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A Dielectric Ink Combining Acrylate and Cyanate Moieties for Inkjet 3D Printing with Good Thermal Stability

Chinese Journal of Polymer Science 2024年第6期42卷 766-774页

作者： Yi-Xuan Li Liang-Ying Wu Yan Yang Yao-Zhong lu Zhong-Ying Ji Yu-Xiong guo Xiao-Long Wang Qiao-Sheng Pu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000China State Key Laboratory of Solid lubrication Lanzhou Institute of Chemical PhysicsLanzhou730000China Lanzhou Traditional Chinese Medicine Hospital of Orthopedics and Traumatology Lanzhou730000China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai Zhongke Research Institute of Advanced Materials and Green Chemical EngineeringYantai264006China

Inkjet 3D printing has potential in the additive manufacturing of electronic circuits and ***,inks that can be used for printing layers with T5%>300℃ or hardness>200 MPa have been rarely *** ester(CE)polymers have excellent thermal stability,high strength,and low shrinkage compared to other common dielectric inks for inkjet 3D printing,but cannot be quickly shaped by ultraviolet(UV)irradiation or thermal *** CEs with UV-curable monomers may be a possible way to accelerate crosslinking,but there are challenges from the adverse effects of the dilution of both *** this study,dielectric inks with acrylate and cyanate moieties were *** low viscosity and surface tension of the CE precursor(Bisphenol E cyanate ester)were combined with photocurable acrylate diluent monomers and cross-linker to realize an ink suitable for inkjet 3D *** internal dual three-dimensional cross-linked network structure resin was prepared by a combination of photocuring and thermal curing with T5%up to 326.69℃,hardness up to 431.84 MPa,dielectric constant of 2.70 at 8 GHz,and shrinkage of 1.64%.The developed dielectric inks can be applied to the 3D printing of printed circuit boards and other electronic devices that require dielectric properties.

关键词： Inkjet printing Cyanate ester resin 3D doubly cross-linked network Good thermal stability

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Diabetes mellitus in patients with type 1 autoimmune pancreatitis at diagnosis and after corticosteroid therapy

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 393-398页

作者： Mei-Zi Li Tao guo Yun-lu Feng Sheng-Yu Zhang Xiao-Yin Bai Xi Wu Kai Xu Ai-Ming Yang Department of Gastroenterology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Radiology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

Background:A high prevalence of diabetes mellitus(DM)coexisting with autoimmune pancreatitis(AIP)is ***,evidence on the circumstances under which corticosteroid therapy(CST)for AIP improves or worsens DM is *** study aimed to demonstrate and identify predictors of DM control under the influence of ***:Patients diagnosed with type 1 AIP were enrolled from a prospectively maintained cohort and were classified into three groups according to the chronology in which AIP and DM were diagnosed:pre-existing DM(pDM),concurrent DM(cDM),and non-DM(nDM).The responses of DM to CST were assessed when corticosteroid was ceased or tapered to a maintenance dose and classified as‘improvement’and‘non-improvement’(including‘no change’and‘exacerbation’).Results:Among 101 patients with type 1 AIP,52(51.5%)patients were complicated with DM at the time of AIP diagnosis,with 36 patients in the cDM group and 16 patients in the pDM *** incidences of diffuse pancreatic swelling(72.2%)and pancreatic body/tail involvement(91.7%)were significantly higher in the cDM group than in both the pDM and nDM *** the 52 patients with DM,CST was administered in 48 *** logistic analysis identified that elevated serum gamma-glutamyl transferase(GGT)level at AIP diagnosis[odds ratio(OR)=0.032,95%confidence interval(CI):0.003-0.412,P=0.008]and pancreatic atrophy after CST(OR=0.027,95%CI:0.003-0.295,P=0.003)were negatively associated with DM control ***:Patients with diffuse pancreatic swelling and pancreatic body/tail involvement in pancreatitis tended to be complicated with cDM at AIP *** exerted a beneficial effect on the clinical course of DM in nearly half of the AIP patients complicated with DM at diagnosis,particularly in those without elevated serum GGT levels at diagnosis and who did not experience pancreatic atrophy after CST.

