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Allicin neuroprotective effect during oxidative/inflammatory injury involves AT1-Hsp70-iNOS counterbalance axis

BIOCELL 2020年第4期44卷 671-681页

作者： luciana mazzei MARÍA BELÉN RUIZ-ROSO NATALIA DE LAS HERAS SANDRA BALLESTEROS CAROLINA TORRESPALAZZOLO LEÓN FERDER ALEJANDRA BEATRIZ CAMARGO WALTER MANUCHA Instituto de Medicina y Biología Experimental de Cuyo(IMBECU) Consejo Nacional de Investigaciones Científicas y Tecnológicas(CONICET)Mendoza5500Argentina Área de Farmacología Departamento de PatologíaFacultad de Ciencias MédicasUniversidad Nacional de Cuyo Centro UniversitarioMendoza5500Argentina Departamento de Fisiología Facultad de MedicinaUniversidad ComplutenseMadrid34523España IBAM Universidad Nacional de CuyoCONICETFacultad de Ciencias AgrariasMendozaM5528AHBArgentina Department of Pediatrics Nephrology DivisionMiller School of MedicineUniversity of MiamiMiami33012USA

The ancestral cultures have described many therapeutic properties of garlic,therefore,it is of central interest to elucidate the molecular basis explaining this millenary empirical knowledge.Indeed,it has been demonstrated a neuroprotective effect of allicin–a phytochemical present in garlic-linked to oxidative-inflammatory modulation.Allicin improved neuronal injury by heat shock protein 70(Hsp70)and inducible nitric oxide synthase(iNOS)regulation.Also,allicin exerts renal protection involving a possible angiotensin type 1 receptor(AT1)interaction.In connection,AT1 overexpression has been recognized as a central deleterious factor in many brain diseases.However,there are no studies that evaluate AT1-Hsp70-iNOS interaction as a mechanism linked to neuroinflammation.Thus,our central aim is to evaluate if the allicin protective effect is associated with an AT1-Hsp70-iNOS counterbalance axis.For this study,a murine microglial cell line(BV-2)was injured with lipopolysaccharides and treated or not with allicin.Then,it was evaluated cell viability,proinflammatory cytokine levels,cellular oxidative stress,iNOS,Hsp70,and AT1 protein expression(cellular and mitochondrial fractions),nitrite levels,and protein-protein interactions.The results demonstrated that allicin could prevent neuronal injury due to a reduction in oxidative stress and inflammatory status mediated by an AT1-Hsp70-iNOS counterbalance axis linked to direct protein-protein interaction.

关键词： Allicin neuroinflammation BV-2 cells AT1 receptors iNOS Hsp70

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Analysis of the fluid-bed stability of FCC catalysts at high temperature in terms of bed elasticity

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Particuology 2008年第1期6卷 30-37页

作者： Paola Lettieri Luca mazzei Department of Chemical Engineering University College London Torrington Place London WC1E 7JE UK

The effect of temperature on the fluid-bed stability of three FCC catalysts has been analyzed through considerations on fluid-bed elasticity. Experimental findings on the effect of temperature on the elasticity modulus at minimum bubbling conditions, （E）mb, were analyzed using the hydrodynamic fluid-bed stability model developed by Foscolo and Gibilaro （1984） and adopting the interparticle-forces-based stability criterion developed by Mutsers and Rietema （1977）. For both models, the parameters which control changes in （E）mb with temperature are discussed, in order to establish the origin of the fluid-bed elasticity and analyze the ability of these models to discriminate between the relative importance of the hydrodynamic and interoarticle forces on the stability of the fluidized catalysts.

关键词： Fluidization FCC catalysts High temperature Stability Bed elasticity

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Light intensity and hydrogel soil amendment differentially affect growth and photosynthesis of successional tree species

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Journal of Forestry Research 2023年第1期34卷 257-268页

作者： Léo Vieira Leonel Fabrício de Oliveira Reis Fábio Afonso mazzei Moura de Assis Figueiredo Tiago Massi Ferraz Sebastiao de Oliveira Maia Júnior Patrick Costa Silva Jailma Ribeiro de Andrade Graduate Program in Agroecology State University of MaranhaoAv.Lourenco Vieira da Silva1000Jardim Sao CristovaoSao LuísMaranhao 65055-310Brazil State University of Maranhao Av.Lourenco Vieira da Silva1000Jardim Sao CristovaoSao LuísMaranhao 65055-310Brazil Graduate Program in Agriculture and Environment State University of MaranhaoPraca Goncalves Diass/nCentroBalsasMaranhao 65800-000Brazil

