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Microbiota revolution:How gut microbes regulate our lives

World Journal of Gastroenterology 2023年第28期29卷 4368-4383页

作者： Marica Colella Ioannis Alexandros Charitos Andrea Ballini Concetta Cafiero Skender Topi Raffaele Palmirotta luigi santacroce Interdisciplinary Department of Medicine Section of Microbiology and VirologyUniversity of Bari“Aldo Moro”Bari 70124Italy Maugeri Clinical Scientific Research Institutes(IRCCS)of Pavia-Division of Pneumology and Respiratory Rehabilitation Scientific Institute of BariBari 70124Italy Department of Clinical and Experimental Medicine University of FoggiaFoggia 71122Italy Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy Area of Molecular Pathology Anatomic Pathology UnitFabrizio Spaziani HospitalFrosinone 03100Italy Department of Clinical Disciplines School of Technical Medical SciencesUniversity of Elbasan“A.Xhuvani”Elbasan 3001Albania

The human intestine is a natural environment ecosystem of a complex of diversified and dynamic microorganisms,determined through a process of competition and natural selection during *** intestinal microorganisms called microbiota and are involved in a variety of mechanisms of the organism,they interact with the host and therefore are in contact with the organs of the various ***,they play a crucial role in maintaining host homeostasis,also influencing its ***,microorganisms perform a series of biological functions important for human *** host provides the microorganisms with the environment and nutrients,simultaneously drawing many benefits such as their contribution to metabolic,trophic,immunological,and other *** these reasons it has been reported that its quantitative and qualitative composition can play a protective or harmful role on the host ***,a dysbiosis can lead to an association of unfavourable factors which lead to a dysregulation of the physiological processes of ***,it has previously noted that the gut microbiota can participate in the pathogenesis of autoimmune diseases,chronic intestinal inflammation,diabetes mellitus,obesity and atherosclerosis,neurological disorders(e.g.,neurological diseases,autism,etc.)colorectal cancer,and more.

关键词： Microbiology Human microbiota Intestinal microbiota Immune system Metabolites Dysbiosis Probiotics Diseases Cancer

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Special features of SARS-CoV-2 in daily practice

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World Journal of Clinical Cases 2020年第18期8卷 3920-3933页

作者： Ioannis A Charitos Andrea Ballini Lucrezia Bottalico Stefania Cantore Pier Carmine Passarelli Francesco Inchingolo Antonio D'Addona luigi santacroce Department of Emergency and Urgency National Poisoning CentreRiuniti University Hospital of FoggiaFoggia 71122Italy Department of Biosciences Biotechnologies and BiopharmaceuticsUniversity Campus"E.Quagliariello"University of Bari“Aldo Moro”Bari 70125Italy Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy Interdepartmental Research Center for Pre-Latin Latin and Oriental Rights and Culture Studies(CEDICLO)University of BariBari 70121Italy Department of Interdisciplinary Medicine University of Bari“Aldo Moro”Bari 70124Italy Sorriso&Benessere-Ricerca e Clinica S.R.L Bari 70129Italy Department of Head Neck and Sense OrgansDivision of Oral Surgery and ImplantologyFondazione Policlinico Universitario A.Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Department of Interdisciplinary Medicine Section of Dental MedicineUniversity of Bari“Aldo Moro”Bari 70124Italy Department of Head and Neck and Sensory Organs Division of Oral Surgery and ImplantologyFondazione Policlinico Universitario A.Gemelli IRCCS—UniversitàCattolica del Sacro CuoreRoma 00168Italy Ionian Department Microbiology and Virology LaboratoryPoliclinico University HospitalUniversity of Bari“Aldo Moro”Bari 70124Italy

The severe acute respiratory syndrome-coronavirus-2(commonly known as SARS-CoV-2)is a novel coronavirus(designated as 2019-nCoV),which was isolated for the first time after the Chinese health authorities reported a cluster of pneumonia cases in Wuhan,China in December *** management of the Coronavirus Disease-2019 disease is evolving quickly and treatment guidelines,based on scientific evidence and experts’opinions with clinical experience,are constantly being *** January 30,2020,the World Health Organization declared the SARS-CoV-2 outbreak as a"Public Health Emergency of International Concern".The total lack of immune protection brought about a severe spread of the contagion all over the *** this reason,diagnostic tools,patient management and therapeutic approaches have been tested along the way,in the desperate race to break free from the widespread infection and its fatal respiratory *** medical knowledge and research on severe and critical patients’management and experimental treatments are still evolving,but several protocols on minimizing risk of infection among the general population,patients and healthcare workers have been approved and diffused by International Health Authorities.

