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Complications of the locking plate for displaced proximal humeral fractures

Chinese Medical Journal 2010年第19期123卷 2671-2675页

作者： lu yi wang man-yi zhu yi-ming jiang chun-yan Shoulder and Elbow Service Department of Sports Medicine Jishuitan Hospital 4th Clinical Hospital of Peking University Beijing 100035 China

Background Although the locking plate has become popular for treating displaced proximal humeral fractures in recent years, the complications of this method are still underestimated. We tried to evaluate the factors that have an influence on the complications experienced after proximal humeral fractures fixed by locking plates and compare the results from patients having complications with those having no complications. Methods From September 2004 to September 2007, 92 out of 111 displaced proximal humeral fractures treated by open reduction and internal fixation with a locking plate were available for follow-up, with an average time of 15.2 months （12-36 months）. The range of motion, Visual Analog Score （VAS） for pain, American Shoulder and Elbow Surgeons＇ Form （ASES）, Constant-Murley, University of California-Los Angles scoring system （UCLA） score, and Simple Shoulder Test （SST） for function evaluation was all recorded at the latest follow-up. The results from patients with complications were evaluated according to the indices listed above and compared with those patients without any complications. Results There were 17 patients with complications, an 18.5% complication rate. Among them, the forward flexion, external rotation and internal rotation were 139.1°±24.3°, 24.1°±19.6°, and up to T10 level on average. The mean VAS score was 1.0±1.1, the ASES score was 82.9±13.8, the Constant 82.1±11.8, the UCLA 28.5±4.1 and the mean SST 9.5 on average. There was no significant difference of complication rate among different age, sex, and injured side, fresh or delayed fracture, combined with other injury or not groups. Compared with the group without complications, patients with complications showed significantly less external rotation and lower Constant-Murley and UCLA functional scores （P 〈0.05）. A significant difference in results was seen between patients with complications and those without complications. Conclusion The indication control and appropriate surgical tec

关键词： proximal humeral fractures locking plate complication

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TRIANGLE operation,combined with adequate adjuvant chemotherapy,can improve the prognosis of pancreatic head cancer:A retrospective study

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1773-1786页

作者： Jia-Hao Chen Li-Yong zhu Zhi-Wei Cai Xiao Hu Abousalam Abdoulkader Ahmed Jie-Qiong Ge Xiao-yan Tang chun-Jing Li Yun-Long Pu Chong-yi jiang Department of Hepato-Biliary-Pancreatic Surgery Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Shanghai Key Laboratory of Clinical Geriatric Medicine Fudan UniversityShanghai 200040China Department of Nursing Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China

BACKGROUND The TRIANGLE operation involves the removal of all tissues within the triangle bounded by the portal vein-superior mesenteric vein,celiac axis-common hepatic artery,and superior mesenteric artery to improve patient *** previously promising in patients with locally advanced pancreatic ductal adenocarcinoma(PDAC),data are limited regarding the long-term oncological outcomes of the TRIANGLE operation among resectable PDAC patients undergoing pancreaticoduodenectomy(PD).AIM To evaluate the safety of the TRIANGLE operation during PD and the prognosis in patients with resectable *** This retrospective cohort study included patients who underwent PD for pancreatic head cancer between January 2017 and April 2023,with or without the TRIANGLE *** were divided into the PD_(TRIANGLE)and PD_(non-TRIANGLE)*** and survival outcomes were compared between the two *** adjuvant chemotherapy was defined as adjuvant chemotherapy≥6 *** The PD_(TRIANGLE)and PD_(non-TRIANGLE) groups included 52 and 55 patients,*** were no significant differences in the baseline characteristics or perioperative indexes between the two ***,the recurrence rate was lower in the PD_(TRIANGLE) group than in the PD_(non-TRIANGLE) group(48.1%vs 81.8%,P<0.001),and the local recurrence rate of PDAC decreased from 37.8%to 16.0%.Multivariate Cox regression analysis revealed that PD_(TRIANGLE)(HR=0.424;95%CI:0.256-0.702;P=0.001),adequate adjuvant chemotherapy≥6 months(HR=0.370;95%CI:0.222-0.618;P<0.001)and margin status(HR=2.255;95%CI:1.252-4.064;P=0.007)were found to be independent factors for the recurrence *** The TRIANGLE operation is safe for PDAC patients undergoing ***,it reduces the local recurrence rate of PDAC and may improve survival in patients who receive adequate adjuvant chemotherapy.

