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HDAC3抑制剂RGFP966通过下调TGF-β1/SMAD3/STAT-1信号通路抑制AIM2炎症小体活化和EMT缓解子宫内膜纤维化

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医学分子生物学杂志 2024年第3期21卷 211-216页

作者：卢建军张新悦内蒙古医科大学附属医院妇产科呼和浩特市010059

目的探讨HDAC3抑制剂RGFP966缓解子宫内膜纤维化的分子机制。方法将18只6~8周雌性SD大鼠随机分为3组,Control组、IUA模型组(即宫内粘连大鼠模型组)、RGFP966治疗组(IUA模型组给予HDAC3抑制剂RGFP966治疗),每组6只。建立IUA大鼠模型。EL... 详细信息

目的探讨HDAC3抑制剂RGFP966缓解子宫内膜纤维化的分子机制。方法将18只6~8周雌性SD大鼠随机分为3组,Control组、IUA模型组(即宫内粘连大鼠模型组)、RGFP966治疗组(IUA模型组给予HDAC3抑制剂RGFP966治疗),每组6只。建立IUA大鼠模型。ELISA测定大鼠血清炎症因子TNF-α、IL-1β和IL-6水平。qPCR法测定大鼠子宫内膜组织上皮间质转化标志物E-cadherin、N-cadherin、α-SMA、Vimentin mRNA相对表达水平。蛋白质印迹法测定大鼠子宫内膜组织TGF-β1、SMAD3、p-STAT-1、STAT-1、AIM2、IL-18、cleaved-IL-1β、IL-1β的表达水平。结果与Control组相比,IUA模型组大鼠子宫角壁变薄,血清炎症因子TNF-α、IL-1β、IL-6水平升高(P0.05)。结论HDAC3的抑制剂RGFP966可通过下调TGF-β1/SMAD3/STAT-1信号通路抑制AIM2炎症小体和EMT,缓解子宫内膜纤维化。

关键词：子宫内膜纤维化宫内粘连 HDAC3抑制剂RGFP966 TGF-β1/SMAD3/STAT-1信号通路 AIM2炎症小体

广东省垦造水田项目农田水利优化设计及应用——以南雄市珠玑镇古田村项目为例

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广东水利水电 2024年第4期 31-35,42页

作者：陆建君陈伟平广东粤水电勘测设计有限公司广东佛山528000

为贯彻落实“占优补优、占水田补水田”耕地占补平衡要求,保障粮食安全,努力实现“藏粮于田”,2016年初广东省政府正式谋划垦造水田工作,南雄市珠玑镇古田村是全省垦造水田试点项目和市级示范项目。该文以古田村项目为例,对垦造水田工... 详细信息

为贯彻落实“占优补优、占水田补水田”耕地占补平衡要求,保障粮食安全,努力实现“藏粮于田”,2016年初广东省政府正式谋划垦造水田工作,南雄市珠玑镇古田村是全省垦造水田试点项目和市级示范项目。该文以古田村项目为例,对垦造水田工作的选址、设计、施工、验收及入库形成水田指标几个阶段进行了分析。该项目通过对符合条件的旱地、荒地水源条件及灌排系统进行改造和设计,结合土壤改良等其他技术措施,最终将旱地、荒地垦造为水田,水利设施的优化设计起到关键作用,研究成果可为垦造水田工作提供技术支持。

关键词：垦造水田设计关键技术应对措施

基于移动三维激光扫描技术的地铁隧道接触网导高检测新方法

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城市轨道交通研究 2024年第1期27卷 200-205,209页

作者：卢建军黄小斌吴勇郑佳佳鲍艳浙江华东测绘与工程安全技术有限公司杭州310014 杭州杭港地铁有限公司杭州310018 北京工业大学城市与工程安全减灾教育部重点实验室北京100124

[目的]地铁隧道内接触网导高是保证列车正常受电的重要参数,需定期进行检测。针对其他导高检测方式存在的误差大、精度低的问题,需提出基于移动三维激光扫描技术的地铁隧道接触网导高检测新方法。[方法]基于移动三维激光扫描技术提出了... 详细信息

