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Role of the Cu-ZrO_(2) interface in the hydrogenation of levulinic acid to γ-valerolactone

Journal of Energy Chemistry 2021年第10期30卷 446-458,I0012页

作者： Ziyi Li Haigang Hao jingjing lu Chengming Wu Rui Gao Jifan Li Chun-Ling Liu Wen-Sheng Dong Key Laboratory of Applied Surface and Colloid Chemistry(SNNU) MOESchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710062ShaanxiChina College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021Inner MongoliaChina

Here we exquisitely fabricated Cu/ZrO_(2)-dp catalysts with plentiful Cu-ZrO_(2)interfaces by depositing amorphous ZrO_(2)onto Cu nanoparticles for the hydrogenation of levulinic acid(LA)to y-valerolactone(GVL).With the created plentiful CU-ZrO_(2)interfaces,the optimal catalyst 3 Cu/ZrO_(2)-dp exhibited exceptional catalytic performance under mild reaction conditions,and achieved the highest GVL mass productivity of 266.0 mmol GVL·h^(-1)·g^(-1)Cu,which was 12.5 and 2.3 times of CU/ZrO_(2)catalysts with equivalent Cu loadings prepared by traditional impregnation(3 Cu/ZrO_(2)-im)or co-precipitation(3 Cu/ZrO_(2)-cp).As far as we know,this GVL mass productivity stood at the highest level compared with those obtained using non-noble metal catalysts under similar reaction *** systematic investigation with multiple characterizations,density functional theory(DFT)calculations,and kinetic studies,it was found that interfacial active centers were created at Cu-ZrO_(2)interfaces,which contained oxygen vacancies(O_(v)),negatively charged Cu^(δ)-and partially reduced Zr^(3+)The O_(v) favored the adsorption and activation of LA via its ketone group,while negatively charged Cu^(δ)-was able to enhance heterolysis of H2,which resulted in the formation of H^(+)-Cu^(δ)-and Zr^(3+)-H^(-)active species via hydrogen ***,plentiful acid sites,which derived from coordinatively unsaturated and defective Zr species,generated at Cu-ZrO_(2)*** the cooperation of interfacial active centers(Cu^(δ-)-O_(v)-Zr^(3+))and acid sites,the fabricated 3 Cu/ZrO_(2)-dp with plentiful Cu-ZrO_(2)interfaces achieved excellent catalytic performance for the hydrogenation of LA to ***,the synergistic catalysis of Cu-ZrO_(2)interfaces provided an effective strategy for designing catalysts with a satisfactory performance for the hydrogenation of LA,which also can be expanded to other hydrodeoxygenation reactions.

关键词： Cu-ZrO_(2)interface γ-Valerolactone Levulinic acid Oxygen vacancy Hydrodeoxygenation

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Effects of caveolin-1 on bone marrow mesenchymal stem cells differentiating into neuron-like cells An atomic force microscopy observation

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Neural Regeneration Research 2011年第16期6卷 1227-1231页

作者： jingjing lu Lijun Jing Yonglin Jia Jinyi Li Liudong Wang Tao Peng Yanjie Jia Department of Neurology First Affifiated Hospital of Zhengzhou University Zhengzhou 450052 Henan Province China

Bone marrow mesenchymal stem cells （MSCs） from rats were transfected with Rn-siRNA-caveolin-1 and differentiated into neuron-like cells using fasudil hydrochloride. Membrane ultrastructural changes in MSCs were observed under atomic force microscopy. Caveolin-l-transfected rat MSCs exhibited weak nuclear refraction, dense caveolae and long finger-like cellular processes prior to fasudil hydrochloride treatment. MSCs differentiating into neuron-like cells exhibited weak nuclear refraction and large cellular processes without caveolae. We hypothesize that caveolin-1 plays an important role in the regulation of bone marrow MSC differentiating into neuron-like cells.

