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Polysaccharide of Alocasia cucullata Exerts Antitumor Effect by Regulating Bcl-2, Caspase-3 and ERK1/2 Expressions during Long-Time Administration

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Chinese Journal of Integrative Medicine 2024年第1期30卷 52-61页

作者： ZHOU Qi-chun XIAO Shi-lin LIN Ru-kun LI Chan CHEN Zhi-jie CHEN Yi-fei luo chao-hua MO Zhi-xian LIN Ying-bo School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Clinical and Basic Research Team of TCM Prevention and Treatment of Non-Small Cell Lung Cancer the Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou(510120)China Department of Chinese Medicine Zhujiang Hospital Affiliated to Southern Medical UniversityGuangzhou(510282)China Department of Pharmacy Jiangmen Central HospitalJiangmen(529000)China

Objective: To study the in vitro and in vivo antitumor effects of the polysaccharide of Alocasia cucullata(PAC) and the underlying mechanism. Methods: B16F10 and 4T1 cells were cultured with PAC of 40 μg/m L, and PAC was withdrawn after 40 days of administration. The cell viability was detected by cell counting kit-8. The expression of Bcl-2 and Caspase-3 proteins were detected by Western blot and the expressions of ERK1/2 mRNA were detected by quantitative real-time polymerase chain reaction(qRT-PCR). A mouse melanoma model was established to study the effect of PAC during long-time administration. Mice were divided into 3 treatment groups: control group treated with normal saline, positive control group(LNT group) treated with lentinan at 100 mg/(kg·d), and PAC group treated with PAC at 120 mg/(kg·d). The pathological changes of tumor tissues were observed by hematoxylin-eosin staining. The cell apoptosis of tumor tissues was detected by TUNEL staining. Bcl-2 and Caspase-3 protein expressions were detected by immunohistochemistry, and the expressions of ERK1/2, JNK1 and p38 mRNA were detected by qRT-PCR. Results: In vitro, no strong inhibitory effects of PAC were found in various tumor cells after 48 or 72 h of administration. Interestingly however, after 40 days of cultivation under PAC, an inhibitory effect on B16F10 cells was found. Correspondingly, the long-time administration of PAC led to downregulation of Bcl-2 protein(P <0.05), up-regulation of Caspase-3 protein(P<0.05) and ERK1 mRNA(P<0.05) in B16F10 cells. The above results were verified by in vivo experiments. In addition, viability of B16F10 cells under long-time administration culture in vitro decreased after drug withdrawal, and similar results were also observed in 4T1 cells. Conclusions: Long-time administration of PAC can significantly inhibit viability and promote apoptosis of tumor cells, and had obvious antitumor effect in tumor-bearing mice.

关键词： polysaccharide of Alocasia cucullata tumor cells Bcl-2 Caspase-3 ERK1/2 Chinese medicine

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“雅颂之音”与“讽谕之鸣”:论礼乐复兴视域下的宋初文学

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新疆大学学报（哲学社会科学版） 2024年第1期52卷 131-138页

作者：罗超华山东大学文学院山东济南250100

宋初文坛纷繁复杂,不仅呈现出南北对峙、难以融合的紧张局面,还产生了时文与古文的创作分歧。而于此之外,士人群体内又共同含纳着一股颂美君王功业、宣扬帝国政治的风气。尽管从传统文艺审美的角度看,这种风气催生的文学作品多属程式化... 详细信息

宋初文坛纷繁复杂,不仅呈现出南北对峙、难以融合的紧张局面,还产生了时文与古文的创作分歧。而于此之外,士人群体内又共同含纳着一股颂美君王功业、宣扬帝国政治的风气。尽管从传统文艺审美的角度看,这种风气催生的文学作品多属程式化的礼仪书写,但若将之置于宋初礼乐复兴视域下进行更深层次解读,则于某些赋颂中可观觇士大夫政治主体意识的觉醒迹象,且雅颂主旋律中讽喻之声的鸣起,又宣示了宋初文人对唐人风雅观的进一步开拓。这些被程式化书写遮蔽的内容,实质是政治与文学的合奏交响,二者间表里经纬的错综关系及由此生成的强力互动,正体现出此间特殊的文学生态。

关键词：礼乐宋代雅颂文学风气儒道

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Laser Powder Bed Fusion of Beta-Type Titanium Alloys for Biomedical Application:A Review

