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Catalytic Performance of Carbon Smoke over Ag-LSCF Composite Catalysts

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 30-34页

作者： GUO Guanlun han ming lu Shaomin YU Jing JU Hongling 无 Hubei Key Laboratory of Advanced Technology for Automotive Components&Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of TechnologyWuhan 430070China College of Mechanical and Transportation Southwest Forestry UniversityKunming 650000China

To improve the catalytic performance of La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3)(LSCF)towards carbon soot,we utilized the impregnation method to incorporate Ag into the prepared LSCF *** conducted a series of characterization tests and evaluated the soot catalytic activity of the composite catalyst by comparing it with the LaCoO_(3) group,LaFeO_(3) group,and catalyst-free *** results indicate that the Ag-LSCF composite catalyst exhibits the highest soot catalytic activity,with the characteristic temperature values of 376.3,431.1,and 473.9℃at 10%,50%,and 90%carbon soot conversion,*** values are 24.8,20.2,and 23.1℃lower than those of the LSCF *** also shows that LSCF can improve the catalytic activity of soot after compounding with Ag,and reflects the necessity of using catalysts in soot combustion *** characterization and BET test show that Ag-LSCF has more abundant surface-adsorbed oxygen species,larger specific surface area and pore volume than LSCF,which also proves that Ag-LSCF has higher soot catalytic activity.

关键词： metallic composites carbon smoke oxidation perovskite catalyst soot

High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie Mao Zhimin Zhang han Lin Qixin Yan Xiangyu lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao mingkai Zhang Qimeng Li Xuemin Wang Jie lu Ying han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

Optimization of Tetrandrine Treatment in Rat Hepatic Fibrosis Model

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上海交通大学学报（医学版） 2006年第5期26卷 506-506页

作者： PAN Qin LI Ding-guo lu han-ming XU Qin-fang CHEN Xi-mei Department of Gastroenterology Xinhua Hospital School of Medicine Shanghai Jiaotong University Shanghai 200092 China Department of Gastroenterology Tongji Hospital Tongji University Shanghai 200065 China

Objective To optimize the therapeutic dosage of tetrandrine (Tet) in rat hepatic fibrosis model. Methods 50 Wistar ratswere divided into 5 groups at random including normal control, model control, Tet-treated model groups of 10 ***-1.d-1, 5 ***-1.d-1and 2.5 ***-1.d-1(n=10 in each group). All rats, except for the normal controls, were injected with axenic porcine serum(0.5ml each time, twice a week) intraperitoneally for8 weeks to establish hepatic fibrosis. After the 8th week, rats of Tet-treated modelgroups were given by gavage once a day with different doses of Tet for another8 weeks. Then the liver function, serum levels of hyaluron-ic acid (HA), laminin (LM), and procollagen type III (PCIII) were tested. Collagen type I and III, pathological changes in liver tissuewere also assessed. Results Most indices of liver function including alanine minotransferase ( ALT), aspartate aminotransferase(AST), albumin (ALB), albumin /globulin ratio (A/G) and alkaline phosphatase (ALP) improved significantly in Tet-treated groupswith the exception ofγ-glutamyl transpeptidase (γ-GT) and total bilirubin (TBIL). Secondly, markedly lowered levels of HA, LMandcollagen type I, III were also detected by radioimmunology and immunohistochemistry in the 5 ***-1.d-1Tet-treated model ***, pathological findings confirmed the statistically significant improvement in hepatofibrotic degree resulted from the treatment of5 ***-1.d-1rather than other doses of Tet. Conclusion For experimental Wistar rats, Tet exhibited an anti-hepatofibrotic action indoses within the range of 2.5 ***-1.d-1to 10 ***-1.d-1, and 5 ***-1.d-1may be the optimum one among all doses.

