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Identification of a novel inflammatory-related gene signature to evaluate the prognosis of gastric cancer patients

World Journal of Gastrointestinal Oncology 2024年第3期16卷 945-967页

作者： Jia-Li Hu Mei-Jin Huang Halike Halina Kun Qiao Zhi-yuan Wang Jia-Jie lu Cheng-Liang Yin Feng Gao Department of Gastroenterology People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Xinjiang Clinical Research Center for Digestive Disease Urumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Oncology 920th Hospital of PLA Joint Logistics Support ForceKunming 650032Yunnan ProvinceChina Faculty of Medicine Macao University of Science and TechnologyMacao 999078China

BACKGROUND Gastric cancer(GC)is a highly aggressive malignancy with a heterogeneous nature,which makes prognosis prediction and treatment determination *** is now recognized as one of the hallmarks of cancer and plays an important role in the aetiology and continued growth of *** also affects the prognosis of GC *** reports suggest that a number of inflammatory-related biomarkers are useful for predicting tumour ***,the importance of inflammatory-related biomarkers in predicting the prognosis of GC patients is still *** To investigate inflammatory-related biomarkers in predicting the prognosis of GC *** constructed using the least absolute shrinkage and selection operator Cox regression model based on the GEO *** patients from the GSE26253 cohort were used for *** and multivariate Cox analyses were used to determine the independent prognostic factors,and a prognostic nomogram was *** calibration curve and the area under the curve based on receiver operating characteristic analysis were utilized to evaluate the predictive value of the *** decision curve analysis results were plotted to quantify and assess the clinical value of the *** set enrichment analysis was performed to explore the potential regulatory pathways *** relationship between tumour immune infiltration status and risk score was analysed via Tumour Immune Estimation Resource and ***,we analysed the association between risk score and patient sensitivity to commonly used chemotherapy and targeted therapy *** A prognostic model consisting of three inflammatory-related genes(MRPS17,GUF1,and PDK4)was *** prognostic analysis revealed that the risk score was a separate prognostic factor in GC *** to the risk score,GC patients were stratified into high-and low-risk groups,and patients in the high-risk group ha

关键词： Gastric cancer Inflammation Immune infiltration Prognosis signature Subt

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Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A_(2)receptors

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Science China(Life Sciences) 2024年第5期67卷 986-995页

作者： yuan Weng Xinyu Yang Qiansen Zhang Ying Chen Yueming Xu Chenyu Zhu Qiong Xie Yonghui Wang Huaiyu Yang Mingyao Liu Weiqiang lu Gaojie Song Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

The adenosine subfamily G protein-coupled receptors A_(2A)R and A_(2B)R have been identified as promising cancer immunotherapy *** of the A_(2A)R/A_(2B)R dual antagonists,AB928,has progressed to a phaseⅡclinical trial to treat rectal ***,the precise mechanism underlying its dual-antagonistic properties remains ***,we report crystal structures of the A_(2A)R complexed with AB928 and a selective A_(2A)R antagonist *** structures revealed a common binding mode on A_(2A)R,wherein the ligands established extensive interactions with residues from the orthosteric and secondary *** contrast,the cAMP assay and A_(2A)R and A_(2B)R molecular dynamics simulations indicated that the ligands adopted distinct binding modes on A_(2B)*** analysis of their chemical structures suggested that AB928 readily adapted to the A_(2B)R pocket,while 2-118 did not due to intrinsic *** disparity potentially accounted for the difference in inhibitory efficacy between A_(2B)R and A_(2A)*** study serves as a valuable structural template for the future development of selective or dual inhibitors targeting A_(2A)R/A_(2B)R for cancer therapy.

关键词： adenosine receptor A2AR A2BR inhibitor dual-antagonism drug discovery

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Identification of an Aux/IAA regulator for flesh firmness using combined GWAS and bulked segregant RNA-Seq analysis in watermelon

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Horticultural Plant Journal 2024年第5期10卷 1198-1213页

作者： Muhammad Anees Hongju Zhu Muhammad Jawad Umer Chengsheng Gong Pingli yuan Xuqiang lu Nan He Mohamed Omar Kaseb Dongdong Yang Yong Zhao Wenge Liu Henan Joint International Research Laboratory of South Asian Fruits and Cucurbits Zhengzhou Fruit Research InstituteChinese Academy of Agricultural SciencesZhengzhouHenan 450009China Henan Key Laboratory of Fruit and Cucurbit Biology Zhengzhou Fruit Research InstituteChinese Academy of Agricultural SciencesZhengzhouHenan 450009China State Key Laboratory of Cotton Biology Institute of Cotton ResearchChinese Academy of Agricultural Science(ICRCAAS)AnyangHenan 455000China National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops Zhengzhou Fruit Research InstituteChinese Academy of Agricultural SciencesZhengzhouHenan 450009China

