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自体脂肪基质细胞组织-脱细胞骨基质-壳聚糖支架对兔胫骨骨缺损修复作用

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贵州医科大学学报 2020年第1期45卷 29-34页

作者：杨鹏邵擎东李宇飞严旭江峰吕峰霞韦苏中国人民解放军海军特色医学中心骨科上海200052 中国人民解放军海军特色医学中心整形外科上海200052

目的:探究自体脂肪基质细胞组织(SVF)联合脱细胞骨基质-壳聚糖支架修复兔胫骨缺损的效果。方法:取新西兰兔背部皮下脂肪制备获取SVF细胞、取股骨干制备获取脱细胞骨基质,将SVF细胞种植于脱细胞骨基质-壳聚糖支架上,于种植当日及种植第7... 详细信息

目的:探究自体脂肪基质细胞组织(SVF)联合脱细胞骨基质-壳聚糖支架修复兔胫骨缺损的效果。方法:取新西兰兔背部皮下脂肪制备获取SVF细胞、取股骨干制备获取脱细胞骨基质,将SVF细胞种植于脱细胞骨基质-壳聚糖支架上,于种植当日及种植第7天时,扫描电镜观察支架上SVF细胞生长情况,计算种植当日及种植第3天时的SVF细胞存活率;将20只兔胫骨缺损动物模型均分为研究组和对照组,研究组用SVF-脱细胞骨基质-壳聚糖支架修复,对照组用脱细胞骨基质-壳聚糖支架修复;于术后6及12周时检测2组胫骨缺损部位的骨密度,并进行X线拍照,于术后12周时检测2组骨缺损部位最大弯曲度负荷、抗弯钢度及破坏扰度的力学特征,检测缺损骨骨膜中血管内皮细胞生长因子(VEGF)和表皮生长因子(EGF)水平。结果:电镜结果显示,SVF细胞种植第7天,支架上黏附大量的SVF细胞,并且SVF细胞在支架表面上生长、增殖;SVF种植当日的SVF细胞存活率为100.0%,种植第3天SVF细胞的存活率为(98.54±1.83)%,2者比较差异无统计学意义(P>0.05);术后第6及12周时,研究组新西兰兔骨缺损处的支架材料和周围骨组织之间的界限模糊,周围骨组织有骨茄形成;2组新西兰兔术后第12周时骨缺损部位骨密度均高于同组术后第6周,研究组术后同时点的骨缺损部位骨密度均高于对照组,差异有统计学意义(P<0.05);术后第12周时,研究组新西兰兔最大弯曲度负荷和抗弯钢度大于对照组,破坏扰度低于对照组,差异有统计学意义(P<0.05);术后第12周时,研究组新西兰兔骨缺损部位骨膜中的VEGF和EGF蛋白水平均高于对照组,差异有统计学意义(P<0.05)。结论:SVF-脱细胞骨基质-壳聚糖支架可促进兔胫骨骨缺损修复,可能机制与SVF促进骨膜内的血管新生有关。

关键词： SVF细胞脱细胞骨基质壳聚糖兔胫骨缺损血管内皮细胞生长因子类表皮生长因子

基于弹流润滑及时变载荷分配模型的直齿轮效率研究

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机械制造与自动化 2018年第3期47卷 53-56,80页

作者：杨剑飞陆凤霞张沁薇刘伟平南京航空航天大学机电学院江苏南京210016

结合弹流摩擦系数模型及直齿轮的啮合特性,推导直齿轮齿面载荷的分布规律;结合啮合过程中齿面载荷、齿面摩擦力的时变性、单双齿啮合特性,对一个啮合周期内齿轮副的输入输出功耗进行积分,获得同时考虑弹流效应及时变载荷分配模型的直齿... 详细信息

结合弹流摩擦系数模型及直齿轮的啮合特性,推导直齿轮齿面载荷的分布规律;结合啮合过程中齿面载荷、齿面摩擦力的时变性、单双齿啮合特性,对一个啮合周期内齿轮副的输入输出功耗进行积分,获得同时考虑弹流效应及时变载荷分配模型的直齿轮啮合效率计算公式;建立基于Matlab的直齿轮效率数值分析模型,将仿真结果、ISO/TR 14179-1、ISO/TR 14179-2效率计算结果、试验数据进行对比分析。结果表明:基于弹流润滑及时变载荷分配模型的直齿轮效率计算方法与试验数据具有很好的一致性,且对效率预测的准确性好于标准ISO/TR14179-1、ISO/TR 14179-2。

