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Mechanistic research:Selenium regulates virulence factors,reducing adhesion ability and inflammatory damage of Helicobacter pylori

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World Journal of Gastroenterology 2024年第1期30卷 91-107页

作者： Chun Qin Gan-Rong Huang Ai-Xing Guan Wen-Ting Zhou Hao Chen pei-pei luo Xian-Ke luo Yan-Qiang Huang Zan-Song Huang Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Digestive Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology Wujin People’s Hospital affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina Department of Gastroenterology Guangzhou Liwan District People's HospitalGuangzhou 510370Guangdong ProvinceChina

BACKGROUND The pathogenicity of Helicobacter pylori is dependent on factors including the environment and the *** selenium is closely related to pathogenicity as an environmental factor,the specific correlation between them remains *** To investigate how selenium acts on virulence factors and reduces their *** *** strains were induced by sodium *** expression of cytotoxin-associated protein A(CagA)and vacuolating cytotoxin gene A(VacA)was determined by quantitative PCR and Western *** was used to analyze CagA,CagM,CagE,Cag1,Cag3,and CagT.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction,and *** colonization,inflammatory reactions,and the cell adhesion ability of *** were *** CagA and VacA expression was upregulated at first and then downregulated in the *** strains after sodium selenite *** expression was significantly and steadily downregulated after the 5th cycle(10 d).Transcriptome analysis revealed that sodium selenite altered the levels affect *** virulence factors such as CagA,CagM,CagE,Cag1,Cag3,and *** these factors,CagM and CagE expression was continuously downregulated and further downregulated after 2 h of induction with sodium ***,CagT expression was upregulated before the 3rd cycle(6 d)and significantly downregulated after the 5th ***1 and Cag3 expression was upregulated and downregulated,respectively,but no significant change was observed by the 5th cycle.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite *** extent of *** colonization in the stomach increased;however,sodium selenite also induced a mild inflammatory reaction in the gastric mucosa of ***-infected mice,and the cell adhesion ability of *** was significantly *** These results demonstrate that *** displayed virulence attenuation after

关键词： Helicobacter pylori Sodium selenite Virulence factors Adherence Inflammation

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Chemical derivatization strategies for enhancing the HPLC analytical performance of natural active triterpenoids

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Journal of Pharmaceutical Analysis 2024年第3期14卷 295-307页

作者： Xiao-Feng Huang Ying Xue Li Yong Tian-Tian Wang pei luo Lin-Sen Qing Chengdu Institute of Biology Chinese Academy of SciencesChengdu610041China State Key Laboratory for Quality Research in Chinese Medicines Macao University of Science and TechnologyMacaoChina Sichuan Center for Disease Control and Prevention Chengdu610041China University of Chinese Academy of Sciences Beijing100049China

Triterpenoids widely exist in nature,displaying a variety of pharmacological *** triterpenoids in different matrices,especially in biological samples holds great ***-performance liquid chromatography(HPLC)has become the predominant method for triterpenoids analysis due to its exceptional analytical ***,due to the structural similarities among botanical samples,achieving effective separation of each triterpenoid proves challenging,necessitating significant improvements in analytical ***,triterpenoids are characterized by a lack of ultraviolet(UV)absorption groups and chromophores,along with low ionization efficiency in mass ***,routine HPLC analysis suffers from poor *** derivatization emerges as an indispensable technique in HPLC analysis to enhance its *** the structural characteristics of triterpenoids,various derivatization reagents such as acid chlorides,rhodamines,isocyanates,sulfonic esters,and amines have been employed for the derivatization analysis of *** review comprehensively summarized the research progress made in derivatization strategies for HPLC detection of ***,the limitations and challenges encountered in previous studies are discussed,and future research directions are proposed to develop more effective derivatization methods.

