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Upper Paleozoic Shale Gas Accumulation Conditions of the Tiemulike Formation in Yining Basin

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Acta Geologica Sinica(English Edition) 2015年第A01期89卷 147-150页

作者： FENG Yangwei lu jincai JIANG Ting NIU Yazhuo CHEN Gaochao XU Wei Xi' an Center of Geological Survey China Geological Survey Xi' an Shaanxi 710054 Xi'an Institute of Geology and Mineral Resources Xi'an 710054 Shaanxi China Department of Geology Northwest University Xi'an Shaanxi 710069

1 Introduction Yining basin, an independent unit of the Yili- Zhongtianshan micro plate （Wang et al., 2007; Han et al., 2011）, is an intermontane superimposed basin （Dai et al., 2015）. Yining basin has well-developed Tiemulike dark shale with normal lake facies formed in late period of middle Permian, which has good foreground material conditions of shale gas reservoirs from the study of predecessors.

关键词： SHALE gas RESEARCH BASINS (Geology) RESERVOIRS CAP rock NATURAL gas -- Prospecting CHINA

Physicochemical properties and antioxidant activities of polysaccharides extracted from Panax ginseng *** with graded percipitation method

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Asian Journal of Traditional Medicines 2020年第6期15卷 309-319页

作者： Xinying Wang Yue Lin Jia Liu Zhaojun Wang Linlin Liu Yingling Wang jincai lu School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016PR China Liaoning Provincial Key Laboratory of TCM Resources Conservation and Development Shenyang Pharmaceutical UniversityShenyang 110006PR China

Ginseng polysaccharides were extracted by water decoction from Panax ginseng ***(Cultivated Ginseng),named *** polysaccharide fractions,CGPS-20,CGPS-40,CGPS-60 and CGPS-80,were precipitated at final ethanol concentrations of 20%,40%,60%and 80%,*** properties,molecular weight,monosaccharide composition and antioxidant capacity of polysaccharide fractions were all *** results indicated that changing the concentration of ethanol could precipitate polysaccharides into fractions with different molecular weights,functional group composition and physicochemical properties,eventually leading to differences in antioxidant activity,which would help to find a simple,efficient,and reliable method for rapid extraction and purification of antioxidant polysaccharides from Panax ginseng *** the four polysaccharide fractions,CGPS-80 had lower molecular weight,higher contents of uronic acid and total phenolic,and stronger scavenging ability on DPPH∙and ABTS∙+radicals.

关键词： Ginseng polysaccharides graded ethanol precipitation physicochemical property antioxidant activity

中国北方石炭系—二叠系油气地质调查与勘探进展

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地质通报 2018年第1期37卷 7-15页

作者：卢进才牛亚卓姜亭中国地质调查局西安地质调查中心陕西西安710054

近10年来,中国北方(天山-兴蒙构造带)以石炭系—二叠系为目的层的油气基础地质调查在地层划分对比、层序地层、沉积充填与沉积体系、构造改造等基础地质领域,以及石炭系—二叠系烃源岩评价等石油地质领域取得了一系列新认识。天山-兴蒙... 详细信息

近10年来,中国北方(天山-兴蒙构造带)以石炭系—二叠系为目的层的油气基础地质调查在地层划分对比、层序地层、沉积充填与沉积体系、构造改造等基础地质领域,以及石炭系—二叠系烃源岩评价等石油地质领域取得了一系列新认识。天山-兴蒙构造带发育石炭纪—二叠纪与中生代2期叠合盆地,其中中生代盆地群是在未变质的石炭系—二叠系之上发育的上叠盆地。盆地内部及周缘地质体均发现了石炭系—二叠系良好烃源岩。准噶尔、三塘湖、吐哈、银额等盆地以石炭系—二叠系为目的层的油气调查与勘探不断取得新的发现与突破,二连、松辽等盆地相继获得了石炭系—二叠系油气赋存信息。中国北方石炭系—二叠系具有良好的油气地质条件与资源前景,有望成为油气勘探的战略接替新领域。

关键词：天山-兴蒙构造带石炭系—二叠系叠合盆地新领域

Enantioselective epoxidation of olefins using novel chiral binuclear Mn(Ⅲ)-Schiff-base complexes with built-in phase-transfer capability

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Enantioselective epoxidation of olefins using novel chiral b...