关键词： atomic force microscopy bone marrow mesenchymal stem cells caveolin-1 neurons differentiation neural regeneration

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基于深度学习的高光谱图像去噪综述

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南昌工程学院学报 2024年第3期43卷 88-96页

作者：张俊谭耀鑫卢静静徐晨光邓承志南昌工程学院江西省水信息协同感知与智能处理重点实验室江西南昌330099 南昌工程学院工程数学与先进计算重点实验室江西南昌330099

高光谱图像具有图谱合一的优点,已被广泛应用于农业、地球科学和地质灾害等领域。由于噪声的影响往往限制了高光谱图像的应用,高光谱图像去噪已成为一种重要的图像预处理方式。深度学习作为近些年来快速发展的技术之一,已被成功地应用... 详细信息

高光谱图像具有图谱合一的优点,已被广泛应用于农业、地球科学和地质灾害等领域。由于噪声的影响往往限制了高光谱图像的应用,高光谱图像去噪已成为一种重要的图像预处理方式。深度学习作为近些年来快速发展的技术之一,已被成功地应用于高光谱图像去噪中。基于深度学习的高光谱图像去噪研究成果正逐年增加,为了便于对该领域进行更系统全面的研究,本文概述了基于深度学习的高光谱图像去噪研究进展,对现有主要研究成果进行了分类、归纳与总结,并对该领域的未来研究趋势进行了展望。

关键词：高光谱图像去噪深度学习卷积神经网络循环神经网络注意力机制

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正念行走对心房颤动患者焦虑、抑郁情绪及心肺功能的干预效果

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浙江中西医结合杂志 2024年第9期34卷 816-818页

作者：陆晶晶章丽燕王婷张学萍浙江省嘉兴市第二医院心内科嘉兴314000

心房颤动(简称房颤)表现为心房电活动的快速无序颤动,是一种常见的心律失常,具有高患病率及病死率^([1])。临床上,房颤治疗以药物、电复律及射频消融术等治疗为主,各有利弊,且对患者焦虑、抑郁情绪和心肺功能等的治疗效果不一^([2])。... 详细信息

心房颤动(简称房颤)表现为心房电活动的快速无序颤动,是一种常见的心律失常,具有高患病率及病死率^([1])。临床上,房颤治疗以药物、电复律及射频消融术等治疗为主,各有利弊,且对患者焦虑、抑郁情绪和心肺功能等的治疗效果不一^([2])。正念行走是一种心脏康复治疗手段,是将正念练习与行走相结合的冥想练习,以达到减轻压力、改善抑郁、降低血压等效果^([3])。

关键词：心房颤动正念行走焦虑抑郁心肺功能

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Power Reversal Strategies for Hybrid LCC/MMC HVDC Systems

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CSEE Journal of Power and Energy Systems 2020年第1期6卷 203-212页

作者： Gen Li Ting An Jun Liang Wei Liu Tibin Joseph jingjing lu Marcio Szechtman Bjarne R.Andersen Yuanliang Lan School of Engineering Cardiff UniversityCardiffCF243AAU.K. Global Energy Interconnection Research Institute Beijing 102211China Eletrobras Cepel Rio de Janeiro26053-121 Brazil Andersen Power Electronic Solutions Bexhill-On-SeaTN394QL U.K. Global Energy Interconnection Research Institute Europe GmbH Kantstr162 BerlinGermany

Power reversal control strategies for different types of hybrid line-commutated-converter(LCC)/modular multi-level converter(MMC)based high-voltage direct-current(HVDC)systems have been proposed with the consideration of system configurations and MMC’s *** studies show that the full-bridge(FB)MMC gives better performance than half-bridge(HB)MMCs in terms of power reversal in hybrid LCC/MMC *** modulation method employed in this paper can achieve a smooth online polarity reversal for hybrid LCC/FB-MMC HVDC *** DC switches and/or discharging resistors may be needed to reverse the DC polarity of LCC/HB-MMC HVDC *** on the proposed strate-gies,the power reversal processes of the studied systems can be accomplished within several *** speed can be changed according to system operation *** effectiveness of the proposed control strategies has been verified through simulations conducted in PSCAD/EMTDC.

关键词： FB-MMC HB-MMC hybrid LCC/MMC LCC-HVDC MMC-HVDC power reversal

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Fasudil hydrochloride differentiates bone marrow mesenchymal stem cells into neurons via notch signaling

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Neural Regeneration Research 2010年第11期5卷 814-819页

作者： Eryi Zhao Liudong Wang Quanqing Wen Wenjuan Guan jingjing lu Tao Peng Boai Zhang Yanjie Jia Department of Neurology First Affiliated Hospital Zhengzhou University Zhengzhou 450052 Henan Province China