Watermelon is a highly cultivated fruit crop renowned for its quality properties of fruit *** various quality factors,fruit flesh firmness is a crucial quality parameter influencing the fruit texture,shelf life and its commercial *** auxin/indole-3-acetic acid(Aux/IAA)plays a significant role in fruit development and ripening of non-climacteric ***,the regulatory mechanism of Aux/IAA in controlling fruit flesh firmness and ripening in watermelon remains *** this study,we employed an integrative approach combining genome-wide association study(GWAS)and bulked segregant RNA-Seq analysis(BSR-Seq)to identify an overlapping candidate region between 12776310 and 12968331 bp on chromosome 6,underlying an auxin-responsive gene(Aux/IAA)associated with flesh firmness in *** analysis,followed by real-time quantitative reverse transcription PCR(qRT-PCR),confirmed that the expression of Aux/IAA was consistently higher in fruits with high flesh *** sequence alignment revealed a single base mutation in the coding region of Aux/***,the concomitant Kompetitive/Competitive allele-specific PCR(KASP)genotyping data sets for F2 population and germplasm accessions identified Aux/IAA as a strong candidate gene associated with flesh ***/IAA was enriched in the plant hormone signal transduction pathway,involving cell enlargement and leading to low flesh *** determined the higher accumulation of abscisic acid(ABA)in fruits with low flesh firmness than hard ***,overexpression of Aux/IAA induced higher flesh firmness with an increased number of fruit flesh cells while reducing ABA content and flesh cell ***,the allelic variation in Aux/IAA for soft flesh firmness was found to exist in Citrullus mucosospermus and gradually fixed into Citrullus lanatus during domestication,indicating that soft flesh firmness was a domesticated *** findings significantly enhanced our unders

关键词： Watermelon Flesh firmness GWAS BSR-Seq KASP marker analysis Transient overexpression

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Impairment of Autophagic Flux After Hypobaric Hypoxia Potentiates Oxidative Stress and Cognitive Function Disturbances in Mice

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Neuroscience Bulletin 2024年第1期40卷 35-49页

作者： Shuhui Dai yuan Feng Chuanhao lu Hongchen Zhang Wenke Ma Wenyu Xie Xiuquan Wu Peng luo Lei Zhang Fei Fei Zhou Fei Xia Li Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi'an 710000China National Translational Science Center for Molecular Medicine and Department of Cell Biology Fourth Military Medical UniversityXi'an 710000China Department of Neurosurgery The Central Hospital of BaojiBaoji 721000China Department of Ophthalmology Xijing HospitalFourth Military Medical UniversityXi'an 710000China

Acute hypobaric hypoxic brain damage is a potentially fatal high-altitude *** plays a critical role in ischemic brain injury,but its role in hypo-baric hypoxia(HH)remains *** we used an HH chamber to demonstrate that acute HH exposure impairs autophagic activity in both the early and late stages of the mouse brain,and is partially responsible for HH-induced oxidative stress,neuronal loss,and brain *** autophagic agonist rapamycin only promotes the initiation of *** proteome analysis,a screen showed that protein dynamin2(DNM2)potentially regulates autophagic *** of DNM2 significantly increased the formation of autolysosomes,thus maintaining autophagic flux in combination with ***,the enhancement of autophagic activity attenuated oxidative stress and neurological deficits after HH *** results contribute to evidence supporting the conclusion that DNM2-mediated autophagic flux represents a new therapeutic target in HH-induced brain damage.

关键词： Autophagy-Proteomics Oxidative stress Hypobaric hypoxia-Brain injury

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Enhancing alkyne semi-hydrogenation through engineering metal-support interactions of Pd on oxides

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Nano Research 2024年第5期17卷 3707-3713页

作者： Yuefeng Wu Xiaotong lu Pengfei Cui Wenyu Jia Jun Zhou yuan Wang Hussain Zahid Yuxin Wu Muhammad Umer Rafique Xiong Yin Baoshan Li Leyu Wang Guolei Xiang State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China College of Chemical Engineering Beijing University of Chemical TechnologyBeijing 100029China

Supported Pd catalysts show superior activities for olefin productions from alkynes through semi-hydrogenation reactions,but over-hydrogenation into alkanes highly decreases olefin *** phenylacetylene semi-hydrogenation as a model reaction,here we explore the optimization approaches toward better Pd catalysts for alkyne semi-hydrogenation through investigating support effect and metal-support *** results show that the states of Pd with supports can be tuned by varying oxide reducibility,loading ratios,and *** our system,0.06 wt.%Pd on rutile-TiO_(2) nanorods shows the highest activity owing to the synergistic effects of single-atoms and *** reducibility can change the filling degrees of Pd 4d orbitals through varying interfacial bonding strengths,which further affect catalytic activity and selectivity.