Global climate changes have increased temperatures,radiation indexes,and consequently,irregularities in rainfall in mainly tropical countries,considerably hindering plant establishment in recovering degraded areas.The objective of this study was to evaluate the growth and physiological characteristics of one species of each successional group:pioneer,secondary,and climax when subjected to different light intensities and hydrogel as a soil conditioner during rainy and dry periods.The experiment was conducted in the ecotone between Brazil’s two largest biomes,the Cerrado and the Amazon in the State of Maranh?o.The parameters consisted of three species:Guazuma ulmifolia Lam.(pioneer),Astronium fraxinifolium Schott(secondary),and Cariniana rubra Gardner ex Miers(climax).There were two light intensities:70%and 100%,and two planting conditions:with and without soil conditioner(hydrogel).Gas exchanges were higher during the rainy season;the pioneer and secondary species had greater heights and photosynthetic rates in the dry period;the climax species had the lowest gas exchange and lowest recovery as rainfall resumed.The pioneer and secondary species showed higher physiological plasticity,denoting better adaption to environments with high irradiance.Hydrogel improved the photosynthetic performance of these species in the dry season and in areas with 100%sunlight.

关键词： Irradiance Hydrogel Photosynthetic efficiency Physiological plasticity

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Incidental extravascular findings in computed tomographic angiography for planning or monitoring endovascular aortic aneurysm repair: Smoker patients, increased lung cancer prevalence?

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World Journal of Radiology 2017年第7期9卷 304-311页

作者： Maria Antonietta mazzei Susanna Guerrini Francesco Gentili Giuseppe Galzerano Francesco Setacci Domenico Benevento Francesco Giuseppe mazzei Luca Volterrani Carlo Setacci Department of Medical Surgical and Neuro Sciences Diagnostic Imaging University of Siena Azienda Ospedaliera Universitaria Senese Department of Medical Surgical and Neuro Sciences Vascular and Endovascular Unit University of Siena Azienda Ospedaliera Universitaria Senese Vascular and Endovascular Unit Azienda Ospedaliera Universitaria Senese Diagnostic Imaging Azienda Ospedaliera Universitaria Senese

AIM To validate the feasibility of high resolution computed tomography(HRCT) of the lung prior to computed tomography angiography(CTA) in assessing incidental thoracic findings during endovascular aortic aneurysm repair(EVAR) planning or follow-up.METHODS We conducted a retrospective study among 181 patients(143 men, mean age 71 years, range 50-94) referred to our centre for CTA EVAR planning or followup. HRCT and CTA were performed before or after 1 or 12 mo respectively to EVAR in all patients. All HRCT examinations were reviewed by two radiologists with 15 and 8 years experience in thoracic imaging. The results were compared with histology, bronchoscopy or follow-up HRCT in 12, 8 and 82 nodules respectively. RESULTS There were a total of 102 suspected nodules in 92 HRCT examinations, with a mean of 1.79 nodules per patient and an average diameter of 9.2 mm(range 4-56 mm). Eightynine out of 181 HRCTs resulted negative for the presence of suspected nodules with a mean smoking history of 10 pack-years(p-y, range 5-18 p-y). Eighty-two out of 102(76.4%) of the nodules met criteria for computed tomography follow-up, to exclude the malignant evolution. Of the remaining 20 nodules, 10 out of 20(50%) nodules, suspected for malignancy, underwent biopsy and then surgical intervention that confirmed the neoplastic nature: 4(20%) adenocarcinomas, 4(20%) squamous cell carcinomas, 1(5%) small cell lung cancer and 1(5%) breast cancer metastasis); 8 out of 20(40%) underwent bronchoscopy(8 pneumonia) and 2 out of 20(10%) underwent biopsy with the diagnosis of sarcoidosis.CONCLUSION HRCT in EVAR planning and follow-up allows to correctly identify patients requiring additional treatments, especially in case of lung cancer.