关键词： Triterpenoid HPLC Derivatization Quantification

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Two sandwich-type uranyl-containing polytungstates catalyze aerobic synthesis of benzimidazoles

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Rare Metals 2024年第3期43卷 1316-1322页

作者： Yu-Feng Liu Qi-Long Hu Xue-Jiao Chen Ke Li pei luo Guo-Ping Yang School of Chemistry and Material Science Jiangxi Province Key Laboratory of Synthetic ChemistryJiangxi Key Laboratory for Mass Spectrometry and InstrumentationEast China University of TechnologyNanchang330013China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen518055China

Diversified synthetic strategies are extremely important for the structural diversity of uranium-containing polyoxometalates(U-POMs)and their functional ***,two sandwich-type U-POMs were reported,which are Na_(5.6)K_(6.4)[(UO_(2))(H_(2)O)(TeW_(9)O_(33))]_(2)·21H_(2)O(UTeW_(9))and Na_(8.9)K_(2.7)H_(1.19)[K_(0.79)(UO_(2))_(2.21)(PW_(9)O_(34))_(2)]·12H_(2)O(UPW_9)using in-situ strategy and lacunary precursor strategy,***_9 shows a typical Keggin-typeopen or half-sandwich configuration.

关键词： configuration expansion sandwich

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Generic Interpretable Reaction Condition Predictions with Open Reaction Condition Datasets and Unsupervised Learning of Reaction Center

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Research 2024年第2期2023卷 773-794页

作者： Xiaorui Wang Chang-Yu Hsieh Xiaodan Yin Jike Wang Yuquan Li Yafeng Deng Dejun Jiang Zhenxing Wu Hongyan Du Hongming Chen Yun Li Huanxiang Liu Yuwei Wang pei luo Tingjun Hou Xiaojun Yao Dr.Neher's Biophysics Laboratory for lnnovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyMacao999078China innovation Institute for Artificial Intelligence in Medicine of Zhejiang University College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Faculty of Applied Sciences Macao Polytechnic UniversityMacao999078China College of Chemistry and Chemical Engineering Lanzhou UniversityLanzhou730000China Carbon Silicon AI Technology Co. LtdHangzhouZhejiang 310018China Center of Chemistry and Chemical Biology Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510530China College of Pharmacy Shaanxi University of Chinese MedicineXianyangShaanxi712044China

Effective synthesis planning powered by deep learning(DL)can significantly accelerate the discovery of new drugs and ***,most DL-assisted synthesis planning methods offer either none or very limited capability to recommend suitable reaction conditions(RCs)for their reaction ***,the prediction of RCs with a DL framework is hindered by several factors,including:(a)lack of a standardized dataset for benchmarking,(b)lack of a general prediction model with powerful representation,and(c)lack of *** address these issues,we first created 2 standardized RC datasets covering a broad range of reaction classes and then proposed a powerful and interpretable Transformer-based RC predictor named *** careful design of the model architecture,pretraining method,and training strategy,Parrot improved the overall top-3 prediction accuracy on catalysis,solvents,and other reagents by as much as 13.44%,compared to the best previous model on a newly curated ***,the mean absolute error of the predicted temperatures was reduced by about 4℃.Furthermore,Parrot manifests strong generalization capacity with superior cross-chemical-space prediction *** analysis indicates that Parrot effectively captures crucial chemical information and exhibits a high level of interpretability in the prediction of *** proposed model Parrot exemplifies how modern neural network architecture when appropriately pretrained can be versatile in making reliable,generalizable,and interpretable recommendation for RCs even when the underlying training dataset may still be limited in diversity.

关键词： versatile absolute generalization

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Enhancing Generic Reaction Yield Prediction through Reaction Condition-Based Contrastive Learning

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Research 2024年第3期 685-702页

作者： Xiaodan Yin Chang-Yu Hsieh Xiaorui Wang Zhenxing Wu Qing Ye Honglei Bao Yafeng Deng Hongming Chen pei luo Huanxiang Liu Tingjun Hou Xiaojun Yao Dr.Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyMacao 999078China Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China. Faculty of Applied Sciences Macao Polytechnic UniversityMacao 999078China. CarbonSilicon AI Technology Co.Ltd HangzhouZhejiang 310018China Center of Chemistry and Chemical Biology Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510530China.