关键词： alkyne semi-hydrogenation support effect metal-support interaction Pd catalyst single-atom catalyst

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Spectrally resolved Franson interference

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 11-17页

作者： Rui-Bo Jin Zi-Qi Zeng Dan Xu Chen-Zhi yuan Bai-Hong Li You Wang Ryosuke Shimizu Masahiro Takeoka Mikio Fujiwara Masahide Sasaki Pei-Xiang lu Hubei Key Laboratory of Optical Information and Pattern Recognition Wuhan Institute of TechnologyWuhan 430205China School of Physics and Information Science Shaanxi University of Science and TechnologyXi'an 710021China Southwest Institute of Technical Physics Chengdu 610041China Graduate School of Informatics and Engineering University of Electro-CommunicationsTokyo 182-8585Japan Department of Electronics and Electrical Engineering Keio UniversityKanagawa 223-8522Japan National Institute of Information and Communications Technology Tokyo 184-8795Japan

Franson interference can be used to test the nonlocal features of energy-time entanglement and has become a standard in quantum ***,most of the previous Franson interference experiments were demonstrated in the time domain,and the spectral properties of Franson interference have not been fully ***,we theoretically and experimentally demonstrate spectrally resolved Franson interference using biphotons with different correlations,including positive correlation,negative correlation,and *** is found that the joint spectral intensities of the biphotons can be modulated along both the signal and idler directions,which has potential applications in generating high-dimensional frequency entanglement and time-frequency grid *** work may provide a new perspective for understanding the spectral-temporal properties of the Franson interferometer.

关键词： resolved correlation spectral

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Surface engineering of Li-and Mn-rich layered oxides for superior Li-ion battery

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Tungsten 2024年第1期6卷 259-268页

作者： lu-Xiang Ma Tian-Dong Chen Chun-Xi Hai Sheng-De Dong Xin He Qi Xu Hang Feng AXin Ji-Tao Chen yuan Zhou College of Materials and Chemistry and Chemical Engineering Chengdu University of TechnologyChendu 610000China Qinghai Building and Materials Research Co. LtdXining 810000China Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The Li-and Mn-rich layered oxides(R-LNCM)are considered as promising cathode materials for high-energy density lithium-ion batteries(LIBs).However,the interface side reaction aggravates the voltage and capacity fading between cathode material and electrolyte at high voltage,which severely hinders the practical application of LIB ***,lithium polyacrylate(LiPAA)as the binder and coating agent is applied to suppress the voltage and capacity fading of R-LNCM *** flexible LiPAA layers with high elasticity are capable of impeding cathode cracks on the particle surface via mechanical stress ***,superior voltage and capacity fading suppression on R-LNCM electrode is finally *** a result,LiPAA-R-LNCM cathode exhibits a remarkable specific capacity of 186 mA·h·g^(-1)with~73%retention at 1℃after ***,the corresponding average discharge potential is maintained to~3.1 V with only~0.4 V falling.

关键词： LiPAA interphase layer Interface side reaction Cathode cracks Capacity and voltage fading suppression Liand Mn-rich cathode

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Coercivity mechanism of high-performance anisotropic heterostructure SmCo5 magnets

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Journal of Rare Earths 2024年第10期42卷 1882-1888页

作者： yuan Teng Yuqing Li Weiqiang Liu Xiaochang Xu Zhanjia Wang Jianjun Yang Dongtao Zhang Hongguo Zhang Qingmei lu Qiong Wu Weixing Xia Ming Yue Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of Technology School of Mechanical and Electrical Engineering Henan Institute of Science and Technology School of Mechanical Engineering Anyang Institute of Technology Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Material Technology and EngineeringChinese Academy of Sciences

Due to its large magnetocrystalline anisotropy field and high Curie temperature,SmCo-based magnets are irreplaceable in high-temperature applications,The hot-deformed SmCo-based magnets are especially attractive for their excellent corrosion resistance,making them more suitable for harsh ***,it is still challenging for hot-deformed SmCo-based magnets to obtain high magnetization and high coercivity ***,it is necessary to analyze the relationship between its microstructure and magnetic properties and explore its magnetic hardening mechanism to guide the further improvement of magnetic *** this paper,the anisotropic heterostructure SmCo5magnet was prepared by combining large height-reduction and introducing a nano-grained Smrich *** c-axis texture,（BH）m of 16.1 MGOe,and Hciof 9.6 kOe were obtained via the heterostructure with SmCo5micron-grain and Sm-rich nano-scale *** magnetic domain observation and technical magnetization analysis demonstrate that the coe rcivity mechanism is dominated by *** results also show that the smooth and Sm-rich precipitated grain boundary provides weak pinning *** provides a reference for the development of high-pe rformance nanocrystalline SmCo5magnets.

