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Preparation and Antibacterial Activity of Copolymer of Methacryloxyethyldimethyl Dodecyl Ammonium Bromide/Acrylamide

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Chemical Research in Chinese Universities 2012年第6期28卷 1095-1100页

作者： lu gui-qian ZUO Hua-jiang DONG Wei-min WU Ding-cai FU Ruo-wen Key Laboratory for Polymeric Composite and Functiond Materials Ministry of Education Design and Synthesis of New Polymer Materials and Application Laboratory School of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou 510275 P. R. China

Copolymers PMDAB-co-AA with excellent antibacterial activity were designed and prepared（MDAB/AA=methacryloxyethyldimethyl dodecyl ammonium bromide with acrylamide）.The chemical structures of the copolymers were characterized by Fourier transform infrared（FTIR）,1 H NMR,13 C NMR and chemical *** antimicrobial activities and kinetics of the copolymer against *** and *** were examined by viable cell counting *** compositions of the copolymers could be easily controlled by the feed molar ratio of MDAB to ***,the highest antibacterial activity was achieved when the molar fraction of MDAB was in a range of 5%―20%,and the killing rate reached 100% under the test *** addition,the antibacterial activity of PMDAB-co-AA was maintained and stable without any loss after 15 times of repeated *** was proved that the PMDAB-co-AA samples targeted at cell membrane,and caused serious damage to cell integrity and inner membrane *** surrounding conditions,such as pH and inorgainc salts concentrations（CaCl2 or NaCl）,also affected their antibacterial activities.

关键词： Dimethylaminoethyl methacrylate Acrylamide Quaternary ammonium salt Antibacterial activity

Construction of the porcine genome mobile element variations and investigation of its role in population diversity and gene expression

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Journal of Animal Science and Biotechnology 2025年第1期16卷 59-75页

作者： Jianchao Hu lu gui Zhongzi Wu lusheng Huang National Key Laboratory for Swine Genetic Improvement and Germplasm Innovation Ministry of Science and Technology of ChinaJiangxi Agricultural UniversityNanchangPeople’s Republic of China

Background Mobile element variants(MEVs)have a significant and complex impact on genomic diversity and phe-notypic ***,the quantity,distribution,and relationship with gene expression and complex traits of MEVs in the pig genome remain poorly *** We constructed the most comprehensive porcine MEV library based on high-depth whole genome sequencing(WGS)data from 747 pigs across 59 breeds *** database identified a total of 147,993 poly-morphic MEVs,including 121,099 short interspersed nuclear elements(SINEs),26,053 long interspersed nuclear elements(LINEs),802 long terminal repeats(LTRs),and 39 other transposons,among which 54%are newly *** found that MEVs are unevenly distributed across the genome and are strongly influenced by negative selec-tion ***,we identified 514,530,and 584 candidate MEVs associated with population differentiation,domestication,and breed formation,*** example,a significantly differentiated MEV is located in the ATRX intron between Asian and European pigs,whereas ATRX is also differentially expressed between Asian and European pigs in muscle *** addition,we identified 4,169 expressed MEVs(eMEVs)significantly associated with gene expression and 6,914 splicing MEVs(sMEVs)associated with gene splicing based on RNA-seq data from 266 porcine liver *** eMEVs and sMEVs explain 6.24%and 9.47%,respectively,of the observed cis-heritability and high-light the important role of MEVs in the regulation of gene ***,we provide a high-quality SNP–MEV reference haplotype panel to impute MEV genotypes from genome-wide ***,we identified a candidate MEV significantly associated with total teat number,demonstrating the functionality of this reference *** The present investigation demonstrated the importance of MEVs in pigs in terms of population diversity,gene expression and phenotypic traits,which may provide useful resources and theoretic

关键词： Gene expression Genetic diversity Mobile element variants Pig SNP–MEV reference panel

Predicting the efficiency of arsenic immobilization in soils by biochar using machine learning

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Journal of Environmental Sciences 2025年第1期147卷 259-267页