Deep learning(DL)-driven efficient synthesis planning may profoundly transform the paradigm for designing novel pharmaceuticals and ***,the progress of many DL-assisted synthesis planning(DASP)algorithms has suffered from the lack of reliable automated pathway evaluation *** a critical metric for evaluating chemical reactions,accurate prediction of reaction yields helps improve the practicality of DASP algorithms in the real-world ***,accurately predicting yields of interesting reactions still faces numerous challenges,mainly including the absence of high-quality generic reaction yield datasets and robust generic yield *** compensate for the limitations of high-throughput yield datasets,we curated a generic reaction yield dataset containing 12 reaction categories and rich reaction condition ***,by utilizing 2 pretraining tasks based on chemical reaction masked language modeling and contrastive learning,we proposed a powerful bidirectional encoder representations from transformers(BERT)-based reaction yield predictor named *** achieved comparable or even superior performance to the best previous models on 4 benchmark datasets and established state-of-the-art performance on the newly curated *** found that reaction-condition-based contrastive learning enhances the model’s sensitivity to reaction conditions,and Egret is capable of capturing subtle differences between reactions involving identical reactants and products but different reaction ***,we proposed a new scoring function that incorporated Egret into the evaluation of multistep synthesis *** results showed that yield-incorporated scoring facilitated the prioritization of literature-supported high-yield reaction pathways for target *** addition,through meta-learning strategy,we further improved the reliability of the model’s prediction for reaction types with limited data and lower data *** r

关键词： synthesis generic holds

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搜索引擎图片中的职业性别刻板印象——基于跨平台算法审计的研究

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新闻大学 2024年第6期 1-17,118页

作者：周葆华罗沛复旦大学新闻学院上海200433

人们通常将某一类性别占主导的职业与该性别联系在一起。在算法得到广泛应用的今天,这种刻板印象从社会数据进入算法,并在算法与用户交互的界面被呈现为偏见。本文关注中国本土的搜索引擎,通过搜索获取搜索引擎中不同排序的图片,将搜索... 详细信息

人们通常将某一类性别占主导的职业与该性别联系在一起。在算法得到广泛应用的今天,这种刻板印象从社会数据进入算法,并在算法与用户交互的界面被呈现为偏见。本文关注中国本土的搜索引擎,通过搜索获取搜索引擎中不同排序的图片,将搜索引擎图片与人口普查数据中的职业性别比例进行对比,展开算法审计。研究发现,两个主要搜索引擎的图片搜索结果中都存在符合职业性别刻板印象的性别比例夸大现象,且这种夸大现象在女性占比较低的职业中更加明显;同时,二者都存在职业女性整体占比偏低的情况。在搜索结果排序中,有的搜索引擎靠前图片中刻板印象的比例夸张更严重。搜索算法吸收着职业性别刻板印象且直观地呈现在图片搜索结果中,并可能在算法和用户的认知循环之间进一步加深。

关键词：搜索引擎职业性别刻板印象算法偏见算法审计

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Neonatal tachypnea caused by diaphragmatic paralysis:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5253-5257页

作者： Yan Zeng pei luo Di-Ran Zhao Feng-Yang Wang Bin Song Department of Pediatrics People's Hospital of Deyang CityDeyang 618000Sichuan ProvinceChina Department of Ultrasound People's Hospital of Deyang CityDeyang 618000Sichuan ProvinceChina Department of Nephrology People's Hospital of Deyang CityDeyang 618000Sichuan ProvinceChina

BACKGROUND Diaphragmatic paralysis is typically associated with phrenic nerve *** diaphragmatic paralysis diagnosis is easily missed because its manifestations are variable and usually *** SUMMARY We report a 39-week-old newborn delivered via vaginal forceps who presented with tachypnea but without showing other birth-trauma-related *** infant was initially diagnosed with ***,the newborn still exhibited tachypnea despite effective antibiotic *** radiography revealed right diaphragmatic elevation.M-mode ultrasonography revealed decreased movement of the right *** infant was subsequently diagnosed with diaphragmatic *** 4 weeks,tachypnea *** re-examination using M-mode ultrasonography,the difference in bilateral diaphragmatic muscle movement was smaller than *** Appropriate use of M-mode ultrasound to quantify diaphragmatic excursions could facilitate timely diagnosis and provide objective evaluation.

