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基于HGA优化RBF网络的污水总氮软测量

计算机仿真 2008年第7期25卷 137-140,183页

作者：梁倩吕勇哉上海交通大学自动化系上海200240

污水处理系统是一个包含海量信息的非线性复杂系统。目的是对某污水处理厂生物脱氮系统的出水总氮(TN)进行软测量建模。先用主元分析方法实现输入变量的降维和去相关,简化径向基函数(RBF)网络的输入。再应用递阶遗传算法(HGA)确定合理的... 详细信息

污水处理系统是一个包含海量信息的非线性复杂系统。目的是对某污水处理厂生物脱氮系统的出水总氮(TN)进行软测量建模。先用主元分析方法实现输入变量的降维和去相关,简化径向基函数(RBF)网络的输入。再应用递阶遗传算法(HGA)确定合理的RBF网络隐层节点数、基函数宽度和中心。能够同时优化网络参数和拓扑结构,在全局范围内寻找RBF参数的最优解,实现了RBF网络的自适应优化。应用该模型对出水总氮软测量进行仿真,结果表明了该网络模型的可靠和有效,说明该软测量模型具有工业应用价值和意义。

关键词：主元分析径向基函数网络递阶遗传算法污水处理

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin lu Jianzhong Hu yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

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基于成本的车间调度模型及遗传算法求解

控制工程 2007年第B05期14卷 70-72,213页

作者：蒋丽雯吕勇哉陈玉旺上海交通大学自动化系上海200240

制造企业的成本优化,无论在学术界还是工业界,始终是一个热点研究课题。从成本优化思想出发,建立了基于成本的多产品切换作业车间调度问题的经济指标模型,并应用具有新型交叉、变异算子的遗传算法作为求解该调度问题的方法,其目的是使... 详细信息

制造企业的成本优化,无论在学术界还是工业界,始终是一个热点研究课题。从成本优化思想出发,建立了基于成本的多产品切换作业车间调度问题的经济指标模型,并应用具有新型交叉、变异算子的遗传算法作为求解该调度问题的方法,其目的是使企业的综合生产成本(主要包括多产品切换成本、产品作为在制品的存储成本以及产品拖期惩罚等)最低。仿真实例的运行结果表明了该调度模型和优化算法的有效性,且适用于过程工业及离散工业的生产调度系统,实现生产调度和经济效益的有效集成。

关键词：车间作业调度遗传算法优化成本模型

Memetic algorithms-based neural network learning for basic oxygen furnace endpoint prediction

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第11期11卷 841-848页

作者： Peng CHEN yong-zai lu Department of Automation Shanghai Jiao Tong University Shanghai 200240 China Department of Automation Zhejiang University Hangzhou 310027 China

Based on the critical position of the endpoint quality prediction for basic oxygen furnaces （BOFs） in steelmaking, and the latest results in computational intelligence （C1）, this paper deals with the development of a novel memetic algorithm （MA） for neural network （NN） lcarnmg. Included in this is the integration of extremal optimization （EO） and Levenberg-Marquardt （LM） pradicnt search, and its application in BOF endpoint quality prediction. The fundamental analysis reveals that the proposed EO-LM algorithm may provide superior performance in generalization, computation efficiency, and avoid local minima, compared to traditional NN learning methods. Experimental results with production-scale BOF data show that the proposed method can effectively improve the NN model for BOF endpoint quality prediction.

关键词： Memetic algorithm (MA) Neural network (NN) learning Back propagation (BP) Extremal optimization (EO) gevenberg-Marquardt (LM) gradient search Basic oxygen furnace (BOF)

Extremal optimization for optimizing kernel function and its parameters in support vector regression

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第4期12卷 297-306页

作者： Peng CHEN yong-zai lu Department of Automation Shanghai Jiao Tong University Shanghai 200240 China Department of Automation Zhejiang University Hangzhou 310027 China

The performance of the support vector regression (SVR) model is sensitive to the kernel type and its *** determination of an appropriate kernel type and the associated parameters for SVR is a challenging research topic in the field of support vector *** this study,we present a novel method for simultaneous optimization of the SVR kernel function and its parameters,formulated as a mixed integer optimization problem and solved using the recently proposed heuristic 'extremal optimization (EO)'.We present the problem formulation for the optimization of the SVR kernel and parameters,the EO-SVR algorithm,and experimental tests with five benchmark regression *** results of comparison with other traditional approaches show that the proposed EO-SVR method provides better generalization performance by successfully identifying the optimal SVR kernel function and its parameters.

