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A phenylphenthiazide anchored Tb（Ⅲ）-cyclen complex for fluorescent turn-on sensing of ClO-

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Chinese Chemical Letters 2025年第2期 297-301页

作者： Ya-Ping Liu Zhi-Rong gui Zhen-Wen Zhang Sai-Kang Wang Wei Lang Yanzhu Liu qian-Yong Cao School of Chemistry and Chemical Engineering Nanchang University

A phenylphenothiazine anchored Tb（Ⅲ）-cyclen complex PTP-Cy-Tb for hypochlorite ion（ClO-） detection has been designed and prepared. PTP-Cy-Tb shows a weak Tb-based emission with AIE-characteristics in aqueous solutions. After addition of ClO-, the fluorescence of PTP-Cy-Tb gives a large enhancement for oxidization the thioether to sulfoxide group. The detection limit of PTP-Cy-Tb toward ClO-is as low as 8.85 nmol/L. The sensing mechanism was detailedly investigated by time of flight mass spectrometer（TOF-MS）, Fourier transform infrared spectroscopy（FT-IR） and density functional theory（DFT） *** addition, PTP-Cy-Tb has been successfully used for on-site and real-time detection of ClO-in real water samples by using the smartphone-based visualization method and test strips.

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一种基于离散各向异性辐射传输模型的光线追踪算法

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西北林学院学报 2025年第1期40卷 1-10页

作者：钱文陆鑫云挺朱正礼南京林业大学信息科学技术学、人工智能学院江苏南京210037 南京林业大学林草学院、水土保持学院江苏南京210037

光合有效辐射是作物生产力模型、陆地生态系统模型和生物地化模型的一个重要参量,研究光合有效辐射对植物生长有重要意义。在如今,不同类型的模型可以模拟树林的激光雷达波形,即使用计算机模型来生成再树林中使用激光雷达时可观测到的波... 详细信息

光合有效辐射是作物生产力模型、陆地生态系统模型和生物地化模型的一个重要参量,研究光合有效辐射对植物生长有重要意义。在如今,不同类型的模型可以模拟树林的激光雷达波形,即使用计算机模型来生成再树林中使用激光雷达时可观测到的波形,而半经验模型和几何模型精确度不够高。蒙特卡洛射线追踪(MCRT)模型虽有较高的精确度,但对计算需求很高。本研究提出了一种新的LiDAR光线追踪模型,基于在离散各向异性辐射传输(DART)模型中引入准蒙特卡洛射线跟踪方法。以实现了“盒方法”和“射线卡罗方法”这2种新方法的结合。在离散辐射传输中,加入模拟光子对光能的微小样本进行模拟;将俄罗斯轮盘赌思想加入蒙特卡洛射线追踪中,以便在达到精度要求的同时减少大量的计算需求;同时对场景模型进行网格化剖分,更加准确地对光线进行追踪。结果表明,6月中旬至7月期间,地表太阳辐射估计值与实际测量值的平均相对误差为3.8%~4.2%,光合有效辐射的估计值与实际测量值的平均相对误差为3.5%~3.9%,估算效果较好,其精确度相较于传统的蒙特卡洛算法提高了1.6%。对比实际测量与该算法模拟的拦截效率,得出误差率在1.66%~2.72%,精确度较高。试验结果对于研究植物生理过程具有重要意义。

关键词：光合有效辐射盒方法射线卡罗方法射线追踪蒙特卡洛

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1例心脏射频消融术后并发冠状动脉痉挛患者急救致阴囊血肿的护理

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中华护理杂志 2025年第2期60卷 158-161页

作者：陆柯盈秦彩萍钱慧丽珠宋月霞江苏省常州市第一人民医院心血管内科 213003

总结1例心脏射频消融术后短时间内反复发生冠状动脉痉挛的患者抢救过程中致阴囊血肿的护理经验。护理要点:心脏射频消融术后并发冠状动脉痉挛的识别与急救护理;加强心理护理,针对性指导戒烟管理;实施中西医结合的阴囊血肿护理方案;做好... 详细信息