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 17-28页

作者： Xuan luo chao Yang Dongdong Li Lai-Chang Zhang State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China National Engineering Research Center of Near-Net-Shape Forming for Metallic Materials Guangdong Provincial Key Laboratory for Processing and Forming of Advanced Metallic MaterialsSouth China University of TechnologyGuangzhou510640China Centre for Advanced Materials and Manufacturing School of EngineeringEdith Cowan University270 Joondalup DriveJoondalupPerthWA6027Australia

Additive manufacturing ofβ-type titanium alloy is expected to replace Ti-6Al-4V alloy in the field of orthopedic implantation because of their low elastic modulus,excellent corrosion resistance,and *** briefly introducing the laser powder bed fusion(LPBF)process and physical phenomena,this paper reviews the recent progresses in LPBF-edβ-type Ti *** strategies to strengthening and tougheningβ-type Ti alloys are critically *** is followed by the processing routes employed to achieve to low modulus for orthopedic applications,especially a new methodology for tailoring crystallographic orientation called multi-track coupled directional *** effect of processing and compositions on performance metrics ofβ-type Ti alloys included corrosion behavior,and biocompatibility is *** the end,challenges in additive manufacturing ofβ-type Ti alloys in future are highlighted,with the aim to ensue clinical application of LPBF-edβ-type Ti alloys.

关键词： β-type Ti alloys Laser powder bed fusion Mechanical properties Elastic modulus Biocompatibility

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Side Information-Based Stealthy False Data Injection Attacks Against Multi-Sensor Remote Estimation

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1054-1056页

作者： Haibin Guo Zhong-hua Pang chao Li the Key Laboratory of Fieldbus Technology and Automation of Beijing North China University of TechnologyBeijing 100144China

Dear Editor,This letter investigates a novel stealthy false data injection(FDI)attack scheme based on side information to deteriorate the multi-sensor estimation performance of cyber-physical systems(CPSs).Compared with most existing works depending on the full system knowledge,this attack scheme is only related to attackers'sensor and physical process *** design principle of the attack signal is derived to diverge the system estimation ***,it is proven that the proposed attack scheme can successfully bypass the residual-based ***,all theoretical results are verified by numerical simulation.

关键词： estimation scheme system

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Preparation of PVA/GO/h-BN Janus Film with High Thermal Conductivity and Excellent Flexibility via a Density Deposition Self-assembly Method

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CHINESE JOURNAL OF POLYMER SCIENCE 2024年第8期42卷 1217-1226页

作者： luo, Fang-hua Dong, Zhi-Tao Chen, Guo-hua Ma, Chen Wang, huai-Yuan Northeast Petr Univ Coll Chem & Chem Engn Daqing 163318 Peoples R China huaqiao Univ Coll Mat Sci & Engn Xiamen 361000 Peoples R China Tianjin Univ Sch Chem Engn & Technol Tianjin 300350 Peoples R China Tianjin Univ State Key Lab Chem Engn Tianjin 300350 Peoples R China

Janus films with asymmetric physical/chemical properties have attracted considerable attention due to their promising applications in personal thermal management, electronic skins, sensors, actuators, etc. However, traditional methods for fabricating Janus films conventionally need the assistance of an interface or auxiliary equipment, which are usually complex and time-consuming. Herein, flexible poly(vinyl alcohol) (PVA)/graphene oxide (GO)/h-BN (recorded as PVA/GO/h-BN) Janus films with thermally, optically, and electrically anisotropic properties are fabricated by a simple density deposition self-assembly method, which just utilizes the density difference between GO and h-BN during water evaporation. Experimental results show that the two sides of the acquired Janus films have obvious asymmetric characteristics. In the original state of the PVA/GO/h-BN Janus films, the thermal conductivity of the GO side (10.06 Wm(-1)K-1) is generally lower than that of the h-BN side (10.48 Wm(-1)K-1). But after GO is reduced, the thermal conductivity of the rGO side reaches 12.17 Wm(-1)K-1, surpassing that of the h-BN side. In addition, the relative reflectance of the h-BN side of Janus film is also significantly higher than that of the rGO side, and the surface resistance difference between the two sides is about 4 orders of magnitude. The prepared PVA/GO/h-BN Janus films show great application potential in human thermal management, light conversion switches, and electronic skins. This study provides a simple and versatile strategy for fabricating Janus films with multifunctional (such as thermal, optical, and electrical) anisotropies.

