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ON ZrO_2-NiCr COMPOSITE POWDER FOR SPRAYING

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Journal of Wuhan University of Technology(Materials Science) 1995年第4期10卷 42-47页

作者：邱凤襄罗志平邵刚勤潘牧 Wuhan Univ of Technology Wuhan China

Composite powder prepared of calcium oxide stabilzed ZrO2(CSZ) and NiCr by vacuum sintering is studied,and the effect of additive TiO2 on its properties is discussed. The morphology and phases of the powder were measured and determined by SEM. EPMA, XRD methods and the testing of flowability, bulk density and microhard-ness. The results show that the metallic components in the powder are in homogeneous distribution , the flowability, bulk density and microhardness are superior to the ZrO2-NiCr powder prepared by mechanically mixing. All components in the coating made of the composite powder are well-distributed because of avoiding segregation in the middle of mixing. It proves that the composite powder is an excellent material for plasma spraying.

关键词： composite powder ZrO2 vacuum sin-tering plasma spraying

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大型混流式水轮机的应用现状与技术发展

水利水电技术 2009年第8期40卷 108-112页

作者：唐澍潘罗平中国水利水电科学研究院北京100038

根据我国水力资源特点，分析总结了我国大型混流式水轮机技术的应用需求和应用现状，以及大型混流式水轮机技术的发展趋势，并分析提出了当今国内外混流式水轮机的技术发展水平。混流式水轮机模型的最优效率已从20世纪80年代的92％～93... 详细信息

根据我国水力资源特点，分析总结了我国大型混流式水轮机技术的应用需求和应用现状，以及大型混流式水轮机技术的发展趋势，并分析提出了当今国内外混流式水轮机的技术发展水平。混流式水轮机模型的最优效率已从20世纪80年代的92％～93％到90年代的93％-94％，提高到现阶段94％～95％的水平，部分水头段已超过95％，空化性能和水力稳定性较过去有了相当大的改善。

关键词：大型混流式水轮机水力性能应用现状技术发展

Application of Fusobacterium nucleatum as a biomarker in gastrointestinal malignancies

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2271-2283页

作者： Long-Chen Yu Ya-Ping Li Yue-Ming Xin Mai Mao Ya-Xin pan Yi-Xuan Qu Zheng-Dong luo Yi Zhang Xin Zhang Department of Clinical Laboratory Qilu Hospital of Shandong UniversityShandong Engineering Research Center of Biomarker and Artificial Intelligence ApplicationJinan 250012Shandong ProvinceChina

The morbidity and mortality of gastrointestinal(GI)malignancies are among the highest in the world,posing a serious threat to human *** of the insidious onset of the cancer,it is difficult for patients to be diagnosed at an early stage,and it rapidly progresses to an advanced stage,resulting in poor treatment and *** nucleatum(***)is a gram-negative,sporefree anaerobic bacterium that primarily colonizes the oral cavity and is implicated in the development of colorectal,esophageal,gastric,and pancreatic cancers via various intricate *** development in novel research suggests that *** may function as a biomarker in GI *** the abundance of *** in stool,saliva,and serum samples of patients may aid in the diagnosis,risk assessment,and prognosis monitoring of GI *** editorial systematically describes the biological roles and mechanisms of *** in GI malignancies focusing on the application of *** as a biomarker in the diagnosis and prognosis of GI malignancies to promote the clinical translation of *** and GI tumors-related research.

关键词： Gastrointestinal malignancies Fusobacterium nucleatum Biomarker Diagnosis Prognosis

The Plasma Boundary in Low-Parameter Divertor Discharges on the HL-2A Tokamak

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Southwestern Institute of Physics Annual Report

Southwestern Institute of Physics Annual Report 2004年第1期 81-84页

作者： LI Qiang MAO Suying luo Cuiwen pan Li ZHANG Jinhua YANG Qingwei SONG Xianming

Because the last closed flux-surface （LCFS） finally determines the shape of plasma cross-section, and the shaping of plasma is a key issue directly related with lots of the hot subjects of an advanced tokamak（AT） and of a reactor, e. g., the control on the current density, equilibrium, scrapeoff layer（SOL）, aspects of edge particle and energy, high plasma kinetic energy, and of course, the MHD instability suppression, the further studies on the LCFS related subjects, e. g., its determination, flux loss, etc., are still tokamak research. It equilibrium, poloidal needed for present is also important to get precise LCFS-related equilibrium or configuration properties for the controls on an AT and for the understandings on the underlying basic physical issues in a discharge.