Activity of xanthones isolated from Lomatogonium rotatum

甘肃省化学会第二十四届年会

作者： Yang SUN, Ning TANG, Guangnong lu, jincai WU College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000

Chiral epoxides are of great interest for the synthesis of chiral intermediates in the pharmaceutical and agrochemical field . Therefore, the design of new chiral catalysts for enantioselective epoxidation of alkenes constitutes an important strategy for the synthesis of those chiral Pharmaceuticals and fine chemicals . Among several catalytic systems, the Jacobsen epoxidation had emerged as a powerful method for the asymmetric oxidation of unfunctionalized olefins,almost at the same lime, Katsuki and his colleagues had developed another set of salen -Mn (III) complexes which containing two extra stereogenic axes. Soon after these key findings, a number of reports appeared describing efforts to expand this catalytic system. We are interested in the synthesis and catalytic activity of novel dimeric salen ligands and their Mn(III) complexes based on some previous results, and furthermore, we found these dimeric salen-Mn(III) complexes have certain built-in phase-transfer capability under biphasic reaction condition(H2O/CH2Cl2, NaCIO as oxidant). In our present study, pyridine N-oxide, 1,4-dioxane and HMPA had been used as proximal ligand respectively, and they all stabilized the catalytically active intermediate Mn (V)-oxo and imparted the requisite activity and selectivity in the catalysts. For example, even water-soluble O-coordinating ligand (1,4-dioxane, 10mol%, catalyst 1) do the same work (epoxidation of indene with conversion 80%, e.e. 52%, time 4h). This feature maybe attributed to the built-in phase-transfer capability of these complexes, because they have two active metal sites on the catalysts and make the transportation of HOC1 from water phase to organic phase more conveniently. The structure of catalyst 1:

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Asian Journal of Traditional Medicines 2020年第3期15卷 113-120页

作者： Qingdi Mu Qin He Mengyuan Tan Ruoning Wang Jing Wang Chongning Lv Hang He jincai lu Lingyun Jia School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityBox 79Shenyang 110016Liaoning ProvincePR China

Thirteen xanthones were isolated from ***,which were established as l,8-dihydroxy-3,4,5-trimethoxyxanthone(1);l-hydroxy-3异,8-trimethoxyxanthone(2);8-hydroxy-l,3?5-trimethoxyxaiithone(3);l-hydroxy-3,4,5-trimethoxyxanthone(4);l-hydroxy-3,5,8-trimethoxyxanthone(5);l,4,8-trihydroxy-5,6-dimethoxyxanthone(6);l,3,8-trihydroxy-4,7-dimethoxyxanthone(;7)l,8-dihydroxy-3,7-dimethoxyxanthone(8);l-hydroxy-3,5-dimethoxyxanthone(9);l-hydroxy-2,3,4,5-tetramethoxyxanthone(;10)l-hydroxy-2,3,4,7-tetramethoxyxanthone(11);l,7-dihydroxy-3,8-dimethoxyxanthone(12);rel-l,3,5,8-tetrahydroxy-2,4,6,7-tetrahydroxanthen-9-one(13).Compounds 4,6,7,9,10,11,12 and 13 are reported for the first time from ***,the activity of xanthones was assessed.

