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近10年深圳市短时强降水及风险统计分析

广东气象 2024年第3期46卷 22-25页

作者：胡媛媛张丽罗红艳李磊杨红龙深圳市国家气候观象台广东深圳518040 中山大学大气科学学院广东珠海519082

利用深圳市近10年全市自动气象站逐时降水量资料,分析深圳市短时强降水气候特征、风险指数、影响系统,结果表明:(1)深圳市短时强降水日数呈现逐年增长的趋势,2009年至今一直处于高位波动中。短时强降水日数月变化呈现倒U型分布,6—8月... 详细信息

利用深圳市近10年全市自动气象站逐时降水量资料,分析深圳市短时强降水气候特征、风险指数、影响系统,结果表明:(1)深圳市短时强降水日数呈现逐年增长的趋势,2009年至今一直处于高位波动中。短时强降水日数月变化呈现倒U型分布,6—8月是防范短时强降水风险的关键时期,中午至傍晚是短时强降水的易发时段。(2)建立了短时强降水风险指数,结果表明该指数可以指示各区的高风险地区。(3)深圳市短时强降水的天气系统分为5种类型:热带气旋和热带扰动外围环流影响、切变线和冷空气影响、季风低压、西南风急流辐合、副高边缘东风波动。

关键词：气候学短时强降水风险指数天气分型深圳市

新医科生物化学“核苷酸代谢”微课案例教学研究

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教育教学论坛 2024年第32期 128-131页

作者：车志群罗艳红邓钎钎孙仁杰右江民族医学院生物医药与大健康现代产业学院广西百色533000 右江民族医学院医学检验学院广西百色533000

思政教育必须贯穿理论课教学全过程,促使学生养成良好的学习习惯和积极的学习态度,培养学生实事求是的科学态度和团结合作精神,培养学生最基础的创新意识与创新能力,提高其心理素质,使学生以积极严谨的态度解决学习过程中遇到的问题,促... 详细信息

思政教育必须贯穿理论课教学全过程,促使学生养成良好的学习习惯和积极的学习态度,培养学生实事求是的科学态度和团结合作精神,培养学生最基础的创新意识与创新能力,提高其心理素质,使学生以积极严谨的态度解决学习过程中遇到的问题,促使学生养成探索的习惯,以保证学生全面发展,提升自身的思想道德水平,成为高素质人才。以生物化学“核苷酸代谢”教学内容为例,从课程思政融入教学的整体设计思路、教学内容思政教学点、教学效果和教师感悟等方面进行了简要介绍,取得了一定的教学效果,希望为其他学科的课程思政融入提供一定的帮助和指导作用。

关键词：核苷酸代谢课程思政案例教学

Lyophilized lymph nodes:A paradigm shift in CAR T-cell delivery for solid tumor therapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3774-3776页

作者： Qiuhua luo Xiaojing yan hong-Xu Liu Heran Li Department of Pharmacy the First Hospital of China Medical UniversityShenyang 110001China School of Pharmacy China Medical UniversityShenyang 110122China Department of Hematology the First Hospital of China Medical UniversityShenyang 110001China Liaoning Cancer Hospital&Institute Cancer Hospital of Dalian University of TechnologyShenyang 110042China

CAR T(chimeric antigen receptor T-cell)therapy represents a paradigm shift in cancer *** empowering immune cells to target malignant cells directly,it opens another door to precision medicine,promising cures for once refractory ***,the extension of CAR T therapy to solid tumors confronts formidable *** physical and biochemical barriers within the tumor microenvironment,such as dense extracellular matrices and immunosuppressive factors,impede CAR T cell infiltration and function,leading to diminished success rates in solid tumor treatment2.

关键词： CAR therapy tumor

Quasi-in-situ Observation and SKPFM Studies on Phosphate Protective Film and Surface Micro-Galvanic Corrosion in Biological Mg-3Zn-xNd Alloys

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 648-664页

作者： Zhaochen Yu Kaixuan Feng Shuyun Deng yang Chen hong yan honggun Song Chao luo Zhi Hu School of Advanced Manufacturing Nanchang UniversityNanchang330031China Institute for Advanced Study Nanchang UniversityNanchang330031China

