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2022年中国12~30岁人群轻断食行为及影响因素

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中国公共卫生 2024年第4期40卷 461-465页

作者：文啸天武璐丽牛丕业首都医科大学基础医学院北京100069 首都医科大学公共卫生学院北京100069

目的了解中国12~30岁人群轻断食行为发生情况及其影响因素。方法本研究数据来自“2022中国居民心理与行为调查研究”。于2022年6—8月采用多阶段抽样对23个省、5个自治区、4个直辖市的居民进行问卷调查,选取其中12~30岁8858人作为研究对... 详细信息

目的了解中国12~30岁人群轻断食行为发生情况及其影响因素。方法本研究数据来自“2022中国居民心理与行为调查研究”。于2022年6—8月采用多阶段抽样对23个省、5个自治区、4个直辖市的居民进行问卷调查,选取其中12~30岁8858人作为研究对象,采用广泛性焦虑障碍量表(GAD-7)、孤独量表(T-ILS)、轻断食行为自编量表进行问卷调查,采用单因素分析和多因素logistic回归分析发生轻断食行为的影响因素。结果最终纳入分析的8858名研究对象中有1036人近1年内有轻断食行为,发生率为11.70%;有轻断食行为的人群平均年龄为(20.83±4.56)岁,无轻断食人群平均年龄为(20.67±4.80)岁,2组人群年龄差异无统计学意义。多因素非条件logistic回归分析结果显示,女性(OR=1.991,95%CI=1.718~2.309)、居住地为城镇(OR=1.262,95%CI=1.082~1.472)、吸烟(OR=1.411,95%CI=1.123~1.774)、饮酒(OR=1.432,95%CI=1.216~1.687)、体质指数高(OR_(肥胖)=2.153,95%CI=1.528~3.032)、焦虑(OR_(重度焦虑)=4.157,95%CI=3.164~5.463)和孤独(OR=1.258,95%CI=1.070~1.479)是发生轻断食行为的危险因素(P<0.05)。结论12~30岁人群中轻断食行为的发生受自身因素与心理因素多重影响,需从生理和心理双层面考虑轻断食行为。

关键词：轻断食间歇性禁食青少年青年焦虑

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清代医家刘吉人伏热论治经验探析

中国中医急症 2024年第3期33卷 519-521页

作者：虞亚楠张璐砾广西中医药大学广西南宁530022

清末著名医家刘吉人在论治伏热时承经典、抒己见,不仅详细辨析伏热为病的症状,还重视误治所引起的病证。其临床治疗伏热时,分经论治,尤重阳明;又提出伏热应先治疗内症,顾复正气,再解决外症,驱邪外出;以复旧真元,外解邪热为治疗大法。

关键词：伏热刘吉人临证经验

Oblique Cutting Based Mechanical Model for Insertion Torque of Dental Implant

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Chinese Journal of Mechanical Engineering 2022年第3期35卷 92-105页

作者： luli Li Song Zhang Quhao Li Cuirong Bian Airong Zhang School of Mechanical Engineering Shandong UniversityJinan 250061China Key Laboratory of High-efficiency and Clean Mechanical Manufacture of Ministry of Education JinanChina Department of Prosthodontics Qilu Hospital of Shandong UniversityJinan 250012China.

The insertion torque of a dental implant is an important indicator for the primary stability of dental ***,the preoperative prediction for the insertion torque is crucial to improve the success rate of implantation *** this present research,an alternative method for prediction of implant torque was ***,the mechanical model for the insertion torque was established based on an oblique cutting *** the proposed mechanical model,three factors,including bone quality,implant geometry and surgical methods were considered in terms of bone-quality coefficients,chip load and insertion speeds,***,the defined bone-quality coefficients for cancellous bone with the computed tomography(CT)value of 235–245,345–355 and 415–425 Hu were obtained by a series of insertion experiments of IS and ITI ***,the insertion experiments of DIO implants were carried out to verify the accuracy of developed *** predicted insertion torques calculated by the mechanical model were compared with those acquired by insertion experiments,with good agreement,the relative error being less than 15%.This method allows the insertion torque for different implant types to be quickly established and enhances prediction accuracy by considering the effects of implants’geometries and surgical methods.

