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Heat exposure and hospitalizations for chronic kidney disease in China: a nationwide time series study in 261 major Chinese cities

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Military Medical Research 2024年第4期11卷 469-478页

作者： Fu-Lin Wang Wan-Zhou Wang Fei-Fei zhang Su-Yuan Peng Huai-Yu Wang Rui Chen Jin-Wei Wang Peng-Fei Li Yang Wang Ming-Hui Zhao Chao Yang lu-Xia zhang Institute of Medical Technology Peking University Health Science CenterBeijing 100191China National Institute of Health Data Science at Peking University Beijing 100191China Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Renal Division Department of MedicinePeking University First HospitalPeking University Institute of NephrologyBeijing 100034China Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases Chinese Academy of Medical SciencesBeijing 100034China Advanced Institute of Information Technology Peking UniversityHangzhou 311215China National Climate Center China Meteorological AdministrationBeijing 100081China Peking-Tsinghua Center for Life Sciences Beijing 100034China

Background:Climate change profoundly shapes the population health at the global ***,there was still insufficient and inconsistent evidence for the association between heat exposure and chronic kidney disease(CKD).Methods:In the present study,we studied the association of heat exposure with hospitalizations for cause-specific CKD using a national inpatient database in China during the study period of hot season from 2015 to *** time-series regression models and random-effects Meta-analysis were developed to estimate the city-specific and national averaged associations at a 7 lag-day span,***:A total of 768,129 hospitalizations for CKD was recorded during the study *** results showed that higher temperature was associated with elevated risk of hospitalizations for CKD,especially in sub-tropical *** a 1℃ increase in daily mean temperature,the cumulative relative risks(RR)over lag 0-7 d were 1.008[95% confidence interval(CI)1.003-1.012]for *** attributable fraction of CKD hospitalizations due to high temperatures was 5.50%.Stronger associations were observed among younger patients and those with obstructive *** study also found that exposure to heatwaves was associated with added risk of hospitalizations for CKD compared to non-heatwave days(RR=1.116,95%CI 1.069-1.166)above the effect of daily mean ***:Short-term heat exposure may increase the risk of hospitalization for *** findings provide insights into the health effects of climate change and suggest the necessity of guided protection strategies against the adverse effects of high temperatures.

关键词： Chronic kidney disease Hospitalization Climate change Temperature Time-series study

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Growth and Interactions of Multi-Source Perturbations in Convection-Allowing Ensemble Forecasts

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Journal of Tropical Meteorology 2024年第2期30卷 118-131页

作者：张璐闵锦忠庄潇然王世璋魏莉青 Key Laboratory of Meteorological Disaster of Ministry of Education/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044 China Jiangsu Meteorological Observatory Jiangsu Meteorological ServiceNanjing 210008 China Nanjing Joint Institute for Atmospheric Sciences Nanjing 210000 China

This study investigated the growth of forecast errors stemming from initial conditions(ICs),lateral boundary conditions(LBCs),and model(MO)perturbations,as well as their interactions,by conducting seven 36 h convectionallowing ensemble forecast(CAEF)*** cases,one with strong-forcing(SF)and the other with weak-forcing(WF),occurred over the Yangtze-Huai River basin(YHRB)in East China,were selected to examine the sources of uncertainties associated with perturbation growth under varying forcing backgrounds and the influence of these backgrounds on *** perturbations exhibited distinct characteristics in terms of temporal evolution,spatial propagation,and vertical distribution under different forcing backgrounds,indicating a dependence between perturbation growth and forcing background.A comparison of the perturbation growth in different precipitation areas revealed that IC and LBC perturbations were significantly influenced by the location of precipitation in the SF case,while MO perturbations were more responsive to convection triggering and dominated in the WF *** vertical distribution of perturbations showed that the sources of uncertainties and the performance of perturbations varied between SF and WF cases,with LBC perturbations displaying notable case ***,the interactions between perturbations were considered by exploring the added values of different source *** the SF case,the added values of IC,LBC,and MO perturbations were reflected in different forecast periods and different source uncertainties,suggesting that the combination of multi-source perturbations can yield positive *** the WF case,MO perturbations provided a more accurate estimation of uncertainties downstream of the Dabie Mountain and need to be prioritized in the research on perturbation development.

