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Positive effects of music therapist's selected auditory stimulation on the autonomic nervous system of patients with disorder of consciousness: a randomized controlled trial

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Neural Regeneration Research 2021年第7期16卷 1266-1272页

作者： Xiao-Ying Zhang jian-Jun Li Hai-Tao lu wen-jia Teng Song-Huai Liu School of Rehabilitation Medicine Capital Medical UniversityBeijingChina China Rehabilitation Science Institute BeijingChina Beijing Key Laboratory of Neural Injury and Rehabilitation BeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Music Therapy Center Department of PsychologyChina Rehabilitation Research CenterBeijingChina Department of Neurorehabilitation China Rehabilitation Research CenterBeijingChina

The current randomized controlled trial was performed at the China Rehabilitation Science Institute, China to test the hypothesis that musical auditory stimulation has positive effects on the autonomic nervous system of patients with disorder of *** past studies have recommended that patients with disorder of consciousness listen to patient-preferred music, this practice is not universally accepted by *** patients with severe disorder of consciousness listened to either therapist-selected(n = 10, 6 males and 4 females;43.33 ± 18.76 years old) or patient-preferred(n = 10, 5 males and 5 females, 48.83 ± 18.79 years old) musical therapy, 30 minutes/day, 5 times/week for 6 *** results showed no obvious differences in heart rate variability-related parameters including heart rate, standard deviation of normal-to-normal R-R intervals, and the root-mean-square of successive heartbeat interval differences of successive heartbeat intervals between the two groups of ***, percentage of differences exceeding 50 ms between adjacent normal number of intervals, low-frequency power/high-frequency power, high-frequency power norm, low-frequency power norm, and total power were higher in patients receiving therapist-selected music than in patients receiving their own preferred *** contrast, this relationship was reversed for the high-frequency power and very-low-frequency *** results suggest that compared with preferred musical stimulation, therapist-selected musical stimulation resulted in higher interactive activity of the autonomic nervous ***, therapist-selected musical stimulation should be used to arouse the autonomic nervous system of patients with disorder of *** study was approved by the Institutional Ethics Committee of China Rehabilitation Research Center, China(approval No.2018-022-1) on March 12, 2018 and registered with the Chinese Clinical Trial Registry(registration number Chi

关键词： auditory autonomic nerve system disorder of consciousness heart rate misdiagnosis music therapy protection repair subjective score

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Optical coherence tomography angiography of optic disc perfusion in non-arteritic anterior ischemic optic neuropathy

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1402-1406页

作者： jia-wen Ling Xue Yin Qian-Yi lu Yi-Yi Chen Pei-Rong lu Department of Ophthalmology the First Affiliated Hospital of Soochow University Department of Ophthalmology the Third People's Hospital of Zhangjiagang

AIM：To compare the optic disc blood flow of non-arteritic ischemic optic neuropathy（NAION）eyes with normal ***：The optic disc blood flow densities of diagnosed non-acute phase NAION eyes（21 eyes,14 individuals）and normal eyes（19 eyes,12 individuals）were detected via Optovue optical coherence tomography angiography（OCTA）.The optic disc blood flow was measured via Image J *** between optic disc perfusion and visual function variables were assessed by linear regression ***：The average percentage of the optic disc nonperfusion areas in the non-acute phase NAION patients（17.84%±6.18%）was increased,when compared to the normal control eyes（8.61%±1.65%）,and the difference was statistically significant（P〈0.01）.Moreover,there was a proportional correlation between the visual field mean defect（MD）and the optic disc non-perfusion area percentage,and the relationship was statistically significant（t=3.65,P〈0.01,R2=0.4118）.In addition,the critical correlation between the best corrected visual acuity（BCVA）and the optic disc non-perfusion area percentage was statistically significant（t=4.32,P〈0.01,R2=0.4957）.CONCluSION：The optic disc non-perfusion area percentages detected via OCTA in NAION eyes were significantly increased when compared with the normal *** the BCVA and MD were correlated with the optic disc flow detected,revealing that OCTA may be valuable in the diagnosis and estimation of NAION.