关键词：直齿轮啮合效率弹流时变载荷分配

Relationship between Lightning Activity and Tropospheric Nitrogen Dioxide and the Estimation of Lightning-produced Nitrogen Oxides over China

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Advances in Atmospheric Sciences 2017年第2期34卷 235-245页

作者： fengxia GUO Xiaoyu JU Min BAO Ganyi lu Zupei LIU Yawen LI Yijun MU Key Laboratory of Meteorological Disaster Ministry of Education Joint International Research Laboratory of Climate and Environment Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disaster/Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological AdministrationNanjing University of Information Science and TechnologyNanjing 210044China Anhui Meteorological Disaster Prevention Center Anhui 230061China

To better understand the relationship between lightning activity and nitrogen oxides （NOx） in the troposphere and to estimate lightning-produced NOx （LNOx） production in China more precisely, spatial and temporal distributions of vertical column densities of tropospheric nitrogen dioxide （NO2 VCDs） and lightning activity were analyzed using satellite measure- ments. The results showed that the spatial distribution of lightning activity is greater in the east than in the west of China, as with NO2 VCDs. However, the seasonal and annual variation between lightning and NO2 density show different trends in the east and west. The central Tibetan Plateau is sparsely populated without modem industry, and NO2 VCDs across the plateau are barely affected by anthropogenic sources. The plateau is an ideal area to study LNOx. By analyzing 15 years of satellite data from that region, it was found that lightning density is in strong agreement with annual, spatial and seasonal variations of NO2 VCDs, with a correlation coefficient of 0.79 from the linear fit. Combining Beirle＇s method and the linear fit equation, LNOx production in the Chinese interior was determined to be 0.07 （0.02-0.27） TgN yr-1 for 1997-2012, within the range of 0.016-0.384 TgN yr-1 from previous estimates.

关键词： lightning tropospheric NO2 LNOx

Gap engineering of sandwich plasmonic gap nanostructures for boosting plasmon-enhanced electrocatalysis

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Nano Research 2023年第7期16卷 8961-8969页

作者： lu Cheng fengxia Wu Yu Tian Xiali Lv Fenghua Li Guobao Xu Hsien-Yi Hsu Yongjun Zhang Wenxin Niu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Yanshan Branch of Beijing Chemical Research Institute SinopecBeijing 102500China University of Science and Technology of China Hefei 230026Chin a 4 School of Energy and Environment Department of Materials Science and EngineeringCity University of Hong KongKowloon TongHong Kong 999077China Shenzhen Research Institute of City University of Hong Kong Shenzhen 518057China Key Laboratory of Functional Polymer Materials and State Key Laboratory of Medicinal Chemical Biology Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China

Plasmonic catalysis is emerging as a dynamic field in heterogeneous catalysis and holds great promise for the efficient utilization of solar *** to the development of plasmonic catalysis is the design of efficient plasmonic *** this report,plasmonic gap nanostructures(PGNs)on the basis of Au@poly(o-phenylenediamine)(POPD)@Pd sandwich nanostructures are synthesized as plasmonic nanocatalysts by an in-situ reduction synthetic strategy,which allows for the precise engineering of the POPD gap size between plasmonic Au and catalytic Pd *** introduction of conducting POPD nanogap in PGNs not only effectively enhances their light harvesting capability,but also provides an effective charge transfer channel for harnessing the photogenerated hot charge *** this respect,distinct gap-dependent performances in plasmon-enhanced electrocatalysis of ethanol oxidation reactions(EOR)are demonstrated with the PGN nanocatalysts and over 2.5 folds of enhancement can be achieved.A volcano plot is derived to describe the relationship between the catalytic activities and gap size of the PGN nanocatalysts,which is well explained by the interplay of their light harvesting and charge transport *** results highlight the importance of gap engineering in PGNs for plasmonic catalysis and offer the promise of developing efficient plasmonic nanocatalysts for other heterogeneous catalytic reactions.

