检索结果-南通市图书馆

Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

引用

World Journal of Gastroenterology 2024年第11期30卷 1556-1571页

作者： Yan-Chao Hu Xiang-Chun Ding hui-juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Department of Infectious Disease General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Infectious Disease Clinical Research Center of Ningxia Yinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic *** the relationship between certain single probiotics and HBC has been explored,the impact of the complex ready-to-eat Lactobacillus paracasei N1115(LP N1115)supplement on patients with HBC has not been *** To compare the changes in the microbiota,inflammatory factor levels,and liver function before and after probiotic treatment in HBC *** This study included 160 HBC patients diagnosed at the General Hospital of Ningxia Medical University between October 2018 and December *** were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment *** samples were collected at the onset and conclusion of the 12-wk intervention *** structure of the intestinal microbiota and the levels of serological indicators,such as liver function and inflammatory factors,were *** Following LP N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group(PluSION LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota,improving liver function,and reducing inflammatory factor levels.

关键词： Hepatitis B cirrhosis N1115 ready-to-eat lactobacillus Inflammation Liver function Lachnospiraceae incertae sedis Probiotic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Grain boundary engineering for enhancing intergranular damage resistance of ferritic/martensitic steel P92

引用

Nuclear Science and Techniques 2024年第5期35卷 186-199页

作者： Lei Peng Shang-Ming Chen Jing-Yi Shi Yong-Jie Sun Yi-Fei Liu Yin-Zhong Shen Hong-Ya He hui-juan Wang Jie Tian State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China School of Materials Engineering Shanghai University of Engineering Science333 Long Teng RoadShanghai 201620China Experimental Center of Engineering and Material Science University of Science and Technology of ChinaHefei 230026China

Ferritic/martensitic(F/M)steel is widely used as a structural material in thermal and nuclear power ***,it is susceptible to intergranular damage,which is a critical issue,under service *** this study,to improve the resistance to intergranular damage of F/M steel,a thermomechanical process(TMP)was employed to achieve a grain boundary engineering(GBE)microstructure in F/M steel *** TMP,including cold-rolling thickness reduction of 6%,9%,and 12%,followed by austenitization at 1323 K for 40 min and tempering at 1053 K for 45 min,was applied to the as-received(AR)P92 *** prior austenite grain(PAG)size,prior austenite grain boundary character distribution(GBCD),and connectivity of prior austenite grain boundaries(PAGBs)were *** to the AR specimen,the PAG size did not change *** fraction of coincident site lattice boundaries(CSLBs,3≤Σ≤29)and Σ3^(n) boundaries along PAGBs decreased with increasing reduction ratio because the recrystallization fraction increased with increasing reduction *** PAGB connectivity of the 6%deformed specimen slightly deteriorated compared with that of the AR ***,potentiodynamic polarization studies revealed that the intergranular damage resistance of the studied steel could be improved by increasing the fraction of CSLBs along the PAGBs,indicating that the TMP,which involves low deformation,could enhance the intergranular damage resistance.

关键词： Grain boundary engineering Ferritic/martensitic steel Prior austenite grain boundary character distribution Grain boundary connectivity Intergranular damage resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于输出不一致测度的极限学习机集成的基因表达数据分类

引用

计算机学报 2013年第2期36卷 341-348页

作者：陆慧娟安春霖马小平郑恩辉杨小兵中国矿业大学信息与电气工程学院江苏徐州221008 中国计量学院信息工程学院杭州310018 中国计量学院机电工程学院杭州310018

选择性集成学习已经成为分析基因表达数据、获取生物学信息的有力工具.为了更好地挖掘基因表达数据,利用极限学习机的集成,克服单个ELM用于数据分类时性能欠稳定的缺点,文中提出了一种基于输出不一致测度的ELM相异性集成算法(D-D-ELM).... 详细信息

