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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao Wang jia Zeng Donglin Gan Kun Ling Mingfang He jianshu Li Yongping lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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大型铝合金压铸模的性能均匀性与开裂机理

材料热处理学报 2019年第3期40卷 62-69页

作者：陆佳晖闵永安岳加佳苏爱民省部共建高品质特殊钢冶金与制备国家重点实验室上海大学材料学院上海200072 上海皮尔博格有色零部件公司上海201815

通过微观组织观察与力学性能检测,分别对热疲劳龟裂与早期整体开裂失效的大型铝压铸模进行了分析。结果表明:由碳化物偏聚引起的微观组织及性能的不均匀,是导致大型铝合金压铸模热疲劳龟裂的主要原因;模具心部因存在局部的粗晶组织使其... 详细信息

通过微观组织观察与力学性能检测,分别对热疲劳龟裂与早期整体开裂失效的大型铝压铸模进行了分析。结果表明:由碳化物偏聚引起的微观组织及性能的不均匀,是导致大型铝合金压铸模热疲劳龟裂的主要原因;模具心部因存在局部的粗晶组织使其韧性恶化,在薄弱位置处的微裂纹快速扩展为致命性贯穿裂纹导致其早期整体开裂。此外,模具微区硬度的离散度,能较好地反映模具微区组织性能的均匀性。

关键词：铝压铸模失效冲击韧性均匀性

Modular assembly of Co4-thiacalix[4]arene units and Keggin-type SiW12O40 for visible-light photothermal conversion

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Tungsten 2025年第1期7卷 112-119页

作者： jia-hui Li Qing Zhao Dong-Ao Mao Kun Zhou Bao-Kuan Chen Yan-Feng Bi School of Petrochemical Engineering Liaoning Petrochemical University

The construction of metal-organic coordination clusters（MCCs） using modular secondary building units is an important method for preparing functional *** this study,two new MCCs modularly assembled from Keggin-type {SiW12O40}H4TC4A=p-tert-Butylthiacalix[4]arene(SiW12) units and thiacalixarene-supported Co4-thiacalix[4]arene(Co4-TC4A polynuclear second-building units（PSBUs,H4TC4A=p-tert-Butylthiacalix[4]arene） are *** two MCCs,abbreviated as Co4-SiW12and Co8-SiW12,were structurally characterized by single-crystal X-ray *** Co4-SiW12is a supramolecular structure involving cation-anion interactions between Co4-TC4A PSBUs and ***8-SiW12features "barbell-like" shapes with two Co4-TC4A coordinatively linked to a Keggin-type SiW12unit on opposite via W-O_t-Co *** coordination of Co4-TC4A to SiW12in Co8-SiW12resulted in significantly improved photothermal conversion performances compared with Co4-SiW12and pure SiW12or ***-gap determination and photophysical analysis combined with density functional theory calculations indicated the binding mode between Co4-TC4A PSBUs and SiW12,which considerably influences the way of electron transport and the conversion ability of visible light to heat.

关键词： Modular construction Photothermal conversion Polyoxometalate Thiacalixarene

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新疆石河子垦区棉花生产区域优势评价

棉花学报 2007年第1期19卷 76-77页

作者：陆嘉惠吕新新疆石河子大学生命科学学院石河子832003 新疆兵团绿洲生态农业重点实验室

作物生产潜力是进行作物生产区域优势评价的主要指标，应用生产潜力模型评估棉花生产是近十年发展起来的，目前的研究以建立棉花单产潜力模型进行气候风险评估为主，缺乏对棉花生产地区具体区域优势的分析。新疆地域辽阔，不同地区在气... 详细信息

作物生产潜力是进行作物生产区域优势评价的主要指标，应用生产潜力模型评估棉花生产是近十年发展起来的，目前的研究以建立棉花单产潜力模型进行气候风险评估为主，缺乏对棉花生产地区具体区域优势的分析。新疆地域辽阔，不同地区在气候、土壤状况及农技水平上都存在差异。掌握棉花生产的区域差异，进行棉花生产区域优势评价，对棉花生产布局和进一步提高棉花产量具有重要意义。目前，由于FAO农业生态区域法比较全面地考虑了影响作物生育的多个气候因素，所用的参数又可以根据作物的特点进行调整，得到国际上普遍认可和广泛应用。本文应用FAO农业生态区域法，评价新疆棉花主产区石河子垦区棉花生产潜力，并对该地区棉花生产的区域优势和主要限制因子进行分析，为北疆地区的棉花生产发展和规划提供决策平台和依据。

