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Biomedical and Environmental Sciences 2019年第1期32卷 38-41页

作者： YU Juan LI Hong lu nan nan LEI You Ju JIANG Shuang Ying ZHAO Sheng Cang RAO Hua Xiang Center of Hygiene Inspection Qinghai Center for Disease Control and Prevention Institute for Communicable Disease Control and Prevention Qinghai Center for Disease Control and Prevention

Human adenoviruses (HAdVs) belong to the genus Mastadenovirus, family Adenoviridae, and can cause respiratory tract and gastrointestinal tract infections, as well as ocular infections in humans[1]. Till date, a total of 84 unique genotypes of AdVs have been identified and classified as human Mastadenovirus species A to G, and specific types are often associated with certain clinical symptoms, epidemiological settings, and demographic risk groups[2]. Among these species, members of the species HAdV-B (HAdV-3, HAdV-7, HAdV-11, HAdV-16, HAdV-21, HAdV-34, HAdV-35, HAdV-50, etc), HAdV-C (HAdV-1, HAdV-2, HAdV-5, and HAdV-6), and HAdV-E (HAdV-4) have been generally associated with respiratory infections[3]. HAdV infections are mild and self-limited in healthy individuals, whereas they can result in high mortality rates in immunocompetent and immunocompromized patients[4].

关键词： Human adenoviruses (HAdVs) mammivirus Eye infection

Disturbance of cholinergic Grb2-associated-binding protein 1 signaling participate in the pathological process of cognitive dysfunction

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中国药理学与毒理学杂志 2017年第5期31卷 475-476页

作者： TAN Chao lu nan-nan SHAO Ling-xiao LIU Xiu-xiu PAN Yue LIU Yi-jie YU Fang-ying lu Ying-mei 韩峰 College of Pharmaceutical Sciences Zhejiang University School of Medicine Zhejiang University City College 中国毒理学会浙江省毒理学会

OBJECTIVE A causal relationshiphas been postulated between cholinergic dysfunction and the progression of cognitive decline in neurodegenerative disorders. However,the cause of the cognitive dysfunction remains unclear. METHODS Gab1^(loxP/loxP) were bred with ChAT-Cre mice to generate ChAT-Cre; Gab1^(f/f) mice. Excitability of cholinergic neurons wererecorded using whole-cel patch clump. A series of behavioral analyses were used to address the changes of cognitive function in ChAT-Cre; Gab1^(f/f) mice. Neurochemical changes on brain of conditional knockout mice were evaluated by using immunohistochemistry and Western blotting analysis. RESULTS Grb2-associated-binding protein 1(Gab1) is adocking/scaffolding molecule known to play an important role in cell growth and survival. Here,wereport that Gab1 is decreased in cholinergic neurons in a mousemodel of AD. We found that selective downregulation of Gab1 in the septum impaired learning and memory and hippocampal long-term potentiation,whereas overexpression of Gab1 in the same area rescued the cognitive deficitsseen in ChAT-Cre; Gab1^(f/f) and APP^(swe)/PS1 mice.^(18)F-FDGmicroP ET imaging data indicated that Gab1 treatment had no effect on metabolic activity of glucose in APPswe/PS1 mice. Moreover,we identify abnormal function of SKchannelscontributes to increased firing in cholinergic neuronsof ChAT-Cre; Gab1^(f/f) mice. CONCluSION Gab1 signaling may serve as a potential treatment target for neurological disorders involving dysfunction of central cholinergic neurons.

关键词： cholinergic neurons cognitive dysfunction Gab1 therapeutic target

Endothelium-Derived Semaphorin 3G Regulates Synaptic Structure and Plasticity in CA1 Pyramidal Neurons

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神经药理学报 2019年第Z1期 108-109页

作者： lu nan-nan TAN Chao lu Ying-mei HAN Feng Institute of Pharmacology and Toxicology College of Pharmaceutical SciencesZhejiang University School of Medicine Zhejiang University City College Department of Neurobiology Nanjing Medical University Key Laboratory of Cardiovascular & Cerebrovascular Medicine School of PharmacyNanjing Medical University

