检索结果-南通市图书馆

Visible-Light-Driven Four-Component Radical Relay Aminocarbonylation of Unactivated Alkenes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第9期42卷 990-996页

作者： Bin lu Feng-Shuo Bao Zi-Wei He Wen-Jing xiao Jia-Rong Chen Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction College of ChemistryCentralChina Normal University152 Luoyu RoadWuhanHubei 430079China Wuhan Institute of Photochemistry and Technology 7North Bingang RoadWuhanHubei 430083China Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province Gannan Normal UniversityGanzhouJiangxi 341000China

Catalytic four-component radical carbonylation of unactivated alkenes has recently been recognized as a robust protocol for rapid construction of various structurally diverse carbonyl *** the significance of fluorine-containing groups,this reaction class has been extensively applied to assembly of a variety of perfluoroalkyl carboxylic acid derivatives by transition me.al ***,we report a visible-light-driven radical relay 1,2-perfluoroalkylation aminocarbonylation of unactivated alkenes using CO gas as carbonyl source and 4CzIPN as organic photocatalyst.A wide range of alkenes and amines were well tolerated,providing the valuableβ-perfluoroalkylated amides with generally good yields and high chemoselectivity.

关键词： Visible light Photoredox catalysis Radical aminocarbonylation Multicomponent reaction Carbon monoxide Unactivated alkenes AmidesIReactionme.hanisms

SERPINH1 promoted the proliferation and me.astasis of colorectal cancer by activating PI3K/Akt/mTOR signaling pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1890-1907页

作者： xiao-Sheng Jin lu-Xi Chen Ting-Ting Ji Rong-Zhou Li Departme.t of Gastroenterology The Third Affiliated Hospital of Wenzhou Medical UniversityRuian 325000Zhejiang ProvinceChina

BACKGROUND Serpin peptidase inhibitor clade H me.ber 1(SERPINH1)was initially recognized as an oncogene implicated in various human ***,the clinical relevance and functional implications of SERPINH1 in colorectal cancer(CRC)remain largely *** To investigate the effects of SERPINH1 on CRC cells and its specific *** Quantitative real-time.polyme.ase chain reaction,western blotting analysis,The Cancer Genome.Atlas data mining and immunohistochemistry were employed to examine SERPINH1 expression in CRC cell lines and tissues.A series of in-vitro assays were performe. to demonstrate the function of SERPINH1 and its possible me.hanisms in *** SERPINH1 demonstrated elevated expression levels in both CRC cells and tissues,manifested at both mRNA and protein *** SERPINH1 levels correlated closely with advanced T stage,lymph node involveme.t,and distant me.astasis,exhibiting a significant association with poorer overall survival among CRC *** investigations unveiled that SERPINH1 overexpression notably bolstered CRC cell proliferation,invasion,and migration in vitro,while conversely,SERPINH1 knockdown elicited the opposite *** set enrichme.t analysis underscored a correlation between SERPINH1 upregulation and genes associated with cell cycle *** findings underscored the capacity of heightened SERPINH1 levels to expedite G1/S phase cell cycle progression via phosphatidylinositol 3-kinase/AKT/me.hanistic target of rapamycin pathway activation,thereby facilitating CRC cell invasion and *** These findings imply a crucial involveme.t of SERPINH1 in the advanceme.t and escalation of CRC,potentially positioning it as a novel candidate for prognostic assessme.t and therapeutic intervention in CRC manageme.t.

关键词： Serpin peptidase inhibitor clade H me.ber 1 Colorectal cancer Proliferation Cell cycle Phosphatidylinositol 3-kinase/AKT/me.hanistic target of rapamycin

A review on surface coating strategies for anti-hygroscopic of high energy oxidizer ammonium dinitramide

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第3期33卷 237-269页

作者： Hongyu Yang Fuyao Chen Yiwen Hu Qiangqiang lu Lei xiao Yinglei Wang Fengqi Zhao Wei Jiang Gazi Hao National Special Superfine Powder Engineering Research Center of China School of Chemistry and Chemical EngineeringNanjing University of Science and TechnologyNanjing 210094China Xi’an Modern Chemistry Research Institute Xi’an 710065China

Ammonium dinitramide(ADN),which has the advantages of high energy density,no halogen and low characteristic signal,is not only considered as a new high-energy oxidizer that is expected to replace the traditional oxidizer ammonium perchlorate(AP)in solid propellants,but also a good performance explosive in ***,due to the strong hygroscopicity of ADN,its application in solid propellants and explosives is greatly *** the hygroscopicity of ADN is the key to realize the wide application of *** this paper,we systematically review the research progress of anti-hygroscopic strategies of ADN *** surface coating me.hods are focusing on solvent volatilization,solvent-non-solvent,me.t crystallization and atomic layer deposition *** characteristics of the different me.hods are compared and analyzed,and the basis for the classification and selection of the coating materials are introduced in *** addition,the feasibility of material for surface coating of ADN is evaluated by several compatibility analysis *** is highly expected that the liquid phase me.hod(solvent volatilization me.hod,solvent-non-solvent me.hod)would be the promising me.hod for future ADN coating because of its effective,safety and facile ***,polyme. materials,are the preferred coating materials due to their high viscosity,easy adhesion,good anti-hygroscopic effect,and heat resistance,which make ADN weak hygroscopicity,less sensitive,easier to preserve and good compatibility.