关键词： Type 1 autoimmune pancreatitis Diabetes mellitus Corticosteroid therapy Predictive factor Pancreatic atrophy

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Palmitoleic acid on top of HFD ameliorates insulin resistance independent of diacylglycerols and alters gut microbiota in C57BL/6J mice

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Food Science and Human Wellness 2024年第2期13卷 856-868页

作者： Qijian Liang Yan Zheng Fanli Meng Xiaofan Jiang Qingcai Zhen Zhongting lu Shixiu Zhang Lei Du Hao Wu Xin guo Department of Nutrition and Food Hygiene School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Research Center of Translational Medicine Jinan Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013China Department of Hepatology Qilu Hospital of Shandong UniversityJinan 250012China Institute of Hepatology Shandong UniversityJinan 250012China

With the prevalence of obesity and obesity-related metabolic syndrome,such as insulin resistance in recent years,it is urgent to explore effective interventions to prevent the progression of obesity-related metabolic *** acid is a monounsaturated fatty acid that is available from dietary sources,mainly derived from marine products.P almitoleic acid plays a positive role in maintaining glucose homeostasis and reducing ***,it is still unknow the mechanism of palmitoleic acid in ameliorating insulin ***,we investigated the effects of palmitoleic acid on chow diet(CD)-fed and high-fat diet(HFD)-fed mice,which were fed CD or HFD for 12 weeks before *** administrated mice with BSA(control),oleic acid,or palmitoleic acid for 6 weeks on top of CD or HFD *** found that palmitoleic acid only improved glucose homeostasis in HFD-fed obese mice by increasing glucose clearance and reducing *** study explored that palmitoleic acid changed the composition of gut microbiota by decreasing Firmicutes population and increasing Bacteroidetes *** colon,palmitoleic acid increased intestinal tight junction integrity and reduced ***,palmitoleic acid decreased macrophage infiltration in liver and adipose tissue and increase glucose uptake in adipose ***(DAG)in tissue(for example,liver)is found to positively correlated with *** enhanced the levels of DAGs in liver but not in adipose tissue in this *** acid did not reverse the high DAG levels induced by HFD in ***,in HFD-fed mice,palmitoleic acid reduced insulin resistance by an independent-manner of *** might be associated with the beneficial effects of palmitoleic acid on altering the gut microbiota composition,improving of intestinal barrier function,and downregulating the inflammation in colon,liver,and adipose tissue.

关键词： Palmitoleic acid High fat diet Insulin resistance Gut microbiota

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Antecedent snowmelt and orographic precipitation contributions to water supply of Pakistan disastrous floods,2022

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Advances in Climate Change Research 2024年第3期15卷 419-430页

作者： Yan WANG Peng CUI Chen-Di ZHANG guo-Tao ZHANG Jian-Sheng HAO Xu YUAN Yao-Zhi JIANG lu WANG Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Key Laboratory of Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610299China Polar and Marine Research Institute College of Harbor and Coastal EngineeringJimei UniversityXiamen 361021China School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 610054China Hebei Province Tangshan Caofeidian Meteorological Bureau Tangshan 063000China

In 2022,the Pakistan witnessed the hottest spring and wettest summer in *** devastating floods inundated a large portion of Pakistan and caused enormous ***,the primary water source and its contributions to these unprecedented floods remain *** on the reservoir inflow measurements,Multi-Source Weighted-Ensemble Precipitation(MSWEP),the fifth generation ECMWF atmospheric reanalysis(ERA5)products,this study quantified the contributions of monsoon precipitation,antecedent snow-melts,and orographic precipitation enhancement to floods in *** found that the Indus experienced at least four inflow up-rushes,which was mainly supplied by precipitation and snowmelt;In upper Indus,abnormally high temperature continued to influence the whole summer and lead to large amounts of snowmelts which not only was a key water supply to the flood but also provided favorable soil moisture conditions for the latter *** July,the snowmelt has higher contributions than the precipitation to the streamflow of Indus River,with contribution value of more than 60%.Moreover,the snowmelt could still supply 20%-40%water to the lower Indus in July and August;The leading driver of 2022 mega-floods over the southern Pakistan in July and August was dominated by the precipitation,where terrain disturbance induced precipitation account to approximately 33%over the southern *** results help to understand the mechanisms of flood formation,and to better predict future flood risks over complex terrain regions.

