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基于S-R和分解定理的无网格Galerkin法求解几何非线性问题

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湖南大学学报（自然科学版） 2012年第1期39卷 42-46页

作者：陈芳祖罗丹湖南大学汽车车身先进设计制造国家重点实验室湖南长沙410082

针对几何非线性问题,基于S-R和分解定理与更新拖带坐标描述法,从运动变换的角度出发,由虚功率原理建立全局弱式积分方程.采用无网格Galerkin法(EFG)求得该问题的数值解.对于非线性问题的数值计算,通常采用增量和迭代法.S-R和分解定理给... 详细信息

针对几何非线性问题,基于S-R和分解定理与更新拖带坐标描述法,从运动变换的角度出发,由虚功率原理建立全局弱式积分方程.采用无网格Galerkin法(EFG)求得该问题的数值解.对于非线性问题的数值计算,通常采用增量和迭代法.S-R和分解定理给出了一种新的应变张量,该应变张量能合理地反映大位移大转动情况下物体的应变状态及转动情况,而且有利于求解几何非线性问题.数值算例验证了该方法的合理性和有效性.

关键词： S—R和分解定理无网格Galerkin法几何非线性更新拖带坐标法

Effect and mechanism of acute graft versus host disease on early diffuse murine lung injury following allogeneic stem cell transplantation

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Science China(Life Sciences) 2009年第11期52卷 1016-1022页

作者： NING Juan, LIU Qi Fa, luo Xiao dan, FAN Zhi Ping & Zhang Yu Department of Hematology, Southern Hospital, Southern Medical University, Guang Zhou 510515, China Department of Hematology Southern Hospital Southern Medical University Guang Zhou China

To explore the effect and pathogenssis of acute graft-versus-host disease (aGVHD) on early diffuse lung injury in allogeneic hematopoietic stem cell transplantation (allo-HSCT), we established an aGVHD model of C57BL/6→BALB/c mice. Chest computed tomography (CT) scans, histopathology and the levels of cytokines including tumor necrosis factor α (TNFα) and Interferon (IFNγ) in lungs were dynamically detected in recipient mice after transplantation. The incidence of aGVHD was respectively 0%, 0% and 100% in simple irradiation group (A), syngeneic transplant group(B) and allogeneic transplant group (C). Chest CT scans of recipient mice were normal in 3 groups on days +3 and +7 after transplantation. CT showed that two of ten mice had bilateral lung diffuse infiltrate on day +12 (on the brink of death) in group A and 6 of 10 mice had bilateral lung diffuse infiltrate on day +14 (3 d after aGVHD occurring) in group C, and were normal on days +12 and +14 in group B after transplantation. Histopathology of lungs in the 3 groups was similar, consisting of minor interstitial pneumonitis on day +3. Group A showed edema, hyperplasia of epithelial cells and widened alveolar interval on day +7, and epithelial cell necrosis, lymphocyte infiltration, hemorrhage, protein leakage, and local consolidation on day +12. The histopathology of group B showed slight edema of epithelial cells on +7 day, which were slighter than that on day +3, and virtually normal on day +14. The histopathology in group C was characterized by the significant expansion and congestion of capillaries, and lymphocyte infiltration on day +7, the acute pneumonitis was present involving tissue edema, lymphocyte and macrophage infiltration, protein leakage and perivascular inflammation on day +14. In group A, the levels of TNFα were lower on day +7 than on day +3. In group B, the levels of TNFα attained a peak on day +3, which decreased on days +7 and +14. In group C, the levels of TNFα were highest on day +7 and t

关键词： lung injury acute graft-versus-host disease allogeneic hematopoietic stem cell transplantation

Modification Effect of Nano-Graphene Oxide on Properties and Structure of Polysulfone Ultrafiltration Membrane

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Journal of Environmental Protection 2018年第11期9卷 1185-1195页

作者： Hao Yuan Lahua Jin dan luo Chen Ge School of Environment Jinan University Guangzhou China

In order to improve the purification properties of polysulfone (PSF) ultrafiltration membranes (UFM), nano-graphene oxide (nano-GO) was taken as modifier, and the physical blending process was adopted in our experiment. The microstructure, surface morphology and functional groups of modified UFM have been characterized respectively by scanning electron microscopy, atomic force microscopy and Fourier transform infrared spectroscopy, and the static contact angle between the membrane surface and the water droplet has also been detected to show the change of its hydrophilicity. Through experiments, it has been found that modified UFM has larger and more developed finger micro-pores, and there exist a large number of -OH groups on its surface, and also its hydrophilicity has been enhanced. The result of the experiments show that the modified UFM may keep rejection above 97% and its water flux can be reached at about 219.1 L/(m2·h) under pressure of 1 bar if 0.4 wt% of nano-GO was added. Additionally, the nano-GO can increase the flux recovery radio (FRR) of the membranes, and the maximum FRR was observed as 74.4% if 0.3 wt% of nano-GO was appended.

