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三代同堂:代际知识转移对农户亲环境生产行为的影响

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农业技术经济 2024年第1期 4-18页

作者：张露罗必良华中农业大学经济管理学院武汉430070 华南农业大学国家农业制度与发展研究院广州510642

已有研究偏重从政府和市场视角探究农户亲环境生产行为的塑造问题。关于家庭人力资本的研究文献也相对忽略农户行为的本源性动因,未能对代际知识转移的内在影响予以足够重视。本文以农业化肥施用量为例,利用湖北省水稻主产区1470户稻农... 详细信息

已有研究偏重从政府和市场视角探究农户亲环境生产行为的塑造问题。关于家庭人力资本的研究文献也相对忽略农户行为的本源性动因,未能对代际知识转移的内在影响予以足够重视。本文以农业化肥施用量为例,利用湖北省水稻主产区1470户稻农的问卷调查数据,讨论三代同堂农户亲环境行为的生成机理,研究表明:(1)三代同堂能够显著降低农户生产经营中的化肥施用量,诱导其亲环境行为;(2)三代同堂诱致亲环境行为的内生路径在于改善人力资本,并与耕地质量和机械作业紧密关联;(3)家庭第一代成员的饥荒记忆,会强化其对自然的敬畏之心,从而显著增进家庭的亲环境行为;(4)家庭第三代成员的外出务工经历,会扩展其社交网络的宽度和层次,继而驱动农户家庭的亲环境行为。本文认为,农业领域的传统知识并不等同于落后经验,特定历史情景下父辈所积累的农业生产知识,往往具有亲环境的先进性;子代也存在对家庭知识积累的补充与更新,并能够成为亲环境行为的重要驱动力。

关键词：三代同堂代际知识转移农业化肥减量亲环境行为

Extraction of weak values in the process of retrieving quantum entanglement state

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Optoelectronics Letters 2024年第10期20卷 636-640页

作者： DU Shaojiang FENG Hairan zhang lu YANG Lianwu PENG Yonggang School of Physical Science and Intelligent Engineering Jining University School of Physics Shandong University

A reversible operation protocol is provided for a weak-measured quantum entanglement state. The evolution of weak values is studied under different parameter conditions. The weak values can be extracted from the entanglement state and the weak-measured quantum entanglement state can be revived to its initial state theoretically by weak measurement and reversibility operation respectively. We demonstrate the reversible operation protocol by taking Bell's state as an example. The negativity is used to analyze the initial state, the weak-measured state and the reversed state in order to describe the evolution of quantum entanglement degree. Weak values are detected from the quantum entanglement state by weak measurement and the degree of the weak-measured quantum entanglement state can be revived to its initial state through reversible operation. The information of quantum entanglement state would be extracted from weak values detected in the process of the scheme.

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Impact of ursodeoxycholic acid therapy in autoimmune liver disease patients with COVID-19 and its clinical prognosis

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Biosafety and Health 2024年第3期6卷 165-170页

作者： Minghui Li Weihua Cao Tingting Jiang Wen Deng Shiyu Wang Shuling Wu lu zhang Yao lu Min Chang Ruyu Liu Xiaoyan Ding Ge Shen Yuanjiao Gao Hongxiao Hao Xiaoxue Chen Leiping Hu Mengjiao Xu Yuyong Jiang Wei Yi Yao Xie Rui Song Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Medical Oncology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Infectious Disease Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

To explore the impact of ursodeoxycholic acid(UDCA)on severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and clinical outcomes in patients with autoimmune liver disease(AILD).Patients diagnosed with AILD were enrolled and divided into a UDCA group and a non-UDCA group based on whether they received UDCA *** data were collected regarding AILD diagnosis,treatment,biochemical indicators,and imaging *** incidence of SARS-CoV-2 infection and the prognosis of AILD patients were observed.A total of 1,138 patients completed *** usage rate of hormone(P=0.003)and immunosuppressant(P=0.001)used for treating AILD in the non-UDCA group was markedly lower than in the UDCA *** UDCA usage rate was markedly lower in SARS-CoV-2 infected patients than in uninfected patients(P=0.003).The rate of SARS-CoV-2 infection in the non-UDCA group was significantly higher than in the UDCA group(P=0.018).Logistic regression analysis showed that UDCA use(P=0.003)was correlated to a lower incidence of SARS-CoV-2,while immunosuppressant use(P=0.017)increased the *** time from SARS-CoV-2 infection was markedly longer for those receiving UDCA treatment than those in the non-UDCA group(P=0.018).UDCA is associated with low SARS-CoV-2 incidence in AILD patients,while immunosuppressant increases its incidence *** receiving UDCA treatment have a longer recovery time after being infected.