关键词： Extreme heavy rainfall Snowmelt Orographic precipitation Floods Pakistan

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Gas sensor array based on carbon-based thin-film transistor for selective detection of indoor harmful gases

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Rare Metals 2024年第9期43卷 4401-4411页

作者： Can Liu Yu Sun Jia-Yi guo Xiu-Lei Li lu Tao Jin-Yong Hu Jue-Xian Cao Ping-Hua Tang Yong Zhang School of Electrical and Information Engineering Hunan Institute of EngineeringXiangtan 411104China Physics and Optoelectronics&Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China

The identification of indoor harmful gases is imperative due to their significant threats to human health and *** achieve accurate identification,an effective strategy of constructing a sensor array combined with the pattern recognition algorithm is ***-based thin-film transistors are selected as the sensor array unit,with semiconductor carbon nanotubes(CNTs)within the TFT channels modified with different metals(Au,Cu and Ti)for selective responses to NH_(3),H_(2)S and HCHO,*** accurate gas species identification,an identification mode that combines linear discriminant analysis algorithms and logistic regression classifier is *** test results demonstrate that by preprocessing the sensor array’s sensing data with the LDA algorithm and subsequently employing the LR classifier for identification,a 100%recognition rate can be achieved for three target gases(NH3,H2S and HCHO).This work provides significant guidance for future applications of chip-level gas sensors in the realms of the Internet of Things and Artificial Intelligence.

关键词： Carbon-based thin-film transistors Gas sensor arrays Semiconductor carbon nanotubes Multi-gas detection Linear discriminant analysis

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Dammarane-type triterpenoids from Gynostemma longipes and their protective activities on hypoxia-induced injury in PC12 cells

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Chinese Journal of Natural Medicines 2024年第5期22卷 466-480页

作者： LIANG Haizhen CHEN Xiaojuan LI Qi ZHANG Mengmeng lu Pengxin ZHANG Jie SONG Juan ZHANG Tao guo Baolin MA Baiping Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China AnKang Chia Tai Pharmaceutical Co. Ltd.Shaanxi 725000China

Sixteen new dammarane-type triterpenoid saponins(1-16)featuring diverse structural variations in the side chain at C-17,along with twenty-one known analogues(17-37),have been isolated from the rhizomes of Gynostemma longipes ***,a plant renowned for its medicinal and edible *** structural elucidation of these compounds was accomplished through comprehensive analyses of 1D and 2D NMR and HRMS spectroscopic data,supplemented by comparison with previously reported *** assays on the isolates for their protective effects against hypoxia-induced damage in pheochromocytoma cells(PC12 cells)revealed that nine saponins exhibited significant anti-hypoxic *** investigation into the anti-hypoxia mechanisms of the representative saponins demonstrated that compounds 22 and 36 markedly reduced the levels of hypoxia-induced ***,these compounds were found to decrease the release of lactate dehydrogenase(LDH)and malondialdehyde(MDA),while increasing the activity of superoxide dismutase(SOD),thereby indicating that the saponins could mitigate hypoxia-induced injuries by ameliorating apoptosis and oxidative *** findings offer substantial evidence for the future utilization and development of ***,identifying dammarane-type triterpenoid saponins as its active anti-hypoxic constituents.

关键词： Gynostemma longipes Dammarane-type saponins Anti-hypoxia effect Apoptosis

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Advanced Materials for NH_(3)Capture:Interaction Sites and Transport Pathways

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Nano-Micro Letters 2024年第11期16卷 119-155页

作者： Hai‑Yan Jiang Zao‑Ming Wang Xue‑Qi Sun Shao‑Juan Zeng Yang‑Yang guo lu Bai Ming‑Shui Yao Xiang‑Ping Zhang Key Laboratory of Green Process and Engineering State Key Laboratory of Mesoscience and EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190People’s Republic of China School of Future Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China China University of Petroleum Beijing 102249People’s Republic of China Institute for Integrated Cell‑Material Sciences(iCeMS) Kyoto UniversitySakyo‑KuYoshidaKyoto 606‑8501Japan