关键词： Computed tomography angiography Aorta Endovascular aortic aneurysm repair Cigarette smoking Lung cancer

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Magnetic resonance imaging:Is there a role in clinical management for acute ischemic colitis?

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World Journal of Gastroenterology 2013年第8期19卷 1256-1263页

作者： Maria Antonietta mazzei Susanna Guerrini Nevada Cioffi Squitieri Giusi Imbriaco Raffaele Chieca Serenella Civitelli Vinno Savelli Francesco Giuseppe mazzei Luca Volterrani Department of Human Pathology and Oncology Section of Radiological SciencesUniversity of Siena53100 SienaItaly Oncologic Department UOC Gastroenterology and Digestive EndoscopyAzienda Ospedaliera Universitaria Senese53100 SienaItaly Division of Surgery Azienda Ospedaliera Universitaria SeneseUniversity of Siena53100 SienaItaly Department of Surgery and Bioengineering Section of SurgeryUniversity of Siena53100 SienaItaly Department of Diagnostic Imaging Azienda Ospedaliera Universitaria Senese53100 SienaItaly

AIM:To validate the utility of magnetic resonance imaging(MRI) for the clinical management of acute ischemic colitis(IC).METHODS:This is a magnetic resonance(MR) prospective evaluation of 7 patients who were proved to have acute IC on the basis of clinical,endoscopic and computed tomography(CT) findings and who were imaged in our institution between February 2011 and July 2012.The mean age of the patients was 72.28 years.Abdominal CTs were obtained using a 64-detector row configuration for all patients with un-enhanced and contrast-enhanced scans,in the late arterial phase(start delay 45-50 s) and in the portal venous phase(start delay 70-80 s).The MR examinations were performed using a 1.5T superconducting magnet,using Fast Imaging Employing Steady State Acquisition and T2-weighted fast-recovery fast-spin echo sequences in axial and coronal plane.CT and MRI examinations were analysed for the presence of colonic abnormalities and associated findings.RESULTS:Segmental involvement was seen in 6 patients(85.71%),with a mean length of involvement of 412 mm(range 145.5-1000 mm).Wall thickness varied between 6 mm and 17.5 mm(mean 10.52 mm) upon CT examinations and from 5 to 15 mm(mean 8.8 mm) upon MR examinations.The MRI appearance of the colonic wall varied over the time:TypeⅠappearance with a 3 layer sandwich sign was seen in 5 out of 12 examinations(41.66%),patients underwent MR within a mean of 36 h(ranging from 1 to 54 h) after the CT examination.Type Ⅱ and Ⅲ appearance with a 2 layer sign,was seen in 4 examinations(33.33%),patients underwent MR within a mean of 420.5 h(ranging from 121 to 720 h) after the CT examination.In the remaining three MRI examinations,performed within a mean of 410 h(ranging from 99.5 to 720 h) the colonic wall appeared normal.CONCLUSION:MRI,only using precontrast images,may be used as a substitute for invasive procedures in diagnosis and follow-up of acute IC.

关键词： Ischemic colitis Magnetic resonance imaging Medical management Colon Computed tomography

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The Spectrum of <i>ROBO</i>3 Mutations in Horizontal Gaze Palsy with Progressive Scoliosis: An Update

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Neuroscience & Medicine 2018年第4期9卷 187-197页

作者： Carmine Ungaro Rosalucia mazzei Sebastiano Cavallaro Teresa Sprovieri Institute of Neurological Sciences National Research Council Mangone Italy Institute for Agricultural and Forest Systems in the Mediterranean National Research Council Rende Italy

Horizontal Gaze Palsy with Progressive Scoliosis is a rare, congenital autosomal recessive disorder caused by mutations in the ROBO3 gene. It is characterized by the absence of conjugate horizontal eye movements with preserved vertical gaze, variable convergence, and progressive scoliosis, developing in childhood and adolescence. ROBO3 gene mutations are causative of the lack, or at least reduction, of crossing of the descending corticospinal and ascending lemniscal sensory tracts in the medulla. To date, 39 different mutations, including missense, nonsense, frameshift, and splice site mutations have been described in the ROBO3 gene and related to Horizontal Gaze Palsy With Progressive Scoliosis. In addition, a lot of variants of uncertain pathological significance have been reported for the first time by Illumina Clinical Services. Here we report an update on mutations of the ROBO3 gene and some information on the pathogenesis but much remains to be investigated on the consequences of mutations on ROBO3 expression and function. Therefore, further detailed functional analyses are necessary to clarify a possible role of the variants of uncertain pathological significance as the cause of the disease. In conclusion, we hope that this article will help in molecular screening for the ROBO3 gene and will contribute to enlargement of the ROBO3 gene variation database.