关键词： Low-parameter divertor Plasma boundary

The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype,promoting a favorable response to anti-PD-1 therapy via NLRP3 activation

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Cellular & Molecular Immunology 2024年第1期21卷 60-79页

作者： Fan luo Han Li Wenjuan Ma Jiaxin Cao Qun Chen Feiteng Lu Miaozhen Qiu Penghui Zhou Zengfei Xia Kangmei Zeng Jianhua Zhan Ting Zhou Qiuyun luo Wentao pan Lin Zhang Chaozhuo Lin Yan Huang Li Zhang Dajun Yang Hongyun Zhao State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Ascentage Pharma(Suzhou)Co Ltd 218 Xinghu StreetSuzhouJiangsu ProvinceChina

The main challenges in the use of immune checkpoint inhibitors(ICIs)are ascribed to the immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated CD8+T *** the tumor microenvironment(TME)from“cold”to“hot”and thus more likely to potentiate the effects of ICIs is a promising strategy for cancer *** found that the selective BCL-2 inhibitor APG-2575 can enhance the antitumor efficacy of anti-PD-1 therapy in syngeneic and humanized CD34+mouse *** single-cell RNA sequencing,we found that APG-2575 polarized M2-like immunosuppressive macrophages toward the M1-like immunostimulatory phenotype with increased CCL5 and CXCL10 secretion,restoring T-cell function and promoting a favorable immunotherapy ***,we demonstrated that APG-2575 directly binds to NF-κB p65 to activate NLRP3 signaling,thereby mediating macrophage repolarization and the activation of proinflammatory caspases and subsequently increasing CCL5 and CXCL10 chemokine *** a result,APG-2575-induced macrophage repolarization could remodel the tumor immune microenvironment,thus improving tumor immunosuppression and further enhancing antitumor T-cell *** immunohistochemistry confirmed that patients with better immunotherapeutic efficacy had higher CD86,p-NF-κB p65 and NLRP3 levels,accompanied by lower CD206 expression on ***,these data provide evidence that further study on APG-2575 in combination with immunotherapy for tumor treatment is required.

关键词： BCL-2 APG-2575 ICIs Macrophages NLRP3

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临江地下结构抗浮计算方法研究

岩土力学 2017年第10期38卷 2973-2979,2988页

作者：曹洪朱东风骆冠勇潘泓华南理工大学土木与交通学院广东广州510640 华南理工大学亚热带建筑科学国家重点实验室广东广州510640

临江地下结构进行浮力计算时,其抗浮设计水位直接采用地面高程或江河水位是不合理的,需要对场地进行渗流分析才能确定。在沿用本奈特假定的前提下,推导出一种简化算法用于临江二元地层的渗流分析,可得到强透水层中的水头分布。在此基础... 详细信息

临江地下结构进行浮力计算时,其抗浮设计水位直接采用地面高程或江河水位是不合理的,需要对场地进行渗流分析才能确定。在沿用本奈特假定的前提下,推导出一种简化算法用于临江二元地层的渗流分析,可得到强透水层中的水头分布。在此基础上,提出地下结构物底板水压力的实用计算方法为抗浮设计提供依据。其方法适用于堤前、堤后覆盖层有不同的厚度和渗透系数,以及宽度为有限或无限的边界情况。该法计算简便,结果足够精确。经过算例验证和比较,堤后小型结构物对强透水层中的水头分布影响不大,但大型结构物和堤后宽度收窄将会显著抬高水头。位于覆盖层中的地下室底板浮力呈中部大、四周小的分布形态,但位于强透水层中时则呈线性分布。

关键词：地下结构二元地层水头分布浮力

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南方集体林业产权制度改革认识的几个误区

林业经济问题 2007年第3期27卷 262-264页

作者：罗攀柱中南林业科技大学商学院长沙410004

通过对湖南省集体林产权制度改革中存在的几个错误和片面的认识进行分析,指出在现行体制下,实行家庭承包责任制并不会造成严重的森林乱砍盗伐及林农收入低下,而应该是现阶段我国南方集体林业产权明晰的有效途径之一,在明晰产权的基础上... 详细信息