Ammonia(NH3)is a carbon-free,hydrogen-rich chemical related to global food safety,clean energy,and environmental *** an essential technology for meeting the requirements raised by such issues,NH3 capture has been intensively explored by researchers in both fundamental and applied *** four typical methods used are(1)solvent absorption by ionic liquids and their derivatives,(2)adsorption by porous solids,(3)abadsorption by porous liquids,and(4)membrane *** in the development of advanced materials for NH3 capture,we conducted a coherent review of the design of different materials,mainly in the past 5 years,their interactions with NH3 molecules and construction of transport pathways,as well as the structure–property relationship,with specific examples ***,the challenges in current research and future worthwhile directions for NH3 capture materials are proposed.

关键词： Ammonia capture Solvents Porous solids Porous liquids Membranes

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Protective eff ect and mechanism of nanoantimicrobial peptide ND-C14 against Streptococcus pneumoniae infection

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World Journal of Emergency Medicine 2024年第1期15卷 28-34页

作者： Yangyang guo Yaqi Sun Hongxia Wu Jian lu Yuan Lin Jiaqing Zhu Meihong Lai Meiqi Zhang Jun Wang Jungang Zheng Department of Intensive Care Medicine Hangzhou Traditional Chinese Medicine Hospital Affi liated to Zhejiang Chinese Medical UniversityHangzhou 310021China National Children’s Regional Medical Center National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Spleen and Stomach Diseases Hangzhou Traditional Chinese Medicine Hospital Affi liated to Zhejiang Chinese Medical UniversityHangzhou 310021China Department of Ultrasonic Medicine the First Affi liated Hospital of Ningbo UniversityNingbo 315010China Department of Anesthesiology the First Affi liated Hospital of Ningbo UniversityNingbo 315010China Zhejiang University School of Medicine Hangzhou 310058China The First People’s Hospital of Yuexi County Yuexi 616650China

BACKGROUND:Streptococcus pneumoniae(***)is a common pathogen that causes bacterial ***,with increasing bacterial resistance,there is an urgent need to develop new drugs to treat *** *** with a 14-carbon saturated fatty acid(ND-C14)is a novel nanoantimicrobial peptide designed by modifying myristic acid at the C-terminus of humanα-defensin 5(HD5)via an amide ***,it is unclear whether ND-C14 is effective against lung infections caused by ***:In vitro,three groups were established,including the control group,and the HD5 and ND-C14 treatment groups.A virtual colony-count assay was used to evaluate the antibacterial activity of HD5 and ND-C14 against *** morphological changes of *** treated with HD5 or ND-C14 were observed by scanning electron *** vivo,mice were divided into sham,vehicle,and ND-C14 treatment *** in the sham group were treated with 25μL of phosphate-buffered saline(PBS).Mice in the vehicle and ND-C14 treatment groups were treated with intratracheal instillation of 25μL of bacterial suspension with 2×108 CFU/mL(total bacterial count:5×10^(6) CFU),and then the mice were given 25μL PBS or intratracheally injected with 25μL of ND-C14(including 20μg or 50μg),*** rates were evaluated in the vehicle and ND-C14 treatment *** burden in the blood and bronchoalveolar lavage fluid were *** lung histology of the mice was assessed.A propidium iodide uptake assay was used to clarify the destructive eff ect of ND-C14 against ***:Compared with HD5,ND-C14 had a better bactericidal eff ect against *** because of its stronger ability to destroy the membrane structure of *** in *** vivo,ND-C14 significantly delayed the death time and improved the survival rate of mice infected with ***-C14 reduced bacterial burden and lung tissue ***,ND-C14 had a membrane per

关键词： Streptococcus pneumoniae Antimicrobial peptides Humanα-defensin 5 Infection

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Sand control mechanism of radial well filled with phase change material in hydrate reservoir

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Petroleum Science 2024年第4期21卷 2571-2582页

