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Unveiling phosphofructokinase as the key target: an innovative strategy combining pull-down assays with optical imaging for snail-killing mechanism exploration

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Science China Chemistry 2025年

作者： Yuxun lu Weisi Wang le Yu Yuqiang Zhao Ying Chen Yunhai Guo Bingrong luo Yuhua Liu Shizhu Li Liping Duan Ying Zhou Yunnan Characteristic Plant Extraction Laboratory College of Chemical Science and Technology Yunnan University College of Biological and Chemical Engineering Guangxi University of Science and Technology National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical Diseases School of Chemistry and Environment Yunnan Minzu University Dali Institute of Schistosomiasis Control

The Pomacea canaliculata, also known as apple snail, is an invasive species in China, posing a serious threat to agricultural production and public health. To prevent its rampant infestation, we developed a highly efficient snail-killing lead compound, 1-(4-chlorophenyl)-3-(pyridin-3-yl)urea (PBQ). However, the killing mechanism of PBQ remains unclear. To elucidate this, two novel compounds, B-PBQ and J-PBQ, were developed through structural modification of PBQ and were used, through both protein pull-down assay and confocal laser scanning microscopy imaging, to identify and confirm that phosphofructokinase(PFK) in the apple snail is the primary target protein of PBQ. Further studies revealed that PBQ successfully inhibits the activity,content, and expression of PFK in apple snail, disrupting the glycolysis pathway and leading to abnormal energy *** disruptions impair the snail’s tolerance to low oxygen, resulting in its efficient eradication. These findings offer a promising direction for developing next-generation PFK-targeted snail-killing pesticides. Furthermore, the strategy of combining pull-down assays with optical imaging used in this work provides a novel approach for the exploration of mechanisms of other pesticide candidates.

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LiDAR-Visual SLAM with Integrated Semantic and Texture Information for Enhanced Ecological Monitoring Vehicle Localization

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Computers, Materials & Continua 2025年第1期82卷 1401-1416页

作者： Yiqing lu Liutao Zhao Qiankun Zhao Foreign Environmental Cooperation Center Ministry of Ecology and Environment of PRCBeijing100035China Beijing Computing Center Co. Ltd.Beijing Academy of Science and TechnologyBeijing100083China Beijing Guyu Interactive Artificial Intelligence Application Co. Ltd.Beijing100024China

Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental *** vehicles are crucial in various fields,including environmental science research,ecological and environmental monitoring projects,disaster response,and emergency management.A key method employed in these vehicles for achieving high-precision positioning is LiDAR(lightlaser detection and ranging)-Visual Simultaneous Localization and Mapping(SLAM).However,maintaining highprecision localization in complex scenarios,such as degraded environments or when dynamic objects are present,remains a significant *** address this issue,we integrate both semantic and texture information from LiDAR and cameras to enhance the robustness and efficiency of data ***,semantic information simplifies the modeling of scene elements,reducing the reliance on dense point clouds,which can be less ***,visual texture information complements LiDAR-Visual localization by providing additional contextual *** incorporating semantic and texture details frompaired images and point clouds,we significantly improve the quality of data association,thereby increasing the success rate of *** approach not only enhances the operational capabilities of ecological monitoring vehicles in complex environments but also contributes to improving the overall efficiency and effectiveness of ecological monitoring and environmental protection efforts.

关键词： LiDAR-Visual simultaneous localization and mapping integrated semantic texture information

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一种MEMS加速度计的噪声处理与参数训练方法

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仪表技术与传感器 2020年第2期 41-45页

作者：张旭路永乐郭俊启肖明朗吴英重庆邮电大学智能传感技术与微系统重庆市高校工程研究中心重庆400065

为进一步提高微机电系统(MEMS)加速度计的测量精度,建立以测量值为输入、真实值为输出的MEMS加速度计误差补偿模型,利用Allan方差和最小均方(LMS)自适应滤波算法对加速度计在6个位置下的多组实际测量数据进行噪声分析和预处理,处理后的... 详细信息

