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Production of medical radioisotope ^(64)Cu by photoneutron reaction using ELI-NP γ-ray beam

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Nuclear Science and Techniques 2016年第4期27卷 147-151页

作者： wen luo School of Nuclear Science and Technology University of South China Extreme Light Infrastructure - Nuclear Physics (ELI-NP)/‘‘Horia Hulubei’’ National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH)

Copper-64 is a radioisotope of medical interest that could be used for positron emission tomography imaging and targeted radiotherapy of cancer. In this work,we investigated the possibility of producing the^(64)Cu isotope through a^(65)Cu(γ,n) reaction using high-intensity γ-beams produced at the Extreme Light InfrastructureNuclear Physics facility(ELI-NP). The specific activity for^(64)Cu was obtained as a function of target geometry, irradiation time, and electron beam energy, which translates into γ-beam energy. Optimized conditions for the generation of^(64)Cu isotopes at the ELI-NP were discussed. We estimated that an achievable saturation specific activity is of the order of 1–2 m Ci/g for thin targets(radius 1–2 mm,thickness 1 cm) and for a γ-beam flux of 10^(11) s ~1. Based on these results, the ELI-NP could provide great potential for the production of some innovative radioisotopes of medical interest in sufficient quantities suitable for nuclear medicine research.

关键词：放射性同位素设施生产中子反应射线束正电子发射断层成像医用靶向治疗基础设施

Photothermal probiotics delivery of photodynamic agents for enhanced immunogenic cell death within hypoxia center of solid tumors

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Nano Research 2025年第1期18卷 642-652页

作者： wen luo Shiyu Du Yateng Jiang Bangshun He Jun Tang Jingjing Yang Yujun Song Jiangsu Key Laboratory of Artificial Functional Materials State Key Laboratory of Analytical Chemistry for Life ScienceNational Laboratory of Solid State MicrostructuresCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210023China Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Department of Anesthesiology Jinling HospitalMedical School of Nanjing UniversityNanjing 210000China Department of Biochemistry and Molecular Biology School of Medicine&Holistic Integrative MedicineJiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Resulting from harsh hypoxic environmental conditions,central cells in the core of solid tumors are usually more aggressive and malignant with a less stable ***,therapeutic agents with improved penetration for the activation of immunity in tumor centers exhibit promising potential in ***,polydopamine-coated Escherichia coli Nissle 1917(EcN)bearing chlorin e6(Ce6)-loaded and polyethyleneimine(PEI)-coated hollow manganese dioxide(shorted as EP-ChP)are applied for enhanced immunotherapy in deep *** accumulation in tumor center through hypoxia targeting,manganese dioxide is degradated under the tumor microenvironment with released Ce6 and thus generates reactive oxygen species(ROS)upon 660 nm laser irradiation,which can further lower thermalresistance of cancer cells via HSP90α*** to that,heating induced by polydopamine upon 808 nm laser irradiation can achieve effective tumor *** upon dual laser induces enhanced immunogenic cell death,while bacterial infections in tumor tissues also trigger innate *** bacteria-based approach provides enhanced antitumor immune responses in deep tumors with great potential in the reshaping of immunosuppression tumor microenvironment.

关键词： bacteria phototherapies immunotherapy hypoxia targeting tumor penetration

Medium-Mn steels for hot forming application in the automotive industry

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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 741-753页

作者： Shuo-shuo Li Hai-wen luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

Advanced high-strength steels have been widely used to improve the crashworthiness and lightweight of *** from the popular cold stamping,hot forming of boron-alloyed manganese steels,such as 22MnB5,could produce ultra-high-strength steel parts without springback and with accurate control of ***,hot-formed medium-Mn steels could have many advantages,including better mechanical properties and lower production cost,over hot-formed *** paper reviews the hot forming process in the automotive industry,hot-formed steel grades,and medium-Mn steel grades and their application in hot forming in *** particular,the adaptabilities of medium-Mn steels and the presently popular 22MnB5 into hot forming were compared *** research should focus on the technological issues encountered in hot forming of medium-Mn steels to promote their commercialization.

关键词： medium-Mn transformation-induced plasticity steel hot forming mechanical properties retained austenite baking

A thermodynamic model on predicting density of medium-Mn steels with experimental verification

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Journal of Iron and Steel Research International 2017年第11期24卷 1078-1084页

作者： Guo-hui Shen Peng-yu wen Hal-wen luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

A new model on predicting the density of hot-rolled multi-phased medium-Mn steel has been presen ted on the basis of thermodynamic calculations. This is an integrated model, which includes one for calculating the retained austenite （RA） fraction and the other for volume expansion during the aus tenite-to martensite transformation, because both of them are key parameters for calculating the den- sity of steel at ambient temperature. The existing empirical equations for calculating Mx temperature and lattice constants of both martensite and austenite have been all rcassessed by the XRD measure ments on the microstructures of seven hot-rolled medium-Mn steels. Finally, the densities ot seven steels were calculated merely from compositions and compared with the measured ones. The differ ence between them is no more than 1 %, suggesting that the presented model should be of good value in designing the low density steels.