作者： Xiao-Qiang Liu Zhong-Xi Han Zhi-Lin luo Hai-Long lu Ying Sun Qing You Tian-Kui guo Zhan-Qing Qu School of Energy Resources China University of Geosciences (Beijing) Beijing Key Laboratory of Unconventional Natural Gas Geological Evaluation and Development Engineering China University of Geosciences (Beijing) China Research Institute of Petroleum Exploration and Development Engineering Technology Research Institute of Southwest Oil & Gas Field Company PetroChina Beijing International Center for Gas Hydrate School of Earth and Space Sciences Peking University School of Advanced Material Peking University Shenzhen Graduate School School of Petroleum Engineering China University of Petroleum (East China)

Radial well filled with phase change material has been proposed as a novel sand control method for hydrate exploitation. In order to reveal the sand control mechanism, CFD-DEM coupling method is applied to simulate the migration, settlement, and blockage processes of sand particles in the radial *** obtained results indicate that three scenarios have been recognized for sand particles passing through sand control medium, based on the diameter ratio of sand control medium to sand particle（Dd）:fully passing（Dd= 8.75-22.5）, partially passing and partially blocked（Dd= 3.18-5.63）, and completely blocked（Dd= 2.18-3.21）. After being captured by the sand control medium, sand particles can block pores, which increases fluid flow resistance and causes a certain pressure difference in the radial *** pressure in the radial well should be lower than the hydrate phase equilibrium pressure during sand control design, for the purpose of promoting hydrate decomposition, and sand capture. The length of the radial well should be optimized based on the reservoir pore pressure, production pressure difference,bottom hole pressure, and the pressure gradient in the radial well. It should be noticed that the sand control medium leads to a decrease in permeability after sand particles captured. Even the permeability is reduced to several hundred millidarcy, it is still sufficient to ensure the effective flow of gas and water after hydrate decomposition. Increasing fluid velocity reduces the blocking capacity of the sand control medium, mainly because of deterioration in bridging between sand particles.

关键词： Hydrate reservoir Sand control Radial well CFD-DEM

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Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models

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World Journal of Gastroenterology 2024年第14期30卷 2038-2058页

作者： Pan Zheng Xue-Yang Li Xiao-Yu Yang Huan Wang Ling Ding Cong He Jian-Hua Wan Hua-Jing Ke Nong-Hua lu nian-Shuang Li Yin Zhu Department of Gastroenterology Digestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Acute pancreatitis(AP)encompasses a spectrum of pancreatic inflammatory conditions,ranging from mild inflammation to severe pancreatic necrosis and multisystem organ *** the challenges associated with obtaining human pancreatic samples,research on AP predominantly relies on animal *** this study,we aimed to elucidate the fundamental molecular mechanisms underlying AP using various AP *** To investigate the shared molecular changes underlying the development of AP across varying severity *** AP was induced in animal models through treatment with caerulein alone or in combination with lipopolysaccharide(LPS).Additionally,using Ptf1αto drive the specific expression of the hM3 promoter in pancreatic acinar cells transgenic C57BL/6J-hM3/Ptf1α(cre)mice were administered Clozapine N-oxide to induce ***,we conducted RNA sequencing of pancreatic tissues and validated the expression of significantly different genes using the Gene Expression Omnibus(GEO)*** Caerulein-induced AP showed severe inflammation and edema,which were exacerbated when combined with LPS and accompanied by partial pancreatic tissue *** with the control group,RNA sequencing analysis revealed 880 significantly differentially expressed genes in the caerulein model and 885 in the caerulein combined with the LPS *** Encyclopedia of Genes and Genomes enrichment analysis and Gene Set Enrichment Analysis indicated substantial enrichment of the TLR and NOD-like receptor signaling pathway,TLR signaling pathway,and NF-κB signaling pathway,alongside elevated levels of apoptosis-related pathways,such as apoptosis,P53 pathway,and phagosome *** significantly elevated genes in the TLR and NOD-like receptor signaling pathways,as well as in the apoptosis pathway,were validated through quantitative real-time PCR experiments in animal *** from the GEO database revealed that only MYD88 concurred in both mouse panc

关键词： Acute pancreatitis RNA-sequencing Experimental acute pancreatitis models Inflammatory Apoptosis TLR and NOD-like signaling pathways

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