BACKGROUND： Notch signaling regulates bone marrow mesenchymal stem cell （MSC） proliferation, differentiation, and apoptosis, Notch signaling and Rho kinase signaling exhibit a crosstalk phenomenon with JAK/STAT, and both participate in the neuronal dendritic spine development. Inhibition of RhoA/Rho kinase signaling may regulate MSC differentiation into neuronal-like cells. OBJECTIVE： To investigate the effect of Notch1 signaling on the differentiation of rat MSCs into neurons induced by fasudil hydrochloride （C14H17N3O2S-HCI）, a Rho kinase inhibitor, through a siRNA approach. DESIGN, TIME AND SETTING： An in vitro cytological experiment was performed in the Cell Laboratory of Henan Academy of Medical and Pharmaceutical Sciences between December 2007 and May 2009. MATERIALS： MSCs were obtained from Wistar rat femoral bone, fasudil hydrochloride was provided by -Tianjin Chase Sun Pharmaceutical Co., Ltd. Rn-notchl-siRNa, negative control siRNA （Cy3 label） and Rn-MAPK1 control siRNA were provided by QIAGEN, Coloqne, German. METHODS： The cultured MSCs were divided into non-transfected, transfected group （transfected with Rn-Notchl-siRNA）, positive control （transfected with Rn-MAPK-1 control siRNA）, and negative control （transfected with negative control siRNA） groups. Fasudil hydrochloride was applied to induce MSCs to differentiate into neurons. MAIN OUTCOME MEASURES： The fluorescence expression by the transfected MSCs was observed under an inverted fluorescence microscope; the expression of Notch1 mRNA, Hesl mRNA, and MAPK1 mRNA in MSCs was detected by reverse transcription polymerase chain reaction; the expression of Notch1 protein, nestin, neurofilament M, and glial fibrillary acidic protein was detected by immunocytochemistry. The viability of MSCs was detected by tetrazolium bromide assay. RESULTS： MSC fluorescence increased following a 72-hour siRNA transfection, with transfection efficiencies of up to （0.91 ± 0.04）; the Notch1 mRNA and Hesl mRNA expressed by tra

关键词： Notch Rho fasudil hydrochloride marrow mesenchymal stem cells neuronal-like cells transfection nerve stem cells neural regeneration

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骨髓间充质干细胞通过前列腺素E2调控NLRP3抑制肺泡巨噬细胞相关炎症反应

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中国呼吸与危重监护杂志 2024年第7期23卷 495-503页

作者：潘天宇邓圣洁林婷婷万慧敏单梦田陆晶晶上海市奉贤区中心医院同济大学附属东方医院

目的探讨骨髓间充质干细胞（bone marrow mesenchymal stem cell,BMSC）对脂多糖（lipopolysaccharide,LPS）诱导的炎症反应中肺泡巨噬细胞相关炎症通路的作用及可能机制。方法采用慢病毒转染ptges及ptges shRNA至BMSC，建立稳定的pt... 详细信息

目的探讨骨髓间充质干细胞（bone marrow mesenchymal stem cell,BMSC）对脂多糖（lipopolysaccharide,LPS）诱导的炎症反应中肺泡巨噬细胞相关炎症通路的作用及可能机制。方法采用慢病毒转染ptges及ptges shRNA至BMSC，建立稳定的ptges过表达BMSC细胞株[BMSC-PGE2（+）]及ptges沉默的BMSC细胞株[BMSC-PGE2（–）]。将巨噬细胞分为对照组、LPS组、LPS+BMSC组、LPS+BMSC-PGE2（+）组、LPS+BMSC-PGE2（–）组，收集各组细胞，Western blot检测核苷酸结合寡聚化结构域样受体3(nucleotide-bound oligomerized domain-like receptor 3,NLRP3)、半胱氨酸天冬氨酸蛋白酶1前体（precursor cysteinyl aspartate specific proteinase 1,pro-Caspase-1）、Caspase-1及白细胞介素1β前体（precursor interleukin-1β,pro-IL-1β）蛋白表达水平；RT-PCR测定NLRP3、Caspase-1 mRNA表达水平；ELISA检测细胞上清液中肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、IL-1β、IL-10、IL-18及前列腺素E2(prostaglandin E2,PGE2)的表达水平。结果 LPS的干预显著升高了巨噬细胞内NLRP3、pro-Caspase-1、Caspase-1和pro-IL-1β的表达，与BMSC共培养后，各蛋白表达量明显减少。加入PGE2过表达后，蛋白表达差异进一步下降。LPS组NLRP3、Caspase-1 mRNA表达量明显升高，与BMSC共培养后表达显著降低，PGE2过表达可以加大这种差异，而PGE2沉默组无明显变化。ELISA结果显示细胞上清液中TNF-α、IL-1β及IL-18含量在LPS组中最高，加入BMSC及过表达PGE2后可使得相关炎症因子下降。LPS组IL-10和PGE2水平较对照组有升高趋势，在LPS+BMSC组和LPS+BMSC-PGE2（+）组中水平进一步升高且有显著差异。结论当LPS诱导的炎症反应发生时，BMSC能够显著减轻巨噬细胞中的炎症反应，这一过程可能是通过过表达PGE2从而抑制NLRP3介导的细胞焦亡通路来实现的。