关键词： Ammonium dinitramide(ADN) Energetic materials Anti-hygroscopic Surface coating Compatibility analysis

A comprehensive review of recent advanceme.ts and developme.ts in heat exchanger network synthesis techniques

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2024年第2期67卷 335-356页

作者： XU Yue LIU WeiWei ZHANG lu CUI Guo Min xiao Yuan ZHANG GuanHua YANG QiGuo School of Energy and Power Engineering University of Shanghai for Science and TechnologyShanghai 200093China

The rapid developme.t of computational technology and the increasing energy demand have improved heat exchanger network(HEN)*** HEN synthesis involves several optimizations of matches,distributions of heat loads,and stream splitting of heat ***,obtaining good results at high efficiency has been the main standard for evaluating the techniques in the research area of HEN *** paper first summarizes and analyzes the main contributions of the existing HEN synthesis *** compare related data quantitively,information on ten typical cases is presented in this ***,recently improved solutions for commonly encountered existing literature cases demonstrate the evolution and competition trends in the field of HEN *** comparison data presented in this paper not only provide a useful reference for future research but also present the optimization *** on the findings of this study,it is noted that there is still a large room for improveme.t,and current approaches are incapable of dealing with all HEN ***,it is still difficult to escape a local optimum and overcome.structural constraints when seeking the global *** a follow-up to the current work,the parallel computing mode and adaptively coordinating the ratio of global and local searching abilities are major developme.t trends for future investigation.

关键词： heat integration heat exchanger network synthesis sequential synthesis me.hod simultaneous synthesis me.hod optimization techniques developme.t optimization quality

Matrix me.alloproteinase 2 degrades collagen I to regulate ovarian developme.t by association with an insulin-like peptide

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Insect Science 2024年第4期31卷 1090-1106页

作者： Yi Wei xiao-Lin Zhou Peng Chen Tai-Hang Liu Cheng lu Min-Hui Pan State Key Laboratory of Silkworm Genome.Biology Southwest UniversityChongqingChina Key Laboratory for Sericulture Functional Genomics and Biotechnology of Agricultural Ministry Southwest UniversityChongqingChina Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang ProvinceChina

The ovary generally undergoes tissue remodeling during larval to pupal transition,which includes me.brane degeneration and ovariole *** the same.time.the hormones produced by insects significantly change during ***,the regulatory me.hanism for ovarian developme.t and hormones is not fully understood in ***,we found that matrix me.alloproteinase 2(MMP2)was highly expressed in the ovarian capsules and ovarioles,and the developme.t was abnormal after knocking out MMP2 in Bombyx *** process of abnormal degradation of collagen I due to MMP2 deletion,which resulted in abnormal developme.t of ovarioles and eggs,was analyzed in *** proteomics of ovaries in the MMP2-knock out and wild type strains showed a critically significant difference in the expression of a protein,insulin-like peptide(ILP).Additional analysis revealed significant alteration of ILP during ovarian developme.t,and abnormal expression of ILP significantly affected ovarian developme.t in vivo and MMP2 expression in vitro and in *** results showed that MMP2 regulation of ovarian tissue remodeling is closely related to ILP *** study provides new insights into the regulatory me.hanism of MMP2 and ovarian developme.t in ***.

关键词： Bombyx mori collagen I insulin-like peptide matrix me.alloproteinase ovarian developme.t

Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第2期16卷 414-435页

作者： You-Wang lu Zhao-Li Ding Rui Mao Gui-Gang Zhao Yu-Qi He xiao-lu Li Jiang Liu Departme.t of Dermatology and Venereology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Kunming Biological Diversity Regional Center of Large Apparatus and Equipme.ts Public Technical Service CenterKunming Institute of ZoologyKunming 650223Yunnan ProvinceChina School of Stomatology Kunming Medical UniversityKunming 650500Yunnan ProvinceChina Genome.Center of Biodiversity Kunming Institute of ZoologyChinese Academy of ScienceKunming 650223Yunnan ProvinceChina Departme.t of Reproduction and Genetics The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Aberrant me.hylation is common during the initiation and progression of colorectal cancer(CRC),and detecting these changes that occur during early adenoma(ADE)formation and CRC progression has clinical *** To identify potential DNA me.hylation markers specific to ADE and *** Here,we performe. SeqCap targeted bisulfite sequencing and RNA-seq analysis of colorectal ADE and CRC samples to profile the epigenomic-transcriptomic *** Comparing 22 CRC and 25 ADE samples,global me.hylation was higher in the forme.,but both showed similar me.hylation patterns regarding differentially me.hylated gene positions,chromatin signatures,and repeated ***-grade CRC tended to exhibit elevated me.hylation levels in gene promoter regions compared to those in low-grade *** with RNA-seq gene expression data,we identified 14 me.hylation-regulated differentially expressed genes,of which only AGTR1 and NECAB1 me.hylation had prognostic *** Our results suggest that genome.wide alterations in DNA me.hylation occur during the early stages of CRC and demonstrate the me.hylation signatures associated with colorectal ADEs and CRC,suggesting prognostic biomarkers for CRC.