[目的]地铁隧道内接触网导高是保证列车正常受电的重要参数,需定期进行检测。针对其他导高检测方式存在的误差大、精度低的问题,需提出基于移动三维激光扫描技术的地铁隧道接触网导高检测新方法。[方法]基于移动三维激光扫描技术提出了导高检测的新方法,分析了误差来源;提出通过在移动式三维激光扫描仪上增设刚性倾斜组件来改变扫描仪激光线入射角度,进而减少隧道断面点云模型的毛刺数量,并采用等角兰勃特投影来获取隧道真实点云模型。与导高仪检测结果进行对比,以验证其导高检测精度是否满足相关要求。[结果及结论]基于移动式三维激光扫描技术建立的隧道断面点云模型存在毛刺,是因激光脚点垂直入射接触网发生散射和漫反射导致的。增加倾斜组件,可有效减少隧道断面点云模型的毛刺数量。移动式三维激光扫描仪与导高仪的导高检测数据对比结果表明,基于移动式三维激光扫描技术的导高检测精度基本在±3 mm以内,能够满足相关规范对导高检测的精度要求。

关键词：地铁隧道移动三维激光扫描技术接触网导高检测精度

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NLK通过调控paxillin促进膀胱癌细胞的增殖、迁移、侵袭及上皮间质转化

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哈尔滨医药 2024年第1期44卷 1-7页

作者：陆建军余琴陈利雄杭州市余杭区第三人民医院泌尿外科浙江杭州311115 宁波市北仑区人民医院泌尿外科浙江宁波315000

目的探讨Nemo样激酶(nemo-like kinase;NLK)及桩蛋白(paxillin)对膀胱癌细胞增殖、迁移、侵袭及上皮间质转化(epithelial mesenchymal transition,EMT)的作用和机制,为膀胱癌的基础研究及临床预防和治疗提供理论依据。方法生物信息学分... 详细信息

目的探讨Nemo样激酶(nemo-like kinase;NLK)及桩蛋白(paxillin)对膀胱癌细胞增殖、迁移、侵袭及上皮间质转化(epithelial mesenchymal transition,EMT)的作用和机制,为膀胱癌的基础研究及临床预防和治疗提供理论依据。方法生物信息学分析NLK在膀胱癌组织中的表达。EdU染色实验、克隆形成实验以及transwell实验检测膀胱癌细胞的增殖、迁移和侵袭。RNA pull down实验检测膀胱癌细胞中NLK与paxillin的互作关系。Western blot实验检测膀胱癌细胞中NLK、p-paxillin、及EMT相关蛋白的表达。结果NLK和p-paxillin在膀胱癌中高表达;NLK与paxillin具有相互作用关系;沉默NLK抑制了膀胱癌细胞的增殖、迁移、侵袭及EMT、并抑制p-paxillin的表达;而paxillin过表达则逆转了沉默NLK对膀胱癌细胞增殖、迁移、侵袭、EMT及p-paxillin表达的作用。结论NLK通过调控paxillin促进膀胱癌细胞的增殖、迁移、侵袭及EMT,为膀胱癌的基础研究及临床预防和治疗提供理论依据。

关键词：膀胱癌 NLK paxillin EMT

Effects of land-use patterns on soil microbial diversity and composition in the Loess Plateau,China

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Journal of Arid Land 2024年第3期16卷 415-430页

作者： ZHANG Jian GUO Xiaoqun SHAN Yujie lu Xin CAO jianjun College of Geography and Environmental Science Northwest Normal UniversityLanzhou 730070China

