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HPV感染宫颈病变危险因素及cGAS/STING/TBK1信号通路基因表达水平

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中华医院感染学杂志 2024年第7期34卷 1076-1080页

作者：刘洁罗春艳王小兵郭艳琴刘丽珍吉安市中心人民医院妇产科江西吉安343000

目的探讨环鸟嘌呤核苷酸腺嘌呤核苷酸合成酶/干扰素激活蛋白/TANK结合激酶1(cGAS/STING/TBK1)信号通路基因在HPV感染宫颈病变患者中的表达及其易感因素。方法回顾性分析2019年3月-2023年3月吉安市中心人民医院收治的151例人乳头瘤病毒(H... 详细信息

目的探讨环鸟嘌呤核苷酸腺嘌呤核苷酸合成酶/干扰素激活蛋白/TANK结合激酶1(cGAS/STING/TBK1)信号通路基因在HPV感染宫颈病变患者中的表达及其易感因素。方法回顾性分析2019年3月-2023年3月吉安市中心人民医院收治的151例人乳头瘤病毒(HPV)感染宫颈病变患者的临床资料,并作为研究组,151例同期无HPV感染的宫颈病变患者的临床资料作为对照组。比较两组临床资料,采用单因素及多因素分析法分析宫颈病变患者HPV感染的易感因素;采用实时荧光定量聚合酶链式反应(RT-qPCR)检测cGAS、STING、TBK1mRNA表达水平;比较研究组和对照组cGAS、STING、TBK1mRNA表达水平;采用受试者工作特征(ROC)曲线分析cGAS、STING、TBK1单独及联合检测对宫颈病变患者HPV感染的诊断价值。结果多因素Logistic回归分析结果显示,年龄大、既往宫颈炎病史、性生活频率高、未使用避孕套、性生活前后无外阴清洗、初次性生活年龄≤20岁、有宫颈癌家族史、初中及以下文化、性伴侣个数≥2个均是宫颈病变患者HPV感染的易感因素(P<0.05);研究组cGAS、STING、TBK1 mRNA表达水平均高于对照组(P<0.05);cGAS、STING、TBK1水平联合检测诊断宫颈病变患者HPV感染的曲线下面积(AUC)为0.902,高于各项单独检测(P<0.05),且联合检测的敏感度和特异度为82.80%和82.10%,诊断价值均较高。结论宫颈病变患者HPV感染后cGAS/STING/TBK1信号通路被激活;联合检测cGAS、STING、TBK1有助于诊断宫颈病变患者HPV感染;宫颈病变患者HPV感染与患者年龄、宫颈炎病史、性生活频率等多种因素有关。

关键词：宫颈病变人乳头瘤病毒危险因素环鸟嘌呤核苷酸腺嘌呤核苷酸合成酶干扰素激活蛋白 TANK结合激酶1 诊断价值受试者工作特征曲线

Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion

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World Journal of Gastroenterology 2009年第17期15卷 2145-2150页

作者： Jing Zhao Xiang-Dong luo chun-Li Da yan Xin The Fourth Laboratory of Cancer Institute Department of Tumor Pathology of General Surgery Institute First Affiliated Hospital of China Medical University Shenyang 110001 Liaoning Province China

AIM： To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 （Bmi-1） expression and the clinicopathological features of gastric carcinoma （GC）.METHODS： Immunohistochemistry was used to detect the expression of Bmi-1 and ki-67. Doublelabeling staining was used to display the distribution of Bcl-2^＋/ki-67 cells in 162 cases of GC and its matched normal mucosa and precancerous ***： The positive rate of Bmi-1 expression in GC（52.5%） was significantly higher than that in normal gastric mucosa （21.6%, X^2 = 33.088, P 〈 0.05）. The Bmi-1 expression in GC was closely related with the Lauren＇s and Borrmann＇s classification and clinicalstage （X^2 = 4.400, 6.122 and 11.190, respectively, P〈 0.05）. The expression of ki-67 was related to the Borrmann＇s classification （X^2 = 13.380, P 〈 0.05）.Bcl-2 expression was correlated with the Lauren＇s classification （Z2 = 4.725, P 〈 0.05）, and the Bmi-1 expression both in GC （rk = 0.157, P 〈 0.05） and inintestinal metaplasia （rk = 0.270, P 〈 0.05）.CONCLUSION： Abnormal Bmi-1 expression in GCmay be involved in cell proliferation, apoptosis andcancerization. This marker can objectively indicate theclinicopathological characteristics of GC.

