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Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy

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Neural Regeneration Research 2011年第10期6卷 785-789页

作者： Xiaofeng Yang Yifeng Xu Naiwu lu Yibin Zhang hongmei Wang Xin lu Jiping Cui JinxuZhou Hong Shan Yanxiang Wu Xinping Liu Cell Treatment Center Chinese PLA 463 Hospital Shenyang 110042 Liaoning Province China

Due to their relative abundance,stable biological properties and excellent reproductive activity,umbilical cord mesenchymal stem cells have previously been utilized for the treatment of Duchenne muscular dystrophy,which is a muscular atrophy *** patients who were clinically and pathologically diagnosed with Duchenne muscular dystrophy were transplanted with umbilical cord mesenchymal stem cells by intravenous infusion,in combination with multi-point intramuscular *** were followed up for 12 months after cell *** showed that clinical symptoms significantly improved,daily living activity and muscle strength were enhanced,the sero-enzyme,electromyogram,and MRI scans showed improvement,and dystrophin was expressed in the muscle cell ***-eosin staining of a muscle biopsy revealed that muscle fibers were well arranged,fibrous degeneration was alleviated,and fat infiltration was *** pieces of evidence suggest that umbilical cord mesenchymal stem cell transplantation can be considered as a new regimen for Duchenne muscular dystrophy.

关键词： umbilical cord mesenchymal stem cells Duchenne muscular dystrophy case report dystrophin muscular force activities of daily living

Adaptive interactive genetic algorithms with individual interval fitness

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Progress in Natural Science:Materials International 2008年第3期18卷 359-365页

作者： Dunwei Gong , Guangsong Guo, Li lu, hongmei Ma School of Information and Electrical Engineering, China University of Mining & Technology, Xuzhou 221008, China School of Information and Electrical Engineering China University of Mining & Technology Xuzhou 221008 China

It is necessary to enhance the performance of interactive genetic algorithms in order to apply them to complicated optimization prob- lems successfully. An adaptive interactive genetic algorithm with individual interval fitness is proposed in this paper in which an indi- vidual fitness is expressed by an interval. Through analyzing the fitness, information reflecting the distribution of an evolutionary population is picked up, namely, the difference of evaluating superior individuals and the difference of evaluating a population. Based on these, the adaptive probabilities of crossover and mutation operators of an individual are presented. The algorithm proposed in this paper is applied to a fashion evolutionary design system, and the results show that it can find many satisfactory solutions per generation. The achievement of the paper provides a new approach to enhance the performance of interactive genetic algorithms.

关键词： Optimization Genetic algorithm Interaction Interval Probability of genetic operator

Analysis of soil biogeochemical characteristics in the process of karst rocky desertification

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Chinese Journal Of Geochemistry 2006年第B8期25卷 175-176页

作者： hongmei lu Shijie lu Yuanhua PENG State Key Laboratory of Environment Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China Chemistry College Guizhou University Guiyang 550025 China

Prediction of Structure Similarity of Metabolites via Tandem Mass Spectrometry Spectra Assists Identification

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Prediction of Structure Similarity of Metabolites via Tandem...

<i>Houttuynia cordata</i>Thunb: A Review of Phytochemistry and Pharmacology and Quality Control

2018年中国质谱学术大会（CMSC2018）

作者： Ji Hongchao lu hongmei College of Chemistry and Chemical Engineering Central South University

Tandem mass spectrometry(MS/MS) is frequently used for structural annotation of metabolites, because it provides abundance of structure information of metabolites. Structurally similar metabolites often have related MS/MS spectra, which can facilitate incorporating detected metabolites and identification1,2. However, it is not easy to explore the internal relationship between MS/MS spectra correlation and structure similarity automatically. Therefore, we present a deep-learning based regression model to predict the structure similarity of metabolites via their spectra, with which can obtain a list of structure-related known metabolite of an unknown spectrum. This approach can be used for assisting unknown metabolite identification effectively.

关键词： Tandem mass spectrometry structure similarity identification

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Chinese Medicine 2013年第3期4卷 101-123页

作者： Jiangang Fu Ling Dai Zhang Lin hongmei lu College of Chemistry and Chemical Engineering Central South University Changsha China

Houttuynia cordata Thunb is an important medicinal plant widely distributed in East Asia. The collected information is an attempt to cover recent developments in the pharmacology, phytochemistry and quality control of this species. During the past several decades, the medicinally important phyto-constituents have been identified including essential oil, flavonoids and other polyphenols, fatty acids and alkaloids. A survey of the literatures shows H. cordata possesses a variety of pharmacological activities including antiviral, antitumor, antimicrobial, anti-inflammatory, and antioxidative effects. Little attempt has been done to review the techniques used for its quality control. Future efforts should concentrate more on in vitro, in vivo studies and clinical trials in order to confirm traditional wisdom in the light of a rational phytotherapy. The information summarized here is intended to serve as a reference tool to practitioners in the fields of ethnopharmacology and natural products chemistry.

