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A PET probe targeting polyamine transport system for precise tumor diagnosis and therapy

Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 146-159页

作者： Ming zhou Xiaoqin yin Bei Chen Shuo Hu Wenhu zhou Department of Nuclear Medicine Xiangya HospitalCentral South UniversityChangsha 410008China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China National Clinical Research Center for Geriatric Disorders(Xiangya) Changsha 410008China

Polyamine metabolism dysregulation is a hallmark of many cancers,offering a promising avenue for early tumor *** study presents the development of a nuclear probe derived from spermidine(SPM)for dual-purpose tumor PET imaging and internal radiation *** probe,radiolabeled with either[68Ga]Ga for diagnostic applications or[177Lu]Lu for therapeutic use,was synthesized with exceptional purity,stability,and specific *** testing involving 12 different tumor cell lines revealed remarkable specificity towards B16 melanoma cells,showcasing outstanding tumor localization and target-to-non-target *** investigations employing polyamines,non-labeled precursor,and polyamine transport system(PTS)inhibitor,consistently affirmed the probe?s targetability through recognition of the ***,while previous reports indicated PTS upregulation in various tumor types for targeted therapy,this study observed no positive signals,highlighting a concentration-dependent discrepancy between targeting for therapy and ***,when labeled with[177Lu],the probe demonstrated its therapeutic potential by effectively controlling tumor growth and extending mouse *** into biodistribution,excretion,and biosafety in healthy humans laid a robust foundation for clinical *** study introduces a versatile SPM-based nuclear probe with applications in precise tumor theranostics,offering promising prospects for clinical implementation.

关键词： PET imaging Polyamine metabolism Spermine Radiopharmaceutical Melanoma

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Prediction of Ground Vibration Induced by Rock Blasting Based on Optimized Support Vector Regression Models

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3147-3165页

作者： Yifan Huang Zikang zhou Mingyu Li Xuedong luo Faculty of Engineering China University of GeosciencesWuhan430074China Institute of Geological Survey China University of GeosciencesWuhan430074China

Accurately estimating blasting vibration during rock blasting is the foundation of blasting vibration *** this study,Tuna Swarm Optimization(TSO),Whale Optimization Algorithm(WOA),and Cuckoo Search(CS)were used to optimize two hyperparameters in support vector regression(SVR).Based on these methods,three hybrid models to predict peak particle velocity(PPV)for bench blasting were ***-eight samples were collected to establish the PPV database,eight initial blasting parameters were chosen as input parameters for the predictionmodel,and the PPV was the output *** predictive performance evaluation indicators,the coefficient of determination(R2),rootmean square error(RMSE),mean absolute error(MAE),and a10-index were *** normalizedmutual information value is then used to evaluate the impact of various input parameters on the PPV prediction *** to the research findings,TSO,WOA,and CS can all enhance the predictive performance of the SVR *** TSO-SVR model provides the most accurate *** performances of the optimized hybrid SVR models are superior to the unoptimized traditional prediction *** maximum charge per delay impacts the PPV prediction value the most.

关键词： Blasting vibration metaheuristic algorithms support vector regression peak particle velocity normalized mutual information

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Accelerated thermal ageing on performance of polypropylene-based semiconducting screen for high voltage direct current cable applications-Effect of antioxidants

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High Voltage 2024年第2期9卷 410-418页

作者： Haitian Wang Yi luo Mingyu zhou Xintong Ren George Chen GEIRI BerlinGermany The Tony Davies High Voltage Laboratory University of SouthamptonSouthamptonUK

The potential of using eco-friendly thermoplastic polypropylene(PP)-based insulation for high voltage direct current(HVDC)cable has been widely investigated but much less work on the PP-based semiconducting screen(SC).Considering a long service life(>30 years)under high temperature and high electrical stress is required for typical HVDC cables,and investigations on the effect of antioxidant(AO)concentration and thermal oxidative sta-bility,mechanical,and electrical properties of PP-based SCs have been *** has been demonstrated that an appropriate combination and amounts of AOs are critical for achieving high thermal stability and maintaining the mechanical properties of SC after ageing in a harsh environment(150°C,with Cu,in air,7 days).Although higher amounts of space charges have been observed in SC/PP/SC samples with higher AO concentrations,the impact on space charge behaviours is less after ageing,suggesting that ageing(or operating at high temperature)leads to microstructure evolution in SC and can potentially mitigate space accumulation in PP-based insulating materials.