选择性集成学习已经成为分析基因表达数据、获取生物学信息的有力工具.为了更好地挖掘基因表达数据,利用极限学习机的集成,克服单个ELM用于数据分类时性能欠稳定的缺点,文中提出了一种基于输出不一致测度的ELM相异性集成算法(D-D-ELM).算法首先以输出不一致测度为标准对多个ELM模型进行相异性判断,其次根据ELM的平均分类精度剔除掉相应的模型,最后对筛选后的分类模型用多数投票法进行集成.算法被运用到Breast、Leukemia、Colon、Heart基因表达数据上,并通过理论和实验得到验证.实验结果的统计学分析表明D-D-ELM能够以更少的模型数量达到较稳定的分类精度.

关键词：极限学习机基因表达数据集成算法输出不一致测度分类

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

p16^INK4a在宫颈液基细胞学辅助筛查中的标记意义

引用

中华肿瘤杂志 2008年第3期30卷 211-214页

作者：徐婷陆惠娟何以丰上海市第一妇婴保健院病理科 200040

目的评价p16^INK4a在宫颈液基细胞学检查中的标记意义。方法收集74例宫颈外口和颈管的脱落细胞标本，分别进行液基细胞学检测和p16^INK4a免疫细胞化学染色，并应用杂交捕获二代法检测高危人乳头瘤病毒（HR—HPV）感染。结果74例标本中... 详细信息

目的评价p16^INK4a在宫颈液基细胞学检查中的标记意义。方法收集74例宫颈外口和颈管的脱落细胞标本，分别进行液基细胞学检测和p16^INK4a免疫细胞化学染色，并应用杂交捕获二代法检测高危人乳头瘤病毒（HR—HPV）感染。结果74例标本中，细胞学诊断未见癌细胞或癌前病变细胞（阴性）10例，意义不明的不典型鳞状细胞（ASC—US）15例，鳞状上皮内低度病变（LSIL）28例，不除外上皮内高度病变的不典型鳞状细胞（ASC—H）5例，鳞状上皮内高度病变（HSIL）11例，鳞状细胞癌（SCC）5例。各级别病变中，HR—HPV阳性者分别为1、4、3、9、7和5例，p16^INK4a免疫细胞化学染色阳性者分别为2、5、3、8、9和5例。随着宫颈病变级别的上升，HR—HPV和p16^INK4a免疫细胞化学染色阳性率均增高。结论p16^INK4a免疫细胞化学染色增强了对不典型细胞的区分能力，可以提高宫颈癌筛查的准确性。

关键词： p16^INK4a 人乳头瘤病毒免疫细胞化学液基细胞学检测宫颈肿瘤

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Magnetic resonance imaging of knees:a novel approach to predict recombinant human growth hormone therapy response in short-stature children in late puberty

引用

World Journal of Pediatrics 2024年第7期20卷 723-734页

作者： Xi Bai Zhi‑Bo Zhou Xiao‑Yuan Guo Yi‑Ling He Yue‑lun Zhang Feng‑Dan Wang Feng Feng Hong‑Bo Yang Shi Chen Feng‑Ying Gong hui‑juan Zhu hui Pan Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Key Laboratory of Endocrinology of National Health Commission Department of EndocrinologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina

Background There is no appropriate tool to predict recombinant human growth hormone(rhGH)response before therapy initiation in short-stature children in late *** current study aimed to explore the associations between magnetic resonance imaging(MRI)stages of the knee growth plates and rhGH response in short-stature children in late *** In this prospective cohort study,short-stature children in late puberty were treated with rhGH and followed up for 6 *** proposed a novel knee MRI staging system according to the growth plate states of distal femurs or proximal tibias and divided the participants into three groups:unclosed growth plate group,marginally closed growth plate group,and nearly closed growth plate *** primary outcomes were height gain and growth velocity(GV),which were assessed three months *** Fifty participants were enrolled,including 23 boys and 27 *** and height gain after 6 months of rhGH therapy decreased successively in the three groups with an increased degree of growth plate fusion,especially when grouped by proximal tibias(GV_(1-3 mon)from 9.38 to 6.08 to 4.56 cm/year,GV_(4-6 mon)from 6.75 to 4.92 to 3.25 cm/year,and height gain from 4.03 to 2.75 to 1.95 cm,all Plusion The MRI staging method is expected to be an effective tool for predicting rhGH response before therapy initiation in short-stature children in late puberty.