关键词： Density Medium Mn steel Retained austenite fraction Volume expansion Transformation

A novel cell search scheme for OFDM cellular systems

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第1期8卷 10-17页

作者： DING Ming luo Han-wen WU Yun Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200240 China

A novel cell search scheme for OFDM cellular systems is proposed. It is based on one OFDM symbol with several identical slots as preamble, the time domain repetition structure of which can be utilized to accomplish OFDM timing/frequency synchronization. The cell ID is comprised of two parts: a sub-carrier mask index g and a sequence index x. Each sub-carrier mask activates or deactivates some of the sub-carriers, after which a differentially coded sequence is loaded on pairs of the adjacent active sub-carriers. The user equipment (UE) recognizes the mask with index g via power detection of the received frequency domain signal. Then it estimates the index x from differential demodulation followed by detection of the frequency domain se-quence. In order to improve the performance, a method of jointly estimating g and x is devised. Simulation results showed that the proposed scheme is able to support a very large number of cell IDs while maintaining a good performance even in bad multi-cell environment.

关键词： Orthogonal frequency division multiplexing (OFDM) Cell search Cell ID Multi-cell Mask

A novel MMSE based codebook construction for MIMO precoded spatial multiplexing with limited feedback

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 1894-1900页

作者： SHE Feng luo Han-wen WANG Xin Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200240 China

This paper deals with the design and performance analysis of the transmission precoder optimization for multiple-input multiple-output (MIMO) systems with limited feedback of channel state information (CSI). We assume that the receiver can get perfect channel knowledge by channel estimation while the transmitter only has partial channel knowledge from limited feedback. We present a minimum mean square error (MMSE) criterion based codebook construction algorithm for MIMO pre- coded spatial multiplexing systems under a specific average power constraint. The optimal transmitter structure is employed in this paper. Simulation results show that the MMSE criteria based codebook construction algorithm with hybrid design of power allocation and precoding can achieve better performance than that of equal power allocation based codebook of previous research.

关键词： Multiple-input multiple-output (MIMO) Precoding Channel state information (CSI) Feedback

Progress on statistical models of evaluating inclusions in clean steels

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Journal of Iron and Steel Research International 2022年第8期29卷 1153-1163页

作者： Zheng Wang Yue-hui Guan Hai-wen luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Jiang Yin Xing Cheng Alloy Material Co. Ltd.Jiangyin 214432JiangsuChina

Non-metallic inclusions are critical for the fatigue failure of clean steels in service;especially,the large and hard inclusions are *** it is not possible to measure all the inclusions in the large-volume clean steels,statistical models have been developed to evaluate inclusions,aiming at predicting the maximum inclusion size in the large volume from the data of inclusions,which are derived from the limited observations on small-volume *** statistical models were reviewed together with their supporting *** particular,the block maxima and the threshold types of models were discussed through a thorough comparison as they are both widely used and based on the extreme value *** predicted results not only are used to distinguish the different cleanliness levels of steels,but also help to estimate fatigue ***,future research is proposed to focus on tackling the present difficulties encountered by statistical models,including the sufficient credibility of obtained results and the robustness of models for applications.

关键词： Clean steel Maximum inclusion prediction Statistical model Extreme value theory Fatigue failure

Numerical simulation of flow and heat transfer of n-decane in sub-millimeter spiral tube at supercritical pressure

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Chinese Journal of Chemical Engineering 2023年第8期60卷 173-185页

作者： Jiahao Xing Huaizhi Han Ruitian Yu wen luo School of Chemical Engineering Sichuan UniversityChengdu 610065China Engineering Research Center of Combustion and Cooling for Aerospace Power Ministry of EducationSichuan UniversityChengdu 610065China

The flow and heat transfer characteristics of n-decane in the sub-millimeter spiral tube(SMST) at supercritical pressure(p = 3 MPa) are studied by the RNG k-ε numerical model in this paper. The effects of various Reynolds numbers(Re) and structural parameters pitch(s) and spiral diameter(D) are *** indicate that the average Nusselt numberNu and friction factorNu increase with an increase in Re, and decrease with an increase in D/d(tube diameter). In terms of the structural parameter s/d, it is found that as s/d increases, the Nu first increase, and then decrease. and the critical structural parameter is s/d = 4. Compared with the straight tube, the SMST can improve Nu by 34.8% at best, while it can improve Nu by 102.1% at most. In addition, a comprehensive heat transfer coefficient is applied to analyze the thermodynamic properties of SMST. With the optimal structural parameters of D/d = 6 and s/d = 4, the comprehensive heat transfer factor of supercritical pressure hydrocarbon fuel in the SMST can reach 1.074. At last, correlations of the average Nusselt number and friction factor are developed to predict the flow and heat transfer of n-decane at supercritical pressure.

关键词： Sub-millimeter spiral tube Supercritical pressure Numerical simulation Heat transfer performance

Comparison of nonclassicality between photon-added and photon-subtracted squeezed vacuum states

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Chinese Physics B 2012年第2期21卷 301-308页

作者： Ma Shan-Jun luo wen-Wei College of Physics and Communication Electronics Jiangxi Normal UniversityNanchang 330022China

In this paper, we introduce photon-added and photon-subtracted squeezed vacuum state （PASV and PSSV） and obtain their normalized factors, which have the similar forms involved in Lengendre polynomials. Moreover, we give the compact expressions of Wigner function, which are related to single-variable Hermite polynomials. Especially, we compare their nonclassicality in terms of Mandel Q-factor and the negativity of Wigner function.

关键词： photon-added and photon-subtracted squeezed vacuum state nonclassicality Wigner function