关键词： microstructure thermal high

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Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn

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Current Medical Science 2024年第2期44卷 369-379页

作者： Ji luo Jin zhou Jing-zeng luo Hai-long WANG Xue-ling ZHAO Ru-dan zhou Department of Intensive Care Unit The First People's Hospital of ZiyangZiyang 641300China Department of Orthopedics Kunming Medical University Second Affiliated HospitalKunming 650033China Department of Orthopedics Kunming Medical University First Affiliated HospitalKunming 650032China Department of Orthopedics The Third People's Hospital of Yunnan ProvinceKunming 650200China

Objective:Matrix metalloproteinase 13(MMP13)is an extracellular matrix protease that affects the progression of atherosclerotic plaques and arterial thrombi by degrading collagens,modifying protein structures and regulating inflammatory responses,but its role in deep vein thrombosis(DVT)has not been *** purpose of this study was to investigate the potential effects of MMP13 and MMP13-related genes on the formation of ***:We altered the expression level of MMP13 in vivo and conducted a transcriptome study to examine the expression and relationship between MMP13 and MMP13-related genes in a mouse model of *** screening genes possibly related to MMP13 in DVT mice,the expression levels of candidate genes in human umbilical vein endothelial cells(HUVECs)and the venous wall were *** effect of MMP13 on platelet aggregation in HUVECs was investigated in ***:Among the differentially expressed genes,interleukin 1 beta,podoplanin(Pdpn),and factor VIII von Willebrand factor(F8VWF)were selected for analysis in *** MMP13 was inhibited,the expression level of PDPN decreased significantly in *** HUVECs,overexpression of MMP13 led to an increase in the expression level of PDPN and induced platelet aggregation,while transfection of PDPN-siRNA weakened the ability of MMP13 to increase platelet ***:Inhibiting the expression of MMP13 could reduce the burden of DVT in *** mechanism involves downregulating the expression of Pdpn through MMP13,which could provide a novel gene target for DVT diagnosis and treatment.

关键词： deep vein thrombosis matrix metalloproteinase 13 podoplanin

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A New High-Precision and Lightweight Detection Model for Illegal Construction Objects Based on Deep Learning

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Tsinghua Science and Technology 2024年第4期29卷 1002-1022页

作者： Wenjin Liu Lijuan zhou Shudong Zhang Ning luo Min Xu School of Cyberspace Security(School of Cryptology) Hainan UniversityHaikou 570228China School of Information Engineering Capital Normal UniversityBeijing 100048China

Illegal construction has caused serious harm around the world. However, current methods are difficult to detect illegal construction activities in time, and the calculation complexity and the parameters of them are large. To solve these challenges, a new and unique detection method is proposed, which detects objects related to illegal buildings in time to discover illegal construction activities. Meanwhile, a new dataset and a high-precision and lightweight detector are proposed. The proposed detector is based on the algorithm You Only Look Once (YOLOv4). The use of DenseNet as the backbone of YDHNet enables better feature transfer and reuse, improves detection accuracy, and reduces computational costs. Meanwhile, depthwise separable convolution is employed to lightweight the neck and head to further reduce computational costs. Furthermore, H-swish is utilized to enhance non-linear feature extraction and improve detection accuracy. Experimental results illustrate that YDHNet realizes a mean average precision of 89.60% on the proposed dataset, which is 3.78% higher than YOLOv4. The computational cost and parameter count of YDHNet are 26.22 GFLOPs and 16.18 MB, respectively. Compared to YOLOv4 and other detectors, YDHNet not only has lower computational costs and higher detection accuracy, but also timely identifies illegal construction objects and automatically detects illegal construction activities.