The phosphate protective film and micro-galvanic corrosion of biological Mg-3Zn-xNd (x = 0, 0.6, 1.2) alloys were investigated by scanning and transmission electron microscopy, quasi-in-situ observation, scanning Kelvin probe force microscopy (SKPFM) and electrochemical tests. The results revealed the Mg-Zn-Nd phases formed in Mg-3Zn alloy contained with Nd. Adding Nd resulted in a significant decline in the cracks of the phosphate protective film and micro-galvanic corrosion of alloys, which were recorded by quasi-in-situ observation. In addition, the Volta potential difference of Mg-Zn-Nd/α-Mg (~ 188 mV) was lower than MgZn/α-Mg (~ 419 mV) and Zn-rich/α-Mg (~ 260 mV), and the corrosion rates of alloys markedly decreased after the addition of 0.6 wt% Nd. The improvement in corrosion resistance of Nd-containing alloys was mainly attributed to the following: (i) the addition of Nd reduced the Volta potential difference (second phases/α-Mg);(ii) the phosphate protective film containing Nd_(2)O_(3) deposited on the surface of the alloys, effectively preventing the penetration of harmful anions.

关键词： Magnesium alloys Quasi-in-situ observation Phosphate protective film Scanning Kelvin probe force microscopy(SKPFM) Micro-galvanic corrosion

Homoclinic Solutions for a Class of Perturbed Fractional Hamiltonian Systems with Subquadratic Conditions

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1177-1196页

作者： Ying luo Fei GUO yan LIU School of Mathematics Tianjin UniversityTianjin 300354P.R.China Tianjin Key Laboratory of Brain-Inspired Intelligence Technology Tianjin300354P.R.China

In this paper,we consider the following perturbed fractional Hamiltonian systems{tD_(∞)^(α)(_(-∞)D_(t)^(α)u(t))+L(t)u(t)=■_(u)W(t,u(t))+■(u)G(t,u(t)),t∈R,u∈H^(α)(R,R^(N)),whereα∈(1/2,1],L∈C(R,R^(N×N))is symmetric and not necessarily required to be positive definite,W∈C1(R×R^(N,R))is locally subquadratic and locally even near the origin,and perturbed term G∈C1(R×R^(N,R))maybe has no parity in *** the perturbed method improved by the authors,a sequence of nontrivial homo clinic solutions is obtained,which generalizes previous results.

关键词： Perturbed fractional Hamiltonian systems subquadratic condition perturbed method homoclinic solutions multiplicity

Characterization of semi-coke generated by coal-based direct reduction process of siderite

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Journal of Central South University 2015年第8期22卷 2914-2921页

作者：朱德庆罗艳红潘建周仙霖 School of Mineral Processing and Bioengineering Central South University

Solid wastes derived from metallurgical industries pose a significant threat to environment. The utilization and disposal of these solid wastes are the major concern in the world. Semi-coke generated in coal-based direct reduction process of iron ore is a by-product and its suitable utilization is not available so far. In order to handle it properly, the characteristics of this by-product were comprehensively investigated. A series of analysis methods were used to demonstrate its mineral compositions, petrography and physico-chemical properties. The results reveal that the semi-coke has poor washability. The fixed carbon content of semi-coke reaches 76.11% and the gross calorific value is 28.10 MJ/kg, both of which are similar to those of traditional sinter coke breeze. Also, semi-coke ash possesses lower content of SiO2, Al2O3, S and higher content of CaO and MgO, which could improve the strength of sinter ore when partially substituting for coke breeze in sintering. Semi-coke features well-development porous structure and higher reaction activity, which predicts that the sintering speed could be elevated to some extent when employing it as a partial replacement of coke breeze, so the studies further suggest that the potential adverse effect of the high reactivity on sintering process could be weakened by adequately coarsening the semi-coke's particle size.

关键词： semi-coke coal-based direct reduction non-magnetic product sinter fuel

Quick Weighing of Passing Vehicles Using the Transfer-Learning-Enhanced Convolutional Neural Network

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2507-2524页

作者： Wangchen yan Jinbao yang Xin luo College of Civil Engineering Xiangtan UniversityXiangtan411105China Energy&Environmental Engineering Department China CEC Engineering CorporationChangsha410114China