关键词： B-cell-specific Moloney murine leukemiavirus insertion site 1 Gastric carcinoma Precancerouslesion Cell proliferation Apoptosis

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裂隙灯显微镜下结膜囊肿取出术的疗效

广东医学 2024年第1期45卷 116-120页

作者：余惠英郭舜娜肖惠明罗春燕中山大学中山眼科中心眼病防治全国重点实验室广东省眼科视觉科学重点实验室广东广州510060

目的明确门诊行裂隙灯显微镜下结膜囊肿取出术治疗结膜囊肿的疗效和安全性。方法在门诊病历系统收集2018年3月至2020年3月在中山大学中山眼科中心门诊行裂隙灯显微镜下结膜囊肿取出术共56例57眼结膜囊肿患者。手术过程:术前结膜囊清洁,... 详细信息

目的明确门诊行裂隙灯显微镜下结膜囊肿取出术治疗结膜囊肿的疗效和安全性。方法在门诊病历系统收集2018年3月至2020年3月在中山大学中山眼科中心门诊行裂隙灯显微镜下结膜囊肿取出术共56例57眼结膜囊肿患者。手术过程:术前结膜囊清洁,丙美卡因表面麻醉后,由高年资眼科专科护士在裂隙灯下采用负压抽吸囊肿,完整吸出囊膜,术毕涂抗生素眼药膏。术后随访观察眼表疾病指数(OSDI评分)、复发情况、并发症和患者就医体验。结果56例患者行裂隙灯显微镜下结膜囊肿取出术的手术成功率为100%,患者未出现并发症。患者术后28 d OSDI评分较术前降低,差异有统计学意义(P<0.001),患者就医体验良好,随访1个月、6个月、2年,回访无复发。结论门诊行裂隙灯显微镜下结膜囊肿取出术方便快速,创伤小,术后伤口愈合良好,具有安全性、可行性和有效性,效果好,患者就医体验良好。

关键词：结膜囊肿裂隙灯显微镜取出疗效

Predicting Metabolic Syndrome Using Anthropometric Indices among Chinese Adolescents with Different Nutritional Status:A Multicenter Cross-sectional Study

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Biomedical and Environmental Sciences 2021年第9期34卷 673-682页

作者： LI Ya Mei ZOU Zhi Yong MA Ying Hua luo Jia You JING Jin ZHANG Xin luo chun yan WANG Hong ZHAO Hai Ping PAN De Hong luo Mi yang Xiangya School of Public Health Central South UniversityChangsha 410008HunanChina Institute of Child and Adolescent Health Peking University School of Public HealthNational Health Commission Key Laboratory of Reproductive HealthBeijing 100191China Department of Maternal and Child Health School of Public HealthSun Yat-sen UniversityGuangzhou 510080GuangdongChina School of Public Health Tianjin Medical UniversityTianjin 300070China Department of School Health Shanghai Municipal Center for Disease Control and Prevention&Shanghai Institutes of Preventive MedicineShanghai 200336China School of Public Health and Management Chongqing Medical UniversityChongqing 400016China School of Public Health and Management Ningxia Medical UniversityYinchuan 750004NingxiaChina Liaoning Health Supervision Bureau Shenyang 110000LiaoningChina

Objective To evaluate the predictive performance of anthropometric indices for metabolic syndrome(Met S)among Chinese adolescents with different nutritional *** We recruited 9,513 adolescents aged 10–18 years from seven provinces in China during September *** indices and blood pressure were measured at recruitment,and blood samples were collected for determining fasting plasma glucose and lipid *** operating characteristic(ROC)analyses were used to assess the predictive performance of anthropometric indices,including body mass index(BMI)percentile,waist circumference percentile,waist-height ratio,and waist-hip *** Overall,the four anthropometric indices showed good accuracy for predicting Met S with areas under ROC curves(AUCs)ranging from 0.86 to 0.94;similar AUCs ranging from 0.73 to 0.99 were observed for participants with normal *** performance of all four indices was poor in overweight and obese participants,with AUCs ranging from 0.66 to 0.77 and from 0.60 to 0.67,*** circumference showed relatively better performance in all the subgroup *** We suggest using anthropometric indices with the cutoff values presented here for predicting Met S in the overall and normal-weight adolescent population,but not in the overweight and obese adolescent population where more specific screening tests are required.

关键词： Metabolic syndrome Anthropometry Body mass index Waist circumference Waist-height ratio Waist-hip ratio Adolescents

Long-term phosphorus accumulation and agronomic and environmtal critical phosphorus levels in Haplic Luvisol soil, northern China

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Journal of Integrative Agriculture 2016年第1期15卷 200-208页

作者： XI Bin ZHAI Li-mei LIU Jian LIU Shen WANG Hong-yuan luo chun-yan REN Tian-zhi LIU Hong-bin Key Laboratory of Nonpoint Source Pollution Control Ministry of AgricultureInstitute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences USDA-Agricultural Research Service Pasture Systems and Watershed Management Research Unit Institute of Agro-Environmental Protection Ministry of Agriculture

