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Computational Experiments for Complex Social Systems:Integrated Design of Experiment System

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1175-1189页

作者： xiao Xue Xiangning Yu Deyu Zhou xiao wang Chongke Bi Shufang wang Fei-Yue wang College of Intelligence and Computing Tianjin UniversityTianjin 300350China School of Software Shandong UniversityJinan 250101China School of Artificial Intelligence Anhui UniversityHefei 230601China School of Geographic and Environmental Sciences Tianjin Normal UniversityTianjin 300387China Institute of Automation Chinese Academy of Sciences Beijing 100190China

Powered by advanced information industry and intelligent {1.,more and more complex systems are exhibiting characteristics of the cyber-physical-social systems(CPSS).And human factors have become crucial in the operations of complex social *** mechanical analysis and social simulations alone are powerless for analyzing complex social *** this backdrop,computational experiments have emerged as a new method for quantitative analysis of complex social systems by combining social simulation(e.g.,ABM),complexity science,and domain ***,in the process of applying computational experiments,the construction of experiment system not only considers a large number of artificial society models,but also involves a large amount of data and *** a result,how to integrate various data,model and knowledge to achieve a running experiment system has become a key *** paper proposes an integrated design framework of computational experiment system,which is composed of four parts:generation of digital subject,generation of digital object,design of operation engine,and construction of experiment ***,this paper outlines a typical case study of coal mine emergency management to verify the validity of the proposed framework.

关键词： artificial system operations

Anti-psoriasis molecular targets and active components discovery of Optimized Yinxieling Formula via affinity-purified strategy

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Chinese Journal of Natural Medicines 2024年第2期22卷 127-136页

作者： wang {1. LIU Lijuan YANG Zhuo lu Chuanjian TU Pengfei ZHAO Ruizhi ZENG Kewu State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006China

Psoriasis,a prevalent inherited skin condition,involves an inflammatory response as a key pathogenic *** Optimized Yinxieling Formula(OYF),rooted in traditional Chinese medicine,is extensively utilized in clinical settings to treat *** previous studies have demonstrated OYF’s significant anti-inflammatory effects in psoriasis,its potential molecular targets and active components remain *** study aimed to unveil the anti-psoriasis molecular targets and active components of *** findings indicated that OYF extract markedly reduced the production of several inflammatory mediators,including IL-23,nitric oxide,TNF-α,and IL-1.,in LPS-induced RAW264.7 *** synthesized OYF extract-crosslinked beads to isolate pharmacological targets from RAW264.7 lysates using an affinity purification strategy,known as Target *** enriched target proteins were subsequently identified via LC-MS/MS,followed by bioinformatics analysis to map the psoriasis-associated pathway-gene *** identified a total of 76 potential target proteins,which were highly associated with mRNA transcription *** particular,pathway-gene network analysis revealed that the IL-23 inflammatory pathway was involved in the anti-psoriasis effect of OYF *** further utilized a target protein-based affinity capture strategy,combined with LC-MS and SPR analysis,to globally screen OYF’s active components,focusing on the mRNA transcription regulator,fused in sarcoma(FUS).This process led to the identification of umbelliferone,vanillic acid,protocatechuic acid,gentisic acid,and e{1.coside as key compounds targeting FUS to inhibit IL-23 ***,we formulated a compound cocktail(CpdC),which significantly reduced psoriasis area and severity index(PASI)scores and the expressions of IL-23 and Ki67 in an imiquimod(IMQ)-induced psoriasis mouse ***,our study elucidates the primary molecular targets and active components of OYF,offeri

关键词： Psoriasis Optimized Yinxieling Formula(OYF) FUS protein Molecular targets Affinity-purified strategy

Plasma membrane-anchored fluorescent tracker based on boron-dipyrromethene

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Chinese Journal of Chemical Engineering 2024年第8期72卷 220-225页

作者： Yucong Gong Xiangli Li Daqing Ma Lai wang Lin Zhou Cai{1. lu Yi xiao Xinfu Zhang State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringDalian University of TechnologyDalian 116024China china Academy of Safety Science and {1. Beijing 100012China