作者： Jin-Man Cao Yu-qian Liu Yan-Qing Liu Shu-Dan Xue Hai-Hong Xiong Chong-Lin Xu Qi Xu gui-Lan Duan State Key Lab of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450052China University of Chinese Academy of Sciences Beijing 100049China

Arsenic(As)pollution in soils is a pervasive environmental *** immobilization offers a promising solution for addressing soil As *** efficiency of biochar in immobilizing As in soils primarily hinges on the characteristics of both the soil and the ***,the influence of a specific property on As immobilization varies among different studies,and the development and application of arsenic passivation materials based on biochar often rely on empirical *** enhance immobilization efficiency and reduce labor and time costs,a machine learning(ML)model was employed to predict As immobilization efficiency before biochar *** this study,we collected a dataset comprising 182 data points on As immobilization efficiency from 17 publications to construct three ML *** results demonstrated that the random forest(RF)model outperformed gradient boost regression tree and support vector regression models in predictive *** importance analysis and partial dependence plots based on the RF model were conducted to identify the most crucial factors influencing As *** findings highlighted the significant roles of biochar application time and biochar pH in As immobilization efficiency in ***,the study revealed that Fe-modified biochar exhibited a substantial improvement in As *** insights can facilitate targeted biochar property design and optimization of biochar application conditions to enhance As immobilization efficiency.

关键词： Biochar Arsenic immobilization Soil Machine learning

Long non-coding RNAs as promising targets for controlling disease vector mosquitoes

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INSECT SCIENCE 2025年第1期32卷 24-41页

作者： Han, Yujiao Pu, qian Fan, Ting Wei, Tianqi Xu, Yankun Zhao, lu Liu, Shiping Southwest Univ State Key Lab Resource Insects Chongqing 400716 Peoples R China

Hematophagous female mosquitoes are important vectors of numerous devastating human diseases, posing a major public health threat. Effective prevention and control of mosquito-borne diseases rely considerably on progress in understanding the molecular mechanisms of various life activities, and accordingly, the molecules that regulate the various life activities of mosquitoes are potential targets for implementing future vector control strategies. Many long non-coding RNAs (lncRNAs) have been identified in mosquitoes and significant progress has been made in determining their functions. Here, we present a comprehensive overview of the research advances on mosquito lncRNAs, including their molecular identification, function, and interaction with other non-coding RNAs, as well as their synergistic regulatory roles in mosquito life activities. We also highlight the potential roles of competitive endogenous RNAs in mosquito growth and development, as well as in insecticide resistance and virus-host interactions. Insights into the biological functions and mechanisms of lncRNAs in mosquito life activities, viral replication, pathogenesis, and transmission will contribute to the development of novel drugs and safe vaccines. Thousands of long non-coding RNA (lncRNAs) have been identified from different species of mosquitoes based on high-throughput transcriptome sequencing. Here we present a comprehensive overview of the research advances on mosquito lncRNAs, including their molecular identification, function, and interaction with other non-coding RNAs, as well as the potential mechanisms by which they regulate various mosquito life activities. image

关键词： competitive endogenous RNAs (ceRNAs) insecticide resistance long non-coding RNA (lncRNA) mosquito mosquito-borne diseases pathogen-host interaction

Let-7 microRNA targets BmCentrin to modulate the development and functionality of the middle silk gland in the silkworm, Bombyx mori

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INSECT SCIENCE 2025年第1期32卷 95-114页

作者： Xu, Yankun Du, Na Xu, Lili Zhao, lu Fan, Ting Wei, Tianqi Pu, qian Liu, Shiping Southwest Univ State Key Lab Resource Insects Chongqing 400716 Peoples R China