总结1例心脏射频消融术后短时间内反复发生冠状动脉痉挛的患者抢救过程中致阴囊血肿的护理经验。护理要点:心脏射频消融术后并发冠状动脉痉挛的识别与急救护理;加强心理护理,针对性指导戒烟管理;实施中西医结合的阴囊血肿护理方案;做好个体化随访及延续性康复护理。经过27 d的精心治疗和护理,患者左心室射血分数由术前39%恢复至术后57%,顺利出院。出院后进行延续性康复护理,1个月后,阴囊血肿明显消退。

关键词：心脏射频消融术冠脉痉挛阴囊血肿康复护理

载抗结核兼促成骨缓释微球药物在脊柱结核治疗中的研究进展

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遵义医科大学学报 2025年第2期48卷 193-201页

作者：李贵杜迁曹广如遵义医科大学第二附属医院脊柱外科贵州遵义563006

抗结核药物浓度对于脊柱结核的治疗至关重要,而脊柱结核常造成椎间盘及椎体损害,病灶内骨坏死阻碍抗结核药物的有效分布。传统的脊柱结核治疗中,药物并不能直接到达病灶,局部药物浓度不足易导致结核治疗失败、耐药及复发等问题。载药缓... 详细信息

抗结核药物浓度对于脊柱结核的治疗至关重要,而脊柱结核常造成椎间盘及椎体损害,病灶内骨坏死阻碍抗结核药物的有效分布。传统的脊柱结核治疗中,药物并不能直接到达病灶,局部药物浓度不足易导致结核治疗失败、耐药及复发等问题。载药缓释微球可经局部给药方式直接作用于病灶,解决局部药物浓度不足的问题,且能维持药物长期释放。但存在给药创伤较大、过程复杂及药物释放稳定性不可控的缺点。温敏材料的应用有望弥补这些不足。在缓释微球中加入促成骨药物可同时治疗骨缺损及骨坏死,甚至可诱导退化椎间盘再生。本文旨在对现有脊柱结核治疗中兼具负载抗结核及促成骨药物方案、常用缓释微球载体材料及制备方法进行分析总结,批判性分析各种载药模式及载体材料的优缺点,并指出目前实验进展。本文还介绍了温敏材料在优化给药过程及稳定控释等诸多优势,强化了对抗菌治疗同时治疗骨缺损及椎间盘病变的脊柱结核治疗理念。为进一步实验的载药体系及载体材料选择提供方向,以期在今后的脊柱结核尤其是耐药结核治疗中提供新的给药方式。

关键词：抗结核药物骨再生微球机敏材料结核脊柱

Plastic tube-assisted gastroscopic removal of embedded esophageal metal stents: A case report

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World Journal of Gastroenterology 2013年第38期19卷 6505-6508页

作者： gui-Yong Peng Xiu-Feng Kang Xin lu Lei Chen qian Zhou Department of Gastroenterology of Southwest Hospital The Third Military Medical University

A patient with stent embedding after placement of an esophageal stent for an esophagobronchial fistula was treated with an ST-E plastic tube inserted into the esophagus to the upper end of the stent using *** gastroscope was guided into the esophagus through the ST-E tube,and an alligator forceps was inserted into the esophagus through the ST-E tube alongside the *** gastroscopy,the stent wire was grasped with the forceps and pulled into the ST-E *** resistance was met during withdrawal,the gastroscope was guided further to the esophageal section where the stent was *** forceps were guided through a biopsy hole in the gastroscope to the embedded stent to remove silicone membranes and connection threads linking the Z-shaped wire *** the lower section of the Z-shaped stent was fixed by the biopsy forceps,the alligator forceps were used to pull the upper section of the metal wire until the Z-shaped metal loops *** wire mesh of the stent was then removed in stages through the ST-E *** was taken to avoid bleeding and *** the assistance of an ST-E plastic tube,an embedded esophageal metal stent was successfully removed with no bleeding or *** patient experienced an uneventful recovery after *** tube-assisted gastroscopic removal of embedded metal stents can be minimally invasive,safe,and effective.