关键词：骨髓间充质干细胞炎症反应前列腺素E2 核苷酸结合寡聚化结构域样受体3 炎症小体

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青年价值观教育视角下住培医师认知现状的调查研究

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卫生职业教育 2024年第15期42卷 118-121页

作者：卢晶晶艾莉伟洪学勤陈振虎广州中医药大学第一附属医院针推康复中心广东广州530001 广州中医药大学针灸康复临床医学院广东广州530001

目的调查并分析广州市某三甲中医医院住培医师价值观现状及影响因素,为今后住院医师规范化培训规划的制订提供依据。方法设计中医住培医师价值观认知现状调查表并进行调查。结果大部分住培医师认为开展价值观教育有必要,对案例分享... 详细信息

目的调查并分析广州市某三甲中医医院住培医师价值观现状及影响因素,为今后住院医师规范化培训规划的制订提供依据。方法设计中医住培医师价值观认知现状调查表并进行调查。结果大部分住培医师认为开展价值观教育有必要,对案例分享、专题讲座、理论教授等价值观教育方式较为认可;影响价值观教育工作开展的因素为培训内容的实习性、领导的重视程度等。结论医院针对目前住培医师价值观现状,应适度调整现有价值观教育内容,将中医优秀文化与思政教育相结合。

关键词：中医住院医师规范化培训价值观

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Optical heterodyne-Zeeman modulation magnetic rotation spectroscopic technique

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Chinese Science Bulletin 1999年第20期44卷 1867-1871页

作者： Yangqin Chen Zhiyi Bi Peipei Cai Jingxin Ding Rongjun Wang jingjing lu Longsheng Ma E China Normal Univ Dept Phys Lab Quantum Phys Shanghai 200062 Peoples R China

Optical heterodyne detection using 500 MHz phase modulation was combined with the Zeeman modulation-magnetic rotation spectroscopy (ZM-MRS) to form a new spectroscopic technique, which effectively reduced the amplitude fluctuation from laser source and greatly improved the signal-to-noise ratio in the detection of transient molecules.

关键词： optical heterodyne spectroscopy magnetic rotation spectroscopy transient molecules.

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Effect of salinity on the growth,biological activity and secondary metabolites of some marine fungi

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Acta Oceanologica Sinica 2011年第3期30卷 118-123页

作者： HUANG jingjing lu Chunhua QIAN Xiaoming HUANG Yaojian ZHENG Zhonghui SHEN Yuemao The Key Laboratory of Ministry of Education of Cell Biology and Tumor Engineering School of Life Science Xiamen University Xiamen 361005 China

The study investigated the effects of salinity on growth, antimicrobial activities and secondary metabolites of 47 marine filamentous fungi isolated from the East China Sea near the western shore of the Taiwan Straits. The results indicate that NaCl promoted the growth up to 91.5% of test strains. However, only 14.9% of them showed a significant increase of antimicrobial activity against Candida albicans. When incubated in different concentrations of NaCl, the colony growth, antimicrobial activities and composition of secondary metabolites of the strain Ty01b-8 of Penicillium sp. varied. Treatment with KCl also showed a similar effect. An alkaloid isolated from the fermentation broth of Ty01b-8 was identified as chrysogine, inhibition activity of which against Hela cells was 15.05% at 20μg/ml, and yield was 4.4 and 4.9 times higher in 3 percent and 6 percent NaCl treatments, respectively, compared with the non-salt culture condition. These findings prove that salinity is an important factor influencing growth and secondary metabolites of some marine fungi, which can be used to screen for new metabolites from marine fungi, and to enhance their metabolites production in industrial fermentation.

关键词： marine fungi salinity secondary metabolites antimicrobial activities

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