The silk gland of the silkworm Bombyx mori serves as a valuable model for investigating the morphological structure and physiological functions of organs. Previous studies have demonstrated the notable regulatory role of let-7 microRNA in the silk gland, but its specific molecular mechanism remains to be elucidated across different segments of this organ. In this study, we further investigated the functional mechanism of let-7 in the middle silk gland (MSG). The MSG of a let-7 knockout strain was analyzed using a combined proteomic and metabolomic technique, revealing the enrichment of differential proteins and metabolites in the DNA synthesis and energy metabolism pathways. BmCentrin was identified as a novel target gene of let-7 in the MSG, and its downregulation inhibited the proliferation of BmN4-SID1 cells, which is exactly opposite to the role of let-7 in these cells. CRISPR/Cas9 genome editing and transgenic technologies were employed to manipulate BmCentrin in the MSG. Knockout of BmCentrin led to severe MSG atrophy, whereas the overexpression of BmCentrin resulted in beaded MSG. Further measurements of these knockout or overexpression strains revealed significant changes in the expression levels of sericin protein genes, the weight of the cocoon and the mechanical properties of the silk. Investigating the biological role of BmCentrin in the silk gland offers valuable insights for elucidating the molecular mechanisms by which let-7 controls silk gland development and silk protein synthesis in the silkworm.

关键词： BmCentrin Bombyx mori CRISPR/Cas9 genome editing let-7 microRNA middle silk gland transgenic overexpression

I_(2)-DMSO mediated tetra-functionalization of enaminones for the construction of novel furo[2,3:4,5]pyrimido[1,2-b]indazole skeletons via in situ capture of ketenimine cations

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Chinese Chemical Letters 2025年第1期36卷 277-282页

作者： You Zhou Li-Sheng Wang Shuang-gui Lei Bo-Cheng Tang Zhi-Cheng Yu Xing Li Yan-Dong Wu Kai-lu Zheng An-Xin Wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs The First Dongguan Affiliated HospitalSchool of PharmacyGuangdong Medical UniversityDongguan 523808China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China

The first-ever synthesis of the unknown furo[2,3:4,5]pyrimido[1,2-b]indazole skeleton was demonstrated based on the undiscovered tetra-functionalization of enaminones,with simple substrates and reaction *** key to realizing this process lies in the multiple trapping of the in situ generated ketenimine cation by the 3-aminoindazole,which results in the formation of four new chemical bonds and two new rings in one ***,the products of this new reaction were found to exhibit aggregationinduced emission(AIE)without modification.

关键词： Unknown skeleton Tetra-functionalization Ketenimine cations Aggregation-induced emission

Effects of fumigation and washing with Shujin Huoluo decoction combined with Duhuo Parasitic decoction on TIMP-1 and PON1 levels in KOA patients

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Journal of Hainan Medical University 2020年第22期26卷 14-18页

作者： Wei Zhou Hong-Bo Zheng Sui Feng qiang Liu gui-qian lu Orthop Edics Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhouGuangxi 545006China

Objective:To study the effect of fumigation and washing with Shujin Huoluo Decoction combined with Duhuo Parasitic Decoction on Metalloproteinase inhibitor-1(TIMP-1)and Oxyphosphatase 1,PON1)***:A total of 100 KOA patients,59 males and 41 females,were selected for diagnosis and treatment in our hospital from November 2018 to November *** patients were divided into the control group and the combined group with 50 patients each according to a completely random *** control group was treated with Duhuo Parasitic Decoction and the combined group was treated with Duhuo Parasitic Decoction and Shujinhuoluo *** of TIMP-1,PON1,Matrix metalloproteinase-3(MMP-3),C-reactive protease(CRP),Tumor necrosis factor-alpha(TNF-α)and Superoxide dismutase(SOD)*** score,Lysholm score,and VAS score were ***:The levels of TIMP-1 and PON1 in the combined group were higher than those in the control group after treatment,and the levels of MMP-3 were lower than those in control group(Plusion:The combination of fumigation and washing with Shujin Huoluo Decoction and Duhuo Parasitic Decoction has a significant effect on the treatment of KOA *** improves the levels of TIMP-1 and PON1,improves the knee function of patients and pain.

