检索结果-南通市图书馆

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral Science 2020年第1期12卷 10-24页

作者： Lisha Zhu dan luo Yan Liu Laboratory of Biomimetic Nanomaterials Department of OrthodonticsPeking University School and Hospital of StomatologyNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijingChina State Key Laboratory of Heavy Oil Processing College of New Energy and MaterialsBeijing Key Laboratory of Biogas Upgrading UtilizationChina University of Petroleum(Beijing)BeijingChina

Natural bone is a mineralized biological material, which serves a supportive and protective framework for the body, stores minerals for metabolism, and produces blood cells nourishing the body. Normally, bone has an innate capacity to heal from ***, massive bone defects due to traumatic injury, tumor resection, or congenital diseases pose a great challenge to reconstructive surgery. Scaffold-based tissue engineering(TE) is a promising strategy for bone regenerative medicine, because biomaterial scaffolds show advanced mechanical properties and a good degradation profile, as well as the feasibility of controlled release of growth and differentiation factors or immobilizing them on the material surface. Additionally, the defined structure of biomaterial scaffolds, as a kind of mechanical cue, can influence cell behaviors, modulate local microenvironment and control key features at the molecular and cellular levels. Recently, nano/micro-assisted regenerative medicine becomes a promising application of TE for the reconstruction of bone defects. For this reason, it is necessary for us to have in-depth knowledge of the development of novel nano/micro-based biomaterial scaffolds. Thus, we herein review the hierarchical structure of bone, and the potential application of nano/micro technologies to guide the design of novel biomaterial structures for bone repair and regeneration.

关键词： structure stores protective

Control of gallbladder contractions by cholecystokinin through cholecystokinin-A receptors on gallbladder interstitial cells of cajal

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第18期14卷 2882-2887页

作者： dan Xu Bao-Ping Yu He-Sheng luo Ling-dan Chen Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan 430060 Hubei Province China

AIM: To identify the cholecystokinin (CCK)-A receptors (CCK-AR) on the guniea pig gallbladder interstitial cells of cajal (ICC) and to study CCK-8 induced gallbladder muscle strip contractions through the CCK-AR. METHODS: The existence of CCK-AR was examined by immunohistofluorescence on sectioned tissue and cultured cells. In vitro contractile response of guinea pig gallbladder muscle strips and the strips with ICC removed were also studied with CCK-8 receptors added. RESULTS: In tissue sections, intensely CCKAR- immunoreactive interstitial cells were found mainly in the muscular layers. In cultured cell sections, distinctive double staining of C-kit and CCK-AR ICCs were found. When we removed the ICC of the gallbladder, CCK-8 induced muscle strip contraction dose response curve significantly shifted to the right. CONCLUSION: We proved that both the existence of CCK-AR on the guinea pig gallbladder ICC and CCK evoked contraction are mediated through direct action on CCK-AR on the gallbladder ICC.

关键词： Gallbladder Interstitial cells of cajal Cholecystokinin-A receptor C-kit Immunohistofluorescence

Reduced graphene oxide-supported CoP nanocrystals confined in porous nitrogen-doped carbon nanowire for highly enhanced lithium/sodium storage and hydrogen evolution reaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2019年第11期12卷 2872-2880页

作者： Xiaojun Zhao dan luo Yan Wang Zhi-Hong Liu Key Laboratory for Macromolecular Science of Shaanxi Province School of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an710062China

Rational synthesis of a hierarchical porous architecture with highly active and consecutive conductive network is very critical to achieve the high-performance of nanomaterials in electrochemical energy conversion and *** propose here a hierarchical micro-/nanostructured hybrids constructed by the dual carbon shell nanowire host containing CoP nanocrystals of several nanometers,which generates Co-based metal-organic framework on graphene oxide nanosheets in situ and followed a direct phosphorization(CoP@NC/rGO).The dual carbon shell,consisting of Co-based metal-organic framework derived porous doped carbon(NC)and reduced graphene oxide(rGO),can not only impedes CoP nanocrystals from coalescing,and renders highly exposed the electrochemically accessible active sites,but also provides the multidimensional pathways for rapid electron and ion *** importantly,the covered dual carbon shell on CoP nanocrystals plays a role as a protective layer to impede the nanocrystals’*** virtue of compositional and structural advantages,the micro-/nanostructured CoP@NC/rGO hybrids manifest outstanding energy storage properties when evaluated as anodes for lithium/sodium ion ***,it also reveals highly efficient electrocatalytic performance for hydrogen evolution reaction in acid media with low Tafel slope,overpotential and robust durability.