关键词： Nano-Graphene Oxide Ultrafiltration Membrane Polysulfone Water Purification

Long-term tadalafil once daily in Chinese men with erectile dysfunction:a 2-year final analysis of a post-marketing,multicenter,randomized,open-label trial

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Asian Journal of Andrology 2024年第3期26卷 282-287页

作者： Hui Jiang Lian-Ming Zhao Su Yan Ji-Hong Liu Zhao-Hui Zhu Jin-dan luo Yu-Tian Dai Fu-Biao Li Hao-Cheng Lin Zhi-Chao Zhang Department of Urology Peking University First HospitalBeijing 100000China Department of Urology Peking University Third HospitalBeijing 100191China Department of Urology Peking Union Medical College HospitalBeijing 100730China Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Urology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Urology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Departmentof Andrology Nanjing Drum Tower HospitalNanjing 210008China Department of Andrology The First Hospital of Jilin UniversityChangchun 130021China Andrology Center Department of UrologyPeking University First HospitalBeijing 100034China

The long-term safety and effectiveness of once-daily tadalafil is crucial,but limited data are available in Chinese patients witherectile dysfunction(ED).In this post-marketing,multicenter,randomized,open-label trial with 2-year follow-up,635 ED caseswere randomized to receive daily oral tadalafil 2.5 mg or 5 mg for 3 months,of whom 580 continued once-daily tadalafil 5 mg for21 ***-emergent adverse events in the 12-month and 24-month period were similar,with the most common beingviral upper respiratory tract infection,upper respiratory tract infection,and *** improvement from baseline inthe International Index of Erectile Function-Erectile Function(IIEF-EF)score was detected at month 12(least squares mean[LSM]change:7.9,95%confidence interval[CI]:7.5–8.4,P<0.001)and was maintained to month 24(LSM change:8.6,95%CI:8.1–9.0,P<0.001).The proportions of patients regaining normal erectile function(IIEF-EF score≥26)were 43.7%and 48.0%at months 12 and 24,*** Assessment Questionnaire results showed improved erection function in 97.5%ofpatients and improved ability to engage in sexual activity in 95.9%of patients at month 12;these values were 96.1%and 95.0%at month 24,*** quality of sexual life score based on the Sexual Life Quality Questionnaire(SLQQ)was increased by52.2%at month 12 and by 55.3%at month 24(both P<0.001).The treatment satisfaction score determined by SLQQ(mean±standard deviation)was 62.4±21.0 at month 12 versus 65.9±20.2 at month ***-year daily application of tadalafil 5mg in Chinese men with ED showed a favorable safety profile and durable improvement in sexual performance and satisfaction.

关键词： clinical trial erectile dysfunction long-term safety once-daily dosing tadalafil

SlBBX20 interacts with the COP9 signalosome subunit SlCSN5-2 to regulate anthocyanin biosynthesis by activating SlDFR expression in tomato

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Horticulture Research 2021年第1期8卷 2121-2132页

作者： dan luo Cheng Xiong Aihua Lin Chunli Zhang Wenhui Sun Junhong Zhang Changxian Yang Yongen Lu Hanxia Li Zhibiao Ye Ping He Taotao Wang Key Laboratory of Horticulture Plant Biology Ministry of EducationHuazhong Agriculture University430070 WuhanChina Department of Biochemistry and Biophysics Texas A&M UniversityCollege StationTX 77843USA

Anthocyanins play vital roles in plant stress tolerance and growth ***,we reported that the photomorphogenesis-related transcription factor SlBBX20 regulates anthocyanin accumulation in ***,the underlying mechanism remains ***,we showed that SlBBX20 promotes anthocyanin biosynthesis by binding the promoter of the anthocyanin biosynthesis gene SlDFR,suggesting that SlBBX20 directly activates anthocyanin biosynthesis ***,we found by yeast two-hybrid screening that SlBBX20 interacts with the COP9 signalosome subunit SlCSN5-2,and the interaction was confirmed by bimolecular fluorescence complementation and coimmunoprecipitation ***5 gene silencing led to anthocyanin hyperaccumulation in the transgenic tomato calli and shoots,and SlCSN5-2 overexpression decreased anthocyanin accumulation,suggesting thSlCSN5-2 enhanced the ubiquitination of SlBBX20 and promoted the degradation of SlBBX20 in ***,silencing the SlCSN5-2 homolog in tobacco significantly increased the accumulation of the SlBBX20 *** SlBBX20 is a vital regulator of photomorphogenesis,the SlBBX20-SlCSN5-2 module may represent a novel regulatory pathway in light-induced anthocyanin biosynthesis.

关键词： some anthocyanin vital

Interventricular septal hematoma following pediatric congenital cardiac surgery: A three-case report

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South China Journal of Cardiology 2022年第2期23卷 147-152页

作者： ZHANG Chong-jian luo dan-dong Department of Intensive Care Unit II of Cardiovascular Surgery Guangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou510080China.