关键词：粉防己碱肝纤维化优化技术肝功能

A COMPLEMENT FIXATION TEST FOR THE DETECTION OF ALPHA-FETO-PROTEIN IN THE DIAGNOSIS OF PRIMARY LIVER CANCER

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Science in China,Ser.A 1973年第4期 612-616页

作者：卢锦汉程明 Division of Cancer Research National Vaccine and Serum Institute Peking

The purpose of this paper is to report the results of a study on a complement fixation test for AFP detection in the diagnosis of primary liver cancer. The requirements for a satisfactory complement fixation test are first, an antiserum which is free from anticomplementary effect and, second, monospecificity, i. e., not liable to give cross reaction with normally present protein. When this type of antiserum becomes available, sera from patients proven to be, or highly suspected of suffering from primary liver cancer but giving negative agar diffusion test results are collected for study. Sera from 11 cases proven by histologic examination showed 2 positive reactions by countercurrent electrophoresis assay and 9 positive by complement fixation test. Among 26 sera from cases clinically diagnosed as primary liver cancer, all negative to agar diffusion tests, 6 were positive by countercurrent electrophoresis and 17 by complement fixation test. The amount of AFP detected by complement fixation test was 40—8

关键词： CFT test CEP A COMPLEMENT FIXATION TEST FOR THE DETECTION OF ALPHA-FETO-PROTEIN IN THE DIAGNOSIS OF PRIMARY LIVER CANCER AFP

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肝门阻断对肠道影响的实验研究

中南大学学报(医学版) 1998年第3期 29-31页

作者： Liu Pengxi lu Xinsheng han ming(Department of Surgery, Xiangya Hospital, Hunan Medical University, Changsha 410008)

为了解肝手术后肝昏迷等并发症的发生机制，阻断猪肝门４５ｍｉｎ后松钳６０ｍｉｎ，造成肠瘀血动物模型；观察小肠粘膜的变化，并检测血中肠源性毒物。结果发现：肝门阻断后血中组织蛋白酶Ｄ，内毒素及乳酸明显增高，且肠粘膜出现明显... 详细信息

为了解肝手术后肝昏迷等并发症的发生机制，阻断猪肝门４５ｍｉｎ后松钳６０ｍｉｎ，造成肠瘀血动物模型；观察小肠粘膜的变化，并检测血中肠源性毒物。结果发现：肝门阻断后血中组织蛋白酶Ｄ，内毒素及乳酸明显增高，且肠粘膜出现明显损伤。提示肝手术后并发症的发生与上述结果有关，在肝脏手术中保护肠道功能及其完整性尤有必要

关键词：肝疾病外科手术肝门阻断肠粘膜肠毒素类组织蛋白酶D 猪

幽门螺杆菌感染的胃黏膜上皮细胞环氧合酶-2表达及意义

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中华肿瘤杂志 2005年第4期27卷 232-234页

作者：丁小云李定国陆汉明宁波市第一医院消化科 315010 上海第二医科大学新华医院消化科

目的　探讨幽门螺杆菌(Hp)感染的胃黏膜上皮细胞环氧合酶-2 (COX -2 )的表达及其在胃黏膜癌变过程中的意义。方法　采用快速尿素酶试验和组织学碱性品红染色法检测胃黏膜Hp感染状况;应用免疫组化法检测胃黏膜上皮细胞COX- 2表达状况。... 详细信息