The construction of a stable-membrane tracker has significant implications for the visualization of the membrane in live ***,most current plasma trackers are not suitable for tracking plasma membranes for a long time due to their limited retention ***,Mem580-F-Sulfo is designed to target and anchor cell membranes and therefore track cell membranes for a longer *** tracker is composed of a lipophilic boron-dipyrromethene(BODIPY)derivative and a hydrophilic zwitterion to form an amphiphilic structure,which enables its targeting ability toward cell ***,a reactive ester group is included to bind with proteins through covalent bonds in cell membranes nonspecifically,which extends retention time in cell ***580-F-Sulfo shows intense brightness(94600),with a high molar absorption coefficient of up to about 1.0000 L·mol^(-1.·cm^(-1.and a fluorescence quantum yield of up to *** shows fast cell membrane targeting ability and long retention up to 90 *** brief,this work has not only developed a tracker with good cell membrane targetability but also provided a new strategy for improving the targeting stability of cell membranes.

关键词： Plasma membrane Protein Tracker Imaging Microstructure

An improved lightweight network based on deep learning for grape recognition in unstructured environments

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information Processing in Agriculture 2024年第2期11卷 202-216页

作者： Bingpiao Liu Yunzhi Zhang Jinhai wang {1.feng {1.o Qinghua {1. Huiling wei Wenbo Zhu School of Mechatronic Engineering and Automation Foshan UniversityFoshan 528000China

In unstructured environments,dense grape fruit growth and the presence of occlusion cause difficult recognition problems,which will seriously affect the performance of grape picking *** address these problems,this study improves the YOLOx-Tiny model and proposes a new grape detection model,YOLOX-RA,which can quickly and accurately identify densely growing and occluded grape *** proposed YOLOX-RA model uses a 3×3 convolutional layer with a step size of 2 to replace the focal layer to reduce the computational *** CBS layer in the ResBlock_Body module of the second,third,and fourth layers of the backbone layer is removed,and the CSPLayer module is replaced by the ResBlock-M module to speed up the *** auxiliary network(AlNet)with the remaining network blocks was added after the ResBlock-M module to improve the detection *** depth-separable convolutions(DsC)are used in the neck module layer to replace the normal convolution to reduce the computational *** evaluated the detection performance of SSD,YOLOv4 SSD,YOLOv4-Tiny,YOLO-Grape,YOLOv5-X,YOLOX-Tiny,and YOLOX-RA on a grape test *** results show that the YOLOX-RA model has the best detection performance,achieving 88.75%mAP,a recognition speed of 84.88 FPS,and model size of 1..53 *** can accurately detect densely grown and shaded grape bunches,which can effectively improve the performance of the grape picking robot.

关键词： YOLOX Grape recognition Depthwise separable convolution Res Block-M AINet

Stereodivergent synthesis ofα-fluoroα-azaarylγ-butyrolactones via cooperative copper and iridium catalysis

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Fundamental research 2024年第1期4卷 77-85页

作者： Kui Tian Xin Chang lu {1. Xiu-Qin Dong Chun-Jiang wang College of Chemistry and Molecular Sciences Engineering Research Center of Organosilicon Compounds&MaterialsMinistry of EducationWuhan UniversityWuhan 430072China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryShanghai 230021China Suzhou Institute of Wuhan university Suzhou 215123China

The development of stereodivergent synthetic methods to access all four stereoisomers of biologically importantα-fluoroγ-butyrolactones containing vicinal stereo{1.s is of great importance and poses a formidable challenge owing to ring strain and steric ***,a novel asymmetric[3+2]annulation ofα-fluoroα-azaaryl acetates with vinylethylene carbonate was successfully developed through Cu/Ir-catalyzed cascade allylic alkylation/lactonization,affording a variety of enantioenrichedα-fluoroγ-butyrolactones bearing vicinal stereogenic {1.s with high reaction efficiency and excellent levels of both stereoselectivity and regioselectivity(up to 98%yield,generally>20:1.dr and>99%ee).Notably,all four stereoisomers of these pharmaceutically valuable molecules could be accessed individually via simple permutations of two enantiomeric *** addition,other azaaryl acetates bearingα-methyl,α-chlorine orα-phenyl group were tolerated well in this *** mechanistic investigations were conducted to explore the process of this bimetallic catalysis based on the results of reaction intermediates,isotopic labelling experiments,and kinetic studies.