Transfer learning could reduce the time and resources required by the training of new models and be therefore important for generalized applications of the trainedmachine learning *** this study,a transfer learningenhanced convolutional neural network(CNN)was proposed to identify the gross weight and the axle weight of moving vehicles on the *** proposed transfer learning-enhanced CNN model was expected to weigh different bridges based on a small amount of training datasets and provide high identification *** of all,a CNN algorithm for bridge weigh-in-motion(B-WIM)technology was proposed to identify the axle weight and the gross weight of the typical two-axle,three-axle,and five-axle vehicles as they crossed the bridge with different loading routes and ***,the pre-trained CNN model was transferred by fine-tuning to weigh themoving vehicle on another ***,the identification accuracy and the amount of training data required were compared between the two CNN *** showed that the pre-trained CNN model using transfer learning for B-WIM technology could be successfully used for the identification of the axle weight and the gross weight for moving vehicles on another bridge while reducing the training data by 63%.Moreover,the recognition accuracy of the pre-trained CNN model using transfer learning was comparable to that of the original model,showing its promising potentials in the actual applications.

关键词： Bridge weigh-in-motion transfer learning convolutional neural network

In-situ AFM and quasi-in-situ studies for localized corrosion in Mg-9Al-1Fe-(Gd) alloys under 3.5 wt.% NaCl environment

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Journal of Magnesium and Alloys 2024年第3期12卷 1170-1185页

作者： Junping Shen Tao Lai Zheng Yin yang Chen Kun Wang hong yan honggun Song Ruiliang Liu Chao luo Zhi Hu School of Advanced Manufacturing Nanchang UniversityNanchang 330031China Institute for Advanced Study Nanchang UniversityNanchang 330031China Singapore Centre for Environmental Life Sciences Engineering Nanyang Technological University60 Nanyang Drive 637751Singapore

Revealing the localized corrosion process of Mg alloy is considered as one of the most significant ways for improving its corrosion *** reliable monitor should be high distinguishability and real-time in liquid ***,Mg-9Al-1Fe and Mg-9Al-1Fe-1Gd alloys were designed to highlight the impact of intermetallic on the corrosion ***-situ AFM with a special electrolyte circulation system and quasi-in-situ SEM observation were used to monitor the corrosion process of the designed ***-EDS and TEM-SAED were applied to identify the intermetallic in the designed alloys,and their volta potentials were measured by *** to the real-time and real-space in-situ AFM monitor,the corrosion process consisted of dissolution of anodicα-Mg phase,accumulation of corrosion products around cathodic phase and shedding of some fine cathodic ***,the localized corrosion process of Mg alloy was revealed combined with the results of the monitor of corrosion process and Volta potential difference.

关键词： Magnesium Localized corrosion In-situ AFM SKPFM Corrosion behaviour.

Lindqvist-type Polyoxometalates Act as Anti-breast Cancer Drugs via Mitophagy-induced Apoptosis

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Current Medical Science 2024年第4期44卷 809-819页

作者： Chen-guang YAO Zi-jia ZHAO Ting TAN Jiang-ning yan Zhong-wei CHEN Jun-tao XIONG Han-luo LI yan-hong WEI Kang-hong HU Sino-German Biomedical Center Hubei Provincial Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)Key Laboratory of Fermentation Engineering(Ministry of Education)National“111”Center for Cellular Regulation and Molecular PharmaceuticsHubei University of TechnologyWuhan430068China Center for Evaluation of Hubei Medical Products Administration Wuhan430068China

Objective Lindqvist-type polyoxometalates(POMs)exhibit potential antitumor *** study aimed to examine the effects of Lindqvist-type POMs against breast cancer and the underlying *** Using different cancer cell lines,the present study evaluated the antitumor activities of POM analogues that were modified at the body skeleton based on molybdenum-vanadium-centered negative oxygen ion polycondensations with different side *** colony formation assay,autophagy detection,mitochondrial observation,qRT-PCR,Western blotting,and animal model were used to evaluate the antitumor activities of POMs against breast cancer cells and the related *** MO-4,a Lindqvist-type POM linking a proline at its side strain,was selected for subsequent experiments due to its low half maximal inhibitory concentration in the inhibition of proliferation of breast cancer *** was found that MO-4 induced the apoptosis of multiple types of breast cancer ***,MO-4 activated intracellular mitophagy by elevating mitochondrial reactive oxygen species(ROS)levels and resulting in *** vivo,breast tumor growth and distant metastasis were significantly reduced following MO-4 *** Collectively,the results of the present study demonstrated that the novel Lindqvist-type POM MO-4 may exhibit potential in the treatment of breast cancer.

关键词： antitumor breast cancer polyoxometalate mitochondria mitophagy