关键词： Insertion torque Mechanical model Oblique cutting Dental implant

Matrix stiffness regulates osteoclast fate through integrin-dependent mechanotransduction

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Bioactive Materials 2023年第9期27卷 138-153页

作者： Xiaogang Wang luli Ji Jing Wang Changsheng Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237PR China Key Laboratory for Ultrafine Materials of Ministry of Education East China University of Science and TechnologyShanghai200237PR China

Osteoclasts ubiquitously participate in bone homeostasis,and their aberration leads to bone diseases,such as *** clinical strategies by biochemical signaling molecules often perturb innate bone metabolism owing to the uncontrolled management of ***,an alternative strategy of precise regulation for osteoclast differentiation is urgently *** this end,this study proposed an assumption that mechanic stimulation might be a potential ***,a hydrogel was created to imitate the physiological bone microenvironment,with stiffnesses ranging from 2.43kPa to *** impact of matrix stiffness on osteoclast behaviors was thoroughly *** showed that matrix stiffness could be harnessed for directing osteoclast fate in vitro and in *** particular,increased matrix stiffness inhibited the integrinβ3-responsive RhoA-ROCK2-YAP-related mechanotransduction and promoted ***,preosteoclast development is facilitated by medium-stiffness hydrogel(M-gel)possessing the same stiffness as vessel ranging from 17.5 kPa to 44.6 kPa by partial suppression of mechanotransduction,which subsequently encouraged revascularization and bone regeneration in mice with bone *** works provide an innovative approach for finely regulating osteoclast differentiation by selecting the optimum matrix stiffness and enable us further to develop a matrix stiffness-based strategy for bone tissue engineering.

关键词： Stiffness Mechanotransduction Osteoclast Integrin Bone repair

Effect of hypotonic medium on aquaporin-4 expression in cultured astrocytes

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Neural Regeneration Research 2008年第5期3卷 546-549页

作者： Yanhua Li Shanquan Sun Tiejian Wang luli Li Department of Neurology the People＇s Hospital of Guangxi Zhuang Autonomous Region Nanning 530021 Guangxi Zhuang Autonomous Region China Department of Neurobiology Chongqing University of Medical Science Chongqing 400016 China

BACKGROUND： Aquaporin-4 （AQP4） is abundant in astrocytes, ependymal cells, and the choroid plexus, and is associated with cerebrospinal fluid formation and osmoregulation. AQP4 is speculated to be the hypothalamic osmoreceptor and regulator of water balance. OBJECTIVE： To examine AQP4 expression and its role in cultured rat astrocytes after exposure to hypotonic medium. DESIGN, TIME AND SETTING： Randomized control experiment. This experiment was carried out in the Research Room of Neurobiology, Chongqing University of Medical Science, China, between April and October 2003. MATERIALS： Two-day-old newborn Wistar rats （n =20）, weighing 10- 15 g, were purchased from the Experimental Animal Center of Chongqing University of Medical Science, China. METHODS： Purified rat cerebral cortical astrocytes were isolated fiom Wistar rats for in vitro cell culture experiments. The cells were randomly divided into control and hypotonic groups. The in vitro cell edema model was established by exposing astrocytes to hypotonic medium （268, 254, or 240 mmol/L）. Cells in the control group were cultured in normal culture medium. MAIN OUTCOME MEASURES： Morphological changes in astrocytes were observed under an inverted microscope and a transmission electron microscope after cells were cultured for 3, 6, 12, or 24 hours with hypotonic medium or normal culture medium. In each group, AQP4 protein and mRNA expression were assessed by immunocytochemistry, in situ hybridization, and reverse transcription polymerase chain reaction at the different time points. RESULTS： After astrocytes were cultured for 3, 6, 12, or 24 hours with hypotonic medium （268, 254, 240 mmol/L）, they showed typical features of cell edema. In the control group, no astrocytes developed pathological changes. There were no significant changes in the AQP4 mRNA and protein expression in the control group at any of the time points alter astrocytes were cultured with normal culture medium （P 〉 0.05）. Compared with the control gro