关键词： Janus films PVA/GO/h-BN Density deposition self-assembly method BORON-NITRIDE GRAPHENE COMPOSITE HYBRID SOFT NETWORKS DESIGN

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Genomics,transcriptomics,and peptidomics of the greater wax moth Galleria mellonella neuropeptides and their expression in response to lead stress

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Insect Science 2024年第3期31卷 773-791页

作者： Li-Lin luo Yang Lin Jun-Hong Linghu Wei Gong Yuan-Hong luo Man Liu Dao-chao Jin Guy Smagghe Tong-Xian Liu Shun-hua Gui Tian-Ci Yi Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangGuizhouChina Guizhou Institute of Biology Guizhou Academy of SciencesGuiyangChina Institute of Plant Health and Medicine Guizhou UniversityGuiyangChina

Neuropeptides are crucial in regulation of a rich variety of developmental,physiological,and behavioral functions throughout the life cycle of *** an integrated approach of multiomics,we identified neuropeptide precursors in the greater wax moth Galleria mellonella,which is a harmful pest of honeybee hives with a worldwide ***,a total of 63 and 67 neuropeptide precursors were predicted and annotated in the *** genome and transcriptome,in which 40 neuropeptide precursors were confirmed in the *** ***,we identified 12 neuropeptide precursor genes present in *** but absent in honeybees,which may be potential novel pesticide target *** hives were contaminated with heavy metals such as lead,enabling its bioaccumulation in *** bodies through the food chain,we performed transcriptome sequencing to analyze the effects of Pb stress on the mRNA expression level of *** neuropeptide *** treatment by Pb,the expression of neuropeptide F1 was found to be significantly downregulated,implying that this neuropeptide might be associated with responding to the heavy metal stress in *** study comprehensively identified neuropeptide precursors in ***,and discussed the effects of heavy metals on insect neuropeptides,with the example of *** results are valuable for future elucidation of how neuropeptides regulate physiological functions in *** and contribute to our understanding of the insect's environmental plasticity and identify potential new biomarkers to assess heavy metal toxicity in insects.

关键词： Galleria mellonella genomics heavy metal stress neuropeptide peptidomics transcriptomics

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An advanced 2D/3D g-C_(3)N_(4)/TiO_(2)@MnO_(2) multifunctional membrane for sunlight-driven sustainable water purification

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Nano Research 2024年第4期17卷 2368-2380页

作者： Fan Yu Chunjia luo Xiaohan Niu Min chao Pengfei Zhang Luke Yan Polymer Materials&Engineering Department School of Materials Science&EngineeringChang’an UniversityXi’an 710064China Key Laboratory of Road Construction Technology and Equipment MOEChang’an UniversityXi’an 710064China School of Textile Science and Engineering Xi’an Polytechnic UniversityXi’an 710064China

Graphitic carbon nitride(g-C_(3)N_(4))nanosheets have attracted widespread interest in the construction of advanced separation ***,dense stacking and a single functionality have limited the membrane ***,an advanced two-/three-dimensional(2D/3D)g-C_(3)N_(4)/TiO_(2)@MnO_(2) membrane is constructed by intercalating 3D TiO_(2)@MnO_(2) nanostructures into g-C_(3)N_(4) *** 3D flower-like nanostructures broaden the transport channels of the composite *** membrane can effectively separate five oil-in-water(O/W)emulsions,with a maximum flux of 3265.67±15.01 L·m^(-2)·h^(-1)·bar^(-1) and a maximum efficiency of 99.69%±0.45%for toluene-in-water emulsion(T/W).Meanwhile,the TiO_(2)@MnO_(2) acts as an excellent electron acceptor and provides positive spatial separation of electrons–holes(e^(-)–h^(+)).The formation of 2D/3D heterojunctions allows the material with wider light absorption and smaller bandgap(2.10 eV).These photoelectric properties give the membrane good degradation of three different pollutants,with about 100%degradation for methylene blue(MB)and malachite green(MG).The photocatalytic antibacterial efficiency of the membrane is also about 100%.After cyclic experiment,the membrane maintains its original separation and photocatalytic *** remarkable multifunctional and self-cleaning properties of the g-C_(3)N_(4) based membrane represent its potential value for complex wastewater treatment.