关键词： non-arteritic anterior ischemic optic neuropathy optical coherence tomography angiography visual field visualacuity

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Multi-stage attack weapon target allocation method based on defense area analysis

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Journal of Systems Engineering and Electronics 2020年第3期31卷 539-550页

作者： jia Zhengrong lu Faxing WANG Hangyu National Key Laboratory of Science and Technology on Vessel Integrated Power System Naval University of EngineeringWuhan 430033China College of Weaponry Engineering Naval University of EngineeringWuhan 430033China

For better reflecting the interactive defense between targets in practical combat scenarios,the basic weapon-target allocation(WTA)framework needs to be improved.A multi-stage attack WTA method is ***,a defense area analysis is presented according to the targets’positions and the radii of the defense areas to analyze the interactive coverage and protection between targets’defense ***,with the coverage status and coverage layer number,a multi-stage attack planning method is proposed and the multi-stage attack objective function model is *** is conducted with interactive defense combat scenarios,the traditional WTA method and the multi-stage WTA method are compared,and the objective function model is validated with the Monte-Carlo *** results suggest that if the combat scenario involves interactive coverage of targets’defense areas,it is imperative to analyze the defense areas and apply the multi-stage attack method to weakening the target defense progressively for better combat effectiveness.

关键词： weapon-target allocation(WTA) defense area analysis combat effective analysis

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Fluvial sediments in the Alagxa Plateau as a dust source: iron mineralogical and geochemical evidence

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Journal of Arid Land 2019年第2期11卷 217-227页

作者： WANG Youjun jia jia lu Hao lu Caichen XIA Dunsheng College of Tourism and Environmental Resource Zaozhuang University College of Geography and Environmental Sciences Zhejiang Normal University College of Earth and Environmental Sciences Lanzhou University

The Alagxa Plateau, in the margin of the northeastern Tibetan Plateau, is one of the most important dust source areas in East Asia, and the widespread sandy desert in the area is important both as a reservoir and a source of eolian silty. The northeastern margin of the Tibetan Plateau is one of the most actively-growing mountain belt on earth, and has large amounts of debris, with masses of fine grained material, which were continuously mobilized and deposited in the Alagxa Plateau by rivers, forming broad alluvial fans. It is possible that the role of fluvial sediments as a source of silty dust in the Alagxa Plateau has been underestimated. In this study, we test this hypothesis by investigating the iron mineralogical and geochemical characteristics of the fluvial sediments and the surface material of the sandy desert in the Alagxa Plateau, and comparing them with paleo-eolian dust deposits(loess) in the adjacent Chinese Loess Plateau(CLP) to investigate the possible linkages among the fluvial sediments, sandy desert and the last glacial loess of the CLP. The results show that sandy desert typically have high contents of goethite, and high ratios of goethite to hematite, similar to the fluvial sediments in the Alagxa Plateau. Based on the major element characteristics, field investigations and the results of previous studies, we found a genetic link between the silt component of the fluvial sediments and the sandy desert in the Alagxa Plateau with high value of Gt(goethite) and similarity of the Gt/(Hm(hematite)+Gt) ratio. But the silt component of the sandy desert main come from the adjacent fluvial sediments. The iron mineralogical characteristics(χ(magnetic susceptibility), χARM(anhysteretic susceptibility), SIRM(saturation isothermal remanent magnetization) and SIRM_(AF100 mT)(SIRM demagnetized at 100 mT)) of the CLP samples overlap with those of the fluvial sediments in the Alagxa Plateau, but there is a mismatch with the sandy desert samples. This suggests th

关键词： fluvial sediments silty dust sandy dust iron mineralogical and geochemical characteristic Alagxa Plateau

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Development and validation of a predictive score for perioperative transfusion in patients with hepatocellular carcinoma undergoing liver resection

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Hepatobiliary & Pancreatic Diseases International 2015年第4期14卷 394-400页

作者： Hai-Qing Wang jian Yang jia-Yin Yang wen-Tao Wang lu-Nan Yan Department of Liver Surgery West China Hospital Sichuan University

