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Three-dimensional structural models,evolution and petroleum geological significances of transtensional faults in the Ziyang area,central Sichuan Basin,SW China

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Petroleum Exploration and Development 2024年第3期51卷 604-620页

作者： TIAN Fanglei guo Tonglou HE Dengfa GU Zhanyu MENG Xianwu WANG Renfu WANG Ying ZHANG Weikang lu guo School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China Key Laboratory of Marine Reservoir Evolution and Hydrocarbon Enrichment Mechanism Ministry of EducationBeijing 100083China Sinopec Southwest Oil and Gas Company Chengdu 610031China

With drilling and seismic data of Transtensional(strike-slip)Fault System in the Ziyang area of the central Sichuan Basin,SW China plane-section integrated structural interpretation,3-D fault framework model building,fault throw analyzing,and balanced profile restoration,it is pointed out that the transtensional fault system in the Ziyang 3-D seismic survey consists of the northeast-trending FI19 and FI20 fault zones dominated by extensional deformation,as well as 3 sets of northwest-trending en echelon normal faults experienced dextral shear *** them,the FI19 and FI20 fault zones cut through the Neoproterozoic to Lower Triassic Jialingjiang Formation,presenting a 3-D structure of an“S”-shaped *** before Permian and during the Early Triassic,the FI19 and FI20 fault zones underwent at least two periods of structural ***,the 3 sets of northwest-trending en echelon normal faults are composed of small normal faults arranged in pairs,with opposite dip directions and partially left-stepped *** before Permian,they had formed almost,restricting the eastward growth and propagation of the FI19 fault *** FI19 and FI20 fault zones communicate multiple sets of source rocks and reservoirs from deep to shallow,and the timing of fault activity matches well with oil and gas generation *** there were favorable Cambrian-Triassic sedimentary facies and reservoirs developing on the local anticlinal belts of both sides of the FI19 and FI20 fault zones,the major reservoirs in this area are expected to achieve breakthroughs in oil and gas exploration.

关键词： transtensional(strike-slip)fault three-dimensional structural model structural evolution petroleum geological significance Ziyang area Sichuan Basin

Physical Prediction Model of Compound Hydrodynamic Unload-Load Response Ratio and Its Application in Reservoir Colluvium Landslide

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Journal of Earth Science 2024年第4期35卷 1304-1315页

作者： lu guo Keqiang He Honghua Liu Fandi Meng Xuchun Wang School of Civil Engineering Qingdao University of TechnologyQingdao266520China Key Laboratory of Geological Safety of Coastal Urban Underground Space Ministry of Natural ResourcesQingdao266071China

It is well known that the deformation and damage of reservoir colluvium landslides are often determined by the combined dynamics of reservoir water level change and *** on the systematic analysis of the change law of reservoir water level,rainfall and displacements of reservoir colluvium landslide,this paper proposes the compound hydrodynamic action of rainfall and reservoir water as the unload-load parameter,and the landslide displacement as the unload-load response *** on this,a physical prediction model of the compound hydrodynamic unload-load response ratio of reservoir colluvium landslide was established,and the quantitative relationship between the compound hydrodynamic unload-load response ratio and its stability evolution was in-depth analyzed and *** the basis of the above research,taking Shuping landslide,a typical hydrodynamic pressure landslide as an example,the unload-load response ratio model is used to systematically evaluate and predict the stability evolution law and the change trend of the landslide under compound hydrodynamic *** prediction result shows that the variation law of the compound hydrodynamic unload-load response ratio is consistent with the dynamic evolution law of its ***,the above studies show that the compound hydrodynamic unload-load response ratio parameter is an effective displacement dynamic evaluation parameter for reservoir colluvium landslides,so it can be used in the prediction of the reservoir colluvium landslides.

关键词： landslides reservoir colluvium landslide compound hydrodynamics unload-load response ratio Shuping landslide stability evaluation

Prognostic value of circulating tumor cells combined with neutrophil-lymphocyte ratio in patients with hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 372-385页

作者： Jia-Li Chen lu guo Zhen-Ying Wu Kun He Han Li Chi Yang Yun-Wei Han Department of Oncology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Ophthalmology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Clinical Research Institute The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Plastic Surgery Meguiar's Medical Beauty HospitalChengdu 610000Sichuan ProvinceChina