关键词： graphitic carbon nitride(g-C_(3)N_(4))based membrane three-dimensional(3D)nanostructures self-cleaning multifunction

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Injection of a Self-propelled Polymer into a Small Circular Cavity

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Chinese Journal of Polymer Science 2024年第6期42卷 886-894页

作者： chao Wang Yan-Li Zhou Xiao Yang Fan Wu Meng-Bo luo Department of Physics Taizhou UniversityTaizhou318000China Department of Physics Zhejiang UniversityHangzhou310027China

The injection of a polymer chain into a small circular cavity under tangential self-propelled force is studied by using Langevin dynamics *** indicate that the injection dynamics of the active polymer shows strong correlation with the polymer conformation inside the cavity depending on the polymer rigidity(k_(b)).The injection timeτvaries nonmonotonously with increasing k_(b),and reaches its minimum at k_(b)^(*).When k_(b) is small(k_(b)≪k_(b)^(*)),the polymer is nearly random coil in the cavity,and spends a long time at the final stage of the injection process due to the large repulsion between monomers inside the *** k_(b) is moderate(k_(b)∼k_(b)^(*)),the part of polymer inside the cavity forms spiral configuration under the tangential active force,and the whole polymer moves synchronously with a constant velocity during the injection process,leading to a small injection *** k_(b) is large(k_(b)≫k_(b)^(*)),the polymer is nearly straight at the initial stage of the injection process,and takes a long time to bend itself,leading to a large injection time.

关键词： Active Polymer Injection Dynamics Simulation

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Microstructure and property of laser additive manufactured alloy Ti-6Al-2V-1.5Mo-0.5Zr-0.3Si after aged at different temperatures

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Rare Metals 2024年第5期43卷 2275-2281页

作者： Guo-chao Li Xu Cheng hua-Ming Wang National Engineering Laboratory of Additive Manufacturing for Large Metallic Components and Engineering Research Center of Ministry of Education on Laser Direct Manufacturing for Large Metallic Components School of Materials Science and EngineeringBeihang UniversityBeijing 100191China

The solid solution and aging treatment for conventional manufacturing processes might not be suitable for laser additive manufactured titanium alloys due to the different lamellar *** this study,the influence of aging temperatures(600,700 and 800°C)on microstructure and mechanical properties of titanium alloy Ti-6Al-2V-1.5Mo-0.5Zr-0.3Si was *** results indicate that after solid solution treatment at 970°C followed by water quenching,the alloy mainly consists of coarsening lamellar a phase in martensite α' *** at 600°C will not change the size of primary lamellar α phase but lead to huge amount of secondary a phases(α_(s))generating with very fine *** increasing the aging temperature,the number of α_(s) decreases but with coarsened *** aged at 800°C,the width of the asphase reaches 350 nm,almost 7 times wider than that aged at 600°*** changing size of α_(s) obviously influences the property of the *** fine α_(s) leads to high strength and microhardness but low plasticity,and specimen aged at 700°C with suitable assize has the best comprehensive properties.

关键词： α+βtitanium alloy Laser additive manufacturing Solid solution and aging treatment Microstructure Room temperature tensile property

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Microphysical Insights into a Tornadic Supercell from Dual-Polarization Radar Observations in Jiangsu, China on 14 May 2021

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Journal of Meteorological Research 2024年第2期38卷 303-320页

作者： chao YUAN Yang BAI Pengfei SUN hua BAI Lu XIA China Meteorological Administration Tornado Key Laboratory Foshan 528315 Institute of Atmospheric Environment China Meteorological AdministrationShenyang 110166 Panjin National Climate Observatory Panjin 124010 Yangzhou Meteorological Bureau of Jiangsu Province Yangzhou 225100 Yichun Meteorological Bureau of Heilongjiang Province Yichun 153000

Tornadoes are incredibly powerful and destructive natural events,yet the microphysical characteristics of the parent storm and its effects on tornadogenesis remain *** study analyzed polarization radar data of a tornadic supercell that occurred in Jiangsu Province of China on 14 May 2021,in comparison with another tornadic supercell and two non-tornadic supercells that occurred in the same region in *** two tornadic supercells exhibited lower differential reflectivity(ZDR)in the hook echo region compared with the non-tornadic supercells,indicating smaller median drop sizes.A distinct increase in ZDR from the melting of frozen hydrometeors,observed between2.5-and 4.0-km altitude in the non-tornadic storms,was absent in the tornadic *** non-tornadic supercells also displayed substantially higher specific differential phase(KDP)below the melting level,likely aroused from enhanced melting and *** findings suggest fundamental microphysical contrasts between tornadic and nontornadic ***,tornadic supercells have smaller droplets and may reduce melting in hook ***,greater separation between the ZDR arc and the KDP foot was observed during *** vertical gradient of KDP related to the cooling pool strength of the hook echo,regulating rear-flank downdraft *** the limited number of cases investigated,the findings of this study indicate that monitoring ZDR,KDP,and drop size distribution trends could assist with tornado prediction and warnings.

关键词： tornado polarimetric radar supercell hook echo drop size distribution

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