关键词： object detection lightweight illegal buildings illegal construction objects high-precision

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Chronic Obstructive Pulmonary Disease-Associated Mortality — China, 2014–2021

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China CDC weekly 2024年第43期6卷 1105-1110页

作者： Zifang zhou Lijun Wang Maigeng zhou Peng yin National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:China faces a growing burden of chronic obstructive pulmonary disease(COPD).Previous mortality estimations were primarily based on the underlying cause of *** study analyzed COPD-associated death and its comorbidities using all COPD cases listed on the chain of events on death ***:A retrospective analysis of the National Mortality Surveillance System(NMSS)was conducted to estimate COPD-associated mortality from 2014 to ***-standardized mortality rates(ASMRs)were calculated stratified by sex,region,and *** regression was used to estimate the average annual percentage change(AAPC)during the study ***:From 2014 to 2021,the ASMR of COPD decreased from 91.85 to 45.90 per 100,000 *** but uneven decreases in COPD mortality were observed across gender[females:AAPC:−11.2%,95%confidence interval(CI):−11.9 to−10.4%;males:AAPC:−8.0%,95%CI:−9.2 to−6.8%],regions(eastern:AAPC:−10.7%,95%CI:−11.5 to−9.9%;central:AAPC:−9.9%,95%CI:−10.9 to−8.9%;western:AAPC:−7.7%,95%CI:−10.6 to−4.7%),and residential areas(urban:AAPC:−10.9%,95%CI:−12.3 to−9.5%;rural:AAPC:−8.3%,95%CI:−9.1 to−7.4%).Other than COPD,cardiovascular diseases and respiratory conditions were the major underlying causes of death in COPDassociated ***:COPD is a significant comorbidity of other disorders in *** COPDassociated mortality substantially decreased from 2014 to 2021,the burden remained high in underdeveloped regions.

关键词： mortality listed stratified

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Machine learning for membrane design and discovery

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Green Energy & Environment 2024年第1期9卷 54-70页

作者： Haoyu yin Muzi Xu Zhiyao luo Xiaotian Bi Jiali Li Sui Zhang Xiaonan Wang Department of Chemical Engineering Tsinghua University100084BeijingChina School of Materials Science&Engineering Tsinghua University100084BeijingChina Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore117576Singapore

Membrane technologies are becoming increasingly versatile and helpful today for sustainable *** Learning(ML),an essential branch of artiﬁcial intelligence(AI),has substantially impacted the research and development norm of new materials for energy and *** review provides an overview and perspectives on ML methodologies and their applications in membrane design and dis-covery.A brief overview of membrane technologies isﬁrst provided with the current bottlenecks and potential *** an appli-cations-based perspective of AI-aided membrane design and discovery,we further show how ML strategies are applied to the membrane discovery cycle(including membrane material design,membrane application,membrane process design,and knowledge extraction),in various membrane systems,ranging from gas,liquid,and fuel cell separation ***,the best practices of integrating ML methods and speciﬁc application targets in membrane design and discovery are presented with an ideal paradigm *** challenges to be addressed and prospects of AI applications in membrane discovery are also highlighted in the end.

关键词： Machine learning Membranes AI for Membrane Data-driven Design

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Anthracene-bridged“Texas-sized”box for the simultaneous detection and uptake of tryptophan

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Chinese Chemical Letters 2024年第9期35卷 175-178页

作者： Dan luo Jinya Tian Jianqiao zhou Xiaodong Chi State Key Laboratory of Materials Processing and Die&Mold Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Shenzhen Huazhong University of Science and Technology Research Institute Shenzhen 518057China

Tryptophan(Trp)is an essential amino acid that plays a critical role in human *** increasing demand for Trp has created a highly promising market,underscoring the urgent necessity for the development of efficient strategies for the simultaneous detection and uptake of ***,we report an expanded“Texas-sized”molecular box(An-TxSB),which incorporates luminescent anthracene bridging subunits and molecular recognition *** luminescent molecular box demonstrates exceptional sensitivity to Trp in water,permitting its precise quantification with a notably low limit of detection(LOD)of 0.42μmol/***,An-TxSB facilitates the proficient uptake of Trp from simulated water samples,thereby revealing an impressive Trp adsorption capacity of up to 226.0μmol/g.