关键词： ROBO3 Mutations HGPPS Scoliosis

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Production and quality of eucalyptus mini-cuttings using kaolin-based particle films

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Journal of Forestry Research 2021年第3期32卷 953-965页

作者： Maria de Fátima de Castro Oliveira Diego Pereira Santos Karolline Sena Figueredo Fabrício de Oliveira Reis Tiago Massi Ferraz Heder Braun Eliemar Campostrini Fábio Afonso mazzei Moura de Assis Figueiredo Graduate Program in Agriculture and Environment Centro de Estudos Superiores de BalsasState University of MaranhaoPraca Goncalves Diass/nCentro65800-000 BalsasMABrazil Enraize-E.M.Figueredo Ind.e Com.de Produtos Florestais Br 222Km 09Lote 52Margem Esquerda S/n:Chac.Belo HorizonteZona RualAcailandiaMABrazil Centro de Ciências Agrárias State University of MaranhaoAv.Lourenco Vieira da Silva1000Jardim Sao Cristovao65055-310 Sao LuísMABrazil CCTA Northern Rio de Janeiro State UniversityAv.Alberto Lamego200028013-602 Campos dos GoytacazesRJBrazil

Considering the expansion of forest plantations over the Brazilian territory and the imminent increase in air temperatures due to global warming,the search for technologies that ensure high levels of productivity and high quality plants in clonal nurseries is essential.Applying kaolin-based particle films(KBPF)has been used as a physical barrier to reduce the negative effects of excessive solar radiation and adverse temperatures.The effects of KBPF on production and physiological quality of eucalyptus mini-cuttings were evaluated during two different seasons.A randomized block design was used,consisting of five treatments and four replications.Five concentrations(0,3%,5%,7%,and 10%)were tested here and six weekly replicates of each concentration was applied.The different kaolin concentrations and seasonal variations resulted in a quadratic response of the leaf SPAD reading during both daily evaluation periods.KBPF applications resulted in a quadratic response of photochemical efficiency in the morning period,and an increasing specific leaf weight linear response,and during the dry season,the different kaolin concentrations resulted in a bud length quadratic response.The results indicated that the kaolin application maintained the production and yield index statistically equal between weekly KBPF applications,improving photochemical efficiency,leaf thickness,SPAD reading,and bud length.The use of KBPF could reduce the intervals between collections of mini-cuttings and increase nursery yields in environments that present high temperatures.

关键词： Photoprotector Ecophysiology Forestry Clonal propagation

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Effect of applying a calcined kaolin-based particle film on the photosynthetic capacity and growth of young eucalyptus plants

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Journal of Forestry Research 2021年第6期32卷 2473-2484页

作者： Diego Pereira Santos Mauriana da Rocha Sobrinho Maria de Fatima de Castro Oliveira Niedja Bezerra Costa Tiago Massi Ferraz Fabricio de Oliveira Reis Heder Braum Eliemar Campostrini Fabio Afonso mazzei Moura de Assis Figueiredo Graduate Program in Agriculture and Environment State University of MaranhaoPraca Goncalves Diass/nCentroBalsasMA 65800-000Brazil Graduate Program in Agroecology State University of MaranhaoAv.Lourenco Vieira da Silva1000Jardim Sao CristovaoSao LuisMA 65055-310Brazil Graduate Program in Agronomy Campus SamambaiaEscola de AgronomiaFederal University of GoiasAv.Esperanca s/nGoianiaGO 74690-900Brazil State University of Maranhao Av.Lourenco Vieira da Silva1000Jardim Sao CristovaoSao LuisMA 65055-310Brazil Northern Rio de Janeiro State University Av.Alberto Lamego2000Campos dos GoytacazesRJ 28013-602Brazil