Liver resection is a major surgery requiring perioperative blood transfusion. Predicting the need for blood transfusion for patients undergoing liver resection is of great importance. The present study aimed to develop and validate a model for predicting transfusion requirement in HBV-related hepatocellular carcinoma patients undergoing liver resection. METHODS： A total of 1543 consecutive liver resections were included in the study. Randomly selected sample set of 1080 cases （70% of the study cohort） were used to develop a predic- tive score for transfusion requirement and the remaining 30% （n=463） was used to validate the score. Based on the preopera- tive and predictable intraoperative parameters, logistic regres- sion was used to identify risk factors and to create an integer score for the prediction of transfusion requirement. RESULTS： Extrahepatic procedure, major liver resection, hemoglobin level and platelets count were identified as inde- pendent predictors for transfusion requirement by logistic regression analysis. A score system integrating these 4 factors was stratified into three groups which could predict the risk of transfusion, with a rate of 11.4%, 24.7% and 57.4% for low, moderate and high risk, respectively. The prediction model appeared accurate with good discriminatory abilities, generat- ing an area under the receiver operating characteristic curve of 0.736 in the development set and 0.709 in the validation set. CONCluSIONS： We have developed and validated an integer- based risk score to predict perioperative transfusion for pa- tients undergoing liver resection in a high-volume surgicalcenter. This score allows identifying patients at a high risk and may alter transfusion practices.

关键词： liver resection transfusion hepatocellular carcinoma

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Crystal growth and electrical transport properties of niobium and tantalum monopnictide and dipnictide semimetals

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Frontiers of physics 2017年第3期12卷 1-17页

作者： Hong lu Shuang jia International Center for Quantum Materials School of Physics Peking University Beijing 100871 China Collaborative Innovation Center of Quantum Matter Beijing 100871 China

The discovery of the first Weyl semimetal tantalum monoarsenide has greatly promoted physical re- search on the niobium and tantalum pnictide compounds. Crystallizing into the NbAs- and OsGe2-type structures, these mono-and di-pnictide semimetals manifest exotic electrical transport properties in magnetic field, which only occur in their single-crystalline forms. All the unusual electrical properties correspond to their poor carriers, which are indeed vulnerable to various crystal defects. In this review article, we present a comprehensive comparison of the crystal growth and electrical transport prop- erties of the two semimetal families. We then discuss in detail the possible characteristic transport features, such as the chiral anomaly of Weyl quasiparticles. We emphasize the importance of crystal growth and sample manipulation for exploring the unique topological properties of Weyl semimetals in the future.

关键词： Weyl semimtal crystal growth electrical transport

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Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease

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Neural Regeneration Research 2023年第8期18卷 1818-1826页

作者： Hai-Yang Yu Tong Sun Zhen Wang Hong Li Duo Xu Jing An lu-lu wen jia-Yi Li wen Li Juan Feng Department of Neurology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Pediatrics Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Laboratory of Research in Parkinson’s Disease and Related Disorders Health Sciences InstituteChina Medical UniversityShenyangLiaoning ProvinceChina Neural Plasticity and Repair Unit Department of Experimental Medical ScienceLund UniversityLundSweden

Use of glucagon-like peptide-1 receptor agonist or dipeptidyl peptidase 4 inhibitor has been shown to lower the incidence of Parkinson's disease in patients with diabetes ***,using these two treatments may help treat Parkinson's *** further investigate the mechanisms of action of these two compounds,we established a model of Parkinson's disease by treating mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and then subcutaneously injected them with the glucagon-like peptide-1 receptor agonist exendin-4 or the dipeptidyl peptidase 4 inhibitor *** found that both exendin-4 and linagliptin reversed motor dysfunction,glial activation,and dopaminergic neuronal death in this *** addition,both exendin-4 and linagliptin induced microglial polarization to the anti-inflammatory M2 phenotype and reduced pro-inflammatory cytokine ***,in vitro experiments showed that treatment with exendin-4 and linagliptin inhibited activation of the nucleotide-binding oligomerization domain-and leucine-rich-repeat-and pyrin-domaincontaining 3/caspase-1/interleukin-1βpathway and subsequent pyroptosis by decreasing the production of reactive oxygen *** findings suggest that exendin-4 and linagliptin exert neuroprotective effects by attenuating neuroinflammation through regulation of microglial polarization and the nucleotidebinding oligomerization domain-and leucine-rich-repeat-and pyrin-domain-containing 3/caspase-1/interleukin-1βpathway in a mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,***,these two drugs may serve as novel anti-inflammatory treatments for Parkinson's disease.