关键词： convection-allowing ensemble forecast forcing background perturbation growth interactions added value

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3875-3886页

作者： lu zhang Yan-Ping Chen Min Ji Le-Qian Ying Chun-Chun Huang Jing-Yi Zhou Lin Liu Department of Oncology Zhongda HospitalMedical School of Southeast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND Inflammation-related markers including neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),monocyte-to-lymphocyte ratio(MLR),systemic immune-inflammation index(SII),systemic inflammation response index(SIRI)and prognostic nutritional index(PNI)could reflect tumor immune microenvironment and predict prognosis of ***,it had not been explored in alpha-fetoprotein(AFP)producing gastric cancer(GC).AIM To determine the predictive value of inflammation-related peripheral blood markers including as NLR,PLR,MLR,SII,SIRI and PNI in the prognosis of AFPproducing GC(AFPGC).Besides,this study would also compare the differences in tumor immune microenvironment,clinical characteristics and prognosis between AFPGC and AFP-GC patients to improve the understanding of this *** 573 patients enrolled were retrospectively *** were divided into AFP+group(AFP≥20 ng/mL)and AFP-group(AFP<20 ng/mL),comparing the levels of NLR/PLR/MLR/SII/SIRI/PNI and *** AFP+group,the impact of NLR/PLR/MLR/SII/SIRI/PNI and their dynamic changes on prognosis were further *** Compared with AFP-patients,AFP+patients had higher NLR/PLR/MLR/SII/-SIRI and lower PNI levels and poorer overall survival(OS).In the AFP+group,mortality was significantly lower in the lower NLR/PLR/MLR/SII/SIRI group and higher PNI ***,the dynamic increase(NLR/PLR/MLR/SII/-SIRI)or decrease(PNI)was associated with the rise of mortality within 1 year of *** Compared with AFP-patients,the level of inflammation-related peripheral blood markers significantly increased in AFP+patients,which was correlated with OS of AFP+***,the gradual increase of SII and SIRI was associated with the risk of death within one year in AFP+*** should be considered as a separate type and distinguished from AFP-GC because of the difference in tumor immune *** requires basic experiments and large clinical samples in the f

关键词： Alpha-fetoprotein producing gastric cancer Inflammatory indicator Prognosis Dynamic changes Tumor immune microenvironment

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Association of Cytokines with Clinical Indicators in Patients with Drug-Induced Liver Injury

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Biomedical and Environmental Sciences 2024年第5期37卷 494-502页

作者： CAO Wei Hua JIANG Ting Ting SHEN Ge DENG Wen WANG Shi Yu zhang Zi Yu LI Xin Xin lu Yao zhang lu LIU Ru Yu CHANG Min WU Shu Ling GAO Yuan Jiao HAO Hong Xiao CHEN Xiao Xue HU Lei Ping XU Meng Jiao YI Wei XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective To explore characteristics of clinical parameters and cytokines in patients with drug-induced liver injury(DILI)caused by different drugs and their correlation with clinical *** The study was conducted on patients who were up to Review of Uncertainties in Confidence Assessment for Medical Tests(RUCAM)scoring criteria and clinically diagnosed with *** on Chinese herbal medicine,cardiovascular drugs,non-steroidal anti-inflammatory drugs(NSAIDs),antiinfective drugs,and other drugs,patients were divided into five *** were measured by luminex *** characteristics of clinical biochemical indicators and cytokines in DILI patients and their correlation were *** 73 patients were *** among five groups was statistically different(P=0.032).Alanine aminotransferase(ALT)(P=0.033)and aspartate aminotransferase(AST)(P=0.007)in NSAIDs group were higher than those in chinese herbal medicine ***-6(IL-6)and tumor necrosis factor alpha(TNF-α)in patients with Chinese herbal medicine(IL-6:P<0.001;TNF-α:P<0.001)and cardiovascular medicine(IL-6:P=0.020;TNF-α:P=0.001)were lower than those in NSAIDs *** was a positive correlation between ALT(r=0.697,P=0.025),AST(r=0.721,P=0.019),and IL-6 in NSAIDs *** Older age may be more prone to *** with NSAIDs have more severe liver damage in early stages of DILI,TNF-αand IL-6 may partake the inflammatory process of DILI.