关键词： Colorectal cancer Epigenomic alteration Transcriptome me.hylation-regulated differentially expressed genes

Review on regulation of MnS in non-qquenched and tempered steel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research(International) 2024年第4期31卷 779-789页

作者： Guo-xing Qiu Qing Du Feng lu De-jun Miao Yong-kun Yang xiao-ming Li School of me.allurgical Engineering Xi'an University of Architecture and TechnologyXi'an 710055ShaanxiChina Laigang Technique Center Shandong Iron and Steel Group Co.Ltd.Jinan 271104ShandongChina

An overview of the current research status and control me.hods of MnS in non-quenched and tempered steel was *** a low-me.ting plastic inclusion,the morphology and distribution of MnS were influenced by various production ***,control of MnS is a systematic problem that must be integrated into the entire production *** on the production process,the factors affecting the morphology and distribution of MnS in steel were *** effects of oxygen activity,manganese,sulfur,and some.alloys on MnS inclusion precipitation were summarized,mainly including MnS modification treatme.t and oxygen-sulfide composite precipitation *** is believed that MnS precipitates during the solidification process of steel,and controlling the solidification cooling rate could effectively regulate the size and morphology of MnS,avoiding the precipitation of ***,by changing the deformation rate,deformation amount,deformation temperature during the hot deformation process,and heating time.and temperature during heat treatme.t,the distribution and morphology of MnS could be *** the fine control of the above process parame.ers,the number of II-MnS in steel could be effectively reduced,and their morphology could be improved,thereby enhancing the performance of non-quenched and tempered steel and promoting its wider ***,applying laboratory research results to industrial production is an important direction for future research efforts in this field.

关键词： MnS Non-quenched and tempered steel Control technology Process parame.er Morphology Distribution

A study on the temperature sensitivity of NMR porosity in porous me.ia based on the intensity of magnetization Dedicated to the special issue “Magnetic Resonance in Porous me.ia”

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Magnetic Resonance Letters 2024年第1期4卷 28-39页

作者： lu Zhang Lizhi xiao Wensheng Wu Guangzhi Liao Yan Zhang Sihui luo Xinglong Lei National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China College of Geophysics China University of PetroleumBeijing102249China PetroChina Huabei Oilfield Company China National Petroleum CorporationRenqiu062552China

The me.sureme.t of nuclear magnetic resonance(NMR)porosity is affected by *** considering the impact of NMR logging tools,this phenome.on is mainly caused by variations in magnetization intensity of the me.sured system due to temperature fluctuations and difference between the temperature of the porous me.ium and calibration *** this study,the effect of temperature was explained based on the thermodynamic theory,and the rules of NMR porosity responses to temperature changes were identified through core physics *** addition,a me.hod for correcting the influence of temperature on NMR porosity me.sureme.t was proposed,and the possible factors that may affect its application were also discussed.

关键词： NMR porosity Temperature Porous me.ia Intensity of magnetization

Coming of age:the formation and function of age-associated B cells

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2024年第4期21卷 311-312页

作者： Ke Rui Nan Che Kongyang Ma Hejian Zou Fan xiao Liwei lu Departme.t of Laboratory me.icine Institute of Medical Immunology of Jiangsu UniversityAffiliated Hospital of Jiangsu UniversityZhenjiangChina Departme.t of Rheumatology and Immunology Nanjing First HospitalNanjing Medical UniversityJiangsuChina Centre for Infection and Immunity Studies School of MedicineThe Sun Yat-sen UniversityShenzhen518107GuangdongChina Departme.t of Rheumatology Huashan HospitalFudan UniversityShanghaiChina Departme.t of Pathology and Shenzhen Institute of Research and Innovation HKU Shenzhen HospitalThe University of Hong KongHong KongChina Centre for Oncology and Immunology Hong Kong Science ParkHong KongChina

B cells are generated in the bone marrow during ontogeny and migrate to peripheral lymphoid organs,where they encounter antigens to elicit humoral *** the past decade,many novel B-cell subsets with distinct phenotypes and functions have been identified,and among these subsets,age-associated B cells(ABCs)were first characterized as a B-cell subset that accumulates with age[1].

关键词： organs lymphoid migrate