关键词： plasmonic gap nanostructures electrocatalysis ethanol oxidation reactions light harvesting charge transport

西地那非联合波生坦治疗儿童先心病合并肺动脉高压的临床研究

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南京医科大学学报（自然科学版） 2017年第7期37卷 861-864,868页

作者：孔祥萦陆凤霞周洁顾群张永生黄琼沈沉孟亚玲金珉陈斌顾海涛南京医科大学第一附属医院小儿胸心外科江苏南京210029

目的 :评估西地那非联合波生坦治疗儿童先天性心脏病(congentinal heart disease,CHD)手术前后合并肺动脉高压(pulmonary arterial hypertension,PAH)的临床疗效及安全性。方法 :选取有服药指征的CHD合并PAH患儿共50例,随机分为A组和B... 详细信息

目的 :评估西地那非联合波生坦治疗儿童先天性心脏病(congentinal heart disease,CHD)手术前后合并肺动脉高压(pulmonary arterial hypertension,PAH)的临床疗效及安全性。方法 :选取有服药指征的CHD合并PAH患儿共50例,随机分为A组和B组,A组患儿给予西地那非治疗,B组患儿口服西地那非联合波生坦。用药后定期随访,评估两组治疗前后临床效果、药物不良反应及并发症等。结果:A组共30例,男17例,女13例。B组共20例,男8例,女12例。(1)A、B两组治疗前后心功能均得到明显改善,B组心功能分级改善程度优于A组(P0.05),所有患儿均良好耐受,未出现明显不良反应及并发症。结论:西地那非能够降低儿童CHD手术前后合并PAH的肺动脉压力,而西地那非联合波生坦片治疗儿童CHD术后PAH疗效更显著,且具有较好的安全性。

关键词：先天性心脏病肺动脉高压西地那非波生坦儿童

Hexagonal boron nitride:A metal-free catalyst for deep oxidative desulfurization of fuel oils

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Green Energy & Environment 2020年第2期5卷 166-172页

作者： Peiwen Wu Linjie lu Jing He Linlin Chen Yanhong Chao Minqiang He fengxia Zhu Xiaozhong Chu Huaming Li Wenshuai Zhu School of Chemistry and Chemical Engineering Insitute for Energy ResearchJiangsu UniversityZhenjiang212013China School of the Environment and Safety Engineering Jiangsu University212013China School of Chemistry and Chemical Engineering Huaiyin Normal UniversityHuaian223300China

Oxidative desulfurization(ODS)has been proved to be an efficient strategy for the production of clean fuel *** metal-based materials have been employed as excellent ODS catalysts,but being hindered by their high-cost and potential secondary *** this work,we employed graphene analogous hexagonal boron nitride(h-BN)as a metal-free catalyst for ODS with hydrogen peroxide(H2O2)as the *** h-BN catalyst was characterized and proved to be a few-layered structure with relatively high specific surface *** h-BN catalyst showed a 99.4%of sulfur removal in fuel oil under the optimized reaction ***,the h-BN can be recycled for 8 times without significant decrease in the catalytic *** mechanism analysis found that it is the boron radicals in h-BN activated H2O2 to generate·OH species,which can readily oxidize sulfides to corresponding sulfones for *** work would provide another choice in choosing metal-free catalysts for ODS.

关键词： Boron nitride Metal-free Oxidation Deep desulfurization Fuel oils

Earthquake geochemical scientific expedition and research

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Earthquake Research Advances 2023年第4期3卷 58-64页

作者： Chang lu Xiaocheng Zhou Zhi Chen Zhaofei Liu Le Hu fengxia Sun Giovanni Martinelli Ying Li Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake AdministrationBeijing100036China State Key Laboratory of Geological Processes and Mineral Resources School of Earth Science and ResourcesChina University of Geosciences(Beijing)Beijing100083China INGV-National Institute of Geophysics and Volcanology Dept.of Palermo Palermo90146Italy

Large earthquakes can cause both casualties and economic losses, but they also provide invaluable opportunities for earthquake scientific research. Geofluids, due to their wide distribution, sensitive response to underground conditions, and ease of observation, are widely applied in field investigations after earthquakes. Analyzing the origin of fluids, energy transfer processes, temperature/pressure conditions, and the spatial-temporal evolution of geofluids can provide valuable information concerning the mechanism of earthquake precursor anomalies, shortterm prediction methods, identification of the seismogenic faults, determination of earthquake risk, and the environmental impact of post-earthquake fluids. This article details post-earthquake scientific expeditions and research on fluid geochemistry in China and abroad, aimed at providing ideas and guidance for future scientific expedition work and geochemistry-related earthquake studies.