关键词： Lomatogonium rotatum,xanthones activity

Antimicrobial activities and analysis of the crude extract,fractions and compounds from the Lomatogonium rotatum

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Asian Journal of Traditional Medicines 2020年第4期15卷 145-152页

作者： Ruoning Wang Qin He Qingdi Mu Mengyuan Tan Jing Wang Chongning Lv Hang He jincai lu Lingyun Jia School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityBox 79Shenyang 110016Liaoning ProvincePR China

This study was evaluated the antimicrobial activities of the crude extract,different fractions,and compounds from the plant of Lomatogonium *** fractions of chloroform and compounds 5,2 and 6 exhibited stronger antimicrobial *** 5 was the most active while Staphylococcus aureus and Candida albicans were sensitive to all the tested *** existence of a relationship between the xanthone structures and inhibition of microorganism *** antimicrobial activity of this plant was reported here *** results provided evidence that the studied plant extract,fractions as well as some of the isolated compounds might be potential sources of new antimicrobial drug.

关键词： Lom atogonium carinthiacum fractions compounds antimicrobial activities HPLC-EIS-MS/MS

基于HPLC指纹图谱及多成分定量对刺五加的质量评价

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中草药 2024年第4期55卷 1326-1333页

作者：宋娟张晶玉吕重宁路金才沈阳药科大学中药学院辽宁沈阳110016

目的建立刺五加Acanthopanax senticosus HPLC指纹图谱及原儿茶酸、松柏苷、紫丁香苷、绿原酸、刺五加苷B1、刺五加苷E、丁香树脂酚7种成分含测定方法。方法采用Diamonsil 5μm C18(2)色谱柱(4.6 mm×250 mm,5μm),乙腈-0.1%磷酸水溶液... 详细信息

目的建立刺五加Acanthopanax senticosus HPLC指纹图谱及原儿茶酸、松柏苷、紫丁香苷、绿原酸、刺五加苷B1、刺五加苷E、丁香树脂酚7种成分含测定方法。方法采用Diamonsil 5μm C18(2)色谱柱(4.6 mm×250 mm,5μm),乙腈-0.1%磷酸水溶液为流动相,梯度洗脱;检测波长210 nm,柱温30℃,体积流量0.8 mL/min,进样量10μL。通过“中国色谱指纹图谱相似度评价系统”(2012版),建立了刺五加HPLC指纹图谱,同时测定了7种成分的含量。结合主成分分析、正交偏最小二乘法判别分析和皮尔逊相关性分析对刺五加进行了质量评价。结果建立了刺五加HPLC指纹图谱,共确定了18个共有色谱峰;原儿茶酸、松柏苷、紫丁香苷、绿原酸、刺五加苷B1、刺五加苷E以及丁香树脂酚线性关系良好,r2均大于等于0.9991,平均回收率分别为92.51%、97.63%、95.11%、101.08%、105.29%、98.92%、85.44%、94.89%。主成分分析提取了2个主成分,其方差累积为66.920%,表明这2个主成分可包含原有数据的大部分信息;正交偏最小二乘法判别分析筛选出刺五加样品中2个差异性成分(紫丁香苷、刺五加苷B1);皮尔逊相关性分析显示紫丁香苷、绿原酸和刺五加苷B1与其他化学成分的相关性最强。结论建立的刺五加HPLC指纹图谱及多成分含量测定方法简单、准确、重复性好,可用于刺五加的质量评价,为其质量控制提供依据。

关键词：刺五加指纹图谱原儿茶酸松柏苷紫丁香苷绿原酸刺五加苷B1 刺五加苷E 丁香树脂酚主成分分析

内蒙古西部北山-银额地区石炭纪-二叠纪层序地层与沉积演化

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岩石学报 2018年第10期34卷 3101-3115页

作者：卢进才史冀忠牛亚卓宋博张宇轩余龙中国地质调查局西安地质调查中心西安710054

内蒙古西部北山-银额地区位于华北板块、塔里木板块和哈萨克斯坦板块的交汇带,构造背景复杂,一直是构造研究的热点地区。虽然研究区发育数千米以碎屑岩+火山岩+碳酸盐岩为特征的石炭系-二叠系,但层序地层与沉积演化研究十分薄弱,一定程... 详细信息