关键词： Pandemics Viruses SARS-CoV-2/COVID-19 Sepsis Acute respiratory distress syndrome Acute respiratory distress syndrome Translational medicine Clinical microbiology Clinical biochemistry Antivirals Emergency and critical care medicine

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SARS-CoV-2 induced myocarditis:Current knowledge about its molecular and pathophysiological mechanisms

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BIOCELL 2022年第8期46卷 1779-1788页

作者： DOMENICO MARIA CARRETTA MARINA DI DOMENICO ROBERTO LOVERO ROBERTO ARRIGONI ANGELIKA ELZBIETA WEGIERSKA MARIAROSARIA BOCCELLINO ANDREA BALLINI IOANNIS ALEXANDROS CHARITOS luigi santacroce AOU Policlinico Consorziale di Bari-Ospedale Giovanni XXIII Cardiology UnitPoliclinico University Hospital of BariBari70124Italy Department of Precision Medicine University of Campania Luigi VanvitelliNaples80138Italy AOU Policlinico Consorziale di Bari-Ospedale Giovanni XXIII Clinical Pathology UnitPoliclinico University Hospital of BariBari70124Italy CNR Institute of Biomembranes Bioenergetics and Molecular Biotechnologies(IBIOM)Bari70125Italy Department Interdisciplinary of Medicine University of Bari Aldo MoroBari70124Italy School of Medicine University of Bari Aldo MoroBari70124Italy Department of Emergency and Urgency National Poisoning CentreRiuniti University Hospital of FoggiaFoggia71122Italy

The existence of an inflammatory process in the heart muscle,related to a progressive worsening of myocardial function,different etiopathogenetic mechanisms concur and often overlap,thus making the diagnosis and the therapeutic approach *** the COVID-19 pandemic progresses,the effects of the disease on the organ systems and in particular on the cardiovascular system are becoming more and more *** involvement is a well-known event with a high percentage of findings in the heart’s magnetic field,even in asymptomatic *** are numerous uncertainties regarding their evolution,in the long and short term,due not only to a difficult to determine the varied clinical expression and the rarely performed intramyocardial biopsy which additionally presents diagnostic problems but also in part to different clinical ***,the new SARS-CoV-2 virus that uses the angiotensin converting enzyme 2(ACE2)which is present at high levels in myocardial cells as its entrance it can create even severe heart *** pathophysiology in all of these cases can involve multiple immune and non-immune mechanisms within organs and vessels and can be occur in the clinical *** mechanisms of direct and indirect myocardial infarction in patients with COVID-19 include additional lesion and oxygen-rich and generalized inflammation response with myocardial immune hyperactivity(myocarditis).Therefore,these can occur through the excessive release of cytokines,the presence of thrombocytopenia,endocrine damage,heart failure,arrhythmias and *** can show average signs of myocardial damage,and some develop spontaneous cardiac complications,such as heart failure,arrhythmias and,rarely,rare cardiogenic *** in all of these may involve multiple mechanisms within the cytokine cephalic membrane,endocrine damage and *** diagnosis of this myocardial injuri is mainly based on the myocardial enzyme *** viewpoint paper

关键词： Viruses Infections SARS-CoV-2 Pandemics Myocarditis Molecular diagnosis

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Dental-derived stem cells and biowaste biomaterials:What’s next in bone regenerative medicine applications

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BIOCELL 2022年第4期46卷 923-929页

作者： MICHELE DI COSOLA STEFANIA CANTORE MARIO GIOSUÈBALZANELLI CIRO GARGIULO ISACCO KIEU CAO DIEM NGUYEN RAJIV SAINI ANNARITA MALCANGI MARGHERITA TUMEDEI MARIATERESA AMBROSINO ANTONIO MANCINI SALVATORE SCACCO RICCARDO NOCINI luigi santacroce ANDREA BALLINI EDOARDO BRAUNER Department of Clinical and Experimental Medicine Universitàdegli Studi di FoggiaFoggia71122Italy Department Interdisciplinary of Medicine University of Bari“Aldo Moro”Bari70124Italy SET-118 Department of Pre-Hospital and EmergencySG Giuseppe Moscati HospitalTaranto74010Italy Azienda Sanitaria Locale BAT Trani76125Italy Department of Medical Oral and Biotechnological SciencesUniversity of ChietiChieti66100Italy Department of Basic Medical Sciences Neuroscience and Sense OrgansUniversity of Bari“Aldo Moro”Bari70124Italy Department of Surgical Sciences DentistryGynecology and PediatricUniversity of VeronaVerona37126Italy School of Medicine University of Bari“Aldo Moro”Bari70124Italy Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples80138Italy Department of Oral and Maxillo-Facial Sciences Sapienza University of RomeRoma00161Italy

The human teeth and oral cavity harbor various populations of mesenchymal stem cells(MSCs),so called dental-derived stem cells(D-dSCs)with self-renewing and multilineage differentiation capabilities.D-dSCs properties involves a strong paracrine component resulting from the high levels of bioactive molecules they secrete in response to the local ***,this viewpoint develops a general picture of current innovative strategies to employ D-dSCs combined with biomaterials and bioactive factors for regenerative medicine purposes,and offers information regarding the available scientific data and possible applications.

关键词： Dental-derived stem cells Secretome Biomaterials Bone regenerative medicine Waste medicine

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