关键词： aquaporin-4 astrocytes hypotonic solutions edema

Dynamic damage evolution of bank slopes with serrated structural planes considering the deteriorated rock mass and frequent reservoirinduced earthquakes

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International Journal of Mining Science and Technology 2023年第9期33卷 1131-1145页

作者： Xinrong Liu Yan Wang Bin Xu Xiaohan Zhou Xueyan Guo luli Miao School of Civil Engineering Chongqing UniversityChongqing 400045China State Key Laboratory of Coal Mine Disaster Dynamic and Control Chongqing UniversityChongqing 400044China School of River and Ocean Engineering Chongqing Jiaotong UniversityChongqing 400045China

To investigate the dynamic damage evolution characteristics of bank slopes with serrated structural planes,the shaking table model test and the numerical simulation were *** main findings indicate that under continuous seismic loads,the deformation of the bank slope increased,particularly around the hydro-fluctuation belt,accompanying by the pore water pressure *** soil pressure increased and then decreased showed dynamic variation *** the undulation angle of the serrated structural planes increased(30°, 45°, and 60°),the failure modes were climbing,climbinggnawing,and gnawing *** first-order natural frequency was used to calculate the damage degree(Dd)of the bank *** microseisms and small earthquakes,it was discovered that the evolution of Dd followed the“S”shape,which was fitted by a logic ***,the quadratic function was used to fit the Dd during moderately strong *** the numerical simulation,the variation characteristics of safety factors(Sf)for slopes with serrated structural planes and slopes with straight structural planes were *** continuous seismic loads,the Sf of slopes with straight structural planes reduce stalely,whereas the Sf for slopes with serrated structural planes was greater than the former and the reduction rate was increasing.

关键词： Rock bedded slope Serrated structural planes Reservoir-induced earthquakes Hydro-fluctuation belt Damage evolution

Apelin： a double-edged sword in cardiac hypertrophy

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中国药理学通报 2015年第B11期31卷 161-162页

作者： luli-qun ChenLin-xi InstituteofPharmacyandPharmacology LearningKeyLaboratoryforPharmacoproteomicsUniversityofSouthChinaHengyang421001

Aim As we all know, apelin acts as the endogenous ligand of APJ, being a member of G protein cou- pled receptors family, apelin/APJ system is involved in plentiful diseases and extremely responsible for the occur- rence and the development of cardiovascular diseases, among many kinds of heart diseases, it is the cardiac hyper- trophy that catches our attention. The myocardial expression of apelin/APJ decreased in rats with left ventrieular hypertrophy suggesting us there is a link between apelin and cardiac hypertrophy. Furthermore, it has been repor- ted that apelin is able to alleviate cardiac hypertrophy induced by Ang II, H202 and exercise. Nevertheless, our la- boratory discovered that apelin is certain to induce cardiac hypertrophy through PI3k-Akt-ERK1/2-p70S6K pathway or via up-regulating the levels of ROS to cause oxidative stress. The above-mentioned contradiction indicates us apelin may have dual effects in cardiac hypertrophy. Moreover, we also illuminate that apelin is involved in some diseases such as obesity, diabetes, hypertension, myoearditis and myocardial infarction, eoineidentally, all these diseases are associated with cardiac hypertrophy. Therefore, this review is aim to unveil the intricate relationship between apelin and cardiac hypertrophy.