关键词： TRIANGLE operation Pancreatic ductal adenocarcinoma Heidelberg triangle Adjuvant chemotherapy Prognosis Pancreaticoduodenectomy

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Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

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Science China(Life Sciences) 2024年第7期67卷 1502-1513页

作者： luo-Yuan Xia Xue-Feng wang Xiao-ming Cui yi-ming Zhang Zhen-Fei wang En-Tao Li Chang-Fa Fan Ke Song Yuan-Guo Li Run-Ze Ye Fang-Xu Li Dai-Yun zhu Jie Zhang zhuang-zhuang Shi ming-zhu Zhang Liang-Jing Li Shi-Jing Shen Song Jin Ya-Wei Zhang Wei-Guang Fu Lin Zhao Wen-Hao wang Tie-Cheng wang You-chun wang Jia-Fu jiang yan-Ling Hu Na Jia Yu-Wei Gao Wu-chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China Life Sciences Institute Guangxi Medical UniversityNanning 530020China College of Life Sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

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Evolution of hydrocarbon generation of Jurassic source rock of the Lenke-1 well in Lenghu tectonic belt of Qaidam basin,China

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Mining Science and Technology 2009年第2期19卷 235-240页

作者： zhu yan-ming ZHANG ming jiang Bo PEN De-hua yi Cheng-min ZENG chun-lin WU ying School of Resource and Geoscience China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China Qinghai Oilfield Company PetroChina Dunhuang Gansu 736202 China

The Lenghu tectonic belt is located at or near the northern margin in the Qaidam Basin,which is an intracontinental composite basin evolved during the Mesozoic and Cenozoic *** Lower Jurassic is considered a good source rock with a wide *** the deposit of the Lower Jurassic hydrocarbon source rock,the basin has undergone many tectonic events of subsidence and *** source rocks in the Lengke-1 well,have experienced a complicated tectonic-burial history during which different hydrocarbon generation(HG) evolutions have taken *** have investigated the history of burying,heating and hydrocarbon generation of the Lower Jurassic source rocks,not just on the basis of tectonic disturbance and deep burial,but also from new studies in fluid inclusion measurements and the application of numerical simulation with EASY%*** study reveals the evolution process,tectonic episodes and the strength of the HG of the Jurassic source *** conclude that twice HG processes have taken place since the Lower Jurassic formation and infer from that the important conclusion that more HG of the Lower Jurassic source rock took place during the Eocene-Miocene ***,we discuss the oil and gas tarp formation and destruction in the Lenghu tectonic belt and point out that more attention should be paid to the thrust faults,which formed during the late Himalayan epoch.

关键词： Lower Jurassic source rocks hydrocarbon generation EASY%Ro numerical simulation Lenghu tectonic belt

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应用肱骨近端锁定钢板治疗肱骨近端骨折的临床结果分析

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中华外科杂志 2007年第20期45卷 1375-1378页

作者：鲁谊姜春岩朱以明王满宜北京积水潭医院运动损伤科 100035

目的探讨应用肱骨近端锁定钢板(LPHP)治疗肱骨近端骨折的临床效果和适应证选择。方法 2004年9月至2006年3月收治的84例肱骨近端骨折患者中75例患者获得随访,平均随访时间17个月(12～30个月)。新鲜骨折60例,陈旧骨折15例,均行切开复位 LP... 详细信息

目的探讨应用肱骨近端锁定钢板(LPHP)治疗肱骨近端骨折的临床效果和适应证选择。方法 2004年9月至2006年3月收治的84例肱骨近端骨折患者中75例患者获得随访,平均随访时间17个月(12～30个月)。新鲜骨折60例,陈旧骨折15例,均行切开复位 LPHP 内固定。应用美国肩肘外科医师评分(ASES)、Constant-Murley 评分、UCLA 评分系统以及简易肩关节测验(SST)问卷评估治疗结果,观察肩关节活动范围,肌力、疼痛情况,并对比新鲜骨折与陈旧骨折的治疗效果。结果 75例患者肩关节活动范围平均为前屈上举(147.3±17.7)°,外旋(30.5±16.2)°,内旋达T_9水平。ASES 平均为86.7±12.7;Constant-Murley 评分为87.4±10.5;UCLA 评分系统为30.1±4.2,总体优良率为89.3%。与新鲜骨折相比,陈旧骨折患者前屈上举的范围和 ASES 评分存在明显差异(均为P<0.05)。在9例出现晚期并发症的患者中 ASES、UCLA、Constant-Murley 评分与无并发症的患者相比均存在明显差异(P<0.05)。结论正确选择手术指征和掌握操作技术,应用肱骨近端锁定钢板治疗存在明显移位的肱骨近端骨折可以获得较为满意的临床结果。

关键词：肩骨折内固定器切开复位肱骨近端锁定钢板

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应用肱骨近端锁定型髓内针治疗肱骨近端骨折的临床疗效分析

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中华外科杂志 2007年第20期45卷 1385-1388页