关键词： Ursodeoxycholic acid(UDCA) Autoimmune liver disease(AILD) Coronavirus disease 2019(COVID-19) Primary biliary cholangitis(PBC) Autoimmune hepatitis(AIH)

Uncovering Chemical Interactions between Danshen and Danggui Using Liquid Chromatography–Mass Spectrometry and Network Pharmacology-Based Research on Stroke

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 230-243页

作者： Han-Qing Pang Jia-Xiu Guo Xiao-Yu Shang Jian Wang Hui Liu Jing Tian lu zhang Jian-Bin Wang Wei Shi Bing-Chun Yan Liang Liu Department of Pharmacy School of MedicineInstitute of Translational MedicineYangzhou UniversityYangzhouChina School of Medicine Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile DiseasesYangzhou UniversityYangzhouChina School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Guangxi Normal University)GuilingChina Yangzhou Food and Drug Inspection and Testing Center YangzhouChina

Objective: The objective of this study was to decipher chemical interactions between Danshen and Danggui using liquid chromatography–mass spectrometry(LC-MS) and explore the mechanisms of Danshen–Danggui against stroke using network pharmacology and molecular docking. Materials and Methods: First, the chemical compounds of Danshen–Danggui were profiled using ultra-high-performance liquid chromatography(HPLC)-quadrupole time-of-flight MS. Accurately characterized compounds in various proportions of Danshen–Danggui were quantified using HPLC combined with triple quadrupole electrospray tandem MS. Network pharmacology was used to uncover the essential mechanisms of action of Danshen–Danggui against stroke. Discovery Studio Software was used for the molecular docking verification of key active chemicals and stroke-related targets. Results: A total of 53 compounds were characterized, and 22 accurately identified constituents(10 phenolic acids, 8 phthalides, and 4 tanshinones) were quantified in 15 proportions of Danshen–Danggui. The quantification results showed that Danggui significantly increased the dissolution of most phenolic acids(compounds from Danshen), whereas Danshen promoted the dissolution of most phthalides(compounds from Danggui). Overall, the combination of Danshen and Danggui at a 1:1 ratio resulted in the maximum total dissolution rate. Further network pharmacology and molecular docking results indicated that Danshen–Danggui exerted anti-stroke effects mainly by regulating inflammation-related(tumor necrosis factor, hypoxia-inducible factor, and toll-like receptor) signaling pathways, which ranked among the top three pathways based on Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analysis. Conclusion: The chemical compounds in Danshen–Danggui could interact with each other to increase the dissolution of the most active compounds, which could provide a solid basis for uncovering the compatibility mechanisms of Danshen–Danggui and Danshen–Danggu

关键词： Chemical interactions Danggui Danshen liquid chromatography–mass spectrometry network pharmacology

中药调控间充质干细胞外泌体治疗缺血性心脑血管疾病研究进展

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中国实验方剂学杂志 2024年第13期30卷 250-258页

作者：解冬张露张金生河南中医药大学郑州450046 河南中医药大学第三附属医院郑州450000

缺血性心脑血管疾病包括缺血性心脏病和缺血性脑血管病,具有高患病率、高致残率、高死亡率的特点,目前已成为全球死亡原因首位。缺血性心脏病和缺血性脑血管病的共同病因是血管狭窄、粥样硬化及梗死造成的局部供血减少,而其复杂的病理... 详细信息

缺血性心脑血管疾病包括缺血性心脏病和缺血性脑血管病,具有高患病率、高致残率、高死亡率的特点,目前已成为全球死亡原因首位。缺血性心脏病和缺血性脑血管病的共同病因是血管狭窄、粥样硬化及梗死造成的局部供血减少,而其复杂的病理过程涉及炎症、焦亡、凋亡、自噬等多种机制,干预单一的病理环节治疗作用有限,亟需寻找可同时干预多个病理环节的新的治疗策略或药物。间充质干细胞通过其旁分泌效应起到组织修复的作用,外泌体在其中扮演重要角色,间充质干细胞外泌体具有与母细胞相似的免疫调节和修复特性,同时可减少干细胞直接应用后的不良反应及输注毒性,其在治疗缺血性心脑血管疾病中具有广泛应用前景。中药及组方具有多成分、多靶标、多层次系统调节的作用特点,中药可通过对间充质干细胞源性外泌体的调控改善细胞微环境从而对缺血性心脑血管疾病发挥治疗作用,体现现代中医微观辨证的观点,是中医药现代化的又一重要领域。该文对间充质干细胞外泌体对缺血性心脑血管疾病的治疗作用及机制进行了综述,同时讨论了中药调控间充质外泌体在缺血性心脑血管疾病中的应用作用,为中医药防治缺血性心脑血管病提供新思路。

关键词：中医药间充质干细胞外泌体缺血性心脏病缺血性脑血管疾病

考虑瓦块磨损的可倾瓦径向轴承-转子系统动态特性研究

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振动与冲击 2024年第11期43卷 255-263页

作者：章朝栋余文念张路重庆大学机械与运载工程学院重庆400044 重庆大学高端装备机械传动全国重点实验室重庆400044 中车株洲电力机车有限公司湖南株洲412001

针对含有瓦块磨损故障的可倾瓦径向轴承-转子系统润滑和振动特性耦合建模问题,考虑了瓦块磨损、转子与瓦块平摆振动和轴承混合润滑的影响,提出了可倾瓦径向轴承-转子系统的混合润滑动力学模型,研究了不同磨损率下转子振动特性和轴承润... 详细信息