通过对湖南省集体林产权制度改革中存在的几个错误和片面的认识进行分析,指出在现行体制下,实行家庭承包责任制并不会造成严重的森林乱砍盗伐及林农收入低下,而应该是现阶段我国南方集体林业产权明晰的有效途径之一,在明晰产权的基础上,积极推进"农民自主经营型"林业合作组织是促进南方集体林业发展的根本出路。

关键词：南方集体林产权制度改革认识误区

Analysis of the causes of primary revision after unicompartmental knee arthroplasty: A case series

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World Journal of Clinical Cases 2024年第9期12卷 1560-1568页

作者： Jin-Long Zhao Xiao Jin He-Tao Huang Wei-Yi Yang Jia-Hui Li Ming-Hui luo Jun Liu Jian-Ke pan The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Chinese Medicine The First Affiliated HospitalJinan UniversityGuangzhou 510630Guangdong ProvinceChina The Second School of Clinical Medical Sciences Guangzhou University of Chinese MedicineGuangdong Academy of Traditional Chinese MedicineGuangzhou 510405Guangdong ProvinceChina The Second Affiliated Hospital Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou 510120Guangdong ProvinceChina The Affiliated TCM Hospital Guangzhou Medical UniversityGuangzhou 510405Guangdong ProvinceChina The Research Team on Bone and Joint Degeneration and Injury Guangdong Provincial Academy of Chinese Medical SciencesGuangzhou 510405Guangdong ProvinceChina

BACKGROUND Unicompartmental knee arthroplasty(UKA)has great advantages in the treatment of unicompartmental knee osteoarthritis,but its revision rate is higher than that of total knee *** To summarize and analyse the causes of revision after *** This is a retrospective case series study in which the reasons for the first revision after UKA are *** analysed the clinical symptoms,medical histories,laboratory test results,imaging examination results and treatment processes of the patients who underwent revision and summarized the reasons for primary revision after *** A total of 13 patients,including 3 males and 10 females,underwent revision surgery after *** average age of the included patients was 67.62 *** prosthesis was used for 3 d to 72 *** main reasons for revision after UKA were improper suturing of the surgical opening(1 patient),osteophytes(2 patients),intra-articular loose bodies(2 patients),tibial prosthesis loosening(2 patients),rheumatoid arthritis(1 patient),gasket dislocation(3 patients),anterior cruciate ligament injury(1 patient),and medial collateral ligament injury with residual bone cement(1 patient).CONCLUSION The causes of primary revision after UKA were gasket dislocation,osteophytes,intra-articular loose bodies and tibial prosthesis *** of these factors may greatly reduce the rate of revision after UKA,improve patient satisfaction and reduce medical burden.

关键词： Unicompartmental knee arthroplasty Total knee arthroplasty Causes Revision Case series

Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2114-2131页

作者： Chuan Yang Xueping Wang Kenneth K.W.To Caimei Cui Min luo Shaocong Wu Lamei Huang Kai Fu Can pan Zeyu Liu Teng Fan Caibo Yang Fang Wang Liwu Fu State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060P.R.China School of Pharmacy Faculty of MedicineThe Chinese University of Hong KongHong KongChina LABVIV Technology(Shenzhen)Co. LtdShenzhen 518057China

Circulating tumor cells(CTCs)are precursors of distant metastasis in a subset of cancer patients.A better understanding of CTCs heterogeneity and how these CTCs survive during hematogenous dissemination could lay the foundation for therapeutic prevention of cancer *** remains elusive how CTCs evade immune surveillance and elimination by immune *** this study,we unequivocally identified a subpopulation of CTCs shielded with extracellular vesicle(EVs)-derived CD45(termed as CD45^(+)CTCs)that resisted T cell attack.A higher percentage of CD45^(+)CTCs was found to be closely correlated with higher incidence of metastasis and worse prognosis in cancer ***,CD45^(+)tumor cells orchestrated an immunosuppressive milieu and CD45^(+)CTCs exhibited remarkably stronger metastatic potential than CD45−CTCs in ***,CD45 expressing on tumor surfaces was shown to form intercellular CD45-CD45 homophilic interactions with CD45 on T cells,thereby preventing CD45 exclusion from TCR-pMHC synapse and leading to diminished TCR signaling transduction and suppressed immune ***,these results pointed to an underappreciated capability of EVs-derived CD45-dressed CTCs in immune evasion and metastasis,providing a rationale for targeting EVs-derived CD45 internalization by CTCs to prevent cancer metastasis.

关键词： CD45 metastasis prevention