关键词： Macrocycles Host-guest chemistry Biomolecular sensors Molecular recognition Adsorption

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Progress of semitransparent emerging photovoltaics for building integrated applications

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Green Energy & Environment 2024年第6期9卷 992-1015页

作者： Zhisheng zhou Zhangyu Yuan Zhipeng yin Qifan Xue Ning Li Fei Huang State Key Laboratory of Luminescent Materials and Devices School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou510640China Pazhou Lab Guangzhou510320China

With the rapid development of emerging photovoltaics technology in recent years,the application of building-integrated photovoltaics(BIPVs)has attracted the research interest of photovoltaic *** meet the practical application requirements of BIPVs,in addition to the evaluation indicator of power conversion efficiency(PCE),other key performance indicators such as heat-insulating ability,average visible light transmittance(AVT),color properties,and integrability are equally *** traditional Si-based photovoltaic technology is typically limited by its opaque properties for application scenarios where transparency is *** emerging PV technologies,such as organic and perovskite photovoltaics are promising candidates for BIPV applications,owing to their advantages such as high PCE,high AVT,and tunable *** present,the PCE of semitransparent perovskite solar cells(ST-PSCs)has attained 14%with AVT of 22–25%;for semitransparent organic solar cells(ST-OSCs),the PCE reached 13%with AVT of almost 40%.In this review article,we summarize recent advances in material selection,optical engineering,and device architecture design for high-performance semitransparent emerging PV devices,and discuss the application of optical modeling,as well as the challenges of commercializing these semitransparent solar cells for building-integrated applications.

关键词： Building integrated photovoltaics Emerging photovoltaics Semitransparent solar cells Perovskite solar cells Organic solar cells

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Factors and Their Impact on Treatment Effect of Acupuncture in Different Outcomes:A Meta-Regression of Acupuncture Randomized Controlled Trials

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Chinese Journal of Integrative Medicine 2024年第3期30卷 260-266页

作者： XIU Wen-cui GANG Wei-juan zhou Qi SHI Lan-jun HU Xiang-yu MING Tian-yu luo Zhen ZHANG Yu-qing JING Xiang-hong Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing100700China China Center for Evidence-Based Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing100700China Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonOntarioL8S 4L8Canada Center for Evidence-Based Integrative Medicine-Clarity Collaboration Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China

Background:The effects of acupuncture have varied in different randomized controlled trials(RCTs),and there are many factors that influence treatment effect of acupuncture in different outcomes,with conflicting ***:To identify factors and their impact on the treatment effect of acupuncture in different ***:Acupuncture RCTs were searched from 7 databases including Medline(Pub Med),Embase,Cochrane Central Register of Controlled Trials,China National Knowledge Infrastructure,Wanfang Database,VIP Database,and China Biology Medicine disc between January 1st,2015 and December 31st,*** studies must compare acupuncture to no acupuncture,sham acupuncture,or waiting lists,and report at least 1patient-important outcome.A multi-level meta-regression was conducted using a 3-level robust mixed model and univariate analyses were performed for all independent variables,even those excluded from the multivariable model due to *** used thresholds of 0.2 and 0.4 for the difference of standardized mean differences(SMDs),categorising them as small(2),moderate(0.2–0.4),or large(>0.4) ***:The pain construct analysis involved 211 effect estimates from 153 studies and 14 independent ***-frequency acupuncture treatment sessions produced larger effects compared to low-frequency sessions [large magnitude,the difference of adjusted SMDs 0.46,95% confidence interval(CI) 0.07 to 0.84;P=0.02].The non-pain symptoms construct analysis comprised 323 effect estimates from 231 studies and 15 independent *** acupuncture showed moderately larger effects when compared to non-penetrating acupuncture(0.30,95% CI 0.06 to 0.53;P=0.01).The function construct analysis included 495 effect estimates from 274 studies and 14 independent *** acupuncture and the flexible acupuncture regimen showed moderately larger effects,compared to non-penetrating acupuncture and fixed regimen,respectively(0.40,95% CI 0

关键词： acupuncture randomized controlled trial patient-important outcome meta-regression

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