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Injectable silk/hydroxyapatite nanocomposite hydrogels with vascularization capacity for bone regeneration

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Journal of Materials Science & Technology 2021年第4期63卷 172-181页

作者： Keke Wang Weinan Cheng Zhaozhao Ding Gang Xu Xin Zheng Meirong Li guozhong lu Qiang lu College of Chemistry Chemical Engineering and Materials Science&Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou 215123China Department of Burns and Plastic Surgery The Affiliated Hospital of Jiangnan UniversityWuxi 214041China Department of Orthopedics The First Affiliated Hospital of Xiamen UniversityXiamen 361000China Department of Orthopedics The Second Affiliated Hospital of Soochow UniversitySuzhou 215000China Institute of Basic Medical Science Wound Healing and Cell Biology LaboratoryChinese PLA General HospitalBeijing 100853China

Localized and sustained osteogenic-angiogenic stimulation to bone defects is critical for effective bone ***,desferrioxamine(DFO)was loaded on silk fibroin nanofibers and blended with hydroxyapatite nanorods(HA),forming injectable DFO-loaded silk fibroin-HA nanocomposite *** composite hydrogels remained homogeneous distribution of HA with high ratio(60%)and also higher stiffness than that of pure silk fibroin nanofiber hydrogels,which provided stable osteogenic stimulation niches for tissue *** the scarify of injectability,the hydrogels achieved slow delivery of DFO for above 60 days,resulting in suitable angiogenesis in vitro and in vivo and better osteogenesis than DFO-free *** to previous injectable silk fibroin-HA hydrogels,the introduction of vascularization capacity further stimulated the osteogenic differentiation of stem cells and accelerated new bone *** and better bone healing were detected at defect sites after the injection of DFO-loaded nanocomposite hydrogels,indicating the effective synergistic effect of osteogenic and angiogenic *** work provides a simple and effective strategy of introducing angiogenic cues to bone *** believe that the injectable nanocomposite hydrogels are suitable for the regeneration of bone tissues.

关键词： hydrogel loaded synergistic

Diversity and distribution of soil micro-fungi along an elevation gradient on the north slope of Changbai Mountain

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Journal of Forestry Research 2017年第4期28卷 831-839页

作者： Hong Yang guozhong lu Huiming Jiang Dong-ning Shi Zhiheng Liu College of Environment and Resources Dalian Nationalities UniversityDalian 116600People’s Republic of China College of Life Science Dalian Nationalities UniversityDalian 116600People’s Republic of China College of Life Science Liaoning Normal UniversityDalian 116081People’s Republic of China College of Plant Protection Shenyang Agricultural UniversityShenyang 110866People’s Republic of China

Elevational changes in patterns of diversity are important to understanding of the influence of global changes, yet few studies have addressed the distribution of microorganisms, e.g. soil micro-fungi. We studied the diversity of the forest soil micro-fungi in four vegetation belts along an elevation gradient on the north slope of Changbai Mountain in Changbai National Nature Reserve. The four belts were characterized as coniferous-deciduous mixed forest, coniferous forest, Erman's birch forest, and alpine tundra. We estimated the quantity and distribution of the fungal species in each belt and calculated three indices, viz. Shannon-Wiener diversity (H'), Pielou's evenness (J'), and Margalef's abundance (E), to depict fungal species diversity. A total of 932 strains were recorded and identified, representing 53 genera, and 108 species. Among these, Penicillium, Aspergillus, Trichoderma, Mucor, Rhizopus and Fusarium were the dominant genera. With increasing elevation, the quantity of fungi and values of H', E, and J' gradually declined.

关键词： Altitudinal gradient Distribution Diversities Micro-fungi

Electric field-driven building blocks for introducing multiple gradients to hydrogels

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Protein & Cell 2020年第4期11卷 267-285页

作者： Gang Xu Zhaozhao Ding Qiang lu Xiaoyi Zhang Xiaozhong Zhou Liying Xiao guozhong lu David L K aplan Department of Orthopedics The Second Affiliated Hospital of Soochow UniversitySuzhou 215000China Department of Bums and Plastic Surgery Engineering Research Center of the Ministry of Education for Wound Repair TechnologyThe Affiliated Hospital of Jiangnan UniversityWuxi 214041China National Engineering Laboratory for Modern Silk&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou 215123China Department of Orthopedics Affiliated Hospital of Xuzhou Medical UniversityLianyungang 222061China Department of Biomedical Engineering Tufts UniversityMedfordMA 02155USA