Sufficient soil phosphorus （P） content is essential for achieving optimal crop yields, but accumulation of P in the soil due to excessive P applications can cause a risk of P loss and contribute to eutrophication of surface waters. Determination of a critical soil P value is fundamental for making appropriate P fertilization recommendations to ensure safety of both environment and crop production. In this study, agronomic and environmental critical P levels were determined by using linear-linear and linear-plateau models, and two segment linear model, for a maize （Zea mays L.）-winter wheat （Triticum aestivum L.） rotation system based on a 22-yr field experiment on a Haplic Luvisol soil in northern China. This study included six treatments： control （unfertilized）, no P （NoP）, application of mineral P fertilizer （MinP）, MinP plus return of maize straw （MinP＋StrP）, MinP plus low rate of farmyard swine manure （MinP＋***） and MinP plus high rate of manure （MinP＋ ***）. Based on the two models, the mean agronomic critical levels of soil Olsen-P for optimal maize and wheat yields were 12.3 and 12.8 mg kg-1, respectively. The environmental critical P value as an indicator for P leaching was 30.6 mg Olsen-P kg-1, which was 2.4 times higher than the agronomic critical P value （on average 12.5 mg P kg-1）. It was calculated that soil OIsen-P content would reach the environmental critical P value in 41 years in the MinP treatment, but in only 5-6 years in the two manure treatments. Application of manure could significantly raise soil Olsen-P content and cause an obvious risk of P leaching. In conclusion, the threshold range of soil Olsen-P is from 12.5 to 30.6 mg P kg-1 to optimize crop yields and meanwhile maintain relatively low risk of P leaching in Haplic Luvisol soil, northern China.

关键词： critical phosphorus value crop yield Olsen P phosphorus leaching soil phosphorus test water quality

Present situation of minimally invasive surgical treatment for early gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1154-1165页

作者： chun-yan Li Yi-Feng Wang Li-Kang luo Xiao-Jun yang The First Clinical Medical School Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The First Clinical Medicine College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Centre Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina The Second Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Lanzhou University People's Clinical Hospital Lanzhou 730000Gansu ProvinceChina Gansu Research Center of Prevention and Control Project for Digestive Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Gansu Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

Minimally invasive surgery is a kind of surgical operation,which is performed by using professional surgical instruments and equipment to inactivate,resect,repair or reconstruct the pathological changes,deformities and wounds in human body through micro-trauma or micro-approach,in order to achieve the goal of treatment,its surgical effect is equivalent to the traditional open surgery,while avoiding the morbidity of conventional surgical *** addition,it also has the advantages of less trauma,less blood loss during operation,less psychological burden and quick recovery on patients,and these minimally invasive techniques provide unique value for the examination and treatment of gastric cancer *** minimally invasive surgical techniques have developed rapidly and offer numerous options for the treatment of early gastric cancer(EGC):endoscopic mucosal resection(EMR),underwater EMR(UEMR),endoscopic submucosal dissection(ESD),endoscopic full-thickness resection(EFTR),endoscopic submu-cosal excavation(ESE),submucosal tunnel endoscopic resection,laparoscopic and endoscopic cooperative surgery(LECS);Among them,EMR,EFTR and LECS technologies have a wide range of applications and different modific-ations have been derived from their respective surgical operations,such as band-assisted EMR(BA-EMR),conven-tional EMR(CEMR),over-the-scope clip-assisted EFTR,no-touch EFTR,the inverted LECS,closed LECS,and so *** new and improved minimally invasive surgeries are more precise,specific and effective in treating different types of EGC.

关键词： Minimally invasive surgery Early gastric cancer Endoscopic mucosal resection Endoscopic full-thickness resection Laparoscopic and endoscopic cooperative surgery

Phosphorus losses via surface runoff in rice-wheat cropping systems as impacted by rainfall regimes and fertilizer applications

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Journal of Integrative Agriculture 2016年第3期15卷 667-677页

作者： LIU Jian ZUO Qiang ZHAI Li-mei luo chun-yan LIU Hong-bin WANG Hong-yuan LIU Shen ZOU Guo-yuan REN Tian-zhi Key Laboratory of Nonpoint Source Pollution Control Ministry of AgricultureInstitute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences Department of Plant Science Pennsylvania State University Institute of Plant Nutrition and Resources Beijing Academy of Agriculture and Forestry Sciences Institute of Agro-Environmental Protection Ministry of Agriculture