关键词： Growth hormone Growth velocity Late puberty Magnetic resonance imaging Short stature

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development and validation of a circulating tumor DNA-based optimization-prediction model for short-term postoperative recurrence of endometrial cancer

引用

World Journal of Clinical Cases 2024年第18期12卷 3385-3394页

作者： Yuan Liu Xiao-Ning lu hui-Ming Guo Chan Bao juan Zhang Yu-Ni Jin Department of Gynaecology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Endometrial cancer(EC)is a common gynecological malignancy that typically requires prompt surgical intervention;however,the advantage of surgical management is limited by the high postoperative recurrence rates and adverse *** studies have highlighted the prognostic potential of circulating tumor DNA(ctDNA)monitoring for minimal residual disease in patients with *** To develop and validate an optimized ctDNA-based model for predicting shortterm postoperative EC *** We retrospectively analyzed 294 EC patients treated surgically from 2015-2019 to devise a short-term recurrence prediction model,which was validated on 143 EC patients operated between 2020 and *** factors were identified using univariate Cox,Lasso,and multivariate Cox regressions.A nomogram was created to predict the 1,1.5,and 2-year recurrence-free survival(RFS).Model performance was assessed via receiver operating characteristic(ROC),calibration,and decision curve analyses(DCA),leading to a recurrence risk stratification *** Based on the regression analysis and the nomogram created,patients with postoperative ctDNA-negativity,postoperative carcinoembryonic antigen 125(CA125)levels of<19 U/mL,and grade G1 tumors had improved RFS after *** nomogram’s efficacy for recurrence prediction was confirmed through ROC analysis,calibration curves,and DCA methods,highlighting its high accuracy and clinical ***,using the nomogram,the patients were successfully classified into three risk *** The nomogram accurately predicted RFS after EC surgery at 1,1.5,and 2 *** model will help clinicians personalize treatments,stratify risks,and enhance clinical outcomes for patients with EC.

关键词： Circulating tumor DNA Endometrial cancer Short-term recurrence Predictive model Prospective validation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence and clinical impact of sarcopenia in liver transplant recipients:A meta-analysis

引用

World Journal of Gastroenterology 2024年第8期30卷 956-968页

作者： Min-Jie Jiang Mu-Chen Wu Zhong-hui Duan Jing Wu Xiao-Tong Xu juan Li Qing-Hua Meng Department of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of Emergency Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

BACKGROUND The prevalence of sarcopenia in patients undergoing liver transplantation(LT)remains to be determined partly because of different diagnostic *** has recently been recognized as a new prognostic factor for predicting outcomes in LT *** To estimate the prevalence of sarcopenia and evaluate its clinical effect on LT *** This systematic search was conducted in PubMed,Web of Science,Embase,and Cochrane Library for original English-language articles that investigated the prevalence and influence of sarcopenia in patients undergoing LT from database inception to November 30,*** studies of the definition of sarcopenia that estimate sarcopenia prevalence and evaluate its effect on clinical outcomes and the risk of mortality were *** Twenty-five studies involving 7760 patients undergoing LT were *** pooled prevalence of sarcopenia in patients undergoing LT was 40.7%[95%confidence intervals(95%CI):32.1-49.6].The 1-,3-,and 5-year cumulative probab-ilities of post-LT survival in patients with preoperative sarcopenia were all lower than those without sarcopenia(P<0.05).Sarcopenia was associated with an increased risk of post-LT mortality in patients undergoing LT(adjusted hazard ratio:1.58;95%CI:1.21-2.07).Patients with preoperative sarcopenia had a longer intensive care unit stay,a high risk ratio of sepsis,and serious post-LT complications than those without *** Sarcopenia is prevalent in a substantial proportion of patients undergoing LT and is strongly and independently associated with higher a risk of mortality risk.