Gradient biomaterials are considered as preferable matrices for tissue engineering due to better simulation of native *** introduction of gradient cues usually needs special equipment and complex process but is only effective to limited *** of multiple gradients in the hydrogels remains ***,betasheet rich silk nanofibers(BSNF)were used as building blocks to introduce multiple gradients into different hydrogel systems through the joint action of crosslinking and electric *** blocks migrated to the anode along the electric field and gradually stagnated due to the solution-hydrogel transition of the systems,finally achieving gradient distribution of the blocks in the formed *** gradient distribution of the blocks could be tuned easily through changing different factors such as solution viscosity,which resulted in highly tunable gradient of mechanical *** blocks were also aligned under the electric field,endowing orientation gradient *** cargos could be loaded on the blocks and form gradient cues through the same crosslinking-electric field *** building blocks could be introduced to various hydrogels such as Gelatin and NIPAM,indicating the *** niches with multiple gradient cues could be achieved through the ***-based hydrogels with suitable mechanical gradients were fabricated to control the osteogenesis and ***-osteogenic gradient transition was obtained,which stimulated the ectopic osteochondral tissue regeneration in *** versatility and highly controllability of the strategy as well as multifunction of the building blocks reveal the applicability in complex tissue engineering and various interfacial tissues.

关键词： silk building blocks gradients hydrogel tissue regeneration

Probing microstructure of solid-state synthesized LiCoO_(2)with MAS NMR spectroscopy

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Magnetic Resonance Letters 2023年第4期3卷 298-305页

作者： Suyu Gu guozhong lu Nianrui Guo Juncheng Xu Yu Jiang Ming Shen Bingwen Hu Shanghai Key Laboratory of Magnetic Resonance State Key Laboratory of Precision SpectroscopySchool of Physics and Electronic ScienceEast China Normal UniversityShanghai200241China

LiCoO_(2)is an important category of active cathode materials in lithium-ion batteries due to its high compacted electrode density,good thermal stability,and stable voltage *** works on LiCoO_(2)have focused on the realization of higher charging voltages to fully utilize its high theoretical ***,an unambiguous atomic-level local probe is essential for the understanding of structure-function *** we employ highresolution solid-state nuclear magnetic resonance(NMR)spectroscopy to study the local atomic environments in LiCoO_(2)synthesized with three common sintering *** one-dimensional 7Li NMR shows distinct linewidth and subtle dependence on lithium over-stoichiometry,both 7Li and 59Co relaxation times are highly dependent on the sintering *** prove that the two-step sintering method favors the elimination of unreacted Co3O4,thereby enabling the best discharge capacity in all-solid-state lithium batteries assembled with LiCoO_(2)/LGPS/LiIn,which is in accordance with its narrowest 7Li linewidth and the longest 7Li/59Co T1.

关键词： LiCoO_(2) Solid-state NMR T1 relaxation Local structure

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凝汽器抽真空装置的节能改造技术

电力系统装备 2024年第6期 87-89页

作者：周振华厉昂路国忠高思芳沈继荣国电电力大连庄河发电有限责任公司辽宁庄河116431 河南信安工程技术有限公司河南郑州450001 武汉威龙特泵业有限责任公司湖北武汉430050

文章在阐述水环真空泵和罗茨泵工作原理、结构特点的基础上,将罗茨泵与真空泵组合在一起形成一种新的节能装置:罗茨真空节能机组,探讨其最佳匹配关系,从而达到节能改造的目的。

关键词：水环真空泵汽冷式罗茨真空泵级间换热器节能汽蚀噪声维持真空

Redox-responsive biocompatible nanocarriers based on novel heparosan polysaccharides for intracellular anticancer drug delivery

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Asian Journal of Pharmaceutical Sciences 2020年第1期15卷 83-94页

作者： Lipeng Qiu lu Ge Miaomiao Long Jing Mao Kamel SAhmed Xiaotian Shan Huijie Zhang Li Qin guozhong Lv Jinghua Chen School of Pharmaceutical Sciences Jiangnan UniversityWuxi 214122China Wuxi Higher Health Vocational Technology School Wuxi 214028China Wuxi Third Renmin Hospital Wuxi 214041China

Heparosan is a natural precursor of heparin biosynthesis in mammals. It is stable in blood circulation but can be degraded in lysosomes, showing good biocompatibility and long circulation features. So heparosan can be designed as anticancer drug carriers to increase tumor selectivity and improve the therapeutic effect. A novel redox-sensitive heparosancystamine-vitamin E succinate(KSV) micelle system was constructed for intracellular delivery of doxorubicin(DOX). Simultaneously, the redox-insensitive heparosan-adipic acid dihydrazide-vitamin E succinate copolymer(KV) was synthesized as control. DOX-loaded micelles(DOX/KSV) with an average particle size of 90–120 nm had good serum stability and redox-triggered depolymerization. In vitro drug release test showed that DOX/KSV micelles presented obvious redox-triggered release behavior compared with DOX/KV. Cytotoxicity and cell uptake were investigated using MGC80-3 tumor cells and COS7 fibroblast-like cells. The cell survival rate of blank micelles was more than 90%, and the cytotoxicity of DOX/KSV in MGC80-3 cells was higher than in COS7 cells, indicating that the carrier has better biocompatibility and less toxicity side effect. The cytotoxicity of DOX/KSV against MGC80-3 cells was significantly greater than that of free DOX and DOX/KV. Furthermore, compared with DOX/KV in MGC80-3 cells, DOX/KSV micelles uptook more anticancer drugs and then released DOX faster into the cell nucleus. The micelles were endocytosed by multiple pathways, but clathrin-mediated endocytosis was the main pathway. Therefore, heparosan polysaccharide could be a potential option as anticancer carrier for enhancing efficacy and mitigating toxicity.