为进一步提高微机电系统(MEMS)加速度计的测量精度,建立以测量值为输入、真实值为输出的MEMS加速度计误差补偿模型,利用Allan方差和最小均方(LMS)自适应滤波算法对加速度计在6个位置下的多组实际测量数据进行噪声分析和预处理,处理后的全部测量数据作为样本训练模型参数,利用最小二乘和批量梯度下降相结合的方法获得样本数据对真实模型参数的最优拟合,并利用该模型对加速度计进行误差补偿,实现MEMS加速度计的高精度标定。实验验证表明,利用该模型对MEMS加速度计进行误差补偿后,输出值的均值误差为(0.72~1.19)×10^-4 g,标准差为(0.75~1.61)×10^-4 g,相对于补偿前,均值误差降低了2个数量级,标准差降低了1个数量级,有效提高了MEMS加速度计的测量精度和稳定性。

关键词：数据训练 Allan方差最小均方最小二乘批量梯度下降误差补偿

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A quantum-search-based multi-classifier for image recognition

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 21-31页

作者： lu Liu Xingyu Wu lufan Zhang Chuan Wang School of Artificial Intelligence Beijing Normal University Applied Optics Beijing Area Major Laboratory Beijing Normal University

The multi-class classification of images is a pivotal challenge within the realm of image processing. As the volume of visual data continues to expand, there is a burgeoning interest in harnessing the unique capabilities of quantum computation to augment the efficiency of classification tasks. However, many existing methods for training quantum image multi-classifiers parallel classical machine learning techniques, where the requisite circuit measurements increase linearly with the volume of training data. This work introduces a novel approach for training a quantum image multi-classifier based on the quantum search algorithm. We have meticulously conducted rigorous experiments on a handwritten digit dataset, a classic benchmark in the field. The results have been meticulously compared with previous works, and the comparative analysis not only validates the efficiency of our proposed approach, requiring only O(N/b) measurements during training, but also highlights a significant quadratic speedup of the algorithm.

关键词： quantum computation image recognition quantum search algorithm

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Unraveling the origins of PGY-sRNA-6,BZL-sRNA-20,and XKC-sRNA-h3

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Science China Life Sciences 2025年

作者： Shanfa lu State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical College Engineering Research Center of Chinese Medicine Resource Ministry of Education

Dear Editor,The regulatory role of herbal sRNAs in humans and animals is an interesting research ***,current evidence is insufficient to conclude that herbal sRNAs are novel precision medicines.I previously showed that HJT-sRNA-m1-HJT-sRNA-m8,identified as herbal sRNAs previously (Du et al.,2019),may be derived from humans and/or animals(lu,2023).To minimize errors during herbal sRNA analysis,I provided a list of matters needing special attention and proposed problem-solving solutions for researchers working on sRNA cross-kingdom regulation (lu,2023).

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基于异构多源传感的行人长航时变步长误差修正技术

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科学技术与工程 2021年第19期21卷 8065-8071页

作者：谢金池王伟文丹丹路永乐王汶新刘宇重庆邮电大学生物信息学院重庆400065 重庆邮电大学光电工程学院重庆400065

低成本微机电系统(micro-electro-mechanical system,MEMS)传感器广泛应用于行人定位导航中,但在长航时下,MEMS传感器零位会随时间产生漂移,导致行人变步长误差成为主要误差。且传统的足绑式导航利用MEMS传感器自身信息判断零速时刻会... 详细信息

低成本微机电系统(micro-electro-mechanical system,MEMS)传感器广泛应用于行人定位导航中,但在长航时下,MEMS传感器零位会随时间产生漂移,导致行人变步长误差成为主要误差。且传统的足绑式导航利用MEMS传感器自身信息判断零速时刻会出现错判漏判等问题。针对这两点,根据行人步态变化规律,在判断零速时刻时,加入压力传感器辅助的异构多源传感,同时针对系统误差设计了用于补偿的误差修正算法。对比传统方法,该设计可以明显提高导航定位精度,定位精度可提高一个数量级。

关键词：长航时异构多源压力传感器零速时刻

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Ⅰ类切口手术围手术期预防性使用抗菌药物的干预效果分析

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中国医药指南 2015年第14期13卷 17-19页

作者：刘月玲卢永乐陈洋娣广州医科大学附属第三医院药学部广东广州510150 广州医科大学 2009级实习生广东广州510150

目的调查我院Ⅰ类切口手术围手术期预防性使用抗菌药物的情况,评价干预措施的实施效果,为进一步规范抗菌药物的合理使用提供依据。方法查阅我院2013年1-4月（下称第一阶段）和2013年12月至2014年3月（下称第二阶段）符合标准的Ⅰ类切口... 详细信息