关键词： micro-/nanostructured metal-organic framework CoP@NC/rGO lithium/sodium ion batteries hydrogen evolution reaction

Vestigial suppresses apoptosis and cell migration in a manner dependent on the level of JNK-Caspase signaling in the Drosophila wing disc

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2021年第1期28卷 63-76页

作者： Wen-Min Fan dan luo Jun-Zheng Zhang dan Wang Jie Shen Department of Entomology and MOA Lab for Pest Monitoring and Green Control China Agricultural UniversityBeijingChina

The Decapentaplegic(Dpp)and Wingless(Wg)signal pathways play important roles in numerous biological processes in *** Drosophila vestigial(vg)gene is selectively required for wing imaginal disc cell proliferation,which is essential for the formation of the adult wing and halter structures,and is regulated by Dpp and Wg *** a Drosophila invasion model of wing epithelium,we showed herein that inhibition of Dpp or Wg signaling promoted cells to migrate across the cell lineage restrictive anterior/posterior(A/P)compartment *** downstream of both Dpp and Wg signaling,vg can block cell migration induced by loss of either *** addition,suppression of vg is sufficient to induce cell migration across the A/P *** analysis revealed potential downstream genes involved in the cell migration after suppressing vg in the wing *** further demonstrated that the c-Jun N-terminal kinase(JNK)signaling promoted cell migration induced by vg suppression by upregulating Caspase *** together,our results revealed the requirement ofVg for suppressing cell migration and clarified how developmental signals collaborate to stabilize cells along the compartment boundary.

关键词： Caspase cell migration Dpp Drosophila wing disc JNK vestigial Wg

Fluctuations of Single-Mode Laser Driven by Two Different Kinds of Colored Noise

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2006年第4期45卷 630-636页

作者： WU dan luo Xiao-Qin ZHU Shi-Qun School of Physical Science and Technology Suzhou University Suzhou 215006 China

A single-mode laser with coupling between additive and multiplicative noise terms is investigated when the multiplicative noise and the coupling between two noise terms are colored fluctuations with finite correlation times T1 and T2. Combining the unified colored noise approximation （UCNA） and the functional analysis, the stationary probability distribution （SPD） and the variance of the laser intensity is derived. It is found that the colored nature of multiplicative noise and the coupling strength between two noise terms can affect both the structure and the height of the SPD, while the colored nature of the coupling between two noise terms can only affect the height of the SPD. The multiplicative noise can enhance the intensity fluctuations while the additive noise can reduce the fluctuations in a laser system. Numerical simulations are presented and consistent to the analytical results.

关键词： single-mode laser colored noise fluctuation coupling variance

Anthracene-bridged“Texas-sized”box for the simultaneous detection and uptake of tryptophan

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第9期35卷 175-178页

作者： dan luo Jinya Tian Jianqiao Zhou Xiaodong Chi State Key Laboratory of Materials Processing and Die&Mold Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Shenzhen Huazhong University of Science and Technology Research Institute Shenzhen 518057China

Tryptophan(Trp)is an essential amino acid that plays a critical role in human *** increasing demand for Trp has created a highly promising market,underscoring the urgent necessity for the development of efficient strategies for the simultaneous detection and uptake of ***,we report an expanded“Texas-sized”molecular box(An-TxSB),which incorporates luminescent anthracene bridging subunits and molecular recognition *** luminescent molecular box demonstrates exceptional sensitivity to Trp in water,permitting its precise quantification with a notably low limit of detection(LOD)of 0.42μmol/***,An-TxSB facilitates the proficient uptake of Trp from simulated water samples,thereby revealing an impressive Trp adsorption capacity of up to 226.0μmol/g.