作者：朱以明姜春岩鲁谊王满宜北京积水潭医院运动损伤科 100035

目的探讨应用肱骨近端髓内针治疗肱骨近端两部分外科颈骨折的疗效。方法回顾性分析22例应用锁定型肱骨近端髓内针治疗两部分外科颈新鲜骨折患者的临床资料,患者平均年龄57岁。最终随访时拍摄肩关节 x 线片以评价愈合情况,并应用可视模... 详细信息

目的探讨应用肱骨近端髓内针治疗肱骨近端两部分外科颈骨折的疗效。方法回顾性分析22例应用锁定型肱骨近端髓内针治疗两部分外科颈新鲜骨折患者的临床资料,患者平均年龄57岁。最终随访时拍摄肩关节 x 线片以评价愈合情况,并应用可视模拟评分法(VAS)评分,美国肩肘外科医师评分(ASES),Constant-Murley 评分,UCLA 评分以及简易肩关节测验(SST)问卷评估。结果所有患者均获随访,平均随访时间为13个月,22例患者骨折均在术后8周内初步愈合。随访过程中未出现感染、肱骨头坏死以及任何与内固定物有关的并发症。术后患肢主动前屈上举平均为147.8°,主动体侧外旋平均为45.5°,主动内旋平均达T10水平。术后患者疼痛 VAS 评分平均为1.5。平均 ASES 评分为81.2,Constant-Murley 评分为85.4,UCLA 评分为29.9,SST 评分为9.5。18例患者的肩关节功能评估为优或良,4例患者肩关节功能评估为差。结论闭合复位、锁定型肱骨近端髓内针固定术是治疗肱骨近端两部分外科颈骨折的一种有效的手术方式。

关键词：肩骨折骨折固定术,髓内肱骨近端髓内针

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Effectiveness and the nomogram of small incision lenticule extraction in the correction of myopic anisometropia in adults

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1838-1844页

作者： Tong Zhang lu zhu Hang-Jia Zuo Zhi-Jun Chen yan Ji Xin yang Xiao-Rong lu Qiong Wu Qing wang Jiu-yi Xia Meng Li chun-jiang Zhou Yao wang Ke Hu Wen-Juan Wan Nomogram of SMILE surgery for adult anisometropia 1Chongqing Medical University Chongqing 400000China The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of OphthalmologyChongqing Eye InstituteChongqing Branch(Municipality Division)of National Clinical Research Center for Ocular DiseasesChongqing 400000China

AIM:To evaluate the safety,effectiveness,and predictability of small incision lenticule extraction(SMILE)for the treatment of anisometropia,and to explore the personalized design scheme of SMILE in correcting adult myopia anisometropia based on the ***:It’s a prospective cohort *** with anisometropic myopia of refractive difference≥2.0 diopters(D)who underwent SMILE between September 2020 and March 2021 were *** features and visual function were assessed preoperatively and at 1wk,1,3,and 6mo after the *** examination included tests for uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),refractive errors,effectiveness index(preoperative CDVA/postoperative UDVA),safety index(postoperative CDVA/preoperative CDVA),nomogram and stereoscopic *** t-test,Wilcoxon signed-rank test and repeated-measures analyses of variance were used for continuous variables,and Pearson Chi-squared test was used for categorical ***:The study involved 45 consecutive patients(average age:25.0±6.9y;82 out of 90 eyes underwent SMILE,while 8 eyes were not operated).The average preoperative spherical equivalent(SE)was-4.74±0.22 *** months after surgery,the effectiveness index was 1.05±0.12,and the safety index was 1.09±*** eyes(85.4%)exhibited SE correction error within±0.5 *** percentage of eyes with Titmus stereoscopic function equal to or less than 200”significantly increased from 55.6%preoperatively to 88.9%postoperatively(Plue/spherical refraction ***:SMILE is safe,effective and predictable in correcting myopic anisometropia,and it improves stereoscopic visual function of anisometropia *** precise and individualized design of the nomogram is a vital element to ensure the balance of both eyes after SMILE.

关键词： refractive surgery small incision lenticule extraction anisometropia nomogram

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Role and mechanism of matrine alone and combined with acitretin for HaCaT cells and psoriasis-like murine models

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Chinese Medical Journal 2019年第17期132卷 2079-2088页

作者： Wei-Wei jiang yi-Meng wang Xiao-Yu wang Qian Zhang Si-man zhu chun-Lei Zhang Department of Dermatology Peking University Third Hospital Beijing 100191 China