BACKGROUND Circulating tumor cell(CTC)count and neutrophil-to-lymphocyte ratio(NLR)are both closely associated with the prognosis of hepatocellular carcinoma(HCC).AIM To investigate the prognostic value of combining these two indicators in *** Clinical data were collected from patients with advanced HCC who received im-mune therapy combined with targeted therapy at the Department of Oncology,the Affiliated Hospital of Southwest Medical University,Sichuan,China,from 2021 to *** optimal cutoff values for CTC programmed death-ligand 1(PD-L1)(+)>1 or CTC PD-L1(+)≤1 and NLR>3.89 or NLR≤3.89 were evaluated using X-Tile *** were categorized into three groups based on CTC PD-L1(+)counts and NLR:CTC-NLR(0),CTC-NLR(1),and CTC-NLR(2).The relationship between CTC-NLR and clinical variables as well as survival rates was *** Patients with high CTC PD-L1(+)expression or NLR at baseline had shorter median progression-free survival(m-PFS)and median overall survival(mOS)than those with low levels of CTC PD-L1(+)or NLR(PluSION HCC patients with high CTC PD-L1(+)or NLR expression tend to exhibit poor prognosis,and a high baseline CTC-NLR score may indicate low ***-NLR may serve as an effective prognostic indicator for patients with advanced HCC receiving immunotherapy combined with targeted therapy.

关键词： Circulating tumor cells Neutrophil–lymphocyte ratio Hepatocellular carcinoma Prognosis Survival Marker

Screened peptides from one-bead one-compound technique extend half-life of peptide drugs in circulation through binding to albumin

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Chinese Chemical Letters 2024年第3期35卷 384-388页

作者： Yi-Jing Li Lingze Zhang Ming-Hao Pang Pei-Pei Yang lu-Ming guo Kuo Zhang Da-Yong Hou Lei Wang Hao Wang Hui Cao State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Peptide drugs are known for their high biological ***,compared with small molecule drugs,peptide drugs are easily oxidized and hydrolyzed as well as short in ***,inspired by the long circulation of albumin in blood,we screened albumin binding peptides(ABPs)from a one-bead one-compound(OBOC)peptide library to increase the half-life of peptide *** displaying random peptides were screened using fluorescent labeled human serum *** beads with specific binding to albumin were isolated for *** selected ABPs can effectively bind to albumin,thus possessing the long circulation of *** dissociation constant(K_(D))of ABPs to albumin is up to 1×10^(-8)mol/*** one of ABPs(ABP2)was coupled to triptorelin,the circulation half-life of triptorelin in mice was significantly prolonged to 263.50 h much longer than that of triptorelin alone(179.07 h).In addition,the combination therapy using ABP-conjugated triptorelin and doxorubicin(DOX)can effectively inhibit the proliferation of tumor cells in *** OBOC screening strategy and resulting ABPs showed great potential for enhancing the delivery efficiency of peptide drugs.

关键词： One-bead one-compound Combinatorial library Albumin binding Drug delivery Triptorelin

认同或重塑:社会性别角色对女大学生创业意向的影响研究

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黑龙江高教研究 2024年第5期42卷 149-160页

作者：郭璐河北大学河北保定071002 厦门大学福建厦门361005

女性创业对于创造新的就业机会和促进社会经济增长越来越重要,特别是女大学生作为高素质女性人才,其创业意向的提升能够有效扭转女性生存性创业的局面,推动社会创新发展。创业意向的性别差异一直存在,社会性别角色被认为是影响女性创业... 详细信息

女性创业对于创造新的就业机会和促进社会经济增长越来越重要,特别是女大学生作为高素质女性人才,其创业意向的提升能够有效扭转女性生存性创业的局面,推动社会创新发展。创业意向的性别差异一直存在,社会性别角色被认为是影响女性创业意向的重要因素。采用质性研究方法,以22名有创业意向的女大学生为研究对象,基于社会性别理论建构分析框架,在女性主体性视角下探究社会性别角色对创业意向的影响及其自我调适策略。研究认为:女大学生的创业意向是其主体性建构的结果,自我实现与创业结果预期的价值拟合是女大学生产生创业意向的起点;不同环境中的社会性别角色感知是女大学生产生创业意向的扰动项,女大学生通过社会性别角色的自我调适推进创业意向的建构。研究结果不仅可以丰富和拓展高等教育与女性创业的相关研究,也可以为高等教育机构和政策制定者提供一些启示和建议,以更好地支持和鼓励有创业意向女大学生群体的发展与教育。

关键词：女大学生创业意向主体性建构社会性别角色

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基于B样条与鲸鱼优化算法的机械臂轨迹规划

东北大学学报（自然科学版） 2024年第5期45卷 683-689页

作者：陆志国王逍东北大学机械工程与自动化学院辽宁沈阳110819

为了提高机械臂的工作效率,构建一种基于B样条与鲸鱼优化算法(whale optimization algorithm,WOA)的机械臂时间最优轨迹规划方法.用蒙特卡罗法描绘机械臂的工作空间,用B样条对给出的路径点进行插值处理,根据机械臂各个关节的性能,引入... 详细信息

为了提高机械臂的工作效率,构建一种基于B样条与鲸鱼优化算法(whale optimization algorithm,WOA)的机械臂时间最优轨迹规划方法.用蒙特卡罗法描绘机械臂的工作空间,用B样条对给出的路径点进行插值处理,根据机械臂各个关节的性能,引入角速度与角加速度约束,同时加入边界条件.在构建时间最优的目标函数后,利用引入惯性权重值的WOA对机械臂运行时间进行优化.用Matlab进行仿真验证,结果表明构建的算法在时间优化方面效果好于传统的5次多项式方法,并且角速度与角加速度曲线连续平滑,验证了算法的有效性和可行性.

