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Comparison of hepatitis B prophylactic outcomes in living donor liver transplantation recipients who meet the Milan or UCSF criteria

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Hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 494-499页

作者： Li jiang lu-Nan Yan Tian-Fu wen Bo Li jia-Yin Yang Liver Transplantation Center Department of Liver SurgeryWest China HospitalSichuan University

BACKGROUND:The tumor burden before liver transplantation indicates that hepatitis B virus(HBV) may hide in the extrahepatic and micrometastatic sites which serve as a source of HBV ***,many liver transplant centers,especially in Western countries,use the Milan or UCSF criteria to select patients with hepatocellular carcinoma for liver *** study was undertaken to compare the HBV prophylactic outcomes in two groups of living donor liver transplantation(LDLT) *** in group A met the Milan criteria and those in group B exceeded the Milan criteria but were within the UCSF ***:A database of adult-to-adult right-lobe LDLT performed at our institution for HBV-related hepatocellular carcinoma within the Milan or UCSF criteria between June 2002 and May 2012 was used to compare the HBV prophylactic outcomes between patients within the Milan criteria(group A,41 patients) and those exceeding the Milan criteria but within the UCSF criteria(group B,19 patients).RESULTS:The 1-,3-,and 5-year survival rates were similar between groups A and B(87.8%,85.1% and 74.0% vs 73.3%,61.1% and 61.1%,respectively,P=0.067).HBV recurred in 1 patient in 3.1 months after LDLT in group A and in 2 patients in group B(1 in 11.9 months and 1 in 24.1 months after LDLT).The 1-,3-,and 5-year HBV recurrence rates were 2.6%,2.6% and 2.6% in group A,and 7.3%,17.9% and 17.9% in group B,respectively(P=0.118).CONCluSION:LDLT recipients who exceed the Milan criteria but remain within the UCSF criteria may have post-transplant HBV prophylactic outcomes similar to those who meet the Milan criteria.

关键词： living donor liver transplantation hepatitis B virus hepatocellular carcinoma antiviral therapy

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Anion-immobilized solid composite electrolytes based on metal-organic frameworks and superacid ZrO_(2) fillers for high-performance all solid-state lithium metal batteries

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International Journal of Minerals,Metallurgy and Materials 2021年第10期28卷 1636-1646页

作者： Tao Wei Zao-hong Zhang Qi Zhang jia-hao lu Qi-ming Xiong Feng-yue Wang Xin-ping Zhou wen-jia Zhao Xiang-yun Qiu School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China Institute of Mechanics and Energy National Research Ogarev Mordovia State UniversitySaransk 430000Russia jiangsu University Jingjiang College Zhenjiang 212003China Department of Chemistry College of ScienceNanjing Agricultural UniversityNanjing 210095China Power&Energy Storage System Research Center College of Mechanical and Electrical EngineeringQingdao UniversityQingdao 266071China

Anion-immobilized solid composite electrolytes(SCEs)are important to restrain the propagation of lithium dendrites for all solid-state lithium metal batteries(ASSLMBs).Herein,a novel SCEs based on metal-organic frameworks(MOFs,UiO-66-NH_(2))and superacid ZrO_(2)(S-ZrO_(2))fillers are proposed,and the samples were characterized by X-ray diffraction(XRD),scanning electron microscope(SEM),energy dispersive X-ray spectroscopy(EDS),thermo-gravimetric analyzer(TGA)and some other electrochemical ***-NH_(2) groups of UiO-66-NH_(2) combines with F atoms of poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)chains by hydrogen bonds,leading to a high electrochemical stability window of 5 *** to the incorporation of UiO-66-NH_(2) and S-ZrO_(2) in PVDF-HFP polymer,the open metal sites of MOFs and acid surfaces of S-ZrO_(2) can immobilize anions by strong Lewis acid-base interaction,which enhances the effect of immobilization anions,achieving a high Li-ion transference number(t_(+))of 0.72,and acquiring a high ionic conductivity of 1.05×10^(-4) S·cm^(-1) at 60℃.The symmetrical Li/Li cells with the anion-immobilized SCEs may steadily operate for over 600 h at 0.05 mA·cm^(-2) without the shortcircuit ***,the solid composite Li/LiFePO_(4)(LFP)cell with the anion-immobilized SCEs shows a superior discharge specific capacity of 158 mAh·g^(-1) at 0.2 *** results illustrate that the anion-immobilized SCEs are one of the most promising choices to optimize the performances of ASSLMBs.