关键词： Support vector regression (SVR) Extremal optimization (EO) Parameter optimization Kernel function optimization

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Cloning and sequence analysis of nine novel MYB genes in Taxodiaceae plants

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Journal of Forestry Research 2014年第4期25卷 795-804页

作者： yong-quan lu Qing JIA zai-kang TONG The Nurturing Station for the State Key Laboratory of Subtropical Silviculture Zhejiang Agriculture and Forestry University

Myeloblastosis （MYB） is one of the largest transcribed factor families in plants. To gain an overall picture of the evolution of MYB genes in relict plants, we cloned nine novel MYB genes in Taxodiaceae plants （ Taxodium distichum, Taxodium ascendens, Cryptomeria japonica var. Sinensis, Cryptomeria japonica cv. Araucarioides, Cryptomer Ja- ponica, Metasequoia glyptostroboides, Cunninghamia lanceolata, Tai- wania cryptomerioides and Glyptostrobus pensilis）. The deduced amino acid sequences for MYBs showed that the nine MYB proteins contained two DNA binding domains. The first domain is from amino acid position 29 to 78, wherein three tryptophanes at 33, 53 and 73 were separated by 19 amino acids, respectively. The second domain is from amino acid position 82 to 127, wherein three tryptophanes at 86, 105 and 124 were separated by 18 amino acids, respectively, whereas the first tryptophane at amino acid position 86 is replaced by a phenylalanine. The characteri- zation of these conserved domains at nine MYBs indicated that they all belong to the R2R3-MYB group. The secondary structure analysis showed that a-helix and 13-turn are the major motifs of the predicted secondary structure of MYBs. The three dimensional model of each MYB protein showed that the structure is like clip, making it more flexi- ble and mobile. The similarities between the nine MYB proteins in Taxodiaceae were calculated. The highest identical value of 99% is be- tween CjsMYB, CjMYB and CjaMYB, whereas the lowest value of 82% is between TaMYB and C1MYB. According to the phylogenetic tree, the distances between different genera were relatively large whereas those within genera were relatively small. As expected, accessions of the same genus formed a subgroup before being grouped with other genera.

关键词： Myeloblastosis Taxodiaceae clone analysis R2R3-MYB group

Development of amplified consensus genetic markers in Taxodiaceae based on Cryptomeria japonica ESTs data

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Journal of Forestry Research 2013年第3期24卷 503-508页

作者： lu yong-quan JIA Qing TONG zai-kang The Nurturing Station for the State Key Laboratory of Subtropical Silviculture Zhejiang Agriculture and Forestry University

Amplified consensus genetic marker （ACGM） is a PCR-based marker technique that uses primers designed within conserved regions of coding sequences. After a comparison of Cryptomeria japonica and Arabidopsis ESTs to search for conserved sequences, 237 single e-PCR products were obtained. We randomly selected 110 candidate ACGM markers to test. Of the 110 candidate ACGM markers tested, 106 yielded stable and clear PCR products in C. japonica. We then tested the utility of these 106 primer pairs in 10 species, representing 7 genera of Taxodi- aceae. The number of specific amplification primer pairs among those 10 species varied from 49 to 103 （or 46.2±97.2%）. The 106 primer pairs （ACGM loci） were high transferable to Cryptomeria fortunei Hooibrenk （97.2%） but were low in Metasequoia glyptostroboides （46.2%）. The number of PCR bands per primer pair ranged from 1.06 to 1.15, which means that most of the ACGM primers can obtain a single band within these 10 Taxodiaceae species. In summary, our study shows that ACGM is a technique applicable for marker development even in species with limited sequence data.

关键词： ACGM Taxodiaceae Cryptomeriajaponica EST database

Periodic Solutions for a Class of n-dimensional Prescribed Mean Curvature Equations

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Acta Mathematicae Applicatae Sinica 2020年第2期36卷 516-526页

作者： zai-tao LIANG Shi-ping lu School of Mathematics and Big Data Anhui University of Science and TechnologyHuainan 232001China College of Mathematics and Statistics Nanjing University of Information Science&TechnologyNanjing 210044China

In this paper,by using an extension of Mawhin’s continuation theorem and some analysis methods,we study the existence of periodic solutions for the following prescribed mean curvature system d/dtφ(x')+▽W(x)=p(t), w... 详细信息

关键词： periodic solutions Mawhin’s continuation theorem prescribed mean curvature equations