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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin luo Hang Li Shan Guo Zhuang Tong Xiaotao Zhou Xu Li Zhaohui Hou Shuquan Liang Guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Solvation

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Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi Min Li Jiazhi Chen Zhuyong Wang Huantao Wen Ming Zhou Minjie luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

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Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life Sciences 2025年第1期68卷 103-115页

作者： Xizi luo Nan Zhang Yuntao Liu Beibei Du Xuan Wang Tianxu Zhao Bingqiang Liu Shishun Zhao Jiazhang Qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University Department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

关键词： SARS-CoV-2 cardiac microthrombosis immune hyperactivation cell competition

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巴丹吉林沙漠边缘沉积物粒度和微形态特征空间分异

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中国沙漠 2018年第5期38卷 945-953页

作者：刘铮瑶董治宝萨日娜杨军怀陈国祥刘永林罗万银杨转玲肖南陕西师范大学地理科学与旅游学院陕西西安710119 阿拉善沙漠世界地质公园管理局内蒙古阿拉善左旗750306 中山大学地理科学与规划学院广州广东510275 中国科学院西北生态环境资源研究所沙漠与沙漠化重点实验室甘肃兰州730000

为了探讨巴丹吉林沙漠风沙沉积物特征分异规律,采用野外实地采集和实验分析的方法,对沙漠边缘表层沉积物的粒度和微形态进行分析。结果表明:(1)巴丹吉林沙漠边缘地区整体以细沙为主,中沙与极细沙次之;从局部上看,东南部以中沙为主,北部... 详细信息

为了探讨巴丹吉林沙漠风沙沉积物特征分异规律,采用野外实地采集和实验分析的方法,对沙漠边缘表层沉积物的粒度和微形态进行分析。结果表明:(1)巴丹吉林沙漠边缘地区整体以细沙为主,中沙与极细沙次之;从局部上看,东南部以中沙为主,北部以粉沙黏土为主,西部地区以粗沙和极粗沙为主,与主导风向(西风和西北风)的分选作用一致。(2)北部和南部分别受河流和山脉影响,平均粒径较小,其余地区无明显差异。分选性在东南部最佳。粒度参数关系表明分选性在南部地区随着粒径变小而变好,偏度值随粒径变小而降低,峰度值随粒径变小而变宽,而在其他地区并没有明显的规律。(3)石英沙颗粒形态多为长形和圆形。整体磨圆度适中,其中西北部磨圆度最好,西南部和南部磨圆度最差。表面特征标志以干旱风成环境下的机械沉积作用的坑状为主,西北和东南部出现大量硅质球和硅质鳞片表明除机械沉积作用外,还具备化学沉积作用。

关键词：巴丹吉林沙漠沉积物粒度微形态空间分异

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Effect of Bi/Si Ratio of BiBSi Glass on Its Structure, Properties and Laser Sealing Shear Strength for Vacuum Glazing

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 13-24页

作者： LIU Wei JIAO Jinxu luo Dusha ZHOU Junjie SHI Lifen WANG Weiwei LI Changqing WANG Peng XIONG Dehua LI Hong State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China Silica-Based Materials Laboratory of Anhui Province CNBM Research Institute for Advanced Glass Materials Group Co.LtdBengbu 233018China State Key Laboratory of Advanced Technology for Float Glass CNBM Research Institute for Advanced Glass Materials Group Co.LtdBengbu 233018China

The low-melting glass of Bi2O_(3)-B2O_(3)-SiO_(2)(BiBSi)system was used for the first time for laser sealing of vacuum *** the condition of constant boron content,how the structure and properties vary with Bi/Si ratio in low-melting glass was *** addition,the relationships between laser power,low-melting glass solder with different Bi/Si ratios and laser sealing shear strength were *** results show that a decrease in the Bi/Si ratio can cause a contraction of the glass network of the low-melting glass,leading to an increase of its characteristic temperature and a decrease of its coefficient of thermal *** laser sealing,the copper ions in the low-melting glass play an endothermic role.A change in the Bi/Si ratio will affect the valence state transition of the copper ions in the low-melting *** absorbance of the low-melting glass does not follow the expected correlation with the Bi/Si ratio,but shows a linear correlation with the content of divalent copper *** greater the concentration of divalent copper ions,the greater the absorbance of the low-melting glass,and the lower the laser power required for laser *** shear strength of the low melting glass solder after laser sealing was tested,and it was found that the maximum shear strength of Z1 glass sample was the highest up to 2.67 MPa.

关键词： Bi2O_(3)-B2O_(3)-SiO_(2)(BiBSi) Bi/Si ratio low-melting glass laser sealing vacuum glazing

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Study on System of Faults in the Gulf of Mexico and Adjacent Region based on Gravity Data

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Acta Geologica Sinica(English Edition) 2021年第1期95卷 305-318页

作者： MA Jie WANG wanyin DU Xiangdong luo Xingang CAI Wenjie YANG Min WANG Dingding Institute of Gravity and Magnetic Technology School of Geological Engineering and GeomaticsKey Laboratory of Western China's Mineral Resources and Geological EngineeringMinistry of EducationChang'an UniversityXi'an 710054China CNOOC Research Institute Co. Ltd.Beijing 100028China Department of Earth Sciences Memorial University of NewfoundlandSt.John'sNL A1B3X5Canada