In the Loess Plateau of China,land-use pattern is a major factor in controlling underlying biological ***,the process of land-use pattern was accompanied by abandoned lands,potentially impacting soil ***,limited researches were conducted to study the impacts of land-use patterns on the diversity and community of soil microorganisms in this *** study aimed to investigate soil microbial community diversity and composition using high-throughput deoxyribonucleic acid(DNA)sequencing under different land-use patterns(apricot tree land,apple tree land,peach tree land,corn land,and abandoned land).The results showed a substantial difference(P<0.050)in bacterial alpha-diversity and beta-diversity between abandoned land and other land-use patterns,with the exception of Shannon *** fungal beta-diversity was not considerably impacted by land-use patterns,fungal alpha-diversity indices varied *** relative abundance of Actinobacteriota(34.90%),Proteobacteria(20.65%),and Ascomycota(77.42%)varied in soils with different land-use *** pH exerted a dominant impact on the soil bacterial communities'composition,whereas soil available phosphorus was the main factor shaping the soil fungal communities'*** findings suggest that variations in land-use pattern had resulted in changes to soil properties,subsequently impacting diversity and structure of microbial community in the Loess *** the strong interdependence between soil and its microbiota,it is imperative to reclaim abandoned lands to maintain soil fertility and sustain its function,which will have significant ecological service implications,particularly with regards to soil conservation in ecologically vulnerable areas.

关键词： abandoned lands land-use pattern soil property diversity of soil microbe soil microbial community

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经颅直流电刺激对帕金森病睡眠障碍的影响

实用医学杂志 2024年第11期40卷 1488-1493页

作者：卢健军韩雨余秋敏刘佳文朱明华林劲芝张阳张勇王锦坚广东省第二人民医院神经外科广州510317 开平市中心医院神经外科广东开平529299 江西中医药大学科技学院南昌330004

目的探讨经颅直流电刺激(tDCS)对帕金森病(PD)患者睡眠障碍的疗效。方法选取2021年7月至2023年7月广东省第二人民医院神经外科PD伴睡眠障碍的患者,参照入选及排除标准,将入组患者分为假刺激组(28例)和真刺激组(tDCS)(29例),应用MDS-UPDR... 详细信息

目的探讨经颅直流电刺激(tDCS)对帕金森病(PD)患者睡眠障碍的疗效。方法选取2021年7月至2023年7月广东省第二人民医院神经外科PD伴睡眠障碍的患者,参照入选及排除标准,将入组患者分为假刺激组(28例)和真刺激组(tDCS)(29例),应用MDS-UPDRS、PDSS等评定量表,对两组患者疗效进行评估,并在tDCS治疗前后使用MS-11进行智能睡眠监测,分析两组患者治疗前基线及治疗前后的睡眠障碍改善情况。结果tDCS治疗前两组一般情况及各量表评分差异无统计学意义(P>0.05);治疗前两组多导睡眠监测结果差异无统计学意义(P>0.05);假刺激组中患者睡眠监测结果与治疗前相比,差异无统计学意义(P>0.05),真刺激组中患者睡眠时长、睡眠效率明显升高,夜间清醒时长、夜间觉醒次数、MDS-UPDRS-Ⅲ评分和LEDD剂量明显降低,差异有统计学意义(P<0.05)。结论在药物治疗的基础上,同时配合tDCS治疗,对PD患者睡眠障碍及运动功能有一定的疗效,可以一定程度增加PD睡眠障碍患者的睡眠时间、睡眠效率,减少夜间清醒时长、夜间觉醒次数,从而改善白天的疲劳感症状,同时能够提升PD常规药物治疗的疗效。

关键词：帕金森病睡眠障碍经颅直流电刺激智能睡眠监测

Hexafluoropropylene oxide trimer acid,a perfluorooctanoic acid alternative,induces cardiovascular toxicity in zebrafish embryos

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Journal of Environmental Sciences 2024年第5期139卷 460-472页

作者： Sujie Sun Li Zhang Xue Li lu Zang Ling Huang Junquan Zeng Zigang Cao Xinjun Liao Zilin Zhong Huiqiang lu jianjun Chen Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases Jiangxi Key Laboratory of Developmental Biology of OrgansCenter for Clinical Research Center of the Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Key Laboratory of Anesthesiology and Brain Functional ModulationDepartment of PediatricsShanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants School of Environmental Sciences and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Interventional and Vascular Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Department of Internal Medicine and Hematology Affiliated Hospital of Jinggangshan UniversityJi’an 343009China