关键词： apelin APJ Ang Ⅱ oxidative stress obesity hypertension myocardial infarction cardiac hypertrophy

多规合一背景下村域“三生空间”划定与布局探讨

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现代农业研究 2024年第8期30卷 78-85页

作者：许珠樊卢丽蒋翔陈焰明湖南省地质调查所湖南长沙410000 湖南省交通规划勘察设计院湖南长沙410000

科学划分乡村地区“三生空间”是构建乡村地区国土空间规划体系和落实乡村地区国土空间用途管制的必然要求,也是全面实施乡村振兴战略、开展乡村建设行动、统筹粮食生产安全和生态环境保护的重要举措。本文以湖南省东安县赵家井村为研究... 详细信息

科学划分乡村地区“三生空间”是构建乡村地区国土空间规划体系和落实乡村地区国土空间用途管制的必然要求,也是全面实施乡村振兴战略、开展乡村建设行动、统筹粮食生产安全和生态环境保护的重要举措。本文以湖南省东安县赵家井村为研究区,采用地类归并法和国土空间适宜性评价相结合的方法,运用GIS空间分析手段,按照最适宜和生态-生产-生活的优先原则得到三类空间。划分结果:生态空间面积为113.20 hm^(2),占土地总面积的16.09%,生产空间面积为481.82 hm^(2),占土地总面积的68.49%,生活空间面积为108.52 hm^(2),占土地总面积的15.42%;确定赵家井村的村庄发展模式为农业发展为主的、生态保护和村庄建设并行的、适宜多层次多结构的文旅发展和保护相结合,工业综合发展的特色村庄。

关键词：多规合一乡村三生空间村庄规划

Cohort Studies on Cancer Mortality Among Workers Exposed Only to Chrysotile Asbestos: a Meta-analysis

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Biomedical and Environmental Sciences 2004年第4期17卷 459-468页

作者： luli TONG-DASUN XINGZHANG RUI-NANLAI XIU-YANGLI XUE-JINFAN KENJIMORINAGA InstituteofSocialMedicineandFamilyMedicine ZhejiangUniversityHangzhou310031ZhejiangChina InstituteofHygiene ZhejiangAcademyofMedicalSciencesHangzhou310013ZhejiangChina DepartmentofEpidemiologyandHealthStatistics SchoolofMedicineZhejiangUniversityHangzhou310031ZhejiangChina DepartmentofEpidemiologyandFieldResearch OsakaMedicalCenterforCancerandCardiovascularDiseasesOsaka537-8511Japan

Objective To determine whether there was excessive risk of cancer among workers exposed to chrysotile fiber alone by applying a meta-analysis technique. Methods All data meeting the criteria of cohort studies on cancer mortality among workers exposed only to chrysotile were incorporated into meta-analysis. Pooled standardized mortality ratios (SMRs) and their corresponding 95% confidence intervals (CIs) for main cancer sites were calculated using two approaches of unweighted ratio and random effect model. The heterogeneity and its sources of the results were examined with a Q-statistic and Z-score test. The dose-response effect as reflected in the percentage of all deaths due to mesothelioma served as a proxy measure of chrysotile exposure. Results A cohort of twenty six workers exposed to chrysotile alone was summarized. The significantly elevated meta-SMRs for all deaths (1.27), all cancers (1.28), cancers of respiratory organs (2.51), cancers of lung (2.35) and cancers of stomach (1.24) were observed. The significantly elevated meta-SMRs for lung cancer within occupational strata were observed among textile workers (3.55), asbestos product manufacturers (3.30), miners and millers (2.24), cement product workers (1.22), and for stomach cancer among asbestos product manufacturers (1.49). Meta-SMRs for cancers at other sites were not significant. Meta-SMR for lung cancer showed an increasing trend with an elevated percentage of all deaths from mesothelioma, but no such trend for stomach cancer. Conclusion There are excessive risks of lung cancer and mesothelioma among workers exposed to chrysotile fiber alone, and likely no convincing indication of an etiological association between chrysotile exposure and cancers at other sites.

关键词： Chrysotile asbestos Cancer Mortality Cohort study Meta-analysis