关键词： Permanent magnet Heterostructure Rare earths Coercivity mechanism Hot-deformed SmCo magnet

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A machine learning model for predicting acute kidney injury secondary to severe acute pancreatitis

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Chinese Medical Journal 2024年第5期137卷 619-621页

作者： Wanyue Zhang Yongjian Chang Cuie Cheng Xiaodan Zhao Xiajiao Tang Fenying lu Yanli Hu Chunying Yang yuan Ding Ruihua Shi School of Medicine Southeast UniversityNanjingJiangsu 210009China School of Cyber Science and Engineering Southeast UniversityNanjingJiangsu 210009China Department of Gastroenterology Changshu No.2 People’s HospitalChangshuJiangsu 215500China Department of Gastroenterology Zhongda HospitalSoutheast UniversityNanjingJiangsu 210009China Department of Gastroenterology Pizhou People’s HospitalXuzhouJiangsu 221300China Department of Gastroenterology Pizhou Hospital of Traditional Chinese MedicineXuzhouJiangsu 221300China

To the Editor:Severe acute pancreatitis(SAP)is a common critical disease in gastroenterology,and 69.3%of patients have acute kidney injury(AKI).^([1])Early diagnosis and treatment are very important in improving the prognosis of these *** recent years,machine learning models have been widely used in the medical field due to their excellent prediction *** scholars have developed machine learning models that can solve the AKI prediction problem in specific populations and achieved good results.^([2])However,considering that the occurrence of AKI in patients with pancreatitis is also closely related to factors such as amylase and inflammatory markers,it is necessary to construct an AKI prediction model for the pancreatitis population.

关键词： pancreatitis acute kidney

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Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis

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Bone Research 2024年第1期12卷 215-226页

作者： Yuhang Liu Ruihan Hao Jia Lv Jie yuan Xuelei Wang Churong Xu Ding Ma Zhouyi Duan Bingjun Zhang Liming Dai Yiyun Cheng Wei lu Xiaoling Zhang Department of Orthopedic Surgery Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine(SJTUSM)Shanghai 200092China National Facility for Translational Medicine Shanghai 200240China Shanghai Frontiers Science Center of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory BiologySchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Orthopaedic Surgery The Second Hospital of Shanxi Medical UniversityTaiyuan 030001China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China School of Medicine Shanghai UniversityShanghai 200444China

Osteoarthritis(OA)is a common degenerative disease worldwide and new therapeutics that target inflammation and the crosstalk between immunocytes and chondrocytes are being developed to prevent and treat *** attempts involve repolarizing pro-inflammatory M1 macrophages into the anti-inflammatory M2 phenotype in *** this study,we found that phosphoglycerate mutase 5(PGAM5)significantly increased in macrophages in OA synovium compared to controls based on histology of human samples and single-cell RNA sequencing results of mice *** address the role of PGAM5 in macrophages in OA,we found conditional knockout of PGAM5 in macrophages greatly alleviated OA symptoms and promoted anabolic metabolism of chondrocytes in vitro and in ***,we found that PGAM5 enhanced M1 polarization via AKT-mTOR/p38/ERK pathways,whereas inhibited M2 polarization via STAT6-PPARγpathway in murine bone marrow-derived ***,we found that PGAM5 directly dephosphorylated Dishevelled Segment Polarity Protein 2(DVL2)which resulted in the inhibition ofβ-catenin and repolarization of M2 macrophages into M1 *** knockout of both PGAM5 andβ-catenin in macrophages significantly exacerbated osteoarthritis compared to PGAM5-deficient *** by these findings,we successfully designed mannose modified fluoropolymers combined with siPGAM5 to inhibit PGAM5 specifically in synovial macrophages via intra-articular injection,which possessed desired targeting abilities of synovial macrophages and greatly attenuated murine ***,these findings defined a key role for PGAM5 in orchestrating macrophage polarization and provides insights into novel macrophage-targeted strategy for treating OA.

关键词： osteoarthritis metabolism inhibited

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