关键词： Esophagus Stents Gastroscope Complication

Study on the efficacy and mechanism of dragon-tiger fight needling method in treating lumbar disc herniation

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Journal of Acupuncture and Tuina Science 2025年第1期23卷 73-81页

作者： WU Jun WANG Daoming gui Lin lu’an People’s Hospital of Anhui Province Lu’an 237008China

Objective:To observe the analgesic effect and therapeutic mechanism of the dragon-tiger fight needling method in treating lumbar disc herniation(LDH).Methods:A total of 100 patients with LDH were selected and randomly divided into an observation group and a control group,with 50 patients in each *** groups received the same basic treatment of Western *** observation group received additional acupuncture treatment using the dragon-tiger fight needling method,administered once every other day for a consecutive *** and after treatment,the serum levels of bradykinin(BK),soluble tumor necrosis factor type 1 receptor(sTNF-R1),α1-acid glycoprotein(α1-AGP),phospholipase A2(PLA2),methionine enkephalin(M-ENK),β-endorphin(β-EP),and 6-keto prostaglandin E1α(6-keto-PGE1α)were measured in both ***,the sensory conduction velocities(SCV)of the sural nerve and superficial peroneal nerve,as well as the biomechanical indicators of lumbar muscles(including the lumbar flexion-extension ratio and peak torque and average power in the lumbar extension position)were *** Oswestry disability index(ODI)was evaluated,and traditional Chinese medicine(TCM)symptoms were scored for patients in both *** treatment,the clinical efficacy of the two groups was ***:After treatment,the serum levels ofα1-AGP and PLA2 in both groups decreased compared to their respective pre-treatment levels(P<0.05),and the levels in the observation group were lower than those in the control group(P<0.05).The serum levels of sTNF-R1 in both groups increased compared to their respective pre-treatment levels(P<0.05),and the levels in the observation group were higher than those in the control group(P<0.05).The serum levels of 6-keto-PGE1αand BK in both groups decreased significantly compared to their respective pre-treatment levels(P<0.05),and the levels in the observation group were lower than those in the control group(P<0.05).The serum levels of M-ENK

关键词： Acupuncture Therapy Dragon-tiger Fighting Needling Technique Low Back Pain lumbar Disc Herniation Acupuncture Analgesia Pain Measurement

基于压力分布的办公坐姿疲劳状态识别的研究与应用

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包装工程 2025年第4期46卷 183-190页

作者：卢纯福钱佳蕊王英豪浙江工业大学杭州310023

目的对使用电脑办公的久坐工作者腰背部疲劳状态的监测方法进行研究,并对久坐疲劳监测提出疲劳监测分类模型和产品设计应用。方法基于“以人为本”的设计理念,运用实验法展开人机实验,实验中采集使用电脑办公的久坐工作者的座面臀部体... 详细信息

目的对使用电脑办公的久坐工作者腰背部疲劳状态的监测方法进行研究,并对久坐疲劳监测提出疲劳监测分类模型和产品设计应用。方法基于“以人为本”的设计理念,运用实验法展开人机实验,实验中采集使用电脑办公的久坐工作者的座面臀部体压信号和主观疲劳的Borg值,进而对所采集的主、客观数据进行深入分析,并对工作者的疲劳进行评估。结果在使用电脑办公的工作者中,坐压压力数据的总和(RS)与主观疲劳度呈现负相关,坐压压力中心运动速度(TPV)、直线运动距离(SLD)与主观疲劳度呈现正相关,以上压力中心运动轨迹特征值(RS、TPV、SLD)均与主观疲劳的Borg值现出显著的相关性(P<0.01)。结论验证了主观疲劳感知与压力中心运动轨迹特征值之间存在显著的相关性,特别是臀部压力数据的总和与压力中心运动速度。本文提出了一种基于臀部体压特征的可识别久坐疲劳状态的模型,进而提出将主观评价标准和体压特征融入久坐疲劳监测的设计应用。