关键词： Drug-induced liver injury Cytokines Non-steroidal anti-inflammatory drugs Inflammation

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平台管理内容可见性的权力及其规制

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国家检察官学院学报 2024年第3期32卷 100-117页

作者：张璐中国政法大学光明新闻传播学院

数字时代,平台势力日益强大的同时也更容易引发权力滥用和失范风险,对平台自我治理的治理是基于平台自治权产生的一个新命题。除传统的封禁账号、删除内容外,在算法等技术的加持下,平台内容审查还体现为通过“引流”或“限流”等手段影... 详细信息

数字时代,平台势力日益强大的同时也更容易引发权力滥用和失范风险,对平台自我治理的治理是基于平台自治权产生的一个新命题。除传统的封禁账号、删除内容外,在算法等技术的加持下,平台内容审查还体现为通过“引流”或“限流”等手段影响在线信息内容“被看见”的机会和范围。平台管理内容可见性日益成为平台内容审查的重要形式,虽然利用平台进行内容可见性管理有助于降低监管成本、提高监管效率,但是在私利性的驱动下,平台过分追逐商业利益而未兼顾公平、侵蚀用户权利的风险已经凸显。因而需要确定平台管理内容可见性权力行使的正当程序,建立区隔公私法审查义务的内容标准,保障用户发布内容“被看见”权利的实现,以此对平台管理内容可见性权力进行有效规制,促进数字时代社会整体福祉的提升。

关键词：私权力平台治理内容审查可见性隐形禁止

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丝路开通初期木鹿的城市发展与功能演变

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西域研究 2024年第3期 13-28,170页

作者：张录南开大学历史学院

古代木鹿是希腊化世界东部规模最为宏大的城市之一。丝路开通前,木鹿就在印度、中亚与地中海世界的商贸往来中发挥了一定的作用,只是其商业属性始终附着于政治强力的推动,贸易的形式单一,规模较小。随着丝绸之路的开拓,木鹿因其特殊的... 详细信息

古代木鹿是希腊化世界东部规模最为宏大的城市之一。丝路开通前,木鹿就在印度、中亚与地中海世界的商贸往来中发挥了一定的作用,只是其商业属性始终附着于政治强力的推动,贸易的形式单一,规模较小。随着丝绸之路的开拓,木鹿因其特殊的地理位置、绿洲农业以及手工业生产,成为东西方主要交通网络的交会点,直接促进了其城市发展形态的调整,逐渐完成了从早期的希腊化城市向丝路枢纽城市的转型。在这一转变过程中,木鹿不仅出现了相对独立的本土王朝,还成为基督教、犹太教、摩尼教和佛教等外来宗教汇聚之地,从而在某种程度上重塑了中亚的政治格局与木鹿的文化景观,进一步促使木鹿的城市功能逐渐由此前的行政与军事要地,向更加多元化的方向转变。

关键词：希腊化马尔吉亚纳木鹿城市史丝绸之路

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《能源法》绿化的理论阐释与制度表达

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政法论丛 2024年第2期 112-123页

作者：张璐华东政法大学经济法学院上海200042

法律体系在整体上的绿化转型,已经成为我国生态文明新时代立法发展完善的明确趋势,《能源法》的绿化也势在必行。《能源法》的绿化不仅体现为时代发展的外部需要,更是一种内生的制度需求。《能源法》的绿化应坚持异质思维、协同思维和... 详细信息

法律体系在整体上的绿化转型,已经成为我国生态文明新时代立法发展完善的明确趋势,《能源法》的绿化也势在必行。《能源法》的绿化不仅体现为时代发展的外部需要,更是一种内生的制度需求。《能源法》的绿化应坚持异质思维、协同思维和系统思维,异质思维主要解决《能源法》绿化的基本定位问题,协同思维主要体现《能源法》的目标取向问题,系统思维主要明确《能源法》绿化的立法表达问题。《能源法》绿化的系统表达,应体现在多元立法目的并进、结构性制度优化以及衔接性规范设计等不同立法层次。

关键词：《能源法》绿化立法目的制度结构衔接性规范

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Effect of ellagitannin metabolites ellagic acid and urolithins A-D on the non-enzymatic glycation of human serum albumin and inhibiting mechanisms

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Food Science and Human Wellness 2024年

作者： lu zhang Chun-yan Peng Wen-na Zhou Fei-yan lu Lin-ju Xu Qing-hui Wen Xing Xie Zong-cai Tu National R&D Center of Freshwater Fish Processing， College of Life Science， Jiangxi Normal University State Key Laboratory of Food Science and Resources， Nanchang University