关键词： Sarcopenia Liver transplantation Mortality Clinical outcomes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

海量基因特征中早期癌症生物标记识别仿真

引用

计算机仿真 2013年第10期30卷 403-405,442页

作者：关伟陆慧娟中国计量学院浙江杭州310018

研究早期癌症生物标记准确识别的问题。早期的癌症特征中,癌症的生物表示特征由于变化很小,基因位特征识别筛选过程中,传统的模式识别方式在发现与癌症相关的重要基因集合中搜索,挖掘过程由于特征标记过小,造成可识别实验数据增加,识别... 详细信息

研究早期癌症生物标记准确识别的问题。早期的癌症特征中,癌症的生物表示特征由于变化很小,基因位特征识别筛选过程中,传统的模式识别方式在发现与癌症相关的重要基因集合中搜索,挖掘过程由于特征标记过小,造成可识别实验数据增加,识别能力大幅下降,识别的不准确。提出了一种人工免疫的早期癌症生物标记识别方法。建立向量空间模型,描述早期癌症生物标记的基因特征,利用人工免疫方法,对所有的抗体克隆副本进行统计,获取特征匹配度,利用匹配度与阀值的正比关系,优化早期癌症生物标记的识别过程。实验结果表明,算法进行海量基因特征中的早期癌症生物标记识别中,能够极大地提高识别的准确性。

关键词：基因特征早期癌症生物标记人工免疫

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigation of the cell composition and gene expression in the delayed-type hypersensitivity tuberculin skin test

引用

Military Medical Research 2024年第1期11卷 148-151页

作者： hui-juan Duan Hong-Qian Chu Ting-Ming Cao Guang-Ming Dai Na Tian Gang Sheng Zhao-Gang Sun Beijing Key Laboratory in Drug Resistant Tuberculosis Research Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing Chest HospitalCapital Medical UniversityBeijing 101149China

Dear Editor,The tuberculin skin test(TST)reagents have continuously improved,with the ESAT6-CFP10(EC)test having recently been introduced,but are seldom based on the direction of the delayed-type hypersensitivity(DTH)*** studies only partially showed the infiltration and activation of immune cells and the production of cytokines of the skin induration[1,2],and lack the detailed measurements of cell proportions and gene expression in the DTH ***,in this study,we revealed the comprehensive characteristics of DTH by single-cell RNA sequencing(scRNA-seq)in the guinea pig tuberculosis(TB)model[Experimental Animal Welfare Ethics Committee,Beijing Tuberculosis and Thoracic Tumor Research Institute(2021-064)].

关键词： Tuberculin skin test Delayed-type hypersensitivity Single-cell RNA sequencing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

略论清末民初知识女性的职业状况

引用

石家庄学院学报 2008年第1期10卷 87-92页

作者：逯慧娟中央司法警官学院警察管理系河北保定071000

清末民初女子教育的发展,使得女性获得职业成为一种可能,由此打破了职业领域男子占统治地位的状况,也为女性的发展带来了空前的机遇和挑战。许多女知识分子利用她们掌握的各种知识资源,开始向各个行业渗透,出现了诸如女教师、女医生、... 详细信息

清末民初女子教育的发展,使得女性获得职业成为一种可能,由此打破了职业领域男子占统治地位的状况,也为女性的发展带来了空前的机遇和挑战。许多女知识分子利用她们掌握的各种知识资源,开始向各个行业渗透,出现了诸如女教师、女医生、女护士、女报人等等。知识女性不仅成为独立谋生的人,而且她们的出现,提高了女性的素质和社会地位,是近代中国妇女的荣耀。谋求职业已成为一部分妇女新的人生追求。

关键词：清末民初知识女性职业

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：