关键词： Houttuynia cordata Thunb Phytochemical Constituents Pharmacological Activity Quality Control

直观推导式演进特征投影法分辨枸杞类胡萝卜素的异构体

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色谱 2005年第4期23卷 415-417页

作者：卢红梅中南大学化学化工学院湖南长沙410083

采用高效液相色谱-二极管阵列检测方法,初步分离了枸杞子中的类胡萝卜素。以乙腈-二氯甲烷(体积比为60∶40)为流动相,流速为1·0mL/min,用C18柱从枸杞类胡萝卜素中分离出7个峰。但由于类胡萝卜素的结构多样性,尤其是顺反异构体的出现使... 详细信息

采用高效液相色谱-二极管阵列检测方法,初步分离了枸杞子中的类胡萝卜素。以乙腈-二氯甲烷(体积比为60∶40)为流动相,流速为1·0mL/min,用C18柱从枸杞类胡萝卜素中分离出7个峰。但由于类胡萝卜素的结构多样性,尤其是顺反异构体的出现使得分离并不完全。利用所得三维数据提供的信息和化学计量学方法直观推导式演进特征投影法(HELP),对其中某些在二维色谱中被定性为单组分的峰进行解析,结果发现原来在二维色谱中被定性为单组分的峰大多是一些多组分峰。以其中第4个峰为例对其进行解析,得到了该类胡萝卜素的同分异构体色谱流出曲线及紫外光谱信息。该方法表明,化学计量学方法与现代分析手段有机结合,大大降低了此类复杂体系对色谱分离的要求,对同分异构体的分析具有一定的借鉴和指导意义。

关键词：高效液相色谱-二极管阵列检测直观推导式演进特征投影法类胡萝卜素异构体枸杞

Pigments Production in Wandering Jew Mutant Induced by Heavy Ion Beam Irradiation

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 135-136页

作者： He Jinyu Li Wenjian Xie hongmei lu Dong Guo Junsheng Yu Lixia

时移地震“相对差异法”定量预测疏松砂岩油藏含油饱和度——以西非深海泽塔油田为例

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石油勘探与开发 2019年第2期46卷 409-416页

作者：陆红梅徐海沃玉进谷宁中国石化石油勘探开发研究院北京100083

针对传统时移地震绝对差异(监测地震与基础地震之差)的强弱不仅与含油饱和度变化有关、也与储集层厚度关系密切的弊端,通过流体置换正演模拟研究,提出一种不受储集层厚度影响、仅与流体饱和度变化有关的时移地震"相对差异法"(监测地震... 详细信息

针对传统时移地震绝对差异(监测地震与基础地震之差)的强弱不仅与含油饱和度变化有关、也与储集层厚度关系密切的弊端,通过流体置换正演模拟研究,提出一种不受储集层厚度影响、仅与流体饱和度变化有关的时移地震"相对差异法"(监测地震与基础地震之比)。相同的流体饱和度变化条件下,时移地震的绝对差异符合调谐效应及地震薄层反射规律,基于时移地震绝对差异的剩余油预测方法仅适用于储集层厚度小于调谐厚度但等厚,或储集层厚度大于调谐厚度的油藏。时移地震相对差异不受厚度影响,仅与流体饱和度变化有关,适用于可排除压力、温度、孔隙类型及孔隙度对地震影响的深海疏松砂岩油藏。故可以根据Gassmann流体置换地震正演模拟得到的相对差异与流体饱和度变化关系定量预测油藏含水饱和度变化,进而定量预测剩余油分布。该方法在西非安哥拉深海泽塔油田实际应用表明其合理有效。

关键词：时移地震剩余油定量预测疏松砂岩油藏流体置换绝对差异相对差异法泽塔油田西非

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假日经济的营销创新策略

生产力研究 2006年第2期 97-98页

作者：陆红梅渤海大学辽宁锦州121000

假日经济是在国家扩大内需、刺激消费政策下发展起来。它反映了现代消费的特点和市场经济的客观要求。通过分析假日经济的本特征,提出了影响假日经济发展的制约因素,从文化、市场、观念、手段等几个方面研究假日经济营销的创新策略。

关键词：假日经济营销策略创新假日消费