关键词： Asymmetric catalysis α-Fluoroγ-butyrolactones Synergistic catalysis Cascade reaction Stereodivergent synthesis

Quantum key distribution over a mimicked dynamic-scattering channel

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Science china({1. Sciences) 2024年第4期67卷 323-330页

作者： Qi-Hang lu Fang-Xiang {1. wei CHEN Hai-Yang FU Yin-Jie lu Shuang {1. De-Yong HE Zhen-Qiang YIN Guang-Can GUO Zheng-Fu HAN CAS Key Laboratory of Quantum information University of Science and Technology of China CAS center for Excellence in Quantum {1. and Quantum Physics University of Science and Technology of China Hefei National Laboratory University of Science and Technology of China

Free-space quantum key distribution(QKD) plays an important role in the global quantum network. However, free space channels suffer from the atmospheric turbulence and scattering effects of haze,fog, and dust, which significantly weaken the performance of QKD or even block the secure quantum ***, we prove the performance of QKD over a dynamic scattering channel can be enhanced significantly using a fast wavefront shaping technique. The system achieves on average 1.-dB enhancement of quantum transmission efficiency and establishes a secure quantum link for QKD. Our work demonstrates the feasibility of QKD through free-space dynamic scattering channels and enhances the deployment capability of complex-channel QKD system.

关键词： quantum key distribution free space channel channel turbulence channel scattering wavefront shaping

research trends in exercise therapy for the treatment of pain in postmenopausal osteoporosis over the past decade:A bibliometric analysis

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World Journal of Orthopedics 2024年第10期15卷 950-964页

作者： Zhao-Qiu Dai xiao-Yan Gong Rong Zhang Mei-Qin Jin {1. lu Wen Wen Jie Chen Fang-Jie lu Yi-Fan Yang Lei wang xiao-Jin He Changshu Hospital Affiliated with Nanjing university of Chinese Medicine Changshu 215500Jiangsu ProvinceChina Affiliated Hospital of Nanjing university of Chinese Medicine Jiangsu Province Hospital of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Nanjing university of Chinese Medicine Nanjing 210023Jiangsu ProvinceChina

BACKGROUND Postmenopausal osteoporosis(PMOP)is the most common form of primary osteoporosis among women,and the associated pain often drives patients to seek clinical *** studies have highlighted the unique clinical benefits of exercise therapy(ET)in alleviating PMOP-related ***,bibliometric analyses examining collaboration,development trends,and research frontiers in the field of ET for PMOP pain remain *** To explore the research trends in ET for pain treatment in PMOP patients over the past *** All scholarly works were meticulously sourced from the Science Citation Index-Expanded within the prominent Web of Science Core *** the capabilities of CiteSpace 6.2.R5,we conducted a thorough analysis of publications,authors,frequently cited scholars,contributing nations,institutions,journals of significant citation,comprehensive references,and pivotal ***,our examination explored keyword cooccurrences,detailed timelines,and periods of heightened citation *** comprehensive search,from 201. through 2023,was completed within a single day,on October 1.,*** In total,291. articles were ultimately included in the *** was a rapid increase in annual publication output in 201.,followed by stable growth in subsequent ***,Michael L,is the most prolific author,whereas Ware JE has the most *** United States’global influence is significant,surpassing all other *** university of California System and Harvard university are the most influential academic institutions.J Bone Joint Surg Am is the most influential journal in this field.“Spinal cord injury”is the keyword that has garnered the most attention from *** developmental pattern in this field is characterized by interdisciplinary fusion,with different disciplines converging to drive *** The academic development of the field of ET for pain in PMOP has matured and stabili

关键词： Exercise therapy Pain Postmenopausal osteoporosis CiteSpace Bibliometric analysis Web of Science

All‑Covalent Organic Framework Nanofilms Assembled Lithium‑Ion Capacitor to Solve the Imbalanced Charge Storage Kinetics

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Nano-Micro Letters 2024年第6期16卷 246-260页