Objective:Neurovascular interactions in the central nervous system(CNS) play a critical role in regulation proper neural function. Synaptic properties are regulated by various cell types including neurons and glia cells in the brain to coordinate neural transmission within circuits. Whether vascular cells could directly regulate synaptic function,remains largely unknown. Method:In vivo assays using mice behavioral test,electrophysiological recording,and spine morphology analysis were combined with in vitro assays using primary hippocampus neuron culture for the current study. Result:Our data suggested that brain endothelium-specific expressed secreted protein Semapohrin3 G(Sema3 G) regulates synaptic structure and plasticity in hippocampal neurons through its neuronal neuropilin-2/PlexinA4 holoreceptor. Mice lacking Sema3 G in endothelial cells display memory dysfunction in fear-conditioning tests and Y-maze test,as well as decreased spine density in hippocampal CA1 pyramidal neurons. Further study shows that vascular Sema3 G signals through postsynaptic neuropilin-2/PlexinA4 receptors and intracellular Rac1 small GTPase to increase functional synapse density. Conclusion:Our findings provide the first evidence that vascular endothelial cells work as a key component in regulating synaptic plasticity and cognitive behavior via intercellular communication with neurons in the CNS.

关键词： endothelial cell Semaphorin 3G hippocampus synapse density synaptic plasticity

Endothelium-Derived Semaphorin 3G Regulates Cognitive Function

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神经药理学报 2019年第Z1期 23-24页

作者： HAN Fen lu Ying-mei TAO Chao lu nan-nan Key Laboratory of Cardiovascular & Cerebrovascular Medicine School of PharmacyNanjing Medical University Department of Neurobiology Nanjing Medical University Institute of Pharmacology and Toxicology College of Pharmaceutical SciencesZhejiang University

Objective:The proper interactions between blood vessels and neurons are critical for maintaining the strength of neural circuits and cognitive function. However,the precise molecular events underlying these interactions remain largely unknown. Semaphorin 3 G（Sema3 G） is expressed mainly in endothelial cells,not in neuronal or glial cells in the brain. Here,we want to explore whether and how vascular-derived semaphorin 3 G regulate synaptic structure and plasticity of pyramidal neurons at CA1. Methods:Using biochemistry and transcriptional profiling analysis,to find Sema3 G is expressed almost exclusively in ECs in the brain;To study the function of EC-derived Sema3 G,we generated endothelial Sema3 G conditional-knockout mouse(Cdh5-Cre;Sema3 G;);Through electrophysiology,optogenetic strategies and behavior analysis,to examine endothelial Sema3 G losing lead to learning and memory defects,and synaptic plasticity at CA1 in mice;Finally,The re-expressing Sema3 G in the hippocampus could reverse the defects of spine density loss and cognitive dysfunction observed in Cdh5-Cre;Sema3 G;mice. Results:our data showed that the selective knockout of semaphorin 3 G in endothelial cells impaired hippocampal-dependent memory and reduced dendritic spine density in CA1 neurons in mice;these effects were reversed after restoration of Sema3 G levels in the hippocampus by AAV transfection. We further show that Sema3 G increased excitatory synapse density via neuropilin-2/PlexinA4 signaling and through activation of Rac1. Conclusion:These results provide the first evidence that,in the central nervous system,endothelial Sema3 G serves as a vascular-derived synaptic organizer that regulates synaptic plasticity and hippocampal-dependent memory. Our findings highlight the role of vascular endothelial cells in regulating cognitive function through intercellular communication with neurons in the hippocampus.

关键词： Semaphorin 3G Cognitive dysfunction Endothelial synaptic plasticity Nrp2 PlexinA4

Melting Evaluation of Phase Change Materials Impregnated into Cascaded Metal Foams with Regionalized Enhancement

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Journal of Thermal Science 2025年第1期34卷 223-241页

作者： WEI Xinyi ZHANG nan ZHANG Zhaoli CAO Xiaoling YUAN Yanping School of Mechanical Engineering Southwest Jiaotong University

Metal foam promotes the heat transfer of phase change materials(PCMs) in the penalty of reducing the energy storage density of the composite *** this work,the effects of constant porosity(0.96,0.94,0.92,or 0.90) and pore density(PPI) of metal foam on heat transfer of composite PCMs are *** rate could be enhanced by employing with low porosity copper ***,aiming to the right bottom phase changing "dead region",a regionalized enhancement strategy of cascaded metal foams is *** dynamic melting performances of all the composite PCMs are comprehensively *** results reveal that the cascaded configuration is beneficial for *** show that the horizontal strategy enhances melting performance:a maximum of 17.98% reduction in total melting time could be reached when the rear part porosity is 90%.The energy storage density rate could be raised by 5.48%.Besides,the vertical strategy performs with a better average temperature uniformity of 0.441 and brings a lower temperature in the heated *** sum up,the regionalized enhancement of copper foam provides better performance in the phase change *** shows significant potential for solar heat storage and thermal protection.