目的　探讨幽门螺杆菌(Hp)感染的胃黏膜上皮细胞环氧合酶-2 (COX -2 )的表达及其在胃黏膜癌变过程中的意义。方法　采用快速尿素酶试验和组织学碱性品红染色法检测胃黏膜Hp感染状况;应用免疫组化法检测胃黏膜上皮细胞COX- 2表达状况。结果　32例胃癌中,COX -2表达阳性2 2例(6 8.7%)。1 2例Hp阴性的胃黏膜中,有1例(8.3%)COX -2低表达;1 0例Hp阳性正常胃黏膜中,仅1例(1 0 .0 %)COX -2低表达;9例Hp阳性的胃黏膜充血水肿糜烂者中,有5例(5 5 .6 %)COX 2表达阳性,与Hp阴性者和Hp阳性正常胃黏膜者比较,差异有统计学意义(P <0 .0 5 ) ;1 0例Hp阳性的轻度萎缩性胃炎伴轻度肠化生者中,COX -2表达阳性5例(5 0 .0 %) ;1 0例Hp阳性的中重度萎缩性胃炎伴中重度肠化生者中,COX -2表达阳性8例(80 .0 %) ;8例Hp阳性的中重度不典型增生者中,COX 2表达阳性6例(75 .0 %)。中重度萎缩性胃炎伴中重度肠化生和不典型增生者的COX 2表达高于轻度萎缩性胃炎伴轻度肠化生者(P <0 .0 5 )。结论　Hp感染诱导慢性浅表性胃炎黏膜上皮细胞的COX -2表达与黏膜损伤形成有关;根据胃癌发生模式,COX -2表达上调与Hp感染胃黏膜癌变发生相关,且可能在癌前病变形成早期阶段起作用。

关键词：胃黏膜上皮细胞幽门螺杆菌感染环氧合酶-2 表达及 COX-2表达重度萎缩性胃炎幽门螺杆菌(Hp) 快速尿素酶试验免疫组化法检测重度不典型增生慢性浅表性胃炎 Hp阳性 Hp阴性肠化生癌变过程感染状况碱性品红表达状况

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维生素D与乳腺癌相关的研究进展

全科口腔医学电子杂志 2019年第20期6卷 16-17页

作者：陆汉明贵港市疾病预防控制中心

维生素D(VD)是固醇类家族的一种,在儿童佝偻病和老年骨质疏松疾病中有预防佝偻和抗骨密度低作用。维生素D是一种可溶于脂质的物质,参与人体内多种生物科学的过程,如影响磷、钙的贮存与吸收。近年的深入研究发掘人体内维生素D的水平与人... 详细信息

维生素D(VD)是固醇类家族的一种,在儿童佝偻病和老年骨质疏松疾病中有预防佝偻和抗骨密度低作用。维生素D是一种可溶于脂质的物质,参与人体内多种生物科学的过程,如影响磷、钙的贮存与吸收。近年的深入研究发掘人体内维生素D的水平与人体内多种恶性肿瘤的发生与发展显著相关,因此,在营养学与肿瘤研究领域中探究维生素D的水平与各种肿瘤相关的研究已成为主流。该文针对VD与乳腺癌相关性的研究进行进展性综述,以及针对VD在乳腺癌引发及预后中的分子功能来展开深入概述和未来的临床远景。

关键词： VD 乳腺癌肿瘤

Catalytic Performance of Carbon Smoke over Ag-LSCF Composite Catalysts

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期 30-34页

作者：郭冠伦 han ming lu Shaomin YU Jing 鞠洪玲 Hubei Key Laboratory of Advanced Technology for Automotive Components & Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of Technology College of Mechanical and Transportation Southwest Forestry University

To improve the catalytic performance of La0.6Sr0.4Co0.2Fe0.8O3（LSCF） towards carbon soot,we utilized the impregnation method to incorporate Ag into the prepared LSCF *** conducted a series of characterization tests and evaluated the soot catalytic activity of the composite catalyst by comparing it with the LaCoO3group,LaFeO3group,and catalyst-free *** results indicate that the Ag-LSCF composite catalyst exhibits the highest soot catalytic activity,with the characteristic temperature values of 376.3,431.1,and 473.9 ℃ at 10 %,50 %,and 90 % carbon soot conversion,*** values are 24.8,20.2,and 23.1 ℃ lower than those of the LSCF *** also shows that LSCF can improve the catalytic activity of soot after compounding with Ag,and reflects the necessity of using catalysts in soot combustion *** characterization and BET test show that Ag-LSCF has more abundant surface-adsorbed oxygen species,larger specific surface area and pore volume than LSCF,which also proves that Ag-LSCF has higher soot catalytic activity.

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