关键词： Macrocycles Host-guest chemistry Biomolecular sensors Molecular recognition Adsorption

Immunoregulatory effects of Tripterygium wilfordii Hook Fand its extracts in clinical practice

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2019年第5期13卷 556-563页

作者： dan luo Zhengyun Zuo Hongyan Zhao Yong Tan Cheng Xiao Traditional Chinese Medicine Hospital of Changping District Beijing 102200China Institute of Clinical Medicine China-Japan Friendship HospitalBeijing 100029China Jiangxi University of Traditional Chinese Medicine Nanchang 330004China Experimental Research Center China Academy of Chinese Medical SciencesBeijing 100070China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100070China

Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of T and B cells;ratio of T cell subsets;inflammatory response of monocytes, macrophages, and immunoglobulins;and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation.

关键词： Tripterygium mlfordii Hook F immunoregulation clinical studies

The Chinese Medical Association celebrates its 90th founding anniversary

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2005年第10期118卷 879-880页

作者： luo dan

The Chinese Medical association (CMA) celebrated its 90th founding anniversary from April 12 to 14, 2005. The 23rd Congress of the CMA was held at the same time. Five hundred and sixty CMA member representatives from the mainland of China and 122 guests from Hong Kong, Macao, Taiwan Province and other countries attended the celebration. In addition, 89 specially invited persons presented at the congress. Also at the jubilee were some officers including vice Minister of the Ministry of Civil Affairs Jiang Li, Director of the State Durg and Food Administration Zheng Xiao-yu, vice Ministers of the Ministry of Public Health Wang Long-de, Jiang Zuo-jun, Yu Jing, Huang Jie-fu, Zhang Feng-lou, and Chen Xiao-hong, and the Honorary Chairman Wu Jie-ping.

关键词： ping The Chinese Medical Association celebrates its 90th founding anniversary

Confined cobalt single-atom catalysts with strong electronic metal-support interactions based on a biomimetic self-assembly strategy

在线全文

学校读者我要写书评

暂无评论

Carbon Energy 2024年第9期6卷 156-171页

作者： Bowen Guo Zekun Wang Lei Zheng Guang Mo Hongjun Zhou dan luo State Key Laboratory of Heavy Oil Processing Beijing Key Laboratory of Biogas Upgrading UtilizationCollege of New Energy and MaterialsChina University of Petroleum(Beijing)BeijingChina Beijing Key Laboratory of Micro-Nano Energy and Sensor CAS Center for Excellence in NanoscienceBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijingChina School of Chemical Engineering Shandong Institute of Petroleum and Chemical TechnologyDongyingShandongChina School of Chemistry Beijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijingChina Institute of High Energy Physics Chinese Academy of SciencesBeijingChina

Designing high-performance and low-cost electrocatalysts for oxygen evolu-tion reaction(OER)is critical for the conversion and storage of sustainable energy *** by the biomineralization process,we utilized the phosphorylation sites of collagen molecules to combine with cobalt-based mononuclear precursors at the molecular level and built a three-dimensional(3D)porous hierarchical material through a bottom-up biomimetic self-assembly strategy to obtain single-atom catalysts confined on carbonized biomimetic self-assembled carriers(Co SACs/cBSC)after subsequent high-temperature *** this strategy,the biomolecule improved the anchoring efficiency of the metal precursor through precise functional groups;meanwhile,the binding-then-assembling strategy also effectively suppressed the nonspecific adsorption of metal ions,ultimately preventing atomic agglomeration and achieving strong electronic metal-support interactions(EMSIs).Experimental characterizations confirm that binding forms between cobalt metal and carbonized self-assembled substrate(Co–O_(4)–P).Theoretical calculations disclose that the local environment changes significantly tailored the Co d-band center,and optimized the binding energy of oxygenated intermediates and the energy barrier of oxygen *** a result,the obtained Co SACs/cBSC catalyst can achieve remarkable OER activity and 24 h durability in 1 M KOH(η_(10) at 288 mV;Tafel slope of 44 mV dec^(-1)),better than other transition metal-based catalysts and commercial IrO_(2).Overall,we presented a self-assembly strategy to prepare transition metal SACs with strong EMSIs,providing a new avenue for the preparation of efficient catalysts with fine atomic structures.

关键词： biomimetic self-assembly support electronic metal-support interactions oxygen evolution reaction single atoms catalysts