INTRODUCTION Interventricular septal hematoma(IVSH)is a rare complication of pediatric congenital cardiac *** septal perforating artery is at risk when suturing the ventricular septal defect(VSD)*** injury of a septal perforating artery is thought to be the most likely mechanism of *** during the cardiopulmonary bypass(CPB)surgery may lead to continued bleeding with the formation of IVSH with artery injury.

关键词： septal surgery ventricular

Adverse Effects of Exposure to Fine Particulate Matters and Ozone on Gestational Hypertension

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Current Medical Science 2019年第6期39卷 1019-1028页

作者： Rong YANG dan luo Yi-ming ZHANG Ke HU Zheng-min QIAN Li-qin HU Long-jiao SHEN Hong XIAN Juliet Iwelunmor Su-rong MEI Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital) Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environment HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Wuhan Environmental Monitoring Center Wuhan 430015China College for Public Health&Social Justice Saint Louis University^Saint LouisMO 63104USA

Gestational hypertension(GH)is a common complication during *** is regarded as a potential public health challenge for pregnant women and *** evidence has linked ambient air pollution to an increased GH ***,most of the studies were conducted in developed countries,with inconsistent results *** present study was performed to explore whether exposure to particulate matters with an aerodynamic diameter≤2.5(PM2.5)and ozone(O3)was related to elevated odds of GH in a Chinese *** population-based cohort study involved 38115 pregnant women in Wuhan,*** information was collected from the Wuhan Maternal and Child Health Management Information System,using standardized quality *** daily air pollutant data for PM2.5 and O3 were obtained from the 20 monitoring stations of the Wuhan Environmental Monitoring Center during *** nearest monitor approach was applied to individual exposure assessment of PM2.5 and O3 for each *** adjusting for major confounders and other air pollutants,a 10μg/m^3 increase in PM25 and O3 concentrations was found to correlate to a 1.14-fold[95%confidence interval(95%CI):1.09,1.20]and a 1.05-fold(95%CI:1.02,1.07)increase in GH risk,***,stronger relationships between GH risk and PM25 and O3 exposure were observed in women who conceived in winter and summer,*** findings suggest that air pollutants may contribute to the development of GH.

关键词： air pollution fine particulate matter ozone hypertensive disorders of pregnancy gestational hypertension

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潘懋元职业教育思想研究

职业技术教育 2017年第16期38卷 13-18页

作者：罗丹顺德职业技术学院

潘懋元先生对于高等职业教育进行了大量指引性研究。他从实践问题出发,指出高职学生也是大学生,职业教育乃平民学生"命运之所系",因此,职教政策应基于高职学生的特点和实际来制定;从国际趋势以及教育内外部关系规律出发,指出升级职业教... 详细信息

潘懋元先生对于高等职业教育进行了大量指引性研究。他从实践问题出发,指出高职学生也是大学生,职业教育乃平民学生"命运之所系",因此,职教政策应基于高职学生的特点和实际来制定;从国际趋势以及教育内外部关系规律出发,指出升级职业教育重心是经济社会发展的必然要求,高职教育是中国高等教育地方化的主要力量;并率先提出高等职业教育是"类型"而非"层次",新建本科院校应定位于职业本科,提出建立职业教育独立体系是中国特色职业教育发展道路的基本选择。其基本思想和主要观点,对于今天建立现代职业教育体系、转型高校的发展、高职院校服务区域经济社会发展、服务学生全面发展能力的提升等,有着积极指导意义。

关键词：潘懋元职业教育思想高等职业教育职业本科

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基于模糊均差的低照度图像平滑去噪方法

科学技术与工程 2022年第27期22卷 12061-12067页

作者：罗丹电子科技大学成都学院计算机学院成都611731

为了提高低照度图像去噪处理的整体效果,提出了基于模糊均差的低照度图像平滑去噪方法。采用Sobel梯度检测图像边缘信息,采用大津展之(Nobuyuki otsu, OTSU)阈值分割法分割图像为平坦区域和细节区域;通过模糊均差方法分别估计两个区域... 详细信息

为了提高低照度图像去噪处理的整体效果,提出了基于模糊均差的低照度图像平滑去噪方法。采用Sobel梯度检测图像边缘信息,采用大津展之(Nobuyuki otsu, OTSU)阈值分割法分割图像为平坦区域和细节区域;通过模糊均差方法分别估计两个区域图像的噪声标准差;采用小波域方法对图像进行平滑软阈值去噪,实现低照度图像的平滑去噪。实验结果显示,本文方法可以在不同噪声水平下获取接近真实值噪声标准差,在噪声水平最大时信噪比大小达到了27.97 dB,去噪效果达到92.1%,质量很好的图像数量占比达到了80.58%,图像信息损失较小,去噪效果较好,具有极大的应用价值。

关键词：低照度图像去噪模糊均差图像分割