目的调查我院Ⅰ类切口手术围手术期预防性使用抗菌药物的情况,评价干预措施的实施效果,为进一步规范抗菌药物的合理使用提供依据。方法查阅我院2013年1-4月（下称第一阶段）和2013年12月至2014年3月（下称第二阶段）符合标准的Ⅰ类切口手术患者的出院病历198份和220份,对手术类别、抗菌药物使用率、抗菌药物的种类、用药时间和持续时间、合并用药情况及其合理性进行统计分析。结果采取干预措施后,1Ⅰ类切口围术期抗菌药物使用率从第一阶段的43%下降为第二阶段为32%,药物品种选择不当从第一阶段的80%下降为第二阶段的38%;2术前0.5-2 h内的预防用药率由第一阶段的64%上升至第二阶段的75%;3预防使用抗菌药物疗程≤1 d的病例数占用药例数的比率从第一阶段的34%上升到第二阶段的49%;4无指征更换药物第一阶段和第二阶段分别有10、9例;无指征联合用药第一和第二阶段分别有2例。结论采取干预措施后,我院Ⅰ类切口围手术期预防用抗菌药物在药物使用率、药物的品种选择、预防用药时机、用药疗程方面第二阶段较第一阶段均有明显改善,但仍然存在不同程度的不合理用药现象,应加强Ⅰ类切口手术围手术期抗菌用药的使用管理,促进临床合理用药,减少耐药的发生。

关键词： Ⅰ类切口手术围手术期抗菌药物预防用药

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An embedded electron current layer observed at the edge of the plasma sheet in the Earth’s magnetotail

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Earth and Planetary Physics 2025年第1期9卷 148-158页

作者： ChenChen Zhan RongSheng Wang QuanMing lu San lu XinMin Li Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences(CAS)Center for Excellence in Comparative Planetology/CAS Key Laboratory of Geospace Environment/Anhui Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China

The formation of an embedded electron current sheet within the magnetotail plasma sheet has been poorly *** this article,we present an electron current layer detected at the edge of the magnetotail plasma *** ions were demagnetized inside the electron current layer,but the electrons were still frozen in with the magnetic field ***,this decoupling of ions and electrons gave rise to a strong Hall electric field,which could be the reason for the formation of the embedded thin current *** magnetized electrons,the absence of the nongyrotropic electron distribution,and negligible energy dissipation in the layer indicate that magnetic reconnection had not been triggered within the embedded thin current *** highly asymmetric plasma on the two sides of the current layer and low magnetic shear across it could suppress magnetic *** observations indicate that the embedded electric current layer,probably generated by the Hall electric field,even down to electron scale,is not a sufficient condition for magnetic reconnection.

关键词： magnetotail plasma sheet magnetic reconnection

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Electrocatalytic selective synthesis and tandem utilization of hydroxylamine

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Science China Chemistry 2025年

作者： Yuxuan lu Hengquan Yang Engineering Research Center of Ministry of Education for Fine Chemicals School of Chemistry and Chemical Engineering Shanxi Key Laboratory of Green Catalytic Synthesis of Coal-based High Value Chemicals Shanxi University

The transformation of renewable nitrogen feedstock to nitrogenous chemicals plays a significant role in our modern society,considering the crucial impact of nitrogenous chemicals on life sciences,biomedicine,agriculture,and *** （NH2OH）,a typical nucleophile,has been widely served as the nitrogenous feedstock to produce nitrogenous *** NH2OH synthesis methods rely on harsh reaction conditions,leading to an unfavorable environmental *** contrast,nitric oxide electroreduction promises to produce NH2OH powered by renewable *** achievements have revealed the possibility of this process,but have also identified significant *** activity and selectivity are fundamentally limited by competing hydrogenation reactions,while the performance evaluation with high accuracy and reproducibility is ***,this review aims to provide insight into the mechanism of NH2OH electrosynthesis,especially regarding understanding reaction pathways and the design principle towards efficient ***,the performance evaluation parameters and standard measurement methods for NH2OH synthesis are summarized to screen efficient ***,the prospects and emerging opportunities to synthesize nitrogen-containing organic compounds by tandem reaction are *** review aims to provide a guide for evaluating and exploring efficient electrocatalytic systems for NH2OH production and utilization technology.

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