 nmol/L to 500 nmol/Lat 15, 30, and 60 min. Conclusion: Feeding and reproductive function are closely linked. Many orexigenic and anorexigenic signals may control feeding behavior as well as alter GnRH secretion through their receptors on GnRH neurons.

关键词： GT1-7 cell line bombesin cholecystokinin neuropeptide Y neurotensin orexin leptin gonadorelin

超敏C-反应蛋白、血清降钙素原及白细胞计数在新生儿感染性疾病中的早期诊断价值

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西部医学 2024年第5期36卷 686-690页

作者：王丹丹王瑞罗智花周登余王琍琍安徽医科大学第一附属医院儿科安徽合肥230022

目的研究超敏C-反应蛋白(hs-CRP)、血清降钙素原(PCT)及白细胞(WBC)计数在新生儿感染性疾病的早期诊断价值,为降低临床抗生素使用率及新生儿病死率等提供科学依据。方法将2021年1月—2021年12月本院收治的62例患有感染性疾病的新生儿为... 详细信息

目的研究超敏C-反应蛋白(hs-CRP)、血清降钙素原(PCT)及白细胞(WBC)计数在新生儿感染性疾病的早期诊断价值,为降低临床抗生素使用率及新生儿病死率等提供科学依据。方法将2021年1月—2021年12月本院收治的62例患有感染性疾病的新生儿为病例组,同期同科室收住的50例患新生儿非感染性疾病的病例为对照组,在入院第1天和第7天分别采静脉血对比两组患儿hs-CRP、PCT和WBC的差异,计算hs-CRP、PCT和WBC灵敏度、特异度并绘制ROC曲线。结果入院时病例组hs-CRP、PCT和WBC计数均高于对照组,差异具有统计学意义(P1);入院7天时,病例组hs-CRP、PCT均明显下降,与对照组差异无统计学意义(P>0.05),WBC计数虽较入院时明显下降,但仍较对照组高,差异具有统计学意义(P2、0.732和0.985。Hs-CRP+PCT的约登指数最高,曲线下面积最大,其次是PCT、hs-CRP、WBC,差异均具有统计学意义(P<0.05)。结论hs-CRP、PCT和WBC计数在新生儿患有感染性疾病的早期均具有一定的诊断价值,hs-CRP联合PCT有助于早期判断是否使用抗生素。

关键词：新生儿感染性疾病超敏C-反应蛋白血清降钙素原白细胞计数

Physiological but not morphological adjustments along latitudinal gradients in a human commensal species,the Eurasian tree sparrow

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Integrative Zoology 2023年第5期18卷 891-905页

作者： Qian ZHANG Mo LI Yuan yin Shiyong GE Danjie LI Ibrahim M.AHMAD Ghulam NABI Yanfeng SUN Xu luo Dongming LI Hebei Key Laboratory of Animal Physiology Biochemistry and Molecular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuangChina Key Laboratory for ConservingWildlife with Small Populations in Yunnan Faculty of Biodiversity and ConservationSouthwest Forestry UniversityKunmingChina Ocean College Hebei Agricultural UniversityQinhuangdaoChina Hebei Collaborative Innovation Center for Eco-Environment Hebei Normal UniversityShijiazhuangChina

Human commensal species take advantage of anthropogenic conditions that are less likely to be challenged by the selective pressures of natural *** morphological and physiological phenotypes can therefore dissociate from habitat *** how these species adjust their morphological and physiological traits across latitudinal gradients is fundamental to uncovering the eco-physiological strategies underlying coping ***,we studied morphological traits in breeding Eurasian tree sparrows(ETSs;Passer montanus)among low-latitude(Yunnan and Hunan)and middle-latitude(Hebei)localities in *** then compared body mass;lengths of bill,tarsometatarsus,wing,total body,and tail feather;and baseline and capture stress-induced levels of plasma corticosterone(CORT)and the metabolites including glucose(Glu),total triglyceride(TG),free fatty acid(FFA),total protein,and uric acid(UA).None of the measured morphological parameters varied with latitude except in the Hunan population,which demonstrated longer bills than those in other ***-induced CORT levels significantly exceeded baseline levels and decreased with increasing latitude,but total integrated CORT levels did not vary with *** stress-induced significantly increased Glu levels and decreased TG levels,independent of ***,the Hunan population had significantly higher baseline CORT,baseline and stress-induced FFA levels,but lower UA levels,which differed from other *** results suggest that rather than morphological adjustments,physiological adjustments are mainly involved in coping mechanisms for middle-latitude adaptation in *** is worth investigating whether other avian species also exhibit such dissociation from external morphological designs while depending on physiological adjustments.