内蒙古西部北山-银额地区位于华北板块、塔里木板块和哈萨克斯坦板块的交汇带,构造背景复杂,一直是构造研究的热点地区。虽然研究区发育数千米以碎屑岩+火山岩+碳酸盐岩为特征的石炭系-二叠系,但层序地层与沉积演化研究十分薄弱,一定程度上制约了对构造背景的认识。本文通过石炭纪-二叠纪区域地层对比与层序地层研究,分别建立了北山和银额2个地区石炭纪-二叠纪层序地层格架,明确了不同构造单元石炭纪-二叠纪层序地层具有良好的对比关系,为统一构造环境沉积的地质体。通过沉积演化研究,明确了研究区石炭纪-二叠纪具有"两坳一隆"的构造格架,并控制着沉积相的展布,早石炭世晚期北山地区南部接受沉积,之后逐渐伸展,晚石炭世晚期-早二叠世早期盆地沉积范围最大,盆地演化达到鼎盛。早二叠世晚期盆地开始萎缩,晚二叠世海水基本退出研究区,仅银额东北部接受了海相沉积。总之,层序地层及沉积演化研究指示研究区石炭纪-二叠纪为相同构造环境下形成的统一的陆内(板内)裂谷盆地。

关键词：北山-银额地区石炭纪-二叠纪层序地层沉积演化构造环境陆内裂谷盆地

基于网络药理学的升麻治疗乳腺癌作用机制研究

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药物评价研究 2022年第4期45卷 642-651页

作者：李玥锴李钦琳韩凌路金才吕重宁沈阳药科大学中药学院辽宁沈阳110006 辽宁省中药资源保护与开发重点实验室辽宁沈阳110006 本溪国家中成药工程技术研究中心有限公司辽宁本溪117004

目的通过构建升麻Cimicifugae Rhizoma化学成分-靶点-代谢信号通路网络,探讨其治疗乳腺癌的作用机制。方法利用中药系统药理学数据库与分析平台(TCMSP)和PharmMapper获取升麻化学成分与作用靶点,将其与乳腺癌疾病靶点取交集得到升麻治... 详细信息

目的通过构建升麻Cimicifugae Rhizoma化学成分-靶点-代谢信号通路网络,探讨其治疗乳腺癌的作用机制。方法利用中药系统药理学数据库与分析平台(TCMSP)和PharmMapper获取升麻化学成分与作用靶点,将其与乳腺癌疾病靶点取交集得到升麻治疗乳腺癌的作用靶点,进一步利用靶点-成分反向筛选得到治疗乳腺癌的升麻潜在活性成分;通过Gene MANIA数据库获取间接靶标和“蛋白-靶点”互作网络,并通过蛋白-蛋白相互作用筛选关键靶标;采用Cytoscape构建“成分-靶点”网络图,使用分子对接将潜在活性成分和关键靶标配对,以证实前期靶标筛选和反向药效团匹配的可靠性;通过DAVID网站对作用靶点进行基因本体论(GO)分析和京都基因与基因组百科全书(KEGG)分析,利用R语言和在线绘图网站(omishare tools)将结果可视化。结果获得升麻潜在活性成分共68个,与乳腺癌相关疾病靶点48个,关键靶点为ESR1、SRC和HRAS。GO功能富集分析得到生物过程(BP)条目484条,细胞组成(CC)条目7条,分子功能(MF)条目75条。KEGG通路富集筛选获得到21条信号通路。分子对接结果显示关键靶标与升麻潜在活性成分匹配性较好。结论升麻主要通过作用于ESR1、SRC、HRAS等靶点,调节癌症通路、蛋白多糖通路和雌激素信号通路等起到治疗乳腺癌的作用。

关键词：升麻乳腺癌网络药理学 ESR1 SRC HRAS 癌症通路蛋白多糖通路雌激素信号通路