As an increasingly used alternative to perfluorooctanoic acid(PFOA),hexafluoropropylene oxide trimer acid(HFPO-TA)has been widely detected in global water ***,little is known regarding its toxic effects on cardiovascular ***,zebrafish embryos were treated with egg water containing 0,60,120,or 240 mg/L *** showed that HFPO-TA treatment led to a significant reduction in both larval survival percentage and heart ***,HFPO-TA exposure caused severe pericardial edema and elongation of the sinus venous to bulbus arteriosus distance(SV-BA)in Tg(myl7:GFP)transgenic larvae,disrupting the expression of genes involved in heart development and thus causing abnormal heart *** sprouting angiogenesis was observed in the 120 and 240 mg/L exposed Tg(fli:GFP)transgenic ***-TA treatment also impacted the mRNA levels of genes involved in the vascular endothelial growth factor(VEGF)pathway and embryonic vascular ***-TA exposure significantly decreased erythrocyte number in Tg(gata1:DsRed)transgenic embryos and influenced gene expression associated with the heme metabolism ***-TA also induced oxidative stress and altered the transcriptional levels of genes related to cell cycle and apoptosis,inhibiting cell proliferation while promoting ***,HFPO-TA exposure may induce abnormal development of the cardiovascular and hematopoietic systems in zebrafish embryos,suggesting it may not be a suitable or safe alternative for PFOA.

关键词： Hexafluoropropylene oxide trimer acid Heart development Vascular development Hemopoiesis Zebrafish embryos

Analytical Model and Topology Optimization of Doubly-fed Induction Generator

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CES Transactions on Electrical Machines and Systems 2024年第2期8卷 162-169页

作者： lu Sun Haoyu Kang Jin Wang Zequan Li jianjun Liu Yiming Ma Libing Zhou the State Key Laboratory of Advanced Electromagnetic Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China IEEE Dongfang Electric Machinery Co. LtdDongfang Electric CorporationDeyangChina CSG PGC Energy Storage Research Institute Southern Power Grid Energy Storage Co.LtdGuangzhou 510630China

As the core component of energy conversion for large wind turbines,the output performance of doubly-fed induction generators (DFIGs) plays a decisive role in the power quality of wind *** realize the fast and accurate design optimization of DFIGs,this paper proposes a novel hybriddriven surrogate-assisted optimization *** firstly establishes an accurate subdomain model of DFIGs to analytically predict performance ***,taking the inexpensive analytical dataset produced by the subdomain model as the source domain and the expensive finite element analysis dataset as the target domain,a high-precision surrogate model is trained in a transfer learning way and used for the subsequent multi-objective optimization *** on this model,taking the total harmonic distortion of electromotive force,cogging torque,and iron loss as objectives,and the slot and inner/outer diameters as parameters for optimizing the topology,achieve a rapid and accurate electromagnetic design for ***,experiments are carried out on a 3MW DFIG to validate the effectiveness of the proposed method.

关键词： Doubly-fed induction generators Accurate subdomain model Surrogate-assisted Transfer learning

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基于阵列天线信号处理的防欺骗技术

全球定位系统 2024年第4期49卷 75-85页

作者：卢建军彭新智封帆黄楚涵袁雪林朱祥维中山大学电子与通信工程学院广东深圳518107

GNSS在国家基础设施以及生命安全应用中扮演重要角色,但日益增长的欺骗干扰事件给GNSS带来了巨大威胁.本文介绍了基于阵列天线信号处理的防欺骗技术,根据阵列构型的不同,从均匀阵列和稀疏阵列两个方面总结了欺骗干扰检测与欺骗干扰抑制... 详细信息

GNSS在国家基础设施以及生命安全应用中扮演重要角色,但日益增长的欺骗干扰事件给GNSS带来了巨大威胁.本文介绍了基于阵列天线信号处理的防欺骗技术,根据阵列构型的不同,从均匀阵列和稀疏阵列两个方面总结了欺骗干扰检测与欺骗干扰抑制方法.其中稀疏阵列相较均匀阵列,在相同天线阵元数的情况下,拥有更大的阵列孔径及自由度,极大地降低了设备成本,但其对相干信号处理技术要求更高.最后本文给出了防欺骗干扰技术面临的难题以及其未来的发展趋势.

关键词：欺骗干扰稀疏阵列波达方向估计子空间投影波束成形