关键词： copper metal foam heat transfer enhancement phase change materials regionalized enhancement

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自动铺丝用预浸丝制备工艺研究

固体火箭技术 2014年第5期37卷 718-723页

作者：赵聪陆楠楠闫西涛耿杰肖军南京航空航天大学材料科学与技术学院南京210016

针对预浸料特点,提出平刀与圆刀2种分切刀具形式。以分切预浸丝束宽度与边缘质量为评价标准,对比了2种刀具形式对预浸料的分切质量,研究了刀具形式、工艺参数对分切质量的影响。结果显示,由于平刀刀片薄,弯曲模量低,易发生弯曲变形,所... 详细信息

针对预浸料特点,提出平刀与圆刀2种分切刀具形式。以分切预浸丝束宽度与边缘质量为评价标准,对比了2种刀具形式对预浸料的分切质量,研究了刀具形式、工艺参数对分切质量的影响。结果显示,由于平刀刀片薄,弯曲模量低,易发生弯曲变形,所得预浸丝束宽度稳定性差;同时,由于刃口始终固定、散热性能差,分切过程中刃口处容易发生树脂堆积,使刀片钝化,影响丝束边缘质量,无法实现对预浸料进行高质量连续式分切。而圆刀分切时,由于刀片旋转,刃口不断变化;独特的刀具形式,降低了刀片在分切过程中的侧向移动,使得圆刀分切能够获得宽度均匀,边缘质量良好的自动铺丝用预浸丝束。

关键词：复合材料自动铺丝预浸料分切分切刀具宽度控制

Normalized Solutions of Nonlinear Choquard Equations with Nonconstant Potential

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应用数学 2025年第1期38卷 14-29页

作者： LI nan XU Liping School of Mathematics and Statistics Henan University of Science and TechnologyLuoyang 471000China

In this paper,we mainly focus on a type of nonlinear Choquard equations with nonconstant *** appropriate hypotheses on potential function and nonlinear terms,we prove that the above Choquard equation with prescribed 2... 详细信息

关键词： Nonlinear Choquard equation Potential function Variational method Normalized solution

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基于随机传播图卷积模型的零样本图像分类

图学学报 2022年第4期43卷 624-632页

作者：芦楠楠刘一雄邱铭恺中国矿业大学信息与控制工程学院江苏徐州221116 中国科学技术大学信息科学技术学院安徽合肥230027

零样本图像分类旨在识别训练时从未出现过的全新类别(未见类别),为此需要利用辅助信息建模未见类和可见类之间的关系。利用图卷积网络(GCN)进行零样本分类的模型可以借助知识图显式地表达类别之间的关系,但GCN易受过平滑影响,导致模型... 详细信息

零样本图像分类旨在识别训练时从未出现过的全新类别(未见类别),为此需要利用辅助信息建模未见类和可见类之间的关系。利用图卷积网络(GCN)进行零样本分类的模型可以借助知识图显式地表达类别之间的关系,但GCN易受过平滑影响,导致模型性能下降。针对此问题提出了基于随机传播图卷积模型的零样本图像分类方法。该方法使用随机传播机制处理原始特征以达到特征扰动和数据扩增的目的;利用数据中类别层级生成的知识图建模类别之间的语义关系。其中,图中节点代表类别,节点间的边代表类别之间的关系。再构建GCN对处理后的特征进行训练,从节点中输出包含未见类别的分类器参数,进而实现零样本图像分类。实验结果表明,该方法可以有效地改善零样本图像分类中的时间消耗、分类精度和泛化性能。

关键词：零样本图像分类知识图图卷积网络随机传播机制数据扩增

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