Background: Acitretin and matrine have been used in the treatment of psoriasis in China. This study was designed to investigate the role and related mechanisms of matrine alone and in combination with acitretin in the treatment of psoriasis in vitro and in vivo. Methods: HaCaT cells were treated with matrine at different concentrations of 0 (blank control), 0.2, 0.4, 0.8, and 1.6 mg/mL for 24, 48, 72 h, respectively. 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium cell viability assay was used to assess the growth and proliferation of HaCaT cells. Cell cycle and apoptosis were detected by flow cytometry. Expression of protein was detected by Western blotting. Autophagy was observed by transmission electron microscopy. Then HaCaT cells were assigned to normal saline (NS) control group, matrine (0.4 mg/mL) group, acitretin (10 μmol/L) group, and matrine plus acitretin group, and the above methods were repeated. In animal experiments, the cumulative score (erythema, scaling, thickening) as a measure of the severity of inflammation was used to measure the skin performance of mice after treated with matrine 50 mg/kg, acitretin 4.5 mg/kg or combination of the two drugs on the psoriasis-like mouse models, respectively. Pathological findings of the lesions were observed, and the protein expressions in the lesions were detected by immunohistochemistry. Results: Cell proliferation inhibition was seen in HaCaT cells with treatment of matrine in a dose- and time-dependent manner (P < 0.01, respectively). Cell cycle G0/G1 phase arrest was observed in a dose-dependent way (P < 0.01). The expression of p21 (P < 0.05), LC3II/I (P < 0.01), and Beclin 1 (P < 0.01) increased and the expression of cyclin D1 (P < 0.05) decreased with increasing doses of matrine. Compared with the blank control, more autophagosomes were seen in HaCaT cells treated with matrine at 0.4 mg/mL by transmission electron microscopy (2.667 ± 1.202 vs. 21.33 ± 1.453, t = 9

关键词： Psoriasis Autophagy Phosphoinositide 3-kinase Protein kinase B Mammalian target of rapamycin

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Means and verification of broadcast technology applied to laser transmission on horizontal link

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Optoelectronics Letters 2019年第4期15卷 277-283页

作者： MU yi-ning wang Shuai LIU Guo-zhen LIU chun-yang ZHAO Kai-qiang jiang Hui-lin zhu yan School of Science Changchun University of Science and Technology Changchun 130022 China Space Opto-electronics Institute Changchun University of Science and Technology Changchun 130022 China

At present, there has been great progress in the field of the point-to-point laser communication technology, in other words, the traditional laser communication technology has been advanced day by day. Furthermore, in order to search for an effective means of achieving localized laser broadcasting communication within a limited range, an effective method of horizontal link laser broadcasting communication is presented, and the corresponding verifiable broadcast communication system is designed. In addition, the laser broadcasting is systematically studied by one physical model built at the optimal distribution of optical power. First of all, the theoretical model of laser beam expansion and the theoretical model of parallel light curtain are made comparisons and analyzed from the angle of attenuation of optical power, and the optical power loss model of the parallel light curtain is established as a result. Secondly, combined with the theory of optical imaging transformation based on Gaussian beam, the field distribution of far field of parallel light curtain is simulated by one leading optical and illumination design software and the relation between the filed distribution of far field of light curtain and the distance of transmission is revealed. Finally, the superiority and feasibility of the parallel light curtain theory model are verified by field communication experiments in different information channels.

关键词： broadcast technology applied laser transmission point-to-point laser communication technology

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Pre-transjugular-intrahepatic-portosystemic-shunt measurement of hepatic venous pressure gradient and its clinical application: A comparison study

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World Journal of Gastroenterology 2023年第22期29卷 3519-3533页

作者： Xi-Xuan wang Xiao-chun yin Li-Hong Gu Hui-Wen Guo yang Cheng yan Liu jiang-Qiang Xiao yi wang Wei Zhang Xiao-Ping Zou Lei wang ming Zhang Yu-Zheng zhu-Ge Feng Zhang Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Medical School Southeast UniversityNanjing 210000Jiangsu ProvinceChina Department of Gastroenterology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina

BACKGROUND It is controversial whether transjugular intrahepatic portosystemic shunt(TIPS)placement can improve long-term *** To assess whether TIPS placement improves survival in patients with hepaticvenous-pressure-gradient(HVPG)≥16 mmHg,based on HVPG-related risk *** Consecutive variceal bleeding patients treated with endoscopic therapy+nonselectiveβ-blockers(NSBBs)or covered TIPS placement were retrospectively enrolled between January 2013 and December *** measurements were performed before *** primary outcome was transplant-free survival;secondary endpoints were rebleeding and overt hepatic ence-phalopathy(OHE).RESULTS A total of 184 patients were analyzed(mean age,55.27 years±13.86,107 males;102 in the EVL+NSBB group,82 in the covered TIPS group).Based on the HVPG guided risk stratification,70 patients had HVPGluSION TIPS placement can effectively improve transplant-free survival when the HVPG is greater than 16 mmHg.

关键词： Hepatic venous pressure gradient Transjugular intrahepatic portosystemic shunts Cirrhosis Variceal rebleeding Survival

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