Effect of ellagitannins gut microbiota metabolites ellagic acid (EA) and urolithin A-urolithin D (UroA-UroD) on human serum albumin (HSA) glycation were firstly evaluated in this research. The inhibition mechanisms were investigated by methylglyoxal (MGO) trapping and radical scavenging ability assays， docking studies and Nano LC-Orbitrap-MS/MS technology. Results indicated that the inhibition of urolithins on HSA glycation was highly positive correlated with the number of phenolic hydroxy groups. Addition of UroD and EA could effectively enhance the content of free amino group， suppress dicarbonyl compounds and advanced glycation end-products (AGEs) formation， alleviated tryptophan and protein oxidation， inhibited HSA amyloid-like aggregation. They could also trap MGO and scavenge DPPH· and ABTS·+. Molecular docking indicated that EA and UroA-UroD interact with HSA mainly through hydrogen bound and hydrophobic interaction， among which two or three hydrogen bonds were formed. The number of glycation sites were reduced from 11 to 10， 10， 7， and 10， respectively， when 90 μmol/L of EA， UroA， UroC and UroD were added. However， weak inhibition was observed on UroA and UroB. These findings can provide scientific evidence for the application of ellagitannins-rich foods in alleviating diabetic complications.

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信用数据权利配置基础理论与规范构造研究

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首都师范大学学报（社会科学版） 2024年第2期 194-208页

作者：张路湘潭大学信用风险管理学院

《关于构建数据基础制度更好发挥数据要素作用的意见》(以下简称“数据二十条”)提出了数据“三权分置”的构想。信用数据同样属于数据范畴,信用数据权利配置过程中存在相关概念、类型、权利主体、利益结构、权利属性等基础理论与规范... 详细信息

《关于构建数据基础制度更好发挥数据要素作用的意见》(以下简称“数据二十条”)提出了数据“三权分置”的构想。信用数据同样属于数据范畴,信用数据权利配置过程中存在相关概念、类型、权利主体、利益结构、权利属性等基础理论与规范构造的问题。信用数据是指与特定自然人、法人、非法人组织相关,可以用以识别、分析、判断其法定义务或约定义务履行状态的数据。依据“数据二十条”提出的标准,可以将信用数据分为个人信用数据、企业信用数据、公共信用数据。个人信用数据权利的权利主体是自然人,且在条文表述中不应以“完全民事行为能力”作为限制。个人信用数据权利的利益包含人格精神利益、人格财产利益、社会公共利益。人格精神利益归属于自然人,人格财产利益可采用“一般+特殊”的识别方式确定归属,社会公共利益则归属于国家。个人信用数据权利是兼私益性与公益性、宪法基本权利与私法性质的新型人格权。信用数据“三权”的权利主体是处理者,其中的企业、公共管理机构应作为关注重点。信用数据“三权”的利益包含财产利益与社会公共利益。财产利益归属于处理者,社会公共利益包含了社会管理利益、国家经济发展利益、国家安全利益、国民敏感信息与企业商业秘密安全利益,应归属于国家。赋权强化了处理者信用数据的保护范围,并不会妨碍数据的融通。结合信用数据“三权”私益性与公益性,可将其定位为新型的财产权。

关键词：信用数据个人信用数据权利数据“三权”

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改进鲸鱼优化算法的壁面红外反射特性求解

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中国光学（中英文） 2024年第3期17卷 595-604页

作者：张潞樊金浩鲁宇轩张磊傅莉沈阳航空航天大学辽宁沈阳110136 沈阳飞机设计研究所辽宁沈阳110136

壁面的红外反射特性由双向反射分布函数(BRDF)表征和求解。目前BRDF测量需要大量实验数据,同时存在精度不高的问题。通过构建壁面反射特性测试平台,使用MR170型傅立叶红外光谱辐射计获取2~15μm波段下入射角度和各个反射角度的目标辐射... 详细信息

壁面的红外反射特性由双向反射分布函数(BRDF)表征和求解。目前BRDF测量需要大量实验数据,同时存在精度不高的问题。通过构建壁面反射特性测试平台,使用MR170型傅立叶红外光谱辐射计获取2~15μm波段下入射角度和各个反射角度的目标辐射亮度。针对隐身目标,应用RBF网络对3~5μm以及8~14μm波段的辐射亮度曲线进行拟合,排除大气干扰,进而求解出上述两个波段隐身目标的BRDF值。为了解决BRDF模型精度不高的问题,提出了改进的鲸鱼优化算法(IWOA),对BRDF模型参数进行反演,并设计了基于BRDF的反射率求解方法。IWOA对BRDF计算模型参数反演有良好的效果。根据反射法,应用所得到的BRDF数据求解得到的反射率为0.5496,相对误差为6.17%,满足工程需求。

关键词：双向反射分布函数(BRDF) 鲸鱼优化算法辐射亮度参数反演

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