关键词：棉花生产区域优势石河子垦区新疆作物生产潜力气候因素农业生态

基于真实世界研究的中医药临床数据挖掘方法浅探

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中华中医药杂志 2017年第4期32卷 1640-1643页

作者：许鸣陆嘉惠桐乡市第一人民医院中医科浙江桐乡314500 上海中医药大学附属市中医医院血液科上海200071

中医药的"整体观念""辨证论治"特点虽增加了传统医学在复杂临床环境中的优势,却又不利于中医药研究范式的构建。在全球大数据时代的背景下,中医药临床的数据挖掘工作逐步开展,为提高中医药临床研究整体水平,完善中医药临床疗效评价方法... 详细信息

中医药的"整体观念""辨证论治"特点虽增加了传统医学在复杂临床环境中的优势,却又不利于中医药研究范式的构建。在全球大数据时代的背景下,中医药临床的数据挖掘工作逐步开展,为提高中医药临床研究整体水平,完善中医药临床疗效评价方法,提供了数据支持。相对于随机对照试验(RCT)所需要的高级别临床证据,好的比较效益研究准则(GRACE)更关注贴近真实世界的队列研究。而在真实世界研究(RWS)中引入贝叶斯倾向评分法将为进一步的中医临床数据挖掘工作创制中医药观察性比较研究实施的国际新标准,构建适合中医发展规律的临床科研新范式。

关键词：贝叶斯倾向评分法真实世界研究中医药数据挖掘

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： hui-Feng Wang Wen-Jie Shi Yu-Xin Yang Bao-Xia Dong Tong-Bu lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： hui Yang Nan Mo Le Tong jianhong Dong Ziwei Fan Mengxian jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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黑臭水体综合整治工程的水质改善效果评价

中国农村水利水电 2018年第12期 50-53,58页

作者：鲁佳慧唐德善河海大学水利水电学院南京210098

以盐城市蔷薇河为研究对象,基于因子分析法和优化的非线性灰色伯努利模型,结合2009-2017年的水质数据,分析黑臭水体综合整治工程对河道水质改善和主要污染因子的治理效果。结果证明实施黑臭水体综合整治工程后,蔷薇河水质得到明显提升,... 详细信息

以盐城市蔷薇河为研究对象,基于因子分析法和优化的非线性灰色伯努利模型,结合2009-2017年的水质数据,分析黑臭水体综合整治工程对河道水质改善和主要污染因子的治理效果。结果证明实施黑臭水体综合整治工程后,蔷薇河水质得到明显提升,生活污染以及营养元素污染治理效果明显,但无机污染和水体物理环境状况改善效果不明显,需要进一步加强相应措施的制定和实施,为规划下一阶段黑臭水体整治工程的工作目标及任务提供了参考和依据。

关键词：因子分析法优化的非线性灰色伯努利模型黑臭水体综合整治工程水质改善效果

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中式烹饪食品挥发性风味物质研究进展

中国调味品 2021年第11期46卷 178-182页

作者：赵钜阳陆家慧哈尔滨商业大学旅游烹饪学院哈尔滨150030

中式烹饪食品以色香、味全、状美等特色享誉全球,烹饪食品的风味更是影响其品质的重要因素之一。挥发性风味物质的研究是近年来食品领域的研究热点。文章综述了中式烹饪食品挥发性物质方面的研究,就烹饪中风味物质组成和提取方法、烹饪... 详细信息

中式烹饪食品以色香、味全、状美等特色享誉全球,烹饪食品的风味更是影响其品质的重要因素之一。挥发性风味物质的研究是近年来食品领域的研究热点。文章综述了中式烹饪食品挥发性物质方面的研究,就烹饪中风味物质组成和提取方法、烹饪食品风味物质的分析方法及不同烹饪方式和调味料对风味物质形成和菜品整体风味的影响做了相应的总结和探讨,为进一步探索中式烹饪食品风味物质提供了一定的理论支撑。

关键词：烹饪风味物质提取检测