关键词： Geofluids Geochemistry Earthquake investigation

Evaluation of abundant hydrocarbon-generation depressions in the deepwater area of Qiongdongnan Basin,South China Sea

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Acta Oceanologica Sinica 2016年第2期35卷 137-144页

作者： LIU Zhen SUN Zhipeng WANG Zisong ZHANG Wei LI Tingan HE Weijun LI fengxia CAO Shang LIU Jingjing LIN lu Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum Beijing 102249 China Zhanjiang Branch of China National Offshore Oil Corporation (CNOOC) Limited Zhanjiang 524057 China Petro China Jidong Oilfield Company Tangshan 063000 China Research Institute of Yanchang Petroleum Group Xi'an 710075 China Shenzhen Branch of China National Offshore Oil Corporation (CNOOC) Limited Guangzhou 510240 China

It has been confirmed that the key source rocks of Qiongdongnan Basin are associated with the Yacheng Formation, which was deposited in a transitional marine-continental environment. Because the distribution and evolution patterns of the source rocks in the major depressions are different, it is important to determine the most abundant hydrocarbon-generation depressions in terms of exploration effectiveness. Based on an analysis of organic matter characteristics of the source rocks, in combination with drilling data and seismic data, this paper establishes a model to evaluate the hydrocarbon-generation depressions in the deepwater area of Qiongdongnan Basin. First of all, by using the method of seismic-facies model analysis, the distribution of sedimentary facies was determined. Then, the sedimentary facies were correlated with the organic facies, and the distribution of organic facies was predicted. Meanwhile, the thickness of source rocks for all the depressions was calculated on the basis of a quantitative analysis of seismic velocity and lithology. The relationship between mudstone porosity and vitrinite reflectance（Ro） was used to predict the maturity of source rocks. Second, using the parameters such as thickness and maturity of source rocks, the quantity and intensity of gas generation for Yacheng and Lingshui Formations were calculated. Finally, in combination with the identified hydrocarbon resources, the quantity and intensity of gas generation were used as a guide to establish an evaluation standard for hydrocarbon-generation depressions, which was optimized for the main depressions in the Central Depression Belt. It is proposed that Lingshui, Ledong, Baodao and Changchang Depressions are the most abundant hydrocarbon depressions, whilst Songnan and Beijiao Depressions are rich hydrocarbon depressions. Such an evaluation procedure is beneficial to the next stage of exploration in the deep-water area of Qiongdongnan Basin.

关键词： comprehensive evaluation hydrocarbon-generation depressions source rocks deepwater area Qiongdongnan Basin

Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation

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Journal of Molecular Cell Biology 2016年第6期8卷 477-491页

作者： fengxia He Mengya Zhou Tianyi Yu Dan Zhao Jing Zhang Wen Qiu Yanlai lu Yu Liu lulu Wang Yingwei Wang Department of Immunology Nanjing Medical UniversityNanjing 210029China

The apoptosis of glomerular mesangial cells(GMCs)is considered to be an important contributor to the initiation and development of rat Thy-1 nephritis(Thy-1N)and is accompanied by sublytic C5b-9 ***,the mechanism by which sublytic C5b-9 triggers GMC apoptosis has not been *** this study,functional and histological examinations were performed on GMCs treated with sublytic C5b-9(in vitro)and renal tissues of Thy-1N rats(in vivo).The in vitro studies found that sublytic C5b-9 could trigger GMC apoptosis through upregulating Egr-1,ATF3,and Gadd45 ***-1-mediated post-transcriptional modulation of ATF3,Egr-1/ATF3-enhanced Gadd45 promoter activity,and p300-mediated ATF3 acetylation were all involved in GMC *** importantly,the effective binding elements for Egr-1 and ATF3 to Gadd45β/γpromoters and the ATF3 acetylation site were *** vivo,silencing renal p300,Egr-1,ATF3,and Gadd45β/γsignificantly decreased GMC apoptosis,secondary GMC proliferation,and urinary protein secretion in Thy-1N ***,these findings implicate that sublytic C5b-9-induced activation of Egr-1/p300–ATF3/Gadd45 axis plays a critical role in GMC apoptosis in Thy-1N rats.

关键词： glomerular mesangial cells sublytic C5b-9 Thy-1 nephritis transcription factor acetylation apoptosis