关键词：疲劳监测体压分布产品设计办公久坐

Role of EGFL7/EGFR-signaling pathway in migration and invasion of growth hormone-producing pituitary adenomas

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Science China(Life Sciences) 2018年第8期61卷 893-901页

作者： qian Liu Junwen Zhang Hua Gao Taoyang Yuan Jie Kang lu Jin Songbai gui Yazhuo Zhang Beijing Neurosurgical Institute Capital Medical University Key Laboratory of Central Nervous System Injury Research Beijing Institute for Brain Disorders Brain Tumor Center China National Clinical Research Center for Neurological Diseases Capital Medical University Beijing Tiantan Hospital Capital Medical University

Currently, the primary therapeutic strategy for most growth hormone-producing pituitary adenomas （GHPA） is surgery. Due to the invasiveness of GHPA, high recurrence has limited the benefit of complete adenoma removal surgery. Epidermal growth factor-like domain 7 （EGFL7） is a secreted factor implicated in tumor angiogenesis, growth, invasiveness and metastasis in GHPA. Herein, we observed that the expression level of EGFL7 and p-EGFR in invasive GHPA was much higher than that ofnon-invasive GHPA. The overexpression of EGFL7 was positively correlated with activation of EGFR （p-EGFR）. Noticeably, EGFL7 knockdown sig- nificantly inhibited activation of EGFR signaling cascades, including p-ERGR, p-AKT and p-ERK. Further studies showed that EGFL7 knockdown or pharmacological inhibition of EGFR-pathway, using EGFR inhibitor Tyrphostin AG-1478, significantly suppressed migration and invasion of GH3 and GTI-1 cells. In summary, our findings suggest that EGFL7 is a key factor for regulation of EGFR signaling pathway and plays an important role in migration and invasion of invasive GHPA.

关键词： EGFL7 EGFR growth hormone-producing pituitary adenomas (GHPA) invasion tumorigenesis

Differentiation of Four Pairs of Isomers by Comparing Their Relative Abundances of Fragment Ions

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Chemical Research in Chinese Universities 2010年第1期26卷 27-32页

作者： SUN Ming-qian lu Jian-qiu ZHANG Hong-gui ZHANG Qun-shu XIAO Nan Rui-yun School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing 100102 P R. China Developing Center of Science and Technique Beijing University of Chinese Medicine BeoTng 100029 P. R. China Pharmaceutical University of Shenyang Shenyang 110016 P R. China

Based on the LC-ESI/MSn technique, the four pairs of isomers of psoralen and isopsoralen, imperatorin and isoimperatorin, neohesperidin and hesperidin, naringin and narirutin were distinguished mainly by comparison of the relative abundances of their major fragment ions. Because of the effect of the hydrogen on the C8 of psoralen, the intensity of the fragment ion formed by the loss of CO2 was relatively increased. By comparing the abundance of the product ions formed by the loss of CO and 2CO, the isomers of psoralen and isopsoralen could be distinguished. This method can also be used to distinguish the isomers of imperatorin and isoimperatorin. Because of the different con- nected position between glucose and rhamnose, in the mass spectrum of neohesperidin, the relative abundances of ions at m/z 489 and 343 generated by the ring-cross cleavage of glycan were more than 10%, while in the mass spec- trum of hesperidin, they were all less than 1%. This approach can also be used to distinguish the isomers ofnaringin and narirutin. Although the fragmentation pathways were similar, according to the tiny difference of structure, the change of relative intensity of main fragment ions could be observed and it could be used to distinguish some isomers more accurately and quickly.

关键词： LC-MSn Relative abundance Isomer Product ion Generation opportunity