In scenarios of climatic change when increased global temperatures can be expected,it is essential to search for technologies that favor sapling survival and growth after planting and increase yield in the field.Kaolin-based particle films(KBPF)have been applied as barriers against the deleterious effects of high levels of solar radiation.The objective of the present study was to assess the effects of applying purified calcined kaolin-based particle film to young eucalyptus plants.Five treatments were carried out:0%(just water),3%,5%,7%,and 10%calcined kaolin applied to the adaxial part of the leaves.A complete randomized block design was used with five treatments and ten replicates.The plants were assessed for height,diameter at ground level,gas exchanges(net photosynthetic CO_(2) assimilation,stomatal conductance and transpiration),instantaneous(WUE)and intrinsic water use efficiency(IWUE),chlorophyll a fluorescence(maximum quantum yield of photosystem II(PSII)(Fv/Fm),concentration of active reaction centers in relation to the quantity of photons absorbed(RC/ABS)and the maximum ratio of quantum yields of photochemical and concurrent non-photochemical processes in PSII(Fv/F0),SPAD reading and leaf ontogeny.The 3%KBPF concentration showed the best responses in biometric assessments 80 days after planting(DAP)and were corroborated by the responses of the leaf,stem and shoot dry matter production as a whole.The leaf ontogeny assessments showed positive responses following KBPF application when considering leaf development,with 7%KBPF concentration resulting in the highest mean values.The mean specific leaf mass had negative response to high KBPF concentrations.At 60 DAP,the gas exchange variables during both assessment periods declined with an increase in KBPF concentration.Significant differences as a result of KBPF applications were found only at the start of the assessments(34 DAP)for both WUE and for IWUE.Leaf‘greenness’(SPAD reading)at 47 days showed a quadratic relationship in both periods.The variables of ch

关键词： Ecophysiology Photoprotection Yield Silviculture

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Presacral ganglioneuroma: A case report and review of literature

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World Journal of Gastroenterology 2007年第14期13卷 2129-2131页

作者： Guido Cerullo Daniele Marrelli Bernardino Rampone Clelia Miracco Stefano Caruso Di Martino Marianna Maria Antonietta mazzei Franco Roviello Department of Pathology and Oncology Unit of Surgical Oncology University of SienaSienaItaly Department of Pathology and Oncology University of Siena SienaItaly Department of Radiology University of Siena SienaItaly

骶骨前 ganglioneuromas 是仅仅 17 个案例在文学被报导了的那么稀罕的良性瘤。他们是慢慢地成长的腹的群众并且微分诊断不得不被考虑。因为它代表唯一的治疗学的选择，外科的切除术为权威的诊断是重要的。因为神经节瘤的良性的性质，... 详细信息

骶骨前 ganglioneuromas 是仅仅 17 个案例在文学被报导了的那么稀罕的良性瘤。他们是慢慢地成长的腹的群众并且微分诊断不得不被考虑。因为它代表唯一的治疗学的选择，外科的切除术为权威的诊断是重要的。因为神经节瘤的良性的性质，辅助化学或放射疗法没被显示，但是常规后续为潜在的本地复发的早诊断是必要的。我们与一个骶骨前神经节瘤报导一个 64 岁的人的一个案例。

关键词：骶前肿瘤星形胶质细胞瘤病例报告文献综述

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对军用交换机的新挑战——激光

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电子技术 1976年第2期 76-78页

作者： J.A.mazzei

一九三五年,德国陆军成为第一个采用电子光通信系统的军队。从那时起直至不久以前为止,由于缺少光源和元件,使具有深远影响的这种介质的开拓工作进展受到了阻力。但是,我们正处在一个激光十年探索活动的中期。对光束通信具有特殊意义的... 详细信息

一九三五年,德国陆军成为第一个采用电子光通信系统的军队。从那时起直至不久以前为止,由于缺少光源和元件,使具有深远影响的这种介质的开拓工作进展受到了阻力。但是,我们正处在一个激光十年探索活动的中期。对光束通信具有特殊意义的是能产生极高脉冲调制频率的半导体激光——一种固态激光,它由发光二极管阵、超灵敏光电探测器和新的低损耗等激励。最近,以惊人速度进行的发展工作,直接解决了很多通信问题,即使又正在出现一些新的问题。频率/波长迄今为止,以通信为背景的任何人都有过一个参考系统,它把信号的起始频率范围限制在低频(30千赫),终止范围限制在超

关键词：激光通信系统限制通信线路光电放射

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