关键词： Heparosan Vitamin E succinate Redox-sensitive micelles Drug delivery

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森喜朗上台后的日本外交

国际问题研究 2000年第6期 37-40页

作者：陆国忠中国国际问题研究所北京100005

森喜朗内阁承办的冲绳八国首脑会议，是其首要外交课题，虽有所获，但成果平平。其大国外交，重点是谋求日俄关系取得进展。亚洲外交，将着力打开日朝关系，同时推动与东盟的经济金融合作。多边外交，重点是为它成为安理会常任理事国争... 详细信息

森喜朗内阁承办的冲绳八国首脑会议，是其首要外交课题，虽有所获，但成果平平。其大国外交，重点是谋求日俄关系取得进展。亚洲外交，将着力打开日朝关系，同时推动与东盟的经济金融合作。多边外交，重点是为它成为安理会常任理事国争取支持，并开展体现“森喜朗色彩”的裁军外交。

关键词：森喜朗外交冲绳峰会

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双材料裂纹问题的积分方程方法

浙江工业大学学报 2017年第2期45卷 130-136,158页

作者：吕君柴国钟浙江工业大学机械工程学院浙江杭州310014 义乌工商职业技术学院机电信息学院浙江义乌322000

以双材料单位力基本解为基础,推导得到了单位位移不连续基本解.以裂纹上下表面相对位移为未知量,建立相应的奇异积分方程,为了数值求解积分方程,构建了一种奇异单元,以反映裂纹上下表面相对位移在裂纹周边附近的r^(1/2)奇性(非界面裂纹)... 详细信息

以双材料单位力基本解为基础,推导得到了单位位移不连续基本解.以裂纹上下表面相对位移为未知量,建立相应的奇异积分方程,为了数值求解积分方程,构建了一种奇异单元,以反映裂纹上下表面相对位移在裂纹周边附近的r^(1/2)奇性(非界面裂纹)和r^(1/2)·r^(iε)Ⅰ-Ⅱ型耦合振荡奇性(界面裂纹).对数值计算方法、特别是奇异和超奇异积分的计算进行了研究,最后通过若干算例考证了本方法的精度.所建立的积分方程及数值方法,是一种求解双材料平面内多裂纹系统(界面和非界面)的一般方法.

关键词：双材料裂纹系统应力强度因子积分方程

Animals and Mineralization of Phosphorus: Ore-Forming Mechanism of Insular Phosphorites

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Acta Geologica Sinica(English Edition) 1987年第1期 83-93+119页

作者： Wang guozhong, lu Bingquan and Quan Songqing Marine Engineering and Marine Geology Institute, Tongji University, Shanghai

Phosphorite, or guano, or insular phosphorite, commonly containing 10-35% P;O;, is one of the sources of phosphatic fertilizer. Taking the modern insular phosphorite on the Xisha Islands as an example. this paper discusses the ore-forming mechanism of phosphate and the important contribution made by animals to this *** phosphorite occurs in the middle part of carbonate sand cays of coral reef surrounded by longshore sandbanks, which assumes a dish-shape. The surface of the cays is covered by unconsolidated guano. The phosphorite, yellowish brown to dark brown, is made up of thick-bedded sand and gravel cemented by collophanite, and partly replaced by carbonate *** mechanism of mineralization is as follows:The average content of phosphorus in the sea water is only 0.07 ppm, but through the sea food chain concentration, phosphorus content may become higher. The phytoplanktons, as producers, suck up phosphorus out of sea water. The primary consumers, zooplanktons, obtain phosphorus by eating phytoplanktons, then they are followed by the second and third consumers. Sea birds living on fish, as the third consumers, concentrate and transport the phosphorus to the carbonate sand cays. Finally layers of guano are deposited under the *** the tropical climatic conditions with high temperature and plentiful rainfall soluble matters are leached out of the guano and infiltrated into deeper horizon. In alkaline groundwater with pH greater than 7.0. the phosphoritization takes place, bioclastics are cemented and replaced by collophanite or carbonate apatite. Finally, the phosphorus is fixed and phosphate formed.

关键词： Animals and Mineralization of Phosphorus Ore-Forming Mechanism of Insular Phosphorites