关键词： diabetes mellitus dipeptidyl peptidase 4 inhibitor exendin-4 glucagon-like peptide-1 receptor agonist 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine linagliptin microglia neuroinflammation NLRP3 inflammasome Parkinson's disease pyroptosis

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采用端口阻抗测试的车载充电机传导电磁干扰建模方法研究

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西安交通大学学报 2025年第1期59卷 172-182页

作者：李季风耿宇宇贾晋廖兴林路青洋重庆理工大学电气与电子工程学院重庆400054 重庆理工大学汽车零部件先进制造技术教育部重点实验室重庆400054

针对电动汽车车载充电机的设计过程中普遍存在的电磁干扰频率范围广、干扰源复杂的问题,提出了一种基于端口阻抗测试的等效电路建模和系统级协同仿真方法。首先,通过对车载充电机系统各部件进行阻抗测试和三维电磁仿真,建立了无源器件... 详细信息

针对电动汽车车载充电机的设计过程中普遍存在的电磁干扰频率范围广、干扰源复杂的问题,提出了一种基于端口阻抗测试的等效电路建模和系统级协同仿真方法。首先,通过对车载充电机系统各部件进行阻抗测试和三维电磁仿真,建立了无源器件、端口滤波器和高压屏蔽线缆模型,提取了系统印制电路板关键回路的高频寄生参数。其次,建立了有源器件的仿真电路模拟器等效模型,并通过双脉冲实验验证模型的精度;针对功率因数校正电路控制环节的仿真与建模难以同步实现的问题,采用协同建模的方法构建整个系统的等效电路模型。最后,将各部件模型组合在一起,建立了完整的车载充电机系统传导电磁干扰预测模型,并依据相关测试标准进行了系统传导电磁干扰仿真和实验。结果表明:在150 kHz~30 MHz频率范围内,预测结果与实际结果的误差小于9 dB,具有良好的一致性,表明该模型能够精确预测车载充电机系统高压交流端的传导干扰水平,可以有效指导充电机系统的电磁兼容正向设计。

关键词：车载充电机电磁干扰端口阻抗测试协同仿真

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Role of the postoperative cholesterol in early allograft dysfunction and survival after living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 610-616页

作者： jian Yang Hai-Qing Wang jia-Yin Yang Tian-Fu wen Bo Li wen-Tao Wang lu-Nan Yan Department of Liver Transplantation Center West China Hospital of Sichuan University Chengdu 610041 China

BACKGROUND:Many studies have confirmed that serum total cholesterol(sTC) concentrations were associated with underlying liver damage and the synthesis capacity of ***, the role of postoperative sTC level on evaluating graft function and predicting survival of recipients who underwent liver transplantation has not been ***:Clinical data of 231 living donor liver transplantation recipients from May 2003 to January 2015 were retrospectively collected. Patients were stratified into the low sTC group(sTC luSIONS:sTC <1.42 mmol/L on postoperative day 3 was an independent risk factor of postoperative early allograft dysfunction, 90-day mortality, recipient a

关键词： lipid metabolism graft survival early allograft dysfunction morbidity mortality

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Modeling the effects of urbanization on grain production and consumption in China

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Journal of Integrative Agriculture 2017年第6期16卷 1393-1405页

作者： lu wen-cong Chen Ning-lu Qian wen-xin China Academy for Rural Development Zhejiang University Hangzhou 310058 P.R. China School of Management Zhejiang University Hangzhou 310058 P.R. China

The impact of rapid urbanization on food security of China has received considerable *** is not clear whether China can strike a balance between urbanization and food security,especially grain *** have been numerous studies examining the effects of urbanization on grain production or consumption,but few studies have yet analyzed grain *** on the Chinese World Agricultural Regional Market Equilibrium Model（CWARMEM）,this paper explores the impacts of urbanization on national and regional grain balances through different *** CWARMEM is a global partial equilibrium multimarket model which captures the differences between urban and rural residents as well as the effects of *** results show that urbanization has a small negative effect on maintaining grain *** of that,China is able to achieve the objective of grain security set by its ***,urbanization changes regional grain balances across China：The position of Northeast China and North China,as two dominant grain suppliers of China,will be weaken;Central China and East China will increase dependence on other grain suppliers;the grain surplus of Northwest China will increase ***,in terms of grain category,urbanization helps China achieve self-sufficiency in food grain（rice and wheat）,while expands deficit of feed grain（maize）.

关键词： urbanization grain self-sufficiency grain security

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