关键词： solid composite electrolytes poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP) all solid-state lithium metal batteries metal-organic frameworks anion-immobilized

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Bone marrow inhibition induced by azathioprine in a patient without mutation in the thiopurine S-methyltransferase pathogenic site:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4230-4237页

作者： Xiao-Shuang Zhou Yuan-Yue lu Yan-Fang Gao wen Shao jia Yao College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030012Shanxi ProvinceChina Department of Nephrology The Affiliated People's Hospital of Shanxi Medical UniversityTaiyuan 030032Shanxi ProvinceChina Department of Gastroenterology Shanxi Bethune HospitalTaiyuan 030012Shanxi ProvinceChina

BACKGROUND Azathioprine(AZA)and its close analog 6-mercaptopurine are thiopurines widely used in the treatment of patients with cancer,organ transplantation,and autoimmune or inflammatory diseases,including systemic lupus *** marrow inhibition is a common side effect of AZA,and severe bone marrow inhibition is related to decreased thiopurine S-methyltransferase(TPMT)*** SUMMARY We herein report a patient with proliferative lupus nephritis who was using AZA for maintenance therapy,had no common TPMT pathogenic site mutations,and exhibited severe bone marrow inhibition on the 15th day after oral *** This report alerts physicians to the fact that even though the TPMT gene has no common pathogenic site mutation,severe myelosuppression may also occur.

关键词： Azathioprine Thiopurine S-methyltransferase Bone marrow inhibition lupus nephritis Case report

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Deep learning-based lung sound analysis for intelligent stethoscope

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Military Medical Research 2024年第4期11卷 567-588页

作者： Dong-Min Huang jia Huang Kun Qiao Nan-Shan Zhong Hong-Zhou lu wen-Jin Wang Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongChina The Third People’s Hospital of Shenzhen Shenzhen 518112GuangdongChina Guangzhou Institute of Respiratory Health China State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory Diseasethe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China

Auscultation is crucial for the diagnosis of respiratory system ***,traditional stethoscopes have inherent limitations,such as inter-listener variability and subjectivity,and they cannot record respiratory sounds for offline/retrospective diagnosis or remote prescriptions in *** emergence of digital stethoscopes has overcome these limitations by allowing physicians to store and share respiratory sounds for consultation and *** this basis,machine learning,particularly deep learning,enables the fully-automatic analysis of lung sounds that may pave the way for intelligent *** review thus aims to provide a comprehensive overview of deep learning algorithms used for lung sound analysis to emphasize the significance of artificial intelligence(AI)in this *** focus on each component of deep learning-based lung sound analysis systems,including the task categories,public datasets,denoising methods,and,most importantly,existing deep learning methods,i.e.,the state-of-the-art approaches to convert lung sounds into two-dimensional(2D)spectrograms and use convolutional neural networks for the end-to-end recognition of respiratory diseases or abnormal lung ***,this review highlights current challenges in this field,including the variety of devices,noise sensitivity,and poor interpretability of deep *** address the poor reproducibility and variety of deep learning in this field,this review also provides a scalable and flexible open-source framework that aims to standardize the algorithmic workflow and provide a solid basis for replication and future extension:https://***/contactless-healthcare/Deep-Learning-for-lung-Sound-Analysis.

关键词： Deep learning lung sound analysis Respiratory sounds

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Quantum model for understanding protein misfolding behavior——phase diagram and manual intervention

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Science China(Physics,Mechanics & Astronomy) 2021年第6期64卷 10-16页

作者： wen-wen Mao Li-Hua lu You-Quan Li Zhejiang Province Key Laboratory of Quantum Technology&Device and Department of Physics Zhejiang UniversityHangzhou 310027China Collaberative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210008China

The study of protein folding is fundamental and important in the multidisciplinary field because a diversity of diseases,like Alzheimer’s and Parkinson’s are relevant to protein *** current thermodynamic and geometric approaches only phenomenologically describe but do not provide a mechanistic understanding of the competition between correct folding and *** we present a model to understand the misfolding *** the influence of dissipative strength for all possible sequences and comparing the folding time toward different compact structures,we obtain a phase diagram of the dissipative quantum phase transition that enables us to model the *** also investigate how a perturbation in the Hamiltonian affects the transition point,which motivates us to explore possible manual *** results indicate that the manual intervention may be effective for some specific sequence but not for *** approach is expected to lay a foundation for further studies on manual intervention in protein misfolding.