关键词：机械臂时间最优轨迹规划蒙特卡罗法 B样条鲸鱼优化算法

中美经贸影响力测度与对比——基于贸易增加值的分析

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国际经贸探索 2024年第6期40卷 35-48页

作者：郭路王志远中国社会科学院经济研究所中国社会科学院大学经济学院

文章利用ADB数据库63个经济体35个部门国际投入产出表,将各国贸易增加值进行分解,并通过构建贸易依赖新指标测算2007~2022年各经济体对中美两国最终品出口、中间品出口和产业链支撑方面的贸易依赖程度,以此评估中美经贸影响力。文章发现... 详细信息

文章利用ADB数据库63个经济体35个部门国际投入产出表,将各国贸易增加值进行分解,并通过构建贸易依赖新指标测算2007~2022年各经济体对中美两国最终品出口、中间品出口和产业链支撑方面的贸易依赖程度,以此评估中美经贸影响力。文章发现:在世界主要国家(地区),中美两国经贸影响力都呈现上升态势;相比于其他国家对美国的最终品出口依赖,中国在中间品出口依赖和产业链支撑依赖方面更占优势,且中国在最终品出口方面的影响力也不断增加。根据中美经贸影响力特点,文章给出相应政策建议。

关键词：全球价值链贸易依赖贸易增加值分解经贸影响力

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基于困难样本对激励的小样本图像分类方法

计算机辅助设计与图形学学报 2024年第06期36卷 895-903页

作者：郭璐刘斌李维刚甘平武汉科技大学冶金自动化与检测技术教育部工程研究中心武汉科技大学信息科学与工程学院去哪儿大数据研究院

使用少量标签样本训练得到的传统模型往往预测精度低、泛化能力弱,很难应用到实际生产中.针对小样本图像提出一种基于困难样本对激励分类方法,包括预训练阶段和元学习阶段.预训练阶段在基类数据集上训练编码器,并作为元学习阶段的初始... 详细信息

使用少量标签样本训练得到的传统模型往往预测精度低、泛化能力弱,很难应用到实际生产中.针对小样本图像提出一种基于困难样本对激励分类方法,包括预训练阶段和元学习阶段.预训练阶段在基类数据集上训练编码器,并作为元学习阶段的初始特征编码器;元学习阶段将进一步优化此编码器,元训练过程使用本质特征法降低异常样本对质心的影响;结合度量学习与元学习设计了困难样本对激励损失函数,从样本对角度出发,在训练过程中引导模型扩大正负样本间距离,使同类样本更加紧凑.在公开数据集mini-ImageNet, tiered-ImageNet上进行实验的结果表明,分类精度分别为64.12%, 70.15%,验证了所提方法的有效性和可行性.

关键词：困难样本对小样本学习元学习度量学习

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子宫恶性混合生殖细胞肿瘤患者的保留生育功能治疗病例报道

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中华生殖与避孕杂志 2024年第2期44卷 184-187页

作者：郭路李斌刘晓霞复旦大学附属中山医院、上海市老年医学中心妇科上海201104 复旦大学附属妇产科医院妇科上海200011

目的总结子宫恶性混合生殖细胞肿瘤患者保留生育功能治疗的经验。方法报道1例子宫恶性混合生殖细胞肿瘤患者的保留生育功能治疗,并分析其临床特点,同时进行相关文献回顾。结果该患者化疗结束后卵巢功能逐渐恢复,月经周期恢复正常。术后... 详细信息

目的总结子宫恶性混合生殖细胞肿瘤患者保留生育功能治疗的经验。方法报道1例子宫恶性混合生殖细胞肿瘤患者的保留生育功能治疗,并分析其临床特点,同时进行相关文献回顾。结果该患者化疗结束后卵巢功能逐渐恢复,月经周期恢复正常。术后5年随访至今无肿瘤复发征象。结论子宫恶性混合生殖细胞肿瘤临床罕见,其治疗目前尚无定论,保留生育功能治疗需综合评估并密切随访。

关键词：生殖细胞肿瘤促性腺激素释放激素激动剂保留生育功能治疗