关键词： Diaphragmatic paralysis M-mode ultrasonography Birth trauma Newborn Case report

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政府数据开放能提升民营企业绩效吗——基于多时点双重差分法的验证

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吉林大学社会科学学报 2024年第4期64卷 189-203,239,240页

作者：程波辉罗培锴对外经济贸易大学政府管理学院北京100029

在中国经济转型与创新发展的时代背景下,政府数据开放能否赋能民营企业绩效提升,从而促进民营经济高质量发展有待深入探究。文章基于2009—2021年民营上市公司面板数据,利用地级市政府开通政府数据平台这一准自然实验,检验政府数据开放... 详细信息

在中国经济转型与创新发展的时代背景下,政府数据开放能否赋能民营企业绩效提升,从而促进民营经济高质量发展有待深入探究。文章基于2009—2021年民营上市公司面板数据,利用地级市政府开通政府数据平台这一准自然实验,检验政府数据开放对民营企业绩效提升的促进作用。研究结果表明:政府数据开放能够显著提升民营企业绩效;机制分析结果显示,该作用通过优化区域营商环境、提升企业经营能力的机制实现;拓展分析结果显示,民营企业绩效会随着政府数据开放水平及其细分维度下的制度保障水平、数据质量水平、成果转化水平的提升而提升,对民营企业绩效提升的促进作用在竞争型行业企业与大规模企业中更加明显。基于此,要坚持有序推进政府数据开放工作,利用数据资源变革政府结构与监管模式,引导企业将数据要素融入生产体系当中,并给予管制型行业与中小规模民营企业资源倾斜,着力解决民营经济发展不均衡不充分的问题,从政策供给端支持民营企业发展,为实现民营经济高质量发展提供有力支撑。

关键词：政府数据开放民营企业绩效准自然实验数据要素

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云南威信苗族蜡染工艺艺术特点及文化内涵研究

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鞋类工艺与设计 2024年第18期4卷 79-81页

作者：罗培四川民族学院美术学院四川甘孜626000

苗族是一个人口众多、分布广泛、有着悠久历史的民族。苗族文化丰富多彩,其中蜡染艺术是其文化的主要载体之一,具有独特的艺术价值和文化价值。苗族蜡染是艺术与生活的结合,承载着苗族的文化信息资源,也是历史的真实见证。云南威信县苗... 详细信息

苗族是一个人口众多、分布广泛、有着悠久历史的民族。苗族文化丰富多彩,其中蜡染艺术是其文化的主要载体之一,具有独特的艺术价值和文化价值。苗族蜡染是艺术与生活的结合,承载着苗族的文化信息资源,也是历史的真实见证。云南威信县苗族蜡染是典型的川滇黔特色苗族蜡染,具有很高的研究价值,随着时代的变迁,威信苗族蜡染传承和发展面临着诸多严峻问题。本文着重分析威信苗族蜡染艺术特点及文化内涵,以期为少数民族传统技艺传承和发展寻求可行之路。

关键词：苗族蜡染制作工艺文化内涵

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以数字出版为基打造出版业新质生产力:中外比较、重点环节、实施策略

中国数字出版

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中国数字出版 2024年第3期2卷 29-36页

作者：徐鹏罗培清华大学互联网产业研究院北京100085

随着人工智能等数字技术的不断发展,数据成为新的生产要素,数字空间成为新的发展领域,出版行业数字化转型已是大势所趋。数字出版是文化和科技融合发展下的新业态,是出版行业发展新质生产力的重要抓手。文章旨在通过研究分析中外数字出... 详细信息

随着人工智能等数字技术的不断发展,数据成为新的生产要素,数字空间成为新的发展领域,出版行业数字化转型已是大势所趋。数字出版是文化和科技融合发展下的新业态,是出版行业发展新质生产力的重要抓手。文章旨在通过研究分析中外数字出版发展经验,探讨以数字出版为基打造出版业新质生产力的重点环节和实施策略,推动我国出版行业高质量发展,赋能我国文化强国建设。

关键词：数字出版新质生产力人工智能数字空间文化强国

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