作者： xiaoyang Xu Jia Zhang Zihao Zhang Guandan {1. wei Cao Ning wang Yunmeng Xia Qingliang Feng Shanlin Qiao College of Chemistry and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018People’s Republic of China School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China Hebei Engineering research {1. of Organic Solid Photoelectric Materials for Electronic information Shijiazhuang 050018People’s Republic of China

Free-standing covalent organic framework(COFs)nanofilms exhibit a remarkable ability to rapidly intercalate/de-intercalate Li^(+) in lithium-ion batteries,while simultaneously exposing affluent active sites in *** development of these nanofilms offers a promising solution to address the persistent challenge of imbalanced charge storage kinetics between battery-type anode and capacitor-type cathode in lithium-ion capacitors(LICs).Herein,for the first time,custom-made COFBTMB-TP and COFTAPB-BPY nanofilms are synthesized as the anode and cathode,respectively,for an all-COF nanofilm-structured *** COFBTMB-TP nanofilm with strong electronegative–CF3 groups enables tuning the partial electron cloud density for Li^(+) migration to ensure the rapid anode kinetic *** thickness-regulated cathodic COFTAPB-BPY nanofilm can fit the anodic COF nanofilm in the *** to the aligned 1. channel,2D aromatic skeleton and accessible active sites of COF nanofilms,the whole COFTAPB-BPY//COFBTMB-TP LIC demonstrates a high energy density of 31. mWh cm^(−3) at a high-power density of 6 W cm^(−3),excellent rate capability,good cycle stability with the capacity retention rate of 77%after *** COFTAPB-BPY//COFBTMB-TP LIC represents a new benchmark for currently reported film-type LICs and even film-type *** being comprehensively explored via ex situ XPS,7Li solid-state NMR analyses,and DFT calculation,it is found that the COFBTMB-TP nanofilm facilitates the reversible conversion of semi-ionic to ionic C–F bonds during lithium ***-TP exhibits a strong interaction with Li^(+) due to the C–F,C=O,and C–N bonds,facilitating Li^(+) desolation and absorption from the *** work addresses the challenge of imbalanced charge storage kinetics and capacity between the anode and cathode and also pave the way for future miniaturized and wearable LIC devices.

关键词： Covalent organic frameworks Lithium-ion capacitor Charge storage kinetic

Association of Cytokines with Clinical Indicators in Patients with Drug-Induced Liver Injury

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Biomedical and Environmental Sciences 2024年第5期37卷 494-502页

作者： CAO wei Hua JIANG Ting Ting SHEN Ge DENG Wen {1. Shi Yu ZHANG Zi Yu LI Xin Xin lu Yao ZHANG lu LIU Ru Yu CHANG Min WU Shu Ling GAO Yuan Jiao HAO Hong xiao CHEN xiao Xue HU Lei Ping XU Meng Jiao YI wei XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective To explore characteristics of clinical parameters and cytokines in patients with drug-induced liver injury(DILI)caused by different drugs and their correlation with clinical *** The study was conducted on patients who were up to Review of Uncertainties in Confidence Assessment for Medical Tests(RUCAM)scoring criteria and clinically diagnosed with *** on Chinese herbal medicine,cardiovascular drugs,non-steroidal anti-inflammatory drugs(NSAIDs),antiinfective drugs,and other drugs,patients were divided into five *** were measured by luminex *** characteristics of clinical biochemical indicators and cytokines in DILI patients and their correlation were *** 73 patients were *** among five groups was statistically different(P=0.032).Alanine aminotransferase(ALT)(P=0.033)and aspartate aminotransferase(AST)(P=0.007)in NSAIDs group were higher than those in chinese herbal medicine ***-6(IL-6)and tumor necrosis factor alpha(TNF-α)in patients with Chinese herbal medicine(IL-6:P1.TNF-α:P1.and cardiovascular medicine(IL-6:P=0.020;TNF-α:P=0.001.were lower than those in NSAIDs *** was a positive correlation between ALT(r=0.697,P=0.025),AST(r=0.721.P=0.01.),and IL-6 in NSAIDs *** Older age may be more prone to *** with NSAIDs have more severe liver damage in early stages of DILI,TNF-αand IL-6 may partake the inflammatory process of DILI.

关键词： Drug-induced liver injury Cytokines Non-steroidal anti-inflammatory drugs Inflammation