关键词： Shujin Huoluo decoction fumigation and washing Duhuo Parasitic decoction addition and subtraction Knee osteoarthritis Metalloproteinase inhibitor-1

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新型季铵盐的杀菌活性研究

日用化学工业 2009年第1期39卷 25-28页

作者：鹿桂乾张利萍符若文广州立白企业集团有限公司研发中心广东广州510370 中山大学化学与化学工程学院材料科学研究所广东广州510275

对4种新型季铵盐甲基丙烯酰氧乙基二甲基苄基氯化铵(DMAEMA-BC)、甲基丙烯酰氧乙基二甲基丁基溴化铵(DMAEMA-BB)、甲基丙烯酰氧乙基二甲基十二烷基溴化铵(DMAEMA-DB)和甲基丙烯酰氧乙基二甲基十六烷基溴化铵(DMAEMA-HB),采用最小杀菌浓... 详细信息

对4种新型季铵盐甲基丙烯酰氧乙基二甲基苄基氯化铵(DMAEMA-BC)、甲基丙烯酰氧乙基二甲基丁基溴化铵(DMAEMA-BB)、甲基丙烯酰氧乙基二甲基十二烷基溴化铵(DMAEMA-DB)和甲基丙烯酰氧乙基二甲基十六烷基溴化铵(DMAEMA-HB),采用最小杀菌浓度(MBC)法和抑菌圈直径法对大肠杆菌和金黄色葡萄球菌的杀菌活性分别进行了表征。MBC法研究结果发现,DMAEMA-HB和DMAEMA-DB的MBC值为12μg/mL^24μg/mL,但DMAEMA-BC和DMAEMA-BB的MBC值大于50 000μg/mL,其杀菌活性大小顺序为:DMAEMA-HB≥DMAEMA-DB>DMAEMA-BC≥DMAEMA-BB。通过抑菌圈直径法测定4种季铵盐的杀菌活性,顺序为:DMAEMA-DB>DMAEMA-BC>DMAEMA-HB>DMAEMA-BB。造成两种方法测试结果差异主要是因为通过抑菌圈直径法测定的杀菌活性,不仅与季铵盐的结构有关,还与季铵盐在琼脂上的扩散能力有关。

关键词：季铵盐甲基丙烯酸二甲氨基乙酯杀菌活性

Five-user quantum virtual local area network with an AlGaAs entangled photon source

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Science China(Physics,Mechanics & Astronomy) 2025年第3期Mechanics & Astronomy) .卷 65-77页

作者： Cheng qian Hongkai Tian Xu Jing Yichen Liu Zhe Chen Huiran luo Yuan Du Xiaodong Zheng Tangsheng Chen Yuechan Kong Hua-Lei Yin Dong Jiang Bin Niu Liangliang lu Key Laboratory of State Manipulation and Advanced Materials in Provincial Universities School of Physical Science and TechnologyNanjing Normal University School of Internet Anhui University National Key Laboratory of Solid-State Microwave Devices and Circuits Nanjing Chip Valley Industrial Technology InstituteNanjing Electronic Devices Institute Research Center for Quantum Optics and Quantum Communication School of Science Qingdao University of Technology Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Key Laboratory of Quantum State Construction and Manipulation (Ministry of Education) Renmin University of China Beijing Academy of Quantum Information Sciences National Engineering Research Center of Agro-Ecological Big Data Analysis and Application Anhui University National Laboratory of Solid-State Microstructures and School of Physics Nanjing University Hefei National Laboratory

The promotion of quantum network applications demands the scalable connection of quantum resources. It is preferable to set up multiple logical networks coexisting on a single physical network infrastructure to accommodate a larger number of *** we present a quantum virtual network architecture that offers this level of scalability, without being constrained to a fixed physical-layer network relying solely on passive multiplexing components. The architecture can be understood as arising from the superposition of a fully connected entanglement distribution network and port-based virtual local area network, which group multiusers by access ports. In terms of hardware, we leverage a semiconductor chip with a high figure-of-merit modal overlap to directly generate high-quality polarization entanglement, and a streamlined polarization analysis module, which requires only one single-photon detector for each end user. We experimentally perform the BBM92 QKD protocol on the five-user quantum virtual network and demonstrate voice and image encryption on a campus area network. Our results may provide insights into the realization of large-scale quantum networks with integrated and cost-efficient photonic architecture.

关键词： quantum network quantum entanglement distribution integrated photonics image and voice encryption