In the Gulf of Mexico and adjacent landmasses,faults are very complex,and their distribution is closely related to plate tectonics,ocean-land boundary,and former *** plane position of the faults can be identified by the maximum characteristic of the vertical derivative of the normalized vertical derivative of the total horizontal derivative(NVDR-THDR)of the Bouguer gravity *** apparent depth of the faults is inverted by the Bouguer gravity anomaly curvature *** on tectonic evolutionary processes and the plane distribution and apparent depth characteristics of the faults,a complete fault system for the Gulf of Mexico and adjacent areas has been established,including 102 *** apparent depths of 33 first-class faults are 16-20 km and for 69 second-class faults are 12-16 *** F_(1-2)and F_(1-3)subduction fault zones are two caused by the subduction of the Cocos Plate into the old Yucatan and Chorti landmasses;F_(1-11)and F_(1-12)fault zones extend westward to the coast of Guatemala and do not extend into the continent;F_(1-17)and F_(1-20)faults,which control the boundary of the oceanic crust,do not extend southward into the *** fault system,which radiates in a"fan-shaped"structure as a whole,unfolds to the *** of different nature and sizes are distributed in the Cocos Plate subduction zone,Continental,Gulf of Mexico,Yucatan old landmass and Caribbean Plate in NW,NNW,NS,NE and NEE *** the Gulf of Mexico region,the fault system is a comprehensive reflection of former tectonic movements,such as plate movement,drift of old landmasses and expansion of oceanic *** first-class faults control the plate and ocean-continental *** second-class faults are subordinate to the first-class faults or related to the distribution of different sedimentary layers.

关键词： structural geology tectonism gravity anomaly fault distribution and apparent depth Gulf of Mexico region

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Potassium ions and cyano group modified g-C3N4 for effective generation of H2O2 through two-electron oxygen reduction

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Science China Chemistry 2025年第1期68卷 192-200页

作者： Dongying Wang Shulan Pu Yongmin Chen Ke Lei Yujie Duan Linjiao Mao Xuhui Zeng Xi luo Yuntao Zhang Yuqin Dong Jin Zhong Zhang Yan Sun School of Mechanical Engineering Chengdu University Department of Chemistry and Biochemistry University of California

Potassium ions （K+） doped graphitic carbon nitride （g-C3N4） was prepared by a thermal etching method using potassium hydroxide （KOH） as an ion *** transform infrared spectroscopy （FTIR） and X-ray photoelectron spectroscopy （XPS）results showed that the generation of the cyano group was detected while introducing K+.Under simulated sunlight irradiation,the sample with a K+doping amount of 10%showed the highest hydrogen peroxide （H2O2） generation rate of2,140.2μmol *** apparent quantum yield （AQY） at 400 nm and the solar-to-chemical conversion （SCC） are 4.35%and1.23%,respectively.K+acted as a bridge between g-C3N4layers,which enhanced charge transfer ***,the cyano group enhanced the adsorption capacity of protons （H+） and promoted the yield of *** catalyst exhibited excellent photocatalytic stability based on four-cycle *** addition,a mechanism study showed that superoxide radicals （·O2-）were the most important active species in the reaction *** production of H2O2was achieved through consecutive single-electron *** study deepens the understanding of the oxygen reduction reaction process and opens up a new venue for improving H2O2generation.

关键词： photocatalysis hydrogen peroxide oxygen reduction reaction potassium doping cyano group

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祁连山国家公园草原补奖政策实施效益评估

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中国沙漠 2023年第6期43卷 40-50页

作者：刘民兰赵洪民邵梅张龄慧王彬丁乾平龚丞馗王小军高斌斌潘文旭罗万银甘肃省生态资源监测中心甘肃兰州730000 中国科学院西北生态环境资源研究院甘肃兰州730000

草原补奖政策的实施对促进草原生态恢复和牧区经济可持续发展有重要作用。以祁连山国家公园(张掖段)实地走访调查数据为基础,运用主成分分析、多元线性回归模型和多元有序Logistic回归模型分析草原补奖政策实施后影响农牧民收入的主要... 详细信息

草原补奖政策的实施对促进草原生态恢复和牧区经济可持续发展有重要作用。以祁连山国家公园(张掖段)实地走访调查数据为基础,运用主成分分析、多元线性回归模型和多元有序Logistic回归模型分析草原补奖政策实施后影响农牧民收入的主要因素及政策实施后凸显的其他问题。结果表明:农牧民的收入主要受草原补奖政策生态补贴收入、其他收入、畜牧业生产支出以及存栏数的影响;接近八成农牧民对草原补奖政策持满意态度;对草原生态的改善作用、是否支持草原补奖政策的实施、政府设定的核定载畜量是否合理显著影响政策实施的满意度;政策实施后研究区凸显的主要问题有保护区部分区域由于植被盖度增大,积累生物量提高导致草原防火压力增加;野生动物种群数量扩大,草场破坏度增大;产业转型后对农牧民的社会关注度不够,期望提高补助标准或保底资金。

关键词：祁连山国家公园草原补奖政策实施效益评估多元线性回归多元有序Logistic回归

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High-temperature self-powered X-ray detection in a bilayered hybrid ferroelectric halide perovskite

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Science China Chemistry 2025年

作者： Yingying Zheng Panpan Yu Yunpeng Yao Shihai You Zeng-Kui Zhu Junhua luo School of Chemistry and Chemical Engineering Jiangxi Normal University Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal University School of Environmental and Material Engineering Yantai University Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China

X-ray detectors which convert X-ray irradiation into electrical signals play an important role in diverse applications including medical diagnosis, security examination, nondestructive inspection, personal X-ray dosimeters and fundamental research[1–5]. Recently, metal halide perovskites（MHP） have been developed as a promising family for X-ray detection contributing to their intrinsic advantages, e.g.,simple synthesis, efficient X-ray absorption and excellent semiconducting properties[5–10].

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