关键词： capture stress corticosterone human commensal species latitudinal gradients plasma metabolites

Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG

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Bone Research 2019年第3期7卷 296-309页

作者： Chun-Yuan Chen Shan-Shan Rao Yi-juan Tan Ming-Jie luo Xiong-Ke Hu Hao yin Jie Huang yin Hu Zhong-Wei luo Zheng-Zhao Liu Zhen-Xing Wang Jia Cao Yi-Wei Liu Hong-Ming Li Yang Chen Wei Du Jiang-Hua Liu Yan Zhang Tuan-Hui Chen Hao-Ming Liu Ben Wu Tao Yue Yi-Yi Wang Kun Xia Peng-Fei Lei Si-Yuan Tang Hui Xie Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China Xiangya School of Nursing Central South University Changsha Hunan 410013 China Department of Sports Medicine Xiangya Hospital Central South University Changsha Hunan 410008 China Department of Rehabilitation Xiangya Hospital Central South University Changsha Hunan 410008 China Hunan Key Laboratory of Organ Injury Aging and Regenerative Medicine Changsha Hunan 410008 China Hunan Key Laboratory of Bone Joint Degeneration and Injury Changsha Hunan 410008 China National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha Hunan 410008 China

Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells(USCs),which were noninvasively harvested from unlimited and easily available urine, as a "factory" to obtain extracellular vesicles(USCEVs) and demonstrated that the systemic injection of USC-EVs effectively alleviates bone loss and maintains bone strength in osteoporotic mice by enhancing osteoblastic bone formation and suppressing osteoclastic bone resorption. More importantly, the anti-osteoporotic properties of USC-EVs are not notably disrupted by the age, gender, or health condition(with or without osteoporosis) of the USC donor. Mechanistic studies determined that collagen triple-helix repeat containing 1(CTHRC1) and osteoprotegerin(OPG) proteins are enriched in USC-EVs and required for USC-EV-induced pro-osteogenic and anti-osteoclastic effects. Our results suggest that autologous USC-EVs represent a promising novel therapeutic agent for osteoporosis by promoting osteogenesis and inhibiting osteoclastogenesis by transferring CTHRC1 and OPG.

关键词： stem cells USCs bone loss

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糠醇选择性加氢制备1,2-戊二醇

当代化工 2024年第7期53卷 1654-1658页

作者：罗文星汪永军向明林周冬京邱长玖湖南长炼新材料科技股份公司湖南岳阳414012

糠醇选择性加氢制备1,2-戊二醇是一种复杂的化学反应,存在选择性差、副产多、成本高等问题。合成了一种新型Cu-CLXC催化剂,在固定床模式及温和条件下(反应温度160℃、反应压力5 MPa、空速0.3 h-1)对糠醇加氢表现出优异的催化活性,原料... 详细信息

糠醇选择性加氢制备1,2-戊二醇是一种复杂的化学反应,存在选择性差、副产多、成本高等问题。合成了一种新型Cu-CLXC催化剂,在固定床模式及温和条件下(反应温度160℃、反应压力5 MPa、空速0.3 h-1)对糠醇加氢表现出优异的催化活性,原料转化率>99.9%,1,2-戊二醇选择性>60.0%,并且该催化剂连续运行2 000 h后活性未见下降趋势,催化活性及稳定性远高于现有报道的催化剂水平。

关键词： 1,2-戊二醇固定床活性生产稳定性

新农科背景下园艺植物育种学“三位一体”课程思政教学体系探讨

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安徽农业科学 2024年第14期52卷 275-278页

作者：罗莎周庆红朱强龙单楠孙静宇江西农业大学农学院江西南昌330045

在新农科背景下,高校应围绕立德树人的根本任务,聚焦国家乡村振兴的重大战略,立足培育一批专业知识扎实,既有一定实践能力、创新能力,又懂农业、爱农村、爱农民的应用型创新人才。人才的培养依托于优质专业课程的建设,园艺植物育种学是... 详细信息

在新农科背景下,高校应围绕立德树人的根本任务,聚焦国家乡村振兴的重大战略,立足培育一批专业知识扎实,既有一定实践能力、创新能力,又懂农业、爱农村、爱农民的应用型创新人才。人才的培养依托于优质专业课程的建设,园艺植物育种学是江西农业大学园艺专业的专业主干课程,通过前期探索实践,该课程构建了“三位一体”课程思政教学体系,对农科相关课程思政建设具有一定的参考意义。

关键词：新农科园艺植物育种学三位一体课程思政