针对含有瓦块磨损故障的可倾瓦径向轴承-转子系统润滑和振动特性耦合建模问题,考虑了瓦块磨损、转子与瓦块平摆振动和轴承混合润滑的影响,提出了可倾瓦径向轴承-转子系统的混合润滑动力学模型,研究了不同磨损率下转子振动特性和轴承润滑性能的动态响应,探明了转子偏心量、转速和预载荷系数等参数与磨损率的耦合作用对轴承-转子系统动态特性的影响。结果表明:转子在磨损瓦块位置的振动位移和振动加速度随磨损率的增加而增大;与无磨损轴承相比,磨损轴承的转子加速度峰值频率会额外激起转频的偶次倍频;多瓦块磨损会导致转子振动响应和轴承油膜压力显著增大。该研究结果可为可倾瓦径向轴承-转子系统的状态监测及故障识别提供理论参考依据。

关键词：可倾瓦径向轴承-转子系统瓦块磨损动态特性混合润滑动力学

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数字经济时代经济发展方式转变与创新研究

烟台职业学院学报 2024年第1期19卷 34-37+43页

作者：张鲁峰烟台市市政养护中心

在21世纪的信息化浪潮中，数字经济作为推动全球经济结构转型和创新的主力军，正逐渐塑造新的经济发展模式。随着云计算、大数据、人工智能及区块链等数字技术的快速发展和广泛应用，从传统制造业到服务业，再到农业等各个领域均经历了... 详细信息

在21世纪的信息化浪潮中，数字经济作为推动全球经济结构转型和创新的主力军，正逐渐塑造新的经济发展模式。随着云计算、大数据、人工智能及区块链等数字技术的快速发展和广泛应用，从传统制造业到服务业，再到农业等各个领域均经历了前所未有的变革。文章旨在探讨数字经济时代下经济发展方式的转变与创新，分析数字技术如何影响产业结构、劳动市场及企业经营模式，并提出相应对策，以期为政策制定者和企业决策层提供策略指导，应对数字经济带来的机遇和挑战。

关键词：数字经济经济发展方式创新研究

What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?

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World Journal of Clinical Oncology 2024年第1期15卷 145-158页

作者： lu zhang Zu-Yuan Chen Xiao-Xian Wei Jian-Di Li Gang Chen Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Emerging research suggests that microRNAs(miRNAs)play an important role in the development of hepatocellular carcinoma(HCC).A comprehensive analysis of recent research concerning miRNAs in HCC development could provide researchers with a valuable reference for further *** To make a comprehensive analysis of recent studies concerning miRNAs in *** All relevant publications were retrieved from the Web of Science Core Collection *** software,VOSviewer software and CiteSpace software were used to visually analyze the distribution by time,countries,institutions,journals,and authors,as well as the keywords,burst keywords and thematic *** A total of 9426 publications on this topic were found *** to the keywords analysis,we found that the studies of miRNAs focused on their expression level,effects,and mechanisms on the biological behaviour of *** bursting analysis showed that in the early years(2013–2017),“micro-RNA expression”,“gene expression”,“expression profile”,“functional polymorphism”,“circulating microRNA”,“susceptibility”and“mir 21”started to attract *** the latest phase(2018–2022),the hot topics turned to“sorafenib resistance”,“tumor microenvironment”and so *** This study provides a comprehensive overview of the role of miRNAs in HCC development based on bibliometric *** hotspots in this field focus on miRNAs expression level,effects,and mechanisms on the biological behavior of *** frontiers turned to sorafenib resistance,tumor microenvironment and so on.

关键词： miRNA Hepatocellular carcinoma Bibliometric VOSviewer CiteSpace

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测评经济发展质量:中国五大城市群比较

社会科学战线 2024年第5期 52-62页

作者：赵伟张陆浙江大学民营经济研究中心浙江杭州310058 浙江大学经济学院浙江杭州310058

城市群是中国式现代化和高质量发展的引领者,国家级区域战略划定的五个特大城市群在其中占突出地位。文章基于现有文献,在厘清高质量发展内涵的基础上,重构评价城市群发展质量的测评体系,据此测评与比较国家级区域战略划定的五大城市群... 详细信息

城市群是中国式现代化和高质量发展的引领者,国家级区域战略划定的五个特大城市群在其中占突出地位。文章基于现有文献,在厘清高质量发展内涵的基础上,重构评价城市群发展质量的测评体系,据此测评与比较国家级区域战略划定的五大城市群发展质量。研究结论显示:经济发展质量既不同于新古典增长理论界定的增长效率,也不同于发展经济学所论述的发展模式,而是基于中国社会经济发展现实提出的内涵更宽泛的概念。测度与比较结果显示:综合发展质量排序依次为粤港澳、长三角、京津冀、成渝和武沙昌,但在子系统测评中各城市群皆有优劣。粤港澳和长三角城市群结构上更符合齐普夫法则,发展质量更高,而其余城市群结构不同,发展质量略逊。基于上述结论,文章提出若干政策建议。

关键词：经济发展质量国家级区域战略五大城市群综合评价体系齐普夫法则