Phosphorus（P） losses from agricultural soils contribute to eutrophication of surface waters. This field plot study investigated effects of rainfall regimes and P applications on P loss by surface runoff from rice（Oryza sativa L.） and wheat（Triticum aestivum L.） cropping systems in Lake Taihu region, China. The study was conducted on two types of paddy soils（Hydromorphic at Anzhen site, Wuxi City, and Degleyed at Xinzhuang site, Changshu City, Jiangsu Province） with different P status, and it covered 3 years with low, high and normal rainfall regimes. Four rates of mineral P fertilizer, i.e., no P（control）, 30 kg P ha^（–1） for rice and 20 kg P ha^（–1） for wheat（P_（30＋20））, 75 plus 40（P_（75＋40））, and 150 plus 80（P_（150＋80））, were applied as treatments. Runoff water from individual plots and runoff events was recorded and analyzed for total P and dissolved reactive P concentrations. Losses of total P and dissolved reactive P significantly increased with rainfall depth and P rates（P〈0.0001）. Annual total P losses ranged from 0.36–0.92 kg ha^–1 in control to 1.13–4.67 kg ha^–1 in P150＋80 at Anzhen, and correspondingly from 0.36–0.48 kg h^–1 to 1.26–1.88 kg ha^–1 at Xinzhuang, with 16–49% of total P as dissolved reactive P. In particular, large amounts of P were lost during heavy rainfall events that occurred shortly after P applications at Anzhen. On average of all P treatments, rice growing season constituted 37–86% of annual total P loss at Anzhen and 28–44% of that at Xinzhuang. In both crop seasons, P concentrations peaked in the first runoff events and decreased with time. During rice growing season, runoff P concentrations positively correlated（P〈0.0001） with P concentrations in field ponding water that was intentionally enclosed by construction of field bund. The relative high P loss during wheat growing season at Xinzhuang was due to high soil P status. In conclusion, P should be applied at rates balancing crop removal（20–30 kg P ha^–1 in this study） and at time

关键词： double cropping system intensive agriculture Lake Taihu region phosphorus loss surface runoff water quality

Homoclinic Solutions for a Class of Perturbed Fractional Hamiltonian Systems with Subquadratic Conditions

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1177-1196页

作者： Ying luo Fei GUO yan LIU School of Mathematics Tianjin UniversityTianjin 300354P.R.China Tianjin Key Laboratory of Brain-Inspired Intelligence Technology Tianjin300354P.R.China

In this paper,we consider the following perturbed fractional Hamiltonian systems{tD_(∞)^(α)(_(-∞)D_(t)^(α)u(t))+L(t)u(t)=■_(u)W(t,u(t))+■(u)G(t,u(t)),t∈R,u∈H^(α)(R,R^(N)),whereα∈(1/2,1],L∈C(R,R^(N×N))is symmetric and not necessarily required to be positive definite,W∈C1(R×R^(N,R))is locally subquadratic and locally even near the origin,and perturbed term G∈C1(R×R^(N,R))maybe has no parity in *** the perturbed method improved by the authors,a sequence of nontrivial homo clinic solutions is obtained,which generalizes previous results.

关键词： Perturbed fractional Hamiltonian systems subquadratic condition perturbed method homoclinic solutions multiplicity

Icariin ameliorates viral myocarditis by inhibiting TLR4-mediated ferroptosis

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 106-114,I0002-I0005页

作者： Wei luo Yi Lu Jun-Hua Deng Peng Liu yan Huang Wan-Xi Liu chun-Li Huang Laboratory of the Atherosclerosis and Ischemic Cardiovascular Diseases Department of CardiologyAffiliated Hospital of Youjiang Medical University for NationalitiesYoujiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Critical Care Medicine Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Respiratory and Critical Care Medicine Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Postgraduate School of Youjiang Medical University for Nationalities BaiseGuangxi 533000China Department of Neonatology Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Nephrology People’s Hospital of PubeiQinzhouGuangxi 535300China Urban Community Health Service Center of Youjiang District BaiseGuangxi 533000China

Objective:To explore the mechanism by which icariin alleviates viral ***:CVB3-induced cardiomyocytes were used as an in vitro model of viral myocarditis to assess the effects of icariin treatment on cell viability,inflammation,and ***,the effects of icariin on ferroptosis and TLR4 signaling were *** AC16 cells were transfected with TLR4 overexpression plasmids,the role of TLR4 in mediating the regulatory effect of icariin in viral myocarditis was ***:Icariin significantly elevated cell viability and reduced inflammatory factors TNF-α,IL-1β,IL-6,and *** cytometry revealed that icariin decreased apoptosis rate,and the protein expression of Bax and cleaved caspase 3 and 9 in CVB3-induced ***,it suppressed ferroptosis including lipid peroxidation and ferrous ion,as well as the TLR4 ***,TLR4 overexpression abrogated the modulatory effects of ***:Icariin mitigates CVB3-induced myocardial injury by inhibiting TLR4-mediated *** animal study is needed to verify its efficacy.

关键词： Viral myocarditis CVB3 TLR4 Ferroptosis Icariin