关键词： quantum phase diagram quantum walk mean first-passage time protein folding

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Microstructure and secondary phases in epitaxial LaBaCo_2O_(5.5 + δ) thin films

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Journal of Materials Science & Technology 2018年第2期34卷 398-402页

作者： jiangbo lu lu lu Sheng Cheng Ming Liu Chunlin jia School of Electronic and Information Engineering & State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons Forschungszentrum Jülich GmbH

Aberration-corrected scanning transmission electron microscopy was employed to investigate the microstructures and secondary phases in LaBaCo2O5.5＋δ（LBCO） thin films grown on SrTiO3 （STO） substrates. The as-grown films showed an epitaxial growth on the substrates with atomically sharp interfaces and orientation relationships of [100]LBCO//[100]STO and （001）LBCO//（001）STO. Secondary phases were observed in the films, which strongly depended on the sample fabrication conditions. In the film prepared at a temperature of 900 ℃, nano-scale CoO pillars nucleated on the substrate, and grew along the [001] direction of the film. In the film grown at a temperature of 1000 ℃, isolated nano-scale C0304 particles appeared, which promoted the growth of {111 } twinning structures in the film. The orientation relationships and the interfaces between the secondary phases and the films were illustrated, and the growth mechanism of the film was discussed.

关键词： Nano-structure Faceted interfaces Secondary phase growth Epitaxial thin film Microstructure Aberration-corrected scanning transmission electron microscopy

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Rare earth-based MOF@mesoporous silica nanoplatform for long-term and luminescence trackable chemotherapy

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Rare Metals 2022年第8期41卷 2701-2710页

作者： lu-Min Wang wen-Yan Liu Ming-Liang Hu jia-Sai Yao Ping Wang jia-Hao Liu Miao He Yi Gao Zhen-Xing Li Gastroenterology Department The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710004China Digestive Diseases in Precision Medicine Institute The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710004China State Key Laboratory of Heavy Oil Processing College of New Energy and MaterialsChina University of Petroleum(Beijing)Beijing102249China

Developing the multifunctional nanocarriers for long-term drug release and luminescence traceability is a challenging *** this task,we designed a novel nanoplatform for long-term and luminescence trackable chemotherapy,which is prepared via a hollow ZIF-8(where ZIF is zeolitic imidazolate frameworks)coated by the Eu^(3+)-doped mesoporous silica(ZIF-8@mesoporous silica).The hollow ZIF-8 is used as a drug library for loading the anticancer drug,and the pH-sensitive properties of ZIF-8 can targeted-release drugs in the tumor and cut down the poisonousness of drugs to normal *** shell layer of mesoporous silica can achieve the long-term drug release,which solves the problem of short drug circulation time in the body,reduces the drug administration frequency,and improves the therapeutic ***,the ZIF-8@mesoporous+doxorubicin(DOX)is injected only once during the 14-day *** addition,Eu^(3+)doped in mesoporous silica ensures luminescence tracking and detection of drug pathways in living ***,this nanoplatform provides a whole new strategy for the longterm treatment of tumors.

关键词： Rare earth ZIF-8 Mesoporous silica Long-term chemotherapy luminescence traceability Nanocarrier

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Clinical characteristics of sentinel polyps and their correlation with proximal colon cancer: A retrospective observational study

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World Journal of Clinical Cases 2019年第20期7卷 3217-3225页

作者： Man Wang jia-Jie lu wen-Jie Kong Xiao-Jing Kang Feng Gao Department of Gastroenterology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina

BACKGROUND Colorectal cancer is a common malignant tumor of the digestive *** relationship between sentinel polyps(rectal polyps with proximal colon cancer)and proximal colon cancer has received extensive attention in recent ***,there is still no clear conclusion regarding the *** To investigate the clinical characteristics of sentinel polyps and their correlation with proximal colon *** A retrospective analysis of 2587 patients with rectal polyps from January 2006 to December 2017 was *** to whether or not proximal colon cancer was diagnosed,the patients were divided into either a sentinel polyp group(192 patients)or a pure rectal polyp group(2395 patients).The endoscopic features,clinicopathological features,therapeutic effects,and short-term prognosis were analyzed and compared between the two *** The mean age of patients in the sentinel polyp group was generally higher than that of the pure rectal polyp group,and the positivity rates of anemia,stool occult blood,and tumor markers of the sentinel polyp group were also significantly higher than those in the rectal polyp group(χ^2=90.56,Pwent endoscopic treatment,and all of the patients were cured and *** the sentinel polyp group,65 patients underwent radical operation,and 61 patients received endoscopic submucosal dissection or endoscopic mucosal ***,21 patients were lost to follow-up after 6-12 mo,and the loss rate was 10.94%.A total of 63.16%of patients experienced remission without tumor recurrence or metastasis,33.33%of patients experienced tum

关键词： Sentinel polyps Rectal polyps Proximal colon cancer Ascending colon cancer Transverse colon cancer

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辣椒引进资源主要经济性状调查及应用前景评价

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广东农业科学 2008年第5期35卷 35-37页

作者：龙卫平李智军张衍荣郑锦荣卢文佳广东省农科集团良种苗木中心广东广州510640

对9份境外引进辣椒资源的抗疫病能力及其他主要经济性状进行鉴定,结果表明:来自台湾的F57、F88,墨西哥的F186及韩国的F214、F215苗期抗辣椒疫病,但只有F57、F186、F215的田间抗性表现与苗期一致;9份引进辣椒资源的成熟期、果型、辣度等... 详细信息

对9份境外引进辣椒资源的抗疫病能力及其他主要经济性状进行鉴定,结果表明:来自台湾的F57、F88,墨西哥的F186及韩国的F214、F215苗期抗辣椒疫病,但只有F57、F186、F215的田间抗性表现与苗期一致;9份引进辣椒资源的成熟期、果型、辣度等主要经济性状差异较大,根据综合经济性状表现,符合育种需要的有F88、F171、F186、F214、F215。

关键词：辣椒资源引进性状评估

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Habitat selection and food choice of White-naped Cranes(Grus vipio)at stopover sites based on satellite tracking and stable isotope analysis

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Avian Research 2022年第4期13卷 468-476页

作者： Yunzhu Liu Lan Wu jia Guo Shengwu jiao Sicheng Ren Cai lu Yuyu Wang Yifei jia Guangchun Lei Li wen Liying Su Centre for East Asian-Australasian Flyway Studies Beijing Forestry UniversityBeijing100083China School of Ecology and Nature Conservation Beijing Forestry UniversityBeijing100083China Research Institute of Subtropical Forestry Chinese Academy of ForestryWetland Ecosystem Research Station of Hangzhou BayHangzhou311400China Science Economics and Insights DivisionNSW Department of PlanningIndustry and EnvironmentSydney2150Australia Department of Earth and Environmental Sciences Macquarie UniversitySydney2109Australia International Crane Foundation BarabooWI53913USA

By combining satellite tracking,land-cover extracted from Landsite 8 images,and the traditional stable isotope analysis,we studied the habitat selection and food preference of a vulnerable migratory waterbird,the Whitenaped Crane(Grus vipio),in one of its key stagging sites,the Shandian River Basin in the semi-arid northern China,to provide knowledge that is critical for its conservation in the *** results showed that the White-naped Cranes used both uplands and natural wetlands in the stopover *** the cranes used farmland and natural land cover equally as night-time roosting grounds,they spent most daytime foraging at *** the extensive usage of croplands as their foraging ground,the Bayesian mixing models based on stable isotopic analysis revealed that crop residues after harvesting,such as Maize(Zea mays)and Naked Oat(Avena chinensis),were only a small fraction of the White-naped Cranes’diet(~19%),and their diet composited mainly natural plants,such as Allium ledebourianum,Potentilla anserina,and ***,more than 20%of the total wetlands in the region were modelled as home range of the *** contrast,less than 10%of croplands and about 1%of the unused uplands were identified as home *** addition,the entire core habitats were located in natural *** findings demonstrated the importance of natural wetlands for the survival of the threatened ***,the satellite-derived land cover data showed that croplands increased rapidly in the last decade in this area,at the expense of natural *** the sharp decrease of White-naped Crane population in China,the conservation of stopover sites becomes *** on our analysis,we recommend the following management actions:conserving adequate natural wetland area,regulating anthropogenic pressures such as the use of herbicides,expanding the duration and extent of current conservation regulations,establishing a comprehensive monitoring progr

关